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ZNF649 Gene

protein-coding   GIFtS: 49
GCID: GC19M052392

Zinc Finger Protein 649

  Search for ZNF649
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 6491 2

External Ids:    HGNC: 257411   Entrez Gene: 652512   Ensembl: ENSG000001980937   OMIM: 6119035   UniProtKB: Q9BS313   

Export aliases for ZNF649 gene to outside databases

Previous GC identifers: GC19M057085 GC19M048724


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF649 Gene:
ZNF649 (zinc finger protein 649) is a protein-coding gene. An important paralog of this gene is ZNF175.

UniProtKB/Swiss-Prot: ZN649_HUMAN, Q9BS31
Function: Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1
transcription activities mediated by growth factor signaling pathways

Gene Wiki entry for ZNF649 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF649 gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF649 promoter sequence
   Search Chromatin IP Primers for ZNF649

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF649


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

ZNF649 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF649 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M052392:  view genomic region     (about GC identifiers)

Start:
52,392,477 bp from pter      End:
52,408,305 bp from pter
Size:
15,829 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN649_HUMAN, Q9BS31 (See protein sequence)
Recommended Name: Zinc finger protein 649  
Size: 505 amino acids; 57683 Da
Developmental stage: Expressed in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas
Secondary accessions: A8MYJ5 B2RDC4 Q9H9N2

Explore the universe of human proteins at neXtProt for ZNF649: NX_Q9BS31

Explore proteomics data for ZNF649 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF649 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_075562.2  
    ENSEMBL proteins: 
     ENSP00000347043   ENSP00000468983   ENSP00000471098   ENSP00000471756   ENSP00000469690  
    Reactome Protein details: Q9BS31

    ZNF649 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9BS31

    ProtoNet protein and cluster: Q9BS31

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN649_HUMAN, Q9BS31
    Domain: The KRAB domain is required for transcriptional repression
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF649 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN649_HUMAN, Q9BS31
    Function: Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1
    transcription activities mediated by growth factor signaling pathways

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0046872metal ion binding IEA--
         
    ZNF649 for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN649_HUMAN, Q9BS31: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--

    ZNF649 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF649 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF649
        Generic Transcription Pathway



    ZNF649 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF649
    Interactions:

        Search GeneGlobe Interaction Network for ZNF649

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5 Interacting proteins for ZNF649 (Q9BS311, 3 ENSP000003470434) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADAM15Q134443I2D: score=1 
    DVL3Q929973I2D: score=1 
    SUV39H1O434631EBI-4395789,EBI-349968
    CBX5ENSP000002098754STRING: ENSP00000209875
    SMARCAD1ENSP000003519474STRING: ENSP00000351947
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF649 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF649 (ZN649)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF649 gene: 
    NM_023074.3  

    Unigene Cluster for ZNF649:

    Zinc finger protein 649
    Hs.148322  [show with all ESTs]
    Unigene Representative Sequence: NM_023074
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354957(uc002pxy.3) ENST00000600738 ENST00000599671 ENST00000597882
    ENST00000595418 ENST00000599530 ENST00000596690
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    Additional mRNA sequence: 

    AF086241.1 AK000909.1 AK022706.1 AK225480.1 AK315487.1 AL713677.1 BC005368.1 

    5 DOTS entries:

    DT.438066  DT.91942447  DT.100754781  DT.121426767  DT.121426760 

    Selected AceView cDNA sequences (see all 64):

    AU125298 BM674864 BM678761 BE504735 CB145274 AI424306 BF725119 CD106294 
    BM717588 AK000909 AK022706 CR590368 NM_023074 AF086241 H81971 BM678535 
    BX089598 AA862637 AL713677 BM722022 BM460996 BQ720100 AU117319 BX954697 

    GeneLoc Exon Structure

    6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF649 (see first 5)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:              -     -     -           -     -                                 
    SP2:              -     -     -           -     -           -                     
    SP3:              -     -     -                                                   
    SP4:                    -     -           -     -                                 
    SP5:              -     -     -                                                   
    SP6:                                                                              


    ECgene alternative splicing isoforms for ZNF649

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF649 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF649 Expression
    About this image

    ZNF649 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF649 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.148322

