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Aliases for ZNF648 Gene

Aliases for ZNF648 Gene

  • Zinc Finger Protein 648 2 3 5

External Ids for ZNF648 Gene

Previous GeneCards Identifiers for ZNF648 Gene

  • GC01M178755
  • GC01M180290
  • GC01M153255

Summaries for ZNF648 Gene

GeneCards Summary for ZNF648 Gene

ZNF648 (Zinc Finger Protein 648) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZNF648 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF648 Gene

Genomics for ZNF648 Gene

Regulatory Elements for ZNF648 Gene

Genomic Location for ZNF648 Gene

182,053,766 bp from pter
182,062,505 bp from pter
8,740 bases
Minus strand

Genomic View for ZNF648 Gene

Genes around ZNF648 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF648 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF648 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF648 Gene

Proteins for ZNF648 Gene

  • Protein details for ZNF648 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 648
    Protein Accession:
    Secondary Accessions:
    • B2RP16

    Protein attributes for ZNF648 Gene

    568 amino acids
    Molecular mass:
    62341 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF648 Gene

Proteomics data for ZNF648 Gene at MOPED

Post-translational modifications for ZNF648 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF648 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF648 Gene

Domains & Families for ZNF648 Gene

Gene Families for ZNF648 Gene

Protein Domains for ZNF648 Gene

Suggested Antigen Peptide Sequences for ZNF648 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF648: view

Function for ZNF648 Gene

Molecular function for ZNF648 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF648: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF648 Gene

Localization for ZNF648 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF648 Gene

Subcellular locations from

Jensen Localization Image for ZNF648 Gene COMPARTMENTS Subcellular localization image for ZNF648 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF648 Gene

Pathways & Interactions for ZNF648 Gene

SuperPathways for ZNF648 Gene

No Data Available

Interacting Proteins for ZNF648 Gene

Gene Ontology (GO) - Biological Process for ZNF648 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF648: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF648 Gene

Drugs & Compounds for ZNF648 Gene

No Compound Related Data Available

Transcripts for ZNF648 Gene

mRNA/cDNA for ZNF648 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF648 Gene

Zinc finger protein 648:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF648 Gene

No ASD Table

Relevant External Links for ZNF648 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF648 Gene

mRNA expression in normal human tissues for ZNF648 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF648 Gene

This gene is overexpressed in Testis (x10.7), Liver (x4.6), Pituitary (x4.1), and Ovary (x4.1).

Protein differential expression in normal tissues from HIPED for ZNF648 Gene

This gene is overexpressed in Serum (34.8) and Peripheral blood mononuclear cells (33.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF648 Gene

SOURCE GeneReport for Unigene cluster for ZNF648 Gene Hs.684328

genes like me logo Genes that share expression patterns with ZNF648: view

Protein tissue co-expression partners for ZNF648 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF648 Gene

Orthologs for ZNF648 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF648 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF648 35
  • 83 (n)
  • 75.76 (a)
ZNF648 36
  • 74 (a)
(Canis familiaris)
Mammalia ZNF648 35
  • 84.07 (n)
  • 78.58 (a)
ZNF648 36
  • 77 (a)
(Mus musculus)
Mammalia Zfp648 35
  • 77.76 (n)
  • 71.32 (a)
Zfp648 16
Zfp648 36
  • 70 (a)
(Pan troglodytes)
Mammalia ZNF648 35
  • 99.3 (n)
  • 98.42 (a)
ZNF648 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Zfp648 35
  • 76.19 (n)
  • 68.42 (a)
(Danio rerio)
Actinopterygii znf648 36
  • 38 (a)
Species with no ortholog for ZNF648:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF648 Gene

Gene Tree for ZNF648 (if available)
Gene Tree for ZNF648 (if available)

Paralogs for ZNF648 Gene

(409) SIMAP similar genes for ZNF648 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF648: view

No data available for Paralogs for ZNF648 Gene

Variants for ZNF648 Gene

Sequence variations from dbSNP and Humsavar for ZNF648 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12568050 - 182,057,678(+) GTCTC(C/G/T)TTGAT reference, missense
rs12564283 - 182,057,887(+) GGCCT(C/T)CCCAC reference, missense
rs2332967 -- 182,059,081(+) CTCCC(A/G)AAGTG intron-variant
rs3856101 -- 182,053,803(-) GACAA(C/T)CTTAT utr-variant-3-prime
rs3908801 -- 182,053,911(-) TTGGA(A/G)AAGAA utr-variant-3-prime

Variation tolerance for ZNF648 Gene

Residual Variation Intolerance Score: 91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.91; 67.70% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ZNF648 Gene

Disorders for ZNF648 Gene

Relevant External Links for ZNF648

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF648 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF648 Gene

Publications for ZNF648 Gene

  1. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3 48 67
  2. Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384. (PMID: 24554482) Leger P.D. … Haas D.W. (J. Neurovirol. 2014) 3
  3. Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes. (PMID: 23982368) Qi L. … Doria A. (JAMA 2013) 3
  4. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) . … Abecasis G.R. (Nat. Genet. 2013) 3
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3

Products for ZNF648 Gene

Sources for ZNF648 Gene