ZNF646 Gene
protein-coding GIFtS: 45
GCID: GC16P031085
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zinc finger protein 646
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Aliases
for ZNF646 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 6461 2 | | KIAA02961 3 |
Export aliases for ZNF646 gene to outside databasesPrevious GC identifers: GC16P030995 GC16P028647 |
Summaries
for ZNF646 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN646_HUMAN, O15015Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF646 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF646 gene promoter:
NF-1/L NF-1 Sp1 Pbx1a AP-4 GATA-2 Max Egr-2 AREB6 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF646
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF646 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2ZNF646 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P031085: view genomic region
(about GC identifiers)
Start:
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31,085,743 bp from pter |
End:
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31,095,517 bp from pter |
Size:
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9,775 bases |
Orientation:
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plus strand |
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Proteins
for ZNF646 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN646_HUMAN, O15015 (See
protein sequence)Recommended Name: Zinc finger protein 646 Size: 1829 amino acids; 200762 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAA20756.2; Type=Erroneous initiation;
Secondary accessions: Q8IVD8Alternative splicing: 2 isoforms: O15015-1 O15015-2 Explore the universe of human proteins at neXtProt for ZNF646: NX_O15015
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15015
ZNF646 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055514.3
ENSEMBL proteins: ENSP00000300850 ENSP00000456651 ENSP00000391271 ENSP00000378429
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF646 for ontologies About GeneDecksing
ZNF646 Antibody Products:
Assay Products for ZNF646: |
Protein
Domains /
Families
for ZNF646 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF646 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O15015ProtoNet protein and cluster: O15015 1 Blocks protein family: IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN646_HUMAN, O15015Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 31 C2H2-type zinc fingers |
Function
for ZNF646 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN646_HUMAN, O15015Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF646 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF646
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for ZNF646 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF646 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF646 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZNF646 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF646 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF646
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/7 Interacting proteins for ZNF646 (O150151, 2, 3 ENSP000003008504) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF646 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF646 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF646
Search CenterWatch for drugs/clinical trials and news about ZNF646 / ZN646
|
Transcripts
for ZNF646 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF646 gene: NM_014699.3 Unigene Cluster for ZNF646: Zinc finger protein 646 Hs.119273 [show with all ESTs]Unigene Representative Sequence: AB0022944 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000300850(uc002eap.3) ENST00000564189 ENST00000428260 ENST00000394979(uc021tgu.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF646 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF646
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF646 (NM_014699) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF646 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF646 |
Additional cDNA sequence: AB002294.1 AK304808.1 BC035589.1 5 DOTS entries: DT.447328 DT.97759774 DT.87015662 DT.92022409 DT.100708531 24/75 AceView cDNA sequences (see all 75): BI226067 AA577321 AA936670 BC035589 AW299855 AA541285 AA890161 BQ059636 AB002294 CD251990 BQ061018 BU164841 BE537290 BX333937 AA947870 CR602547 BM560922 BE886091 BV179741 BE545400 AI955569 BG751486 AL535102 BG152465
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF646 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b |
|---|
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| SP1: | | | - | | | | | | |
| SP2: | | | | | | | | |
ECgene alternative splicing isoforms for ZNF646
|
Expression
for ZNF646 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF646 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF646 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF646
SOURCE GeneReport for Unigene cluster: Hs.119273
SABiosciences Custom PCR Arrays for ZNF646
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF646
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF646 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF646 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF646 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF646 |
Orthologs
for ZNF646 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF646 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for ZNF646 (if available)
TreeFam Gene Tree for ZNF646 (if available) |
Paralogs
for ZNF646 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF646 gene
9 SIMAP similar genes for ZNF646 using alignment to 3 protein entries: ZN646_HUMAN (see all proteins):DKFZp434J0650 ZNF323 PLZF ZNF72 ZFS-6 ZNF
ZNF32 ZNF589 ZNF78L1
ZNF646 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF646
PGOHUM00000248408
|
Genomic Variants
for ZNF646 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF646 (31085743 - 31095517 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF646: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF646 |
|
Disorders
/ Diseases
for ZNF646 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF646 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF646 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF646) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (1997)
- Meta-analysis of Parkinson's disease: identification o f a novel locus, RIT2. (PubMed id 22451204)1 Pankratz N....Foroud T. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (2006)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ZNF646 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF646 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF646 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZNF646 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF646 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF646 gene:
Search GeneIP for patents involving ZNF646
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF646 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF646 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF646 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF646 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF646 | | OriGene 3'-UTR Clone for ZNF646 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF646 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF646 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF646 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF646 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF646 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF646 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF646 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF646 |
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 |  |  |  | |
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 | | | ZNF646 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF646 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF646 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF646 |
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