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ZNF646 Gene

protein-coding   GIFtS: 50
GCID: GC16P031085

Zinc Finger Protein 646

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 6461 2
KIAA02963

External Ids:    HGNC: 290041   Entrez Gene: 97262   Ensembl: ENSG000001673957   UniProtKB: O150153   

Export aliases for ZNF646 gene to outside databases

Previous GC identifers: GC16P030995 GC16P028647


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF646 Gene:
ZNF646 (zinc finger protein 646) is a protein-coding gene. Diseases associated with ZNF646 include breast and colorectal cancer, and parkinson's disease.

UniProtKB/Swiss-Prot: ZN646_HUMAN, O15015
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF646 gene promoter:
         NF-1/L   NF-1   Sp1   Pbx1a   AP-4   GATA-2   Max   Egr-2   AREB6   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF646 promoter sequence
   Search Chromatin IP Primers for ZNF646

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF646


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

ZNF646 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF646 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P031085:  view genomic region     (about GC identifiers)

Start:
31,085,743 bp from pter      End:
31,095,517 bp from pter
Size:
9,775 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN646_HUMAN, O15015 (See protein sequence)
Recommended Name: Zinc finger protein 646  
Size: 1829 amino acids; 200762 Da
Sequence caution: Sequence=BAA20756.2; Type=Erroneous initiation;
Secondary accessions: Q8IVD8
Alternative splicing: 2 isoforms:  O15015-1   O15015-2   

Explore the universe of human proteins at neXtProt for ZNF646: NX_O15015

Explore proteomics data for ZNF646 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF646 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055514.3  
    ENSEMBL proteins: 
     ENSP00000300850   ENSP00000456651   ENSP00000391271   ENSP00000378429  

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    Cloud-Clone Corp. CLIAs for ZNF646


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O15015

    ProtoNet protein and cluster: O15015

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZN646_HUMAN, O15015
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 31 C2H2-type zinc fingers


    ZNF646 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN646_HUMAN, O15015
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI16189514
    GO:0046872metal ion binding IEA--
         
    ZNF646 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF646
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    miRNA
    Products:
        
    miRTarBase miRNAs that target ZNF646:
    hsa-mir-378a-5p (MIRT044002), hsa-mir-30b-5p (MIRT046158), hsa-mir-320a (MIRT044630)

    Block miRNA regulation of human, mouse, rat ZNF646 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF646 (see all 16):
    hsa-miR-2052 hsa-miR-520d-5p hsa-miR-877* hsa-miR-9 hsa-miR-3121-3p hsa-miR-4324 hsa-miR-548p hsa-miR-513a-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF646 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF646

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF646


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN646_HUMAN, O15015: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF646 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF646
    Interactions:

        Search GeneGlobe Interaction Network for ZNF646

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for ZNF646 (O150151, 2, 3 ENSP000003008504) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDFIQ997501, 3, ENSP000002303214EBI-745608,EBI-724076 I2D: score=5 STRING: ENSP00000230321
    NINLQ9Y2I63, ENSP000002788864I2D: score=5 STRING: ENSP00000278886
    UBE2IP632793, ENSP000003248974I2D: score=4 STRING: ENSP00000324897
    TRAF2Q129333, ENSP000002476684I2D: score=5 STRING: ENSP00000247668
    GATA5ENSP000002529974STRING: ENSP00000252997
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF646 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF646 (ZN646)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF646 gene: 
    NM_014699.3  

    Unigene Cluster for ZNF646:

    Zinc finger protein 646
    Hs.119273  [show with all ESTs]
    Unigene Representative Sequence: AB002294
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300850(uc002eap.3) ENST00000564189 ENST00000428260 ENST00000394979(uc021tgu.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZNF646 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF646 (see all 16):
    hsa-miR-2052 hsa-miR-520d-5p hsa-miR-877* hsa-miR-9 hsa-miR-3121-3p hsa-miR-4324 hsa-miR-548p hsa-miR-513a-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF646 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF646
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF646
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF646
      QuantiFast Probe-based Assays in human, mouse, rat ZNF646

    Additional mRNA sequence: 

    AB002294.1 AK304808.1 BC035589.1 

    5 DOTS entries:

    DT.447328  DT.97759774  DT.87015662  DT.92022409  DT.100708531 

    Selected AceView cDNA sequences (see all 75):