    UniProtKB/Swiss-Prot: ZN649_HUMAN, Q9BS31
    Tissue specificity: Highly expressed in heart, skeletal muscle, and brain. Lower expression in liver, lung,
    kidney, pancreas and placenta

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF649 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia --
    --
    (see all 10)
    Uncharacterized protein
    (see all 10)
    37(a)
    36(a)
    (see all 10)
    many ↔ many
    many ↔ many
    (see all 10)
    Un(55974197-55999940)
    3(523124018-523216101)


    ENSEMBL Gene Tree for ZNF649 (if available)
    TreeFam Gene Tree for ZNF649 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF649 gene
    ZNF1752  ZNF6742  ZNF4872  ZNF5102  ZIM32  ZNF6142  ZNF1572  ZNF262  
    ZNF6132  ZNF812  ENSG000002673602  ZNF7822  ZNF7932  ZNF252  ZNF5682  ENSG000002365752  
    ENSG000002296312  ZNF5672  ZNF1822  ZNF37A2  ZNF2482  ZNF3002  ZNF3822  RBAK-RBAKDN2  
    Selected SIMAP similar genes for ZNF649 using alignment to 6 protein entries:     ZN649_HUMAN (see all proteins) (see all similar genes):
    ZNF615    FIK    ZNF350    ZNF84    ZNF432    ZNF140
    ZFP90    ZNF177    ZNF613    ZNF625-ZNF20    ZNF624    ZNF527
    ZNF846    ZNF814    ZNF614    ZNF320    KRBOX4    ZNF569

    ZNF649 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF649 (see all 421)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs286086261,2
    C,F--52393326(+) ACCCAT/CGTCAA 1 -- ut31 ese31Minor allele frequency- C:0.05WA 118
    rs1399802321,2
    C--52393371(+) AAAAC-/ATACTTT 1 -- ut310--------
    rs763864681,2
    C,F--52393607(+) CCCCCG/AGAGTA 1 -- ut311Minor allele frequency- A:0.02EA 120
    rs1180217011,2
    C,F--52393836(+) ATTCCG/ACTGGA 1 -- ut311Minor allele frequency- A:0.01NA 120
    rs1898126011,2
    C--52393852(+) TATGAC/TCAAAC 1 -- ut310--------
    rs1814937831,2
    C--52393904(+) CACTGC/TCCTGC 2 G syn10--------
    rs1428049841,2
    C--52393945(+) GCTTTT/CCCCCT 2 /K /E mis11Minor allele frequency- C:0.00NA 4552
    rs1151105621,2
    C,F--52393963(+) TTCACT/CAGGAC 2 /S /G mis12Minor allele frequency- C:0.01WA NA 4670
    rs1139849401,2
    C,F--52393973(+) CTTAAG/ACTGTG 2 /S syn15Minor allele frequency- A:0.01CSA WA NA EU 5995
    rs14330831,2,,4
    C,F,O,H--52393984(+) ACTTGC/TTGTGG 2 T A mis1 ese328Minor allele frequency- T:0.04NA MN NS EA WA EU 8929

    HapMap Linkage Disequilibrium report for ZNF649 (52392477 - 52408305 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZNF649:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912298CNV Loss21882294
    dgv143e55CNV Gain17911159
    dgv425n27CNV Gain19166990
    esv638CNV CNV17122850
    dgv1113e1CNV Complex17122850
    dgv1112e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611903    OMIM disorders: --


    ZNF649 for disorders           About GeneDecksing


    Export disorders for ZNF649 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF649 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with ZNF649)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ZNF649, a novel Kruppel type zinc-finger protein, functions as a transcriptional suppressor. (PubMed id 15950191)1, 2, 3 Yang H.... Liu M. (Biochem. Biophys. Res. Commun. 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    5. Maintenance of silent chromatin through replication requires SWI/SNF- like chromatin remodeler SMARCAD1. (PubMed id 21549307)1 Rowbotham S.P.... Mermoud J.E. (Mol. Cell 2011)
    6. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S.... Obuse C. (Nat. Cell Biol. 2010)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
    10. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 65251 HGNC: 25741 AceView: FLJ12644 Ensembl:ENSG00000198093 euGenes: HUgn65251
    ECgene: ZNF649 H-InvDB: ZNF649

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZNF649 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF649 gene:
    Search GeneIP for patents involving ZNF649

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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