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Aliases for ZNF649 Gene

Aliases for ZNF649 Gene

  • Zinc Finger Protein 649 2 3

External Ids for ZNF649 Gene

Summaries for ZNF649 Gene

GeneCards Summary for ZNF649 Gene

ZNF649 (Zinc Finger Protein 649) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF182.

UniProtKB/Swiss-Prot for ZNF649 Gene

  • Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathways.

Gene Wiki entry for ZNF649 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF649 Gene

Genomics for ZNF649 Gene

Genomic Location for ZNF649 Gene

51,889,224 bp from pter
51,905,052 bp from pter
15,829 bases
Minus strand

Genomic View for ZNF649 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF649 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF649 Gene

Regulatory Elements for ZNF649 Gene

Proteins for ZNF649 Gene

  • Protein details for ZNF649 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 649
    Protein Accession:
    Secondary Accessions:
    • A8MYJ5
    • B2RDC4
    • Q9H9N2

    Protein attributes for ZNF649 Gene

    505 amino acids
    Molecular mass:
    57683 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF649 Gene

Proteomics data for ZNF649 Gene at MOPED

Post-translational modifications for ZNF649 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF649 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF649 Gene

Domains for ZNF649 Gene

Gene Families for ZNF649 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF649 Gene


  • The KRAB domain is required for transcriptional repression:
    • Q9BS31
  • Contains 1 KRAB domain.:
    • Q9BS31
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q9BS31
  • Contains 10 C2H2-type zinc fingers.:
    • Q9BS31
genes like me logo Genes that share domains with ZNF649: view

Function for ZNF649 Gene

Molecular function for ZNF649 Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathways.

Gene Ontology (GO) - Molecular Function for ZNF649 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 23455924
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF649: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF649 Gene

Localization for ZNF649 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF649 Gene

Subcellular locations from

Jensen Localization Image for ZNF649 Gene COMPARTMENTS Subcellular localization image for ZNF649 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF649 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005622 intracellular --
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with ZNF649: view

Pathways for ZNF649 Gene

SuperPathways for ZNF649 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF649: view

Pathways by source for ZNF649 Gene

2 Reactome pathways for ZNF649 Gene

Interacting Proteins for ZNF649 Gene

Gene Ontology (GO) - Biological Process for ZNF649 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF649: view

Transcripts for ZNF649 Gene

Unigene Clusters for ZNF649 Gene

Zinc finger protein 649:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF649 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - -
SP5: - - -

Relevant External Links for ZNF649 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF649 Gene

mRNA expression in normal human tissues for ZNF649 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF649 Gene

SOURCE GeneReport for Unigene cluster for ZNF649 Gene Hs.148322

mRNA Expression by UniProt/SwissProt for ZNF649 Gene

Tissue specificity: Highly expressed in heart, skeletal muscle, and brain. Lower expression in liver, lung, kidney, pancreas and placenta.
genes like me logo Genes that share expressions with ZNF649: view

Orthologs for ZNF649 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF649 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF649 36
  • 99.6 (n)
  • 98.81 (a)
ZNF649 37
  • 99 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 36 (a)
-- 37
  • 35 (a)
-- 37
  • 32 (a)
-- 37
  • 33 (a)
-- 37
  • 36 (a)
-- 37
  • 36 (a)
-- 37
  • 32 (a)
-- 37
  • 31 (a)
-- 37
  • 35 (a)
-- 37
  • 37 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 31 (a)
Species with no ortholog for ZNF649:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF649 Gene

Gene Tree for ZNF649 (if available)
Gene Tree for ZNF649 (if available)

Paralogs for ZNF649 Gene

Selected SIMAP similar genes for ZNF649 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF649: view

Variants for ZNF649 Gene

Sequence variations from dbSNP and Humsavar for ZNF649 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7257221 -- 51,904,605(+) GCAGC(A/G)TTTGG intron-variant
rs7257759 -- 51,904,964(+) CCTGG(A/C)CCTTA utr-variant-5-prime
rs7257987 -- 51,904,963(+) TCCTG(A/G)CCCTT utr-variant-5-prime
rs7258676 -- 51,904,981(+) GGCAC(C/T)GGCCT utr-variant-5-prime
rs8101101 -- 51,905,847(+) gagac(C/G)tgtgc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF649 Gene

Variant ID Type Subtype PubMed ID
esv638 CNV CNV 17122850
dgv143e55 CNV Gain 17911159
dgv1112e1 CNV Complex 17122850
dgv425n27 CNV Gain 19166990
dgv1113e1 CNV Complex 17122850
nsv912298 CNV Loss 21882294

Relevant External Links for ZNF649 Gene

HapMap Linkage Disequilibrium report

Disorders for ZNF649 Gene

No disorders were found for ZNF649 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF649 Gene

Publications for ZNF649 Gene

  1. ZNF649, a novel Kruppel type zinc-finger protein, functions as a transcriptional suppressor. (PMID: 15950191) Yang H. … Liu M. (Biochem. Biophys. Res. Commun. 2005) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  5. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3

Products for ZNF649 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF649
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF649
    • Block miRNA regulation of ZNF649 using miScript Target Protectors

    Sources for ZNF649 Gene

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