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ZNF645 Gene

protein-coding   GIFtS: 47
GCID: GC0XP022200

Zinc Finger Protein 645

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 6451 2 3
CT1382
HAKAIL2
E3 Ubiquitin Ligase2
E3 Ubiquitin-Protein Ligase ZNF6452
EC 6.3.2.-3

External Ids:    HGNC: 263711   Entrez Gene: 1585062   Ensembl: ENSG000001758097   UniProtKB: Q8N7E23   

Export aliases for ZNF645 gene to outside databases

Previous GC identifers: GC0XP022051 GC0XP020031


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF645 Gene:
This gene encodes a member of the zinc finger domain-containing protein family. This family member contains both a
RING-type and a C2H2-type of zinc finger domain, and it may function as an E3 ubiquitin-protein ligase. Protein
localization suggests a role in human sperm production and quality control. (provided by RefSeq, Aug 2011)

GeneCards Summary for ZNF645 Gene:
ZNF645 (zinc finger protein 645) is a protein-coding gene. Diseases associated with ZNF645 include prostate cancer, and endotheliitis. GO annotations related to this gene include ligase activity. An important paralog of this gene is CBLL1.

UniProtKB/Swiss-Prot: ZN645_HUMAN, Q8N7E2
Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
May operate on tyrosine-phosphorylated SRC substrates




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_167197.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF645 gene promoter:
         AML1a   CUTL1   S8   POU2F1   FOXJ2 (long isoform)   POU2F1a   POU2F1b   POU2F1c   FOXJ2   MRF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF645

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF645


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.11   Ensembl cytogenetic band:  Xp22.11   HGNC cytogenetic band: Xp22.11

ZNF645 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF645 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP022200:  view genomic region     (about GC identifiers)

Start:
22,291,060 bp from pter      End:
22,292,574 bp from pter
Size:
1,515 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN645_HUMAN, Q8N7E2 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase ZNF645  
Size: 425 amino acids; 48785 Da
Subunit: Homodimer (By similarity)
Secondary accessions: A0AV29 A0AV31 Q6DJY9

Explore the universe of human proteins at neXtProt for ZNF645: NX_Q8N7E2

Explore proteomics data for ZNF645 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF645 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689790.1  
    ENSEMBL proteins: 
     ENSP00000323348  

    ZNF645 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR015880 Znf_C2H2-like
     IPR017907 Znf_RING_CS
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N7E2

    ProtoNet protein and cluster: Q8N7E2

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: ZN645_HUMAN, Q8N7E2
    Domain: The HYB domain forms a phosphotyrosine-binding pocket upon dimerization, and mediates as well the
    recognition of its flanking acidic amino acids (By similarity)
    Similarity: Contains 1 C2H2-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    ZNF645 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN645_HUMAN, Q8N7E2
    Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
    May operate on tyrosine-phosphorylated SRC substrates

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    ZNF645 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF645:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF645
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF645
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN645_HUMAN, Q8N7E2: Cytoplasm. Note=Localized over the postacrosomal perinuclear theca region and the entire
    length of sperm tail
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    ZNF645 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: ZN645_HUMAN, Q8N7E2
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including ZNF645: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ZNF645

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ZNF645 (ENSP000003233484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KIAA1429ENSP000002975914STRING: ENSP00000297591
    WTAPENSP000003511414STRING: ENSP00000351141
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--

    ZNF645 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF645 (ZN645)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF645 gene: 
    NM_152577.3  

    Unigene Cluster for ZNF645:

    Zinc finger protein 645
    Hs.132485  [show with all ESTs]
    Unigene Representative Sequence: GQ355336
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000323684(uc004dai.2)
    miRNA
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    Additional mRNA sequence: 

    AK098601.1 BC074910.2 BC126190.1 BC126192.1 GQ355336.1 

    1 DOTS entry:

    DT.40129332 

    6 AceView cDNA sequences:

    BX103567 AA922253 BC074910 AK098601 NM_152577 BP370443 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF645 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCGATCACA
    ZNF645 Expression
    About this image

    ZNF645 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF645 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.132485

    UniProtKB/Swiss-Prot: ZN645_HUMAN, Q8N7E2
    Tissue specificity: Exclusively expressed in testis and sperm, including spermatocytes, round and elongated
    spermatids, and Leydig cells

        Pathway & Disease-focused RT2 Profiler PCR Array including ZNF645: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF645

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF645 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia --
    --
    Uncharacterized protein
    45(a)
    37(a)
    many ↔ many
    many ↔ many
    8(159615734-159630041)
    X(32026607-32027998)
    chicken
    (Gallus gallus)
    Aves CBLL16
    Gallus gallus Cbl proto-oncogene, E3 ubiquitin pro...
    35(a)
    1 → many
    1(14621478-14632510)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    41(a)
    1 → many
    5(97627185-97648380)
    zebrafish
    (Danio rerio)
    Actinopterygii cbll16
    CU041386.16
    Uncharacterized protein
    35(a)
    35(a)
    many ↔ many
    many ↔ many
    4(17904979-17909255) ENSDARG00000015222
    25(20230700-20237657) ENSDARG00000045823
    fruit fly
    (Drosophila melanogaster)
    Insecta Hakai6
    Hakai
    16(a)
    1 → many
    2L(19580612-19582474)


    ENSEMBL Gene Tree for ZNF645 (if available)
    TreeFam Gene Tree for ZNF645 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF645 gene
    CBLL12  
    1 SIMAP similar gene for ZNF645 using alignment to 2 protein entries:     ZN645_HUMAN (see all proteins):
    CBLL1

    ZNF645 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF645 (see all 128)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs169819211,2
    C,F,H--22203325(+) TGTTGC/TGTTTT 1 -- us2k19Minor allele frequency- T:0.03NA NS EA WA 554
    rs1905062411,2
    --22203326(+) GTTGCA/GTTTTC 1 -- us2k10--------
    rs128342091,2
    C,F,H--22203332(+) TTTTCA/CCCATT 1 -- us2k15Minor allele frequency- C:0.02NS EA CSA 407
    rs59514191,2
    C,F,H--22203335(+) TCACCA/GTTAGT 1 -- us2k14Minor allele frequency- G:0.01NS EA 412
    rs1509077871,2
    C--22203361(+) CAACTG/TGGCCA 1 -- us2k10--------
    rs65280991,2
    C,F,A--22203433(+) gaagtG/Caggag 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1838947041,2
    --22203508(+) GTGTGA/GTGGCA 1 -- us2k10--------
    rs78854261,2
    C,F--22203518(+) acatgT/Cctata 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs59514201,2
    A,H--22203531(+) cccatC/Ttactt 1 -- us2k15Minor allele frequency- T:0.00NS EA NA 402
    rs2006445991,2
    --22203540(+) TGGAA-/GGGAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF645 (22291060 - 22292574 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF645:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv521384CNV Gain19592680

    Locus Specific Mutation Databases (LSDB): ZNF645

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF645
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF645

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for ZNF645:    About MalaCards
    prostate cancer    endotheliitis    prostatitis


    ZNF645 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF645

    Export disorders for ZNF645 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF645 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with ZNF645)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human RING finger protein ZNF645 is a novel testis-specific E3 ubiquitin ligase. (PubMed id 20657603)1, 2 Liu Y.Q....Zhang S.Z. (Asian J. Androl. 2010)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin. (PubMed id 22252131)2 Mukherjee M.... Sivaraman J. (EMBO J. 2012)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)4 Kerns S.L....Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2010)
    8. Promoter demethylation mediates the expression of ZNF645, a novel cancer/testis gene. (PubMed id 20587329)1 Bai G....Zhang S. (BMB Rep 2010)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 158506 HGNC: 26371 AceView: FLJ25735 Ensembl:ENSG00000175809 euGenes: HUgn158506
    ECgene: ZNF645 H-InvDB: ZNF645

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF645 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF645 gene:
    Search GeneIP for patents involving ZNF645

    GeneCards and IP:
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