Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF646 Gene

Aliases for ZNF646 Gene

  • Zinc Finger Protein 646 2 3 5
  • KIAA0296 4

External Ids for ZNF646 Gene

Previous GeneCards Identifiers for ZNF646 Gene

  • GC16P030995
  • GC16P031085
  • GC16P028647

Summaries for ZNF646 Gene

GeneCards Summary for ZNF646 Gene

ZNF646 (Zinc Finger Protein 646) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZNF646 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF646 Gene

Genomics for ZNF646 Gene

Regulatory Elements for ZNF646 Gene

Promoters for ZNF646 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF646 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF646 Gene

Chromosome:
16
Start:
31,073,756 bp from pter
End:
31,084,196 bp from pter
Size:
10,441 bases
Orientation:
Plus strand

Genomic View for ZNF646 Gene

Genes around ZNF646 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF646 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF646 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF646 Gene

Proteins for ZNF646 Gene

  • Protein details for ZNF646 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15015-ZN646_HUMAN
    Recommended name:
    Zinc finger protein 646
    Protein Accession:
    O15015
    Secondary Accessions:
    • Q8IVD8

    Protein attributes for ZNF646 Gene

    Size:
    1829 amino acids
    Molecular mass:
    200762 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20756.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF646 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF646 Gene

Proteomics data for ZNF646 Gene at MOPED

Post-translational modifications for ZNF646 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF646 Gene

No data available for DME Specific Peptides for ZNF646 Gene

Domains & Families for ZNF646 Gene

Gene Families for ZNF646 Gene

Protein Domains for ZNF646 Gene

Suggested Antigen Peptide Sequences for ZNF646 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15015

UniProtKB/Swiss-Prot:

ZN646_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 31 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 31 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF646: view

Function for ZNF646 Gene

Molecular function for ZNF646 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF646 Gene

genes like me logo Genes that share phenotypes with ZNF646: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF646 Gene

Localization for ZNF646 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF646 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF646 Gene COMPARTMENTS Subcellular localization image for ZNF646 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF646 Gene

Pathways & Interactions for ZNF646 Gene

SuperPathways for ZNF646 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF646 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF646 Gene

Drugs & Compounds for ZNF646 Gene

No Compound Related Data Available

Transcripts for ZNF646 Gene

Unigene Clusters for ZNF646 Gene

Zinc finger protein 646:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF646 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1: -
SP2:

Relevant External Links for ZNF646 Gene

GeneLoc Exon Structure for
ZNF646
ECgene alternative splicing isoforms for
ZNF646

Expression for ZNF646 Gene

mRNA expression in normal human tissues for ZNF646 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF646 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (27.7), Lung (15.3), Frontal cortex (7.4), and Serum (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF646 Gene



SOURCE GeneReport for Unigene cluster for ZNF646 Gene Hs.119273

genes like me logo Genes that share expression patterns with ZNF646: view

Protein tissue co-expression partners for ZNF646 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF646 Gene

Orthologs for ZNF646 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF646 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF646 35
  • 85.67 (n)
  • 81.85 (a)
ZNF646 36
  • 34 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF646 35
  • 84.7 (n)
  • 80.11 (a)
ZNF646 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp646 35
  • 77.88 (n)
  • 71.19 (a)
Zfp646 16
Zfp646 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF646 35
  • 99.65 (n)
  • 99.34 (a)
ZNF646 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp646 35
  • 78.19 (n)
  • 71.89 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF646 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF646 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF646 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732255 35
  • 48.05 (n)
  • 39.78 (a)
zebrafish
(Danio rerio)
Actinopterygii ZNF646 (2 of 2) 36
  • 25 (a)
OneToMany
znf646p 36
  • 27 (a)
OneToMany
Species with no ortholog for ZNF646:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF646 Gene

ENSEMBL:
Gene Tree for ZNF646 (if available)
TreeFam:
Gene Tree for ZNF646 (if available)

Paralogs for ZNF646 Gene

(7) SIMAP similar genes for ZNF646 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF646 Gene

genes like me logo Genes that share paralogs with ZNF646: view

No data available for Paralogs for ZNF646 Gene

Variants for ZNF646 Gene

Sequence variations from dbSNP and Humsavar for ZNF646 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_035594 A breast cancer sample
rs28407985 - 31,076,617(+) ACATG(C/T)TCCTG reference, missense
rs749670 - 31,077,304(-) CTTTC(C/T)CCTCC reference, missense
rs17641067 - 31,078,646(+) GACAT(C/G/T)CCAGG reference, missense
rs35713203 - 31,079,086(-) CCACT(C/G)CTTCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF646 Gene

Variant ID Type Subtype PubMed ID
nsv905729 CNV Loss 21882294
dgv2670n71 CNV Loss 21882294
nsv457483 CNV Loss 19166990
nsv833193 CNV Gain+Loss 17160897
dgv2672n71 CNV Loss 21882294
nsv827615 CNV Gain 20364138
esv993244 CNV Deletion 20482838

Variation tolerance for ZNF646 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.25; 97.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF646 Gene

HapMap Linkage Disequilibrium report
ZNF646

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF646 Gene

Disorders for ZNF646 Gene

Relevant External Links for ZNF646

Genetic Association Database (GAD)
ZNF646
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF646

No disorders were found for ZNF646 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF646 Gene

Publications for ZNF646 Gene

  1. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. (PMID: 22451204) Pankratz N. … Foroud T. (Ann. Neurol. 2012) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. An empirical framework for binary interactome mapping. (PMID: 19060904) Venkatesan K. … Vidal M. (Nat. Methods 2009) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for ZNF646 Gene

Sources for ZNF646 Gene

Back to Top

Content