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Aliases for ZNF646 Gene

Aliases for ZNF646 Gene

  • Zinc Finger Protein 646 2 3 5
  • KIAA0296 4

External Ids for ZNF646 Gene

Previous GeneCards Identifiers for ZNF646 Gene

  • GC16P030995
  • GC16P031085
  • GC16P028647

Summaries for ZNF646 Gene

GeneCards Summary for ZNF646 Gene

ZNF646 (Zinc Finger Protein 646) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZNF646 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF646 Gene

Genomics for ZNF646 Gene

Regulatory Elements for ZNF646 Gene

Enhancers for ZNF646 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G031125 2 FANTOM5 Ensembl ENCODE dbSUPER 17 +57.4 57383 10.7 CREB3L1 MLX AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 KAT8 ITGAX ZNF764 BCL7C ITGAM ZNF646 ZNF668 ENSG00000260267 ENSG00000260304 NPIPB13
GH16G031116 1.8 FANTOM5 ENCODE dbSUPER 9.2 +44.7 44657 3.9 HDGF PKNOX1 ARNT AGO1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 KAT8 ENSG00000261614 ITGAX STX4 ENSG00000260304 BCL7C ENSG00000260625 ENSG00000260267 ZNF646 ITGAM
GH16G030946 1.4 ENCODE dbSUPER 11 -124.7 -124710 4.6 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 ENSG00000260267 HSD3B7 ENSG00000260304 ZNF764 ZNF668 ZNF646 PRR14 ZNF747 ENSG00000235560 RNF40
GH16G030939 1.3 Ensembl ENCODE 11.3 -132.2 -132220 3.6 HDGF PKNOX1 AGO1 WRNIP1 ARID4B ZNF2 YY1 ZNF416 ZNF207 ZNF143 HSD3B7 ZNF668 ZNF720 ZNF785 KAT8 ZNF646 BCL7C MIR762 CTF1 CCDC189
GH16G031427 1.3 ENCODE dbSUPER 10 +355.7 355654 4.5 HDGF CREB3L1 SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF548 KLF13 ZNF263 ZNF747 LOC105371171 ZNF785 ENSG00000260267 MIR762HG ENSG00000260304 ZNF720 ARMC5 PYDC1 PRSS8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF646 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF646 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085295 144 2601 MLX CREB3L1 AGO1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263

Genomic Location for ZNF646 Gene

31,073,756 bp from pter
31,084,196 bp from pter
10,441 bases
Plus strand

Genomic View for ZNF646 Gene

Genes around ZNF646 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF646 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF646 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF646 Gene

Proteins for ZNF646 Gene

  • Protein details for ZNF646 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 646
    Protein Accession:
    Secondary Accessions:
    • Q8IVD8

    Protein attributes for ZNF646 Gene

    1829 amino acids
    Molecular mass:
    200762 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA20756.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF646 Gene


neXtProt entry for ZNF646 Gene

Post-translational modifications for ZNF646 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF646 Gene

No data available for DME Specific Peptides for ZNF646 Gene

Domains & Families for ZNF646 Gene

Gene Families for ZNF646 Gene

Suggested Antigen Peptide Sequences for ZNF646 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF646: view

Function for ZNF646 Gene

Molecular function for ZNF646 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF646 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF646: view
genes like me logo Genes that share phenotypes with ZNF646: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF646 Gene

Localization for ZNF646 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF646 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF646 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ZNF646 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF646: view

Pathways & Interactions for ZNF646 Gene

SuperPathways for ZNF646 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF646 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF646: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF646 Gene

Drugs & Compounds for ZNF646 Gene

No Compound Related Data Available

Transcripts for ZNF646 Gene

Unigene Clusters for ZNF646 Gene

Zinc finger protein 646:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF646 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1: -

Relevant External Links for ZNF646 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF646 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF646 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF646 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (27.7), Lung (15.3), Frontal cortex (7.4), and Serum (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF646 Gene

Protein tissue co-expression partners for ZNF646 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF646 Gene:


SOURCE GeneReport for Unigene cluster for ZNF646 Gene:


Evidence on tissue expression from TISSUES for ZNF646 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF646: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF646 Gene

Orthologs for ZNF646 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF646 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF646 34 35
  • 99.65 (n)
(Bos Taurus)
Mammalia ZNF646 34 35
  • 85.67 (n)
(Canis familiaris)
Mammalia ZNF646 34 35
  • 84.7 (n)
(Rattus norvegicus)
Mammalia Zfp646 34
  • 78.19 (n)
(Mus musculus)
Mammalia Zfp646 34 16 35
  • 77.88 (n)
(Monodelphis domestica)
Mammalia ZNF646 35
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF646 35
  • 58 (a)
(Anolis carolinensis)
Reptilia ZNF646 35
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732255 34
  • 48.05 (n)
(Danio rerio)
Actinopterygii znf646p 35
  • 27 (a)
ZNF646 (2 of 2) 35
  • 25 (a)
Species where no ortholog for ZNF646 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF646 Gene

Gene Tree for ZNF646 (if available)
Gene Tree for ZNF646 (if available)

Paralogs for ZNF646 Gene

(7) SIMAP similar genes for ZNF646 Gene using alignment to 3 proteins: Pseudogenes for ZNF646 Gene

genes like me logo Genes that share paralogs with ZNF646: view

No data available for Paralogs for ZNF646 Gene

Variants for ZNF646 Gene

Sequence variations from dbSNP and Humsavar for ZNF646 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_035594 A breast cancer sample
rs1000169971 -- 31,074,952(+) CAAGG(A/G)CTTTG intron-variant, upstream-variant-2KB
rs1000402423 -- 31,072,655(+) ACGTA(C/G)TGAGC intron-variant, upstream-variant-2KB
rs1000718213 -- 31,083,157(+) TCTCC(A/C)CATTT downstream-variant-500B, utr-variant-3-prime
rs1000822655 -- 31,077,929(+) AAGGT(A/G)GAACT nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZNF646 Gene

Variant ID Type Subtype PubMed ID
esv993244 CNV deletion 20482838
nsv457483 CNV loss 19166990
nsv571820 CNV loss 21841781
nsv827615 CNV gain 20364138
nsv833193 CNV gain+loss 17160897

Variation tolerance for ZNF646 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.25; 97.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF646 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF646 Gene

Disorders for ZNF646 Gene

Relevant External Links for ZNF646

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF646 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF646 Gene

Publications for ZNF646 Gene

  1. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. (PMID: 22451204) Pankratz N. … Foroud T. (Ann. Neurol. 2012) 3 46 64
  2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. (PMID: 25755297) Xiao Z. … Vertegaal A.C. (Mol. Cell. Proteomics 2015) 4 64

Products for ZNF646 Gene

Sources for ZNF646 Gene

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