    BI226067 BE537290 BX333937 AA890161 BQ059636 AA936670 AA577321 AB002294 
    BU164841 AW299855 AA947870 BC035589 BQ061018 AA541285 CD251990 CR602547 
    BG751486 BV179741 AL535102 AA576685 BG339789 BM824182 BE886091 BV197325 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF646    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b
    SP1:        -               
    SP2:                        


    ECgene alternative splicing isoforms for ZNF646

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF646 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF646 Expression
    About this image


    ZNF646 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    ZNF646 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF646 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.119273
        Custom PCR Arrays for ZNF646
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF646

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF646 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp6461 , 5 zinc finger protein 6461, 5 77.88(n)1
    71.19(a)1
      7 (69.80 cM)5
    2339051  NM_172749.41  NP_766337.21 
     1278767965 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF6466
    zinc finger protein 646
    60(a)
    1 ↔ 1
    GL343220.1(2111410-2115474)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017322551 zinc finger protein 646-like 48.05(n)
    39.78(a)
      101732255  XM_004920132.1  XP_004920189.1 
    zebrafish
    (Danio rerio)
    Actinopterygii znf646p6
    ZNF646 (2 of 2)6
    zinc finger protein 646
    27(a)
    25(a)
    many → 1
    many → 1
    12(30494869-30505082) ENSDARG00000061424
    19(5758827-5774356) ENSDARG00000075545


    ENSEMBL Gene Tree for ZNF646 (if available)
    TreeFam Gene Tree for ZNF646 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF646 gene
    7 SIMAP similar genes for ZNF646 using alignment to 3 protein entries:     ZN646_HUMAN (see all proteins):
    DKFZp434J0650    ZNF323    PLZF    ZNF72    ZFS-6    ZNF
    ZNF32

    ZNF646 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF646
    PGOHUM00000248408


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF646 (see all 350)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355944
    A breast cancer sample4--see VAR_0355942 N I mis40--------
    rs1859179061,2
    C--31087660(+) ACACCC/TCCCTC 2 P syn10--------
    rs2003823271,2
    --31087661(+) CACCCC/GCCTCA 2 P A mis10--------
    rs1484762071,2
    C--31087662(+) ACCCCC/GCTCAC 2 P R mis11Minor allele frequency- G:0.00NA 4550
    rs1425321201,2
    F--31087678(+) TGCTCC/TGACTG 2 S syn11Minor allele frequency- T:0.00NA 4550
    rs2018050371,2
    C--31087733(+) AACTGC/TTCCAT 2 L F mis10--------
    rs2007138651,2
    --31087778(+) GCATCA/CCTCGG 2 T P mis10--------
    rs2002546501,2
    C--31087791(+) CTACCG/ATTGTC 2 /H /R mis11Minor allele frequency- A:0.00EU 1321
    rs1443768821,2
    C--31087840(+) GTTAAC/TCATCG 2 N syn11Minor allele frequency- T:0.00NA 4550
    rs284079851,2,,4
    C,F,H--31087938(+) ACATGC/TTCCTG 2 A V mis1 ese313Minor allele frequency- T:0.02NS EA NA WA 6000

    HapMap Linkage Disequilibrium report for ZNF646 (31085743 - 31095517 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ZNF646:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv993244CNV Deletion20482838
    nsv905729CNV Loss21882294
    dgv2670n71CNV Loss21882294
    nsv457483CNV Loss19166990
    dgv2672n71CNV Loss21882294
    nsv827615CNV Gain20364138
    nsv833193CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for ZNF646:    
    About MalaCards
    breast and colorectal cancer    parkinson's disease    colorectal cancer


    ZNF646 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF646

    Export disorders for ZNF646 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF646 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF646)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. (PubMed id 22451204)1, 4 Pankratz N....Foroud T. (Ann. Neurol. 2012)
    2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (DNA Res. 1997)
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    4. An empirical framework for binary interactome mapping. (PubMed id 19060904)1 Venkatesan K....Vidal M. (Nat. Methods 2009)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (Cell 2006)
    6. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    7. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    8. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9726 HGNC: 29004 AceView: KIAA0296 Ensembl:ENSG00000167395 euGenes: HUgn9726
    ECgene: ZNF646 H-InvDB: ZNF646

    (According to HUGE)
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    HUGE: KIAA0296

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF646 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF646 gene:
    Search GeneIP for patents involving ZNF646

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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