ZNF644 Gene
protein-coding GIFtS: 48
GCID: GC01M091380
|
|
zinc finger protein 644
| |
Aliases
for ZNF644 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 6441 2 | | NatF2 | | BM-0051 2 | | ZEP-22 | | KIAA12211 3 | | Zinc Finger Motif Enhancer Binding Protein 22 | | MGC601651 | | ZEP23 | | MGC704101 | | Zep-23 | | MYP212 | | Zinc Finger Motif Enhancer-Binding Protein 23 |
Export aliases for ZNF644 gene to outside databasesPrevious GC identifers: GC01M091093 GC01M091153 GC01M089499 |
Summaries
for ZNF644 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZNF644:
The protein encoded by this gene is a zinc finger transcription factor that may play a role in eye development. Defectsin this gene have been associated with high myopia. Three transcript variants encoding two different isoforms havebeen found for this gene. (provided by RefSeq, Aug 2011)
UniProtKB/Swiss-Prot: ZN644_HUMAN, Q9H582Function: May be involved in transcriptional regulation
Gene Wiki entry for ZNF644
|
Genomic Views
for ZNF644 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF644 gene promoter:
E2F-3a E2F-4 E2F E2F-1 Nkx2-2 E2F-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF644
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF644 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p22.2 Ensembl cytogenetic band: 1p22.2 HGNC cytogenetic band: 1p22.2ZNF644 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M091380: view genomic region
(about GC identifiers)
Start:
|
91,380,855 bp from pter |
End:
|
91,487,829 bp from pter |
Size:
|
106,975 bases |
Orientation:
|
minus strand |
|
Proteins
for ZNF644 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN644_HUMAN, Q9H582 (See
protein sequence)Recommended Name: Zinc finger protein 644 Size: 1327 amino acids; 149565 Da
Subcellular location: Nucleus
Secondary accessions: A2RU71 Q2TAM0 Q5TCC0 Q6BEP7 Q6P446 Q6PI06 Q7LG67 Q9ULJ9Alternative splicing: 3 isoforms: Q9H582-1 Q9H582-2 Q9H582-3 Explore the universe of human proteins at neXtProt for ZNF644: NX_Q9H582
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H582
ZNF644 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_057704.2 NP_115562.3 NP_958357.1
ENSEMBL proteins: ENSP00000359469 ENSP00000340828 ENSP00000354659 ENSP00000337008
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF644 for ontologies About GeneDecksing
ZNF644 Antibody Products:
Assay Products for ZNF644: |
Protein
Domains /
Families
for ZNF644 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF644 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H582ProtoNet protein and cluster: Q9H582 UniProtKB/Swiss-Prot: ZN644_HUMAN, Q9H582Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 7 C2H2-type zinc fingers |
Function
for ZNF644 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN644_HUMAN, Q9H582Function: May be involved in transcriptional regulation
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF644 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF644 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF644 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF644
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for ZNF644 (Q9H5823 ENSP000003370084) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF644 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF644 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF644
Search CenterWatch for drugs/clinical trials and news about ZNF644 / ZN644
|
Transcripts
for ZNF644 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF644 gene (3 alternative transcripts): NM_016620.3 NM_032186.4 NM_201269.2 Unigene Clusters for ZNF644: Zinc finger protein 644 Hs.173001 [show with all ESTs], Hs.744227 [show with all ESTs]Unigene Representative Sequences: BC150177, NM_03218611 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370440(uc001dnv.3 uc001dny.2) ENST00000347275 ENST00000361321
ENST00000467231 ENST00000479798 ENST00000482709 ENST00000498303 ENST00000474405
ENST00000495966 ENST00000482467 ENST00000337393(uc001dnw.3 uc001dnx.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF644 (see all 6)
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OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Additional cDNA sequence: AK291520.1 BC110841.1 XR_159046.1 XR_159350.1 13 DOTS entries: DT.99957002 DT.100823388 DT.114545 DT.95097056 DT.204930 DT.65288268 DT.95265131 DT.121387379 DT.100823387 DT.92009327 DT.100732065 DT.102842761 DT.95262847 24/235 AceView cDNA sequences (see all 235): CB160718 AU143049 AW235184 BM556967 AU131162 BF001954 AW628405 AK001587 BU685524 AA648966 AU185439 AA427982 N51766 AA513728 CF141476 AI224905 AA729606 AA573139 AU133671 AI161320 CB121921 CA447874 NM_201269 AI468601
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF644 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | | | - | | - | | - | | - | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF644
|
Expression
for ZNF644 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF644 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGTATGGCT
About this image
See ZNF644 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF644
SOURCE GeneReport for Unigene clusters: Hs.173001 Hs.744227
UniProtKB/Swiss-Prot: ZN644_HUMAN, Q9H582Tissue specificity: Expressed in liver, placenta, retina and retinal pigment epithelium
SABiosciences Custom PCR Arrays for ZNF644
Primer
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF644 |
Orthologs
for ZNF644 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF644 gene from 4/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ZNF6441 |
zinc finger protein 644 |
76.01(n)
74.56(a) |
|
424510 XM_001232675.1 XP_001232676.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ZNF6446 |
-- |
71(a) |
1 ↔ 1 |
4(94747357-94771402) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.89272 |
Xenopus laevis transcribed sequence with weak similarity more |
77.38(n) |
|
BG554533.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1005375591 |
zinc finger protein 644-like |
46.82(n)
34.46(a) |
|
100537559 XM_003198781.1 XP_003198829.1 |
ENSEMBL Gene Tree for ZNF644 (if available)
TreeFam Gene Tree for ZNF644 (if available) |
Paralogs
for ZNF644 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF644 gene
- WIZ2
ZNF644 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF644 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF644 (91380855 - 91487829 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF644
1 CNV: 5506
Human Gene Mutation Database (HGMD): ZNF644
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF644 |
|
Disorders
/ Diseases
for ZNF644 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF644 for disorders About GeneDecksing
OMIM gene information: 614159
OMIM disorders: --
UniProtKB/Swiss-Prot: ZN644_HUMAN, Q9H582
Defects in ZNF644 are the cause of myopia type 21 (MYP21) [MIM:614167]. A refractive error of the eye, inwhich parallel rays from a distant object come to focus in front of the retina, vision being better for near objectsthan for far
3  diseases for ZNF644: About MalaCardsmyopia refractive error retinitis
1 disease from the University of Copenhagen DISEASES database for ZNF644:Myopia Export disorders for ZNF644 gene to outside databases
|
Publications
for ZNF644 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF644 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with ZNF644) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (1999)
- Exome sequencing identifies ZNF644 mutations in high myopia. (PubMed id 21695231)1, 2 Shi Y.... Yang Z. (2011)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Study of a US cohort supports the role of ZNF644 and h igh-grade myopia susceptibility. (PubMed id 22539872)1 Tran-Viet K.N....Young T.L. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for ZNF644 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF644 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF644 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZNF644 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF644 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF644 gene:
Search GeneIP for patents involving ZNF644
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF644 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |  |  |  |  | | | | |
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 |
 | | | ZNF644 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF644 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF644 |
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