ZNF649 Gene
protein-coding GIFtS: 48
GCID: GC19M052392
|
|
zinc finger protein 649
| |
Aliases
for ZNF649 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 6491 2 | | FLJ126441 |
Export aliases for ZNF649 gene to outside databasesPrevious GC identifers: GC19M057085 GC19M048724 |
Summaries
for ZNF649 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN649_HUMAN, Q9BS31Function: Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1transcription activities mediated by growth factor signaling pathways
Gene Wiki entry for ZNF649
|
Genomic Views
for ZNF649 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF649 gene promoter:
c-Fos AP-1 ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF649
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF649 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.41ZNF649 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M052392: view genomic region
(about GC identifiers)
Start:
|
52,392,488 bp from pter |
End:
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52,408,305 bp from pter |
Size:
|
15,818 bases |
Orientation:
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minus strand |
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Proteins
for ZNF649 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN649_HUMAN, Q9BS31 (See
protein sequence)Recommended Name: Zinc finger protein 649 Size: 505 amino acids; 57683 Da
Subcellular location: Nucleus
Developmental stage: Expressed in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas
Secondary accessions: A8MYJ5 B2RDC4 Q9H9N2Explore the universe of human proteins at neXtProt for ZNF649: NX_Q9BS31
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BS31
ZNF649 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_075562.2
ENSEMBL proteins: ENSP00000347043 Reactome Protein details: Q9BS31
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IDA | -- |
ZNF649 for ontologies About GeneDecksing
ZNF649 Antibody Products:
Assay Products for ZNF649: |
Protein
Domains /
Families
for ZNF649 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF649 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BS31ProtoNet protein and cluster: Q9BS31 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN649_HUMAN, Q9BS31Domain: The KRAB domain is required for transcriptional repressionSimilarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 10 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF649 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN649_HUMAN, Q9BS31Function: Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1transcription activities mediated by growth factor signaling pathways
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF649
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF649
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF649 (NM_023074) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF649 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF649 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF649 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF649
ZNF649 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF649
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
4 Interacting proteins for ZNF649 (Q9BS313 ENSP000003470434) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF649 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF649 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF649
Search CenterWatch for drugs/clinical trials and news about ZNF649 / ZN649
|
Transcripts
for ZNF649 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF649 gene: NM_023074.3 Unigene Cluster for ZNF649: Zinc finger protein 649 Hs.148322 [show with all ESTs]Unigene Representative Sequence: NM_0230741 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000354957(uc002pxy.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF649
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF649
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF649 (NM_023074) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF649 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF649 |
Additional cDNA sequence: AF086241.1 AK000909.1 AK022706.1 AK225480.1 AK315487.1 AL713677.1 BC005368.1 5 DOTS entries: DT.438066 DT.91942447 DT.100754781 DT.121426767 DT.121426760 24/64 AceView cDNA sequences (see all 64): AI424306 BF725119 AK022706 H81971 BM678761 BM674864 AL713677 AU125298 BM678535 BM717588 CB145274 CR590368 AA862637 BM722022 BE504735 BX089598 AK000909 CD106294 NM_023074 AF086241 BM724141 AI588909 CF994209 BX954697
GeneLoc Exon Structure
6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF649 (see first 5) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b |
|---|
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| SP1: | | | | | - | | - | | - | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | | | - | | - | | | | - | | | | | | | | |
| SP3: | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP6: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF649
|
Expression
for ZNF649 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF649 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF649 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF649
SOURCE GeneReport for Unigene cluster: Hs.148322
UniProtKB/Swiss-Prot: ZN649_HUMAN, Q9BS31Tissue specificity: Highly expressed in heart, skeletal muscle, and brain. Lower expression in liver, lung, kidney,pancreas and placenta
SABiosciences Custom PCR Arrays for ZNF649
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF649
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF649 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF649 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF649 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF649 |
Orthologs
for ZNF649 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF649 gene from 1/5 species (see all 5) About this table
ENSEMBL Gene Tree for ZNF649 (if available)
TreeFam Gene Tree for ZNF649 (if available) |
Paralogs
for ZNF649 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF649 gene
- ZNF1752 ZNF6742 LOC1002875152 ZNF6142 ZNF4322 ZNF6132 ZNF262 ZNF3502
- ZNF812 ZNF6052 ZNF5772 ZNF842 ZNF6302 ZFP372 ZNF4842 ENSG000002296312
- ZNF1822 ZNF412 ZNF2682 LOC1009964642 ZNF6152 ZNF3002
18/441 SIMAP similar genes for ZNF649 using alignment to 6 protein entries: ZN649_HUMAN (see all proteins)
(see all similar genes):DKFZp313M0722 ZNF323 ZNF696 DKFZp666C237 ZNF232 ZNF397
ZNF267 ZNF835 zf30 DKFZp686G16228 GLI4 ZFS-1
ZNF316 ZNF432 ZNF501 ZNF502 ZNF544 ZNF623
ZNF649 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF649 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF649 (52392488 - 52408305 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for ZNF649
5 CNVs: 8875 4086 3195 34482 53103 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF649 |
|
Disorders
/ Diseases
for ZNF649 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF649 for disorders About MalaCards
ZNF649 for disorders About GeneDecksing
OMIM gene information: 611903
OMIM disorders: --
Export disorders for ZNF649 gene to outside databases
|
Publications
for ZNF649 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF649 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with ZNF649) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ZNF649, a novel Kruppel type zinc-finger protein, functions as a transcriptional suppressor. (PubMed id 15950191)1, 2, 3 Yang H.... Liu M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Maintenance of silent chromatin through replication r equires SWI/SNF-like chromatin remodeler SMARCAD1. (PubMed id 21549307)1 Rowbotham S.P....Mermoud J.E. (2011)
- Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S....Obuse C. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
|
External Searches for ZNF649 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF649 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF649 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF649 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF649 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF649 gene:
Search GeneIP for patents involving ZNF649
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF649 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | ZNF649 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF649 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF649 |
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