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Aliases for ZNF645 Gene

Aliases for ZNF645 Gene

  • Zinc Finger Protein 645 2 3 4
  • E3 Ubiquitin-Protein Ligase ZNF645 3
  • E3 Ubiquitin Ligase 3
  • EC 6.3.2.- 4
  • HAKAIL 3
  • CT138 3

External Ids for ZNF645 Gene

Previous GeneCards Identifiers for ZNF645 Gene

  • GC0XP022051
  • GC0XP020031

Summaries for ZNF645 Gene

Entrez Gene Summary for ZNF645 Gene

  • This gene encodes a member of the zinc finger domain-containing protein family. This family member contains both a RING-type and a C2H2-type of zinc finger domain, and it may function as an E3 ubiquitin-protein ligase. Protein localization suggests a role in human sperm production and quality control. [provided by RefSeq, Aug 2011]

GeneCards Summary for ZNF645 Gene

ZNF645 (Zinc Finger Protein 645) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is CBLL1.

UniProtKB/Swiss-Prot for ZNF645 Gene

  • E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF645 Gene

Genomics for ZNF645 Gene

Regulatory Elements for ZNF645 Gene

Genomic Location for ZNF645 Gene

Start:
22,272,913 bp from pter
End:
22,274,461 bp from pter
Size:
1,549 bases
Orientation:
Plus strand

Genomic View for ZNF645 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF645 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF645 Gene

Proteins for ZNF645 Gene

  • Protein details for ZNF645 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7E2-ZN645_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase ZNF645
    Protein Accession:
    Q8N7E2
    Secondary Accessions:
    • A0AV29
    • A0AV31
    • E3SBK4
    • Q6DJY9

    Protein attributes for ZNF645 Gene

    Size:
    425 amino acids
    Molecular mass:
    48785 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for ZNF645 Gene

Proteomics data for ZNF645 Gene at MOPED

Post-translational modifications for ZNF645 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF645 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF645 Gene

Domains for ZNF645 Gene

Protein Domains for ZNF645 Gene

Suggested Antigen Peptide Sequences for ZNF645 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N7E2

UniProtKB/Swiss-Prot:

ZN645_HUMAN :
  • Q8N7E2
Domain:
  • The HYB domain forms a phosphotyrosine-binding pocket upon dimerization, and mediates as well the recognition of its flanking acidic amino acids.
Similarity:
  • Contains 1 C2H2-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with ZNF645: view

No data available for Gene Families for ZNF645 Gene

Function for ZNF645 Gene

Molecular function for ZNF645 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates.

Enzyme Numbers (IUBMB) for ZNF645 Gene

Gene Ontology (GO) - Molecular Function for ZNF645 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNF645: view

Phenotypes for ZNF645 Gene

GenomeRNAi human phenotypes for ZNF645:
genes like me logo Genes that share phenotypes with ZNF645: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF645

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF645 Gene

Localization for ZNF645 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF645 Gene

Cytoplasm. Note=Localized over the postacrosomal perinuclear theca region and the entire length of sperm tail.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF645 Gene COMPARTMENTS Subcellular localization image for ZNF645 gene
Compartment Confidence
nucleus 3
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ZNF645 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZNF645: view

Pathways for ZNF645 Gene

SuperPathways for ZNF645 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitin Ligases in human,mouse,rat

UniProtKB/Swiss-Prot Q8N7E2-ZN645_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Interacting Proteins for ZNF645 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000323348%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000323348 for ZNF645 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for ZNF645 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with ZNF645: view

No data available for Pathways by source for ZNF645 Gene

Transcripts for ZNF645 Gene

mRNA/cDNA for ZNF645 Gene

(6) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF645 Gene

Zinc finger protein 645:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF645

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF645
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF645 Gene

No ASD Table

Relevant External Links for ZNF645 Gene

GeneLoc Exon Structure for
ZNF645
ECgene alternative splicing isoforms for
ZNF645

Expression for ZNF645 Gene

mRNA expression in normal human tissues for ZNF645 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF645 Gene

This gene is overexpressed in Testis (51.8).

SOURCE GeneReport for Unigene cluster for ZNF645 Gene Hs.132485

mRNA Expression by UniProt/SwissProt for ZNF645 Gene

Q8N7E2-ZN645_HUMAN
Tissue specificity: Exclusively expressed in testis and sperm, including spermatocytes, round and elongated spermatids, and Leydig cells.
genes like me logo Genes that share expressions with ZNF645: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for ZNF645 Gene

Orthologs for ZNF645 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF645 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF645 35
  • 98.3 (n)
  • 96.36 (a)
ZNF645 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
OneToMany
chicken
(Gallus gallus)
Aves CBLL1 36
  • 35 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 41 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii cbll1 36
  • 35 (a)
ManyToMany
CU041386.1 36
  • 35 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Hakai 36
  • 16 (a)
OneToMany
Species with no ortholog for ZNF645:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF645 Gene

ENSEMBL:
Gene Tree for ZNF645 (if available)
TreeFam:
Gene Tree for ZNF645 (if available)

Paralogs for ZNF645 Gene

Paralogs for ZNF645 Gene

Selected SIMAP similar genes for ZNF645 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF645: view

Variants for ZNF645 Gene

Sequence variations from dbSNP and Humsavar for ZNF645 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
VAR_030340 -
VAR_030341 -

Structural Variations from Database of Genomic Variants (DGV) for ZNF645 Gene

Variant ID Type Subtype PubMed ID
nsv521384 CNV Gain 19592680

Relevant External Links for ZNF645 Gene

HapMap Linkage Disequilibrium report
ZNF645
Locus Specific Mutation Databases (LSDB)
ZNF645

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF645 Gene

Disorders for ZNF645 Gene

Relevant External Links for ZNF645

Genetic Association Database (GAD)
ZNF645
genes like me logo Genes that share disorders with ZNF645: view

No data available for UniProtKB/Swiss-Prot for ZNF645 Gene

Publications for ZNF645 Gene

  1. Human RING finger protein ZNF645 is a novel testis-specific E3 ubiquitin ligase. (PMID: 20657603) Liu Y.Q. … Zhang S.Z. (Asian J. Androl. 2010) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for ZNF645 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitin Ligases in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF645
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF645
    • Block miRNA regulation of ZNF645 using miScript Target Protectors

    Sources for ZNF645 Gene

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