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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF644 Gene

protein-coding   GIFtS: 49
GCID: GC01M091380

Zinc Finger Protein 644

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 6441 2     Zinc Finger Motif Enhancer Binding Protein 22
BM-0052     KIAA12213
MYP212     ZEP23
NatF2     Zep-23
ZEP-22     Zinc Finger Motif Enhancer-Binding Protein 23

External Ids:    HGNC: 292221   Entrez Gene: 841462   Ensembl: ENSG000001224827   OMIM: 6141595   UniProtKB: Q9H5823   

Export aliases for ZNF644 gene to outside databases

Previous GC identifers: GC01M091093 GC01M091153 GC01M089499


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZNF644 Gene:
The protein encoded by this gene is a zinc finger transcription factor that may play a role in eye development.
Defects in this gene have been associated with high myopia. Three transcript variants encoding two different
isoforms have been found for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for ZNF644 Gene: 
ZNF644 (zinc finger protein 644) is a protein-coding gene. Diseases associated with ZNF644 include myopia, and refractive error. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is WIZ.

UniProtKB/Swiss-Prot: ZN644_HUMAN, Q9H582
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF644 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF644 gene promoter:
         E2F-3a   E2F-4   E2F   E2F-1   Nkx2-2   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF644 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF644

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF644


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.2   Ensembl cytogenetic band:  1p22.2   HGNC cytogenetic band: 1p22.2

ZNF644 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF644 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M091380:  view genomic region     (about GC identifiers)

Start:
91,380,855 bp from pter      End:
91,487,829 bp from pter
Size:
106,975 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN644_HUMAN, Q9H582 (See protein sequence)
Recommended Name: Zinc finger protein 644  
Size: 1327 amino acids; 149565 Da
Subcellular location: Nucleus
Secondary accessions: A2RU71 Q2TAM0 Q5TCC0 Q6BEP7 Q6P446 Q6PI06 Q7LG67 Q9ULJ9
Alternative splicing: 3 isoforms:  Q9H582-1   Q9H582-2   Q9H582-3   

Explore the universe of human proteins at neXtProt for ZNF644: NX_Q9H582

Explore proteomics data for ZNF644 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H582

  • ZNF644 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF644 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_057704.2  NP_115562.3  NP_958357.1  

    ENSEMBL proteins: 
     ENSP00000359469   ENSP00000340828   ENSP00000354659   ENSP00000337008  

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    Cloud-Clone Corp. Proteins for ZNF644 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF644 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9H582

    ProtoNet protein and cluster: Q9H582

    UniProtKB/Swiss-Prot: ZN644_HUMAN, Q9H582
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 7 C2H2-type zinc fingers


    ZNF644 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN644_HUMAN, Q9H582
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF644 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidZNF644 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF644

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ZNF644 (Q9H5823 ENSP000003370084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDYLQ9Y2323, ENSP000003807184I2D: score=1 STRING: ENSP00000380718
    SUMO2ENSP000004059654STRING: ENSP00000405965
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF644 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF644 (ZN644)

    Search CenterWatch for drugs/clinical trials and news about ZNF644 / ZN644

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF644 gene (3 alternative transcripts): 
    NM_016620.3  NM_032186.4  NM_201269.2  

    Unigene Clusters for ZNF644:

    Zinc finger protein 644
    Hs.173001  [show with all ESTs], Hs.745048  [show with all ESTs]
    Unigene Representative Sequences: NM_032186, BC150177
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370440(uc001dnv.3 uc001dny.2) ENST00000347275 ENST00000361321
    ENST00000467231 ENST00000479798 ENST00000482709 ENST00000498303 ENST00000474405
    ENST00000495966 ENST00000482467 ENST00000337393(uc001dnw.3 uc001dnx.3)

    miRNA
    Products:
         
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    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF644 (see all 60):
    hsa-miR-607 hsa-let-7d hsa-miR-200a hsa-miR-30d hsa-miR-374a hsa-miR-449a hsa-miR-502-3p hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidZNF644 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Additional mRNA sequence: 

    AB019255.1 AB033047.1 AF208847.1 AK001587.1 AK023596.1 AK024026.1 BC031003.1 BC041138.1 
    BC063683.1 BC092462.1 BC132776.1 BC132778.1 BC150177.1 

    13 DOTS entries:

    DT.99957002  DT.100823388  DT.114545  DT.95097056  DT.204930  DT.95265131  DT.121387379  DT.100823387 
    DT.92009327  DT.100732065  DT.102842761  DT.65288268  DT.95262847 

    24/235 AceView cDNA sequences (see all 235):

    AI623166 AA729606 AU134074 BX477299 AA573139 AU133671 BM856305 AI161320 
    NM_016620 AI952427 AI468601 CB121921 AL121157 AI224905 CF141476 AA427982 
    AA449968 N51766 BF739955 BF436338 AA283954 BQ014639 W38395 AI091339 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF644 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b
    SP1:                          -     -     -           -           -                                                   
    SP2:                                            -     -           -     -     -     -     -     -                     
    SP3:                                                                                                                  
    SP4:                          -     -     -     -     -           -                                                   
    SP5:                                -     -     -     -           -                                                   


    ECgene alternative splicing isoforms for ZNF644

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF644 expression in normal human tissues (normalized intensities)      ZNF644 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGTATGGCT
    ZNF644 Expression
    About this image


    ZNF644 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Uterus (Reproductive System)
             endometrial endothelial cell   
     
     Larynx (Respiratory System)

    See ZNF644 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF644

    SOURCE GeneReport for Unigene clusters: Hs.173001 Hs.745048

    UniProtKB/Swiss-Prot: ZN644_HUMAN, Q9H582
    Tissue specificity: Expressed in liver, placenta, retina and retinal pigment epithelium

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF644 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp6441 , 5 zinc finger protein 6441, 5 86.32(n)1
    85.13(a)1
      5 (51.43 cM)5
    523971  NM_026856.21  NP_081132.21 
     1065008945 
    chicken
    (Gallus gallus)
    Aves ZNF6441 zinc finger protein 644 76.01(n)
    74.56(a)
      424510  XM_001232675.1  XP_001232676.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF6446
    Uncharacterized protein
    71(a)
    1 ↔ 1
    4(94747357-94775793)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.89272 Xenopus laevis transcribed sequence with weak similarity more 77.38(n)    BG554533.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005375591 zinc finger protein 644-like 46.82(n)
    34.46(a)
      100537559  XM_003198781.1  XP_003198829.1 


    ENSEMBL Gene Tree for ZNF644 (if available)
    TreeFam Gene Tree for ZNF644 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF644 gene
    WIZ2  

    ZNF644 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2044 SNPs in ZNF644 are shown (see all 2044)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0663904
    Myopia 21 (MYP21)4--see VAR_0663902 S G mis40--------
    VAR_0663924
    Myopia 21 (MYP21)4--see VAR_0663922 C Y mis40--------
    VAR_0663914
    Myopia 21 (MYP21)4--see VAR_0663912 R G mis40--------
    VAR_0355934
    A breast cancer sample4--see VAR_0355932 E Q mis40--------
    rs677746001,2
    C--89518238(+) AAATAAATG/-  
            
    AACAA
    3 -- int11Minor allele frequency- -:0.50CSA 2
    rs122394591,2
    C--89534910(+) GAAAAG/CAAAAG 3 -- int11Minor allele frequency- C:0.50WA 2
    rs1114022561,2
    C--89543532(+) AAACAAAAC/-  
            
    AAACA
    3 -- int11Minor allele frequency- -:0.00CSA 2
    rs793661391,2
    F--89583653(+) ATCTAC/TGTCTG 3 -- int13Minor allele frequency- T:0.33NA 6
    rs23080061,2
    C,F--91393208(+) AAATGTA/-TACAC 3 -- int14Minor allele frequency- -:0.19EU NA EA 342
    rs1471877181,2
    C--91399239(+) AAATA-/AATG  
            
    AACAA
    3 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF644 (91380855 - 91487829 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF644:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv159370CNV Loss16902084


    Human Gene Mutation Database (HGMD): ZNF644
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF644
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF644

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614159    OMIM disorders: --

    UniProtKB/Swiss-Prot: ZN644_HUMAN, Q9H582
  • Myopia 21 (MYP21) [MIM:614167]: A refractive error of the eye, in which parallel rays from a distant
    object come to focus in front of the retina, vision being better for near objects than for far. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • 3 diseases for ZNF644:    About MalaCards
    myopia    refractive error    retinitis

    1 disease from the University of Copenhagen DISEASES database for ZNF644:
    Myopia

    ZNF644 for disorders           About GeneDecksing


    Export disorders for ZNF644 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF644 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with ZNF644)
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    1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (1999)
    2. Exome sