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Aliases for ZNF646 Gene

Aliases for ZNF646 Gene

  • Zinc Finger Protein 646 2 3 5
  • KIAA0296 4

External Ids for ZNF646 Gene

Previous GeneCards Identifiers for ZNF646 Gene

  • GC16P030995
  • GC16P031085
  • GC16P028647

Summaries for ZNF646 Gene

GeneCards Summary for ZNF646 Gene

ZNF646 (Zinc Finger Protein 646) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZNF646 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF646 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF646 Gene

Genomics for ZNF646 Gene

Regulatory Elements for ZNF646 Gene

Enhancers for ZNF646 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H030367 2 FANTOM5 Ensembl ENCODE dbSUPER 30.6 -697.7 -697724 17 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D ZNF610 GLIS1 SETD1A SRCAP INO80E NPIPB12 SMG1P5 SMG1P2 ZNF764 RNF40 ZNF747 ENSG00000260304
GH16H030656 1.4 ENCODE dbSUPER 30.2 -414.2 -414188 5.8 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B SETD1A SRCAP ENSG00000260304 RNF40 ZNF764 FBRS INO80E ZNF689 ENSG00000260267 ZNF646
GH16H030946 1.4 ENCODE dbSUPER 28.4 -124.7 -124710 4.6 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 RNF40 SETD1A ZNF646 ZNF689 HSD3B7 INO80E FBRS SRCAP ZNF764 KAT8
GH16H030805 1.4 Ensembl ENCODE 27.9 -267.4 -267440 2.6 HDGF MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 RNF40 INO80E FBRS SRCAP SETD1A ZNF646 SMG1P5 ZNF764 ENSG00000260267 C16orf58
GH16H031071 1.4 ENCODE dbSUPER 25.9 -0.1 -116 5 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 SETD1A ZNF785 SRCAP KAT8 ZNF720 FBRS ZNF688 ZNF764 ZNF689 RNF40
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF646 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF646 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085295 144 2601 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610

Genomic Locations for ZNF646 Gene

Genomic Locations for ZNF646 Gene
chr16:31,073,756-31,084,196
(GRCh38/hg38)
Size:
10,441 bases
Orientation:
Plus strand
chr16:31,085,743-31,095,517
(GRCh37/hg19)

Genomic View for ZNF646 Gene

Genes around ZNF646 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF646 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF646 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF646 Gene

Proteins for ZNF646 Gene

  • Protein details for ZNF646 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15015-ZN646_HUMAN
    Recommended name:
    Zinc finger protein 646
    Protein Accession:
    O15015
    Secondary Accessions:
    • Q8IVD8

    Protein attributes for ZNF646 Gene

    Size:
    1829 amino acids
    Molecular mass:
    200762 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20756.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF646 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF646 Gene

Post-translational modifications for ZNF646 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF646 Gene

No data available for DME Specific Peptides for ZNF646 Gene

Domains & Families for ZNF646 Gene

Gene Families for ZNF646 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF646 Gene

Suggested Antigen Peptide Sequences for ZNF646 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15015

UniProtKB/Swiss-Prot:

ZN646_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF646: view

Function for ZNF646 Gene

Molecular function for ZNF646 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF646 Gene

Gene Ontology (GO) - Molecular Function for ZNF646 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF646: view
genes like me logo Genes that share phenotypes with ZNF646: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF646 Gene

Localization for ZNF646 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF646 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF646 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF646 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF646: view

Pathways & Interactions for ZNF646 Gene

SuperPathways for ZNF646 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF646 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF646: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF646 Gene

Drugs & Compounds for ZNF646 Gene

No Compound Related Data Available

Transcripts for ZNF646 Gene

Unigene Clusters for ZNF646 Gene

Zinc finger protein 646:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF646 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1: -
SP2:

Relevant External Links for ZNF646 Gene

GeneLoc Exon Structure for
ZNF646
ECgene alternative splicing isoforms for
ZNF646

Expression for ZNF646 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF646 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF646 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (27.7), Lung (15.3), Frontal cortex (7.4), and Serum (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF646 Gene



Protein tissue co-expression partners for ZNF646 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF646 Gene:

ZNF646

SOURCE GeneReport for Unigene cluster for ZNF646 Gene:

Hs.119273

Evidence on tissue expression from TISSUES for ZNF646 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF646: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF646 Gene

Orthologs for ZNF646 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF646 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF646 33 34
  • 99.65 (n)
cow
(Bos Taurus)
Mammalia ZNF646 33 34
  • 85.67 (n)
dog
(Canis familiaris)
Mammalia ZNF646 33 34
  • 84.7 (n)
rat
(Rattus norvegicus)
Mammalia Zfp646 33
  • 78.19 (n)
mouse
(Mus musculus)
Mammalia Zfp646 33 16 34
  • 77.88 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF646 34
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF646 34
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF646 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732255 33
  • 48.05 (n)
zebrafish
(Danio rerio)
Actinopterygii znf646p 34
  • 27 (a)
OneToMany
ZNF646 (2 of 2) 34
  • 25 (a)
OneToMany
Species where no ortholog for ZNF646 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF646 Gene

ENSEMBL:
Gene Tree for ZNF646 (if available)
TreeFam:
Gene Tree for ZNF646 (if available)

Paralogs for ZNF646 Gene

(7) SIMAP similar genes for ZNF646 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF646 Gene

genes like me logo Genes that share paralogs with ZNF646: view

No data available for Paralogs for ZNF646 Gene

Variants for ZNF646 Gene

Sequence variations from dbSNP and Humsavar for ZNF646 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_035594 A breast cancer sample
rs1000169971 -- 31,074,952(+) CAAGG(A/G)CTTTG intron-variant, upstream-variant-2KB
rs1000402423 -- 31,072,655(+) ACGTA(C/G)TGAGC intron-variant, upstream-variant-2KB
rs1000718213 -- 31,083,157(+) TCTCC(A/C)CATTT downstream-variant-500B, utr-variant-3-prime
rs1000822655 -- 31,077,929(+) AAGGT(A/G)GAACT nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZNF646 Gene

Variant ID Type Subtype PubMed ID
nsv833193 CNV gain+loss 17160897
nsv827615 CNV gain 20364138
nsv571820 CNV loss 21841781
nsv457483 CNV loss 19166990
esv993244 CNV deletion 20482838

Variation tolerance for ZNF646 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.25; 97.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF646 Gene

Human Gene Mutation Database (HGMD)
ZNF646
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF646

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF646 Gene

Disorders for ZNF646 Gene

Relevant External Links for ZNF646

Genetic Association Database (GAD)
ZNF646
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF646

No disorders were found for ZNF646 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF646 Gene

Publications for ZNF646 Gene

  1. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. (PMID: 22451204) Pankratz N … PD GWAS Consortium (Annals of neurology 2012) 3 45 60
  2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for ZNF646 Gene

Sources for ZNF646 Gene

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