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Aliases for ZNF646 Gene

Aliases for ZNF646 Gene

  • Zinc Finger Protein 646 2 3
  • KIAA0296 4

External Ids for ZNF646 Gene

Previous GeneCards Identifiers for ZNF646 Gene

  • GC16P030995
  • GC16P031085
  • GC16P028647

Summaries for ZNF646 Gene

GeneCards Summary for ZNF646 Gene

ZNF646 (Zinc Finger Protein 646) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZNF646 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF646 Gene

Genomics for ZNF646 Gene

Regulatory Elements for ZNF646 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF646 Gene

31,074,260 bp from pter
31,084,196 bp from pter
9,937 bases
Plus strand

Genomic View for ZNF646 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF646 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF646 Gene

Proteins for ZNF646 Gene

  • Protein details for ZNF646 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 646
    Protein Accession:
    Secondary Accessions:
    • Q8IVD8

    Protein attributes for ZNF646 Gene

    1829 amino acids
    Molecular mass:
    200762 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA20756.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF646 Gene


neXtProt entry for ZNF646 Gene

Proteomics data for ZNF646 Gene at MOPED

Post-translational modifications for ZNF646 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF646 Gene

No data available for DME Specific Peptides for ZNF646 Gene

Domains for ZNF646 Gene

Gene Families for ZNF646 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF646 Gene

Suggested Antigen Peptide Sequences for ZNF646 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O15015
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 31 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF646: view

Function for ZNF646 Gene

Molecular function for ZNF646 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF646 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF646: view

Animal Model Products

CRISPR Products

miRNA for ZNF646 Gene

miRTarBase miRNAs that target ZNF646

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF646 Gene

Localization for ZNF646 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF646 Gene

Subcellular locations from

Jensen Localization Image for ZNF646 Gene COMPARTMENTS Subcellular localization image for ZNF646 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF646 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF646: view

Pathways for ZNF646 Gene

SuperPathways for ZNF646 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF646 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF646: view

No data available for Pathways by source for ZNF646 Gene

Transcripts for ZNF646 Gene

Unigene Clusters for ZNF646 Gene

Zinc finger protein 646:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF646

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF646 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1: -

Relevant External Links for ZNF646 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF646 Gene

mRNA expression in normal human tissues for ZNF646 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ZNF646 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (27.7), Lung (15.3), Frontal cortex (7.4), and Serum (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF646 Gene

SOURCE GeneReport for Unigene cluster for ZNF646 Gene Hs.119273

genes like me logo Genes that share expressions with ZNF646: view

Expression partners for ZNF646 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF646 Gene

Orthologs for ZNF646 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF646 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF646 35
  • 85.67 (n)
  • 81.85 (a)
ZNF646 36
  • 34 (a)
(Canis familiaris)
Mammalia ZNF646 35
  • 84.7 (n)
  • 80.11 (a)
ZNF646 36
  • 79 (a)
(Mus musculus)
Mammalia Zfp646 35
  • 77.88 (n)
  • 71.19 (a)
Zfp646 16
Zfp646 36
  • 71 (a)
(Pan troglodytes)
Mammalia ZNF646 35
  • 99.65 (n)
  • 99.34 (a)
ZNF646 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Zfp646 35
  • 78.19 (n)
  • 71.89 (a)
(Monodelphis domestica)
Mammalia ZNF646 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF646 36
  • 58 (a)
(Anolis carolinensis)
Reptilia ZNF646 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732255 35
  • 48.05 (n)
  • 39.78 (a)
(Danio rerio)
Actinopterygii ZNF646 (2 of 2) 36
  • 25 (a)
znf646p 36
  • 27 (a)
Species with no ortholog for ZNF646:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF646 Gene

Gene Tree for ZNF646 (if available)
Gene Tree for ZNF646 (if available)

Paralogs for ZNF646 Gene

Selected SIMAP similar genes for ZNF646 Gene using alignment to 3 proteins: Pseudogenes for ZNF646 Gene

genes like me logo Genes that share paralogs with ZNF646: view

No data available for Paralogs for ZNF646 Gene

Variants for ZNF646 Gene

Sequence variations from dbSNP and Humsavar for ZNF646 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs749670 - 31,077,304(-) CTTTC(C/T)CCTCC reference, missense
rs749671 -- 31,077,026(-) TCCTC(C/T)TCAGC synonymous-codon, reference
rs750952 -- 31,082,633(+) CCTCC(C/T)CTAGT intron-variant
rs750953 -- 31,082,768(+) AAGGA(C/T)AGAAG intron-variant
rs889550 -- 31,082,571(+) GCCGC(A/G)GCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF646 Gene

Variant ID Type Subtype PubMed ID
nsv905729 CNV Loss 21882294
dgv2670n71 CNV Loss 21882294
nsv457483 CNV Loss 19166990
nsv833193 CNV Gain+Loss 17160897
dgv2672n71 CNV Loss 21882294
nsv827615 CNV Gain 20364138
esv993244 CNV Deletion 20482838

Relevant External Links for ZNF646 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF646 Gene

Disorders for ZNF646 Gene

Relevant External Links for ZNF646

Genetic Association Database (GAD)

No disorders were found for ZNF646 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZNF646 Gene

Publications for ZNF646 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 3 4
  2. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. (PMID: 22451204) Pankratz N. … Foroud T. (Ann. Neurol. 2012) 3 48
  3. Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling. (PMID: 25391492) Lamoliatte F. … Thibault P. (Nat Commun 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for ZNF646 Gene

Sources for ZNF646 Gene

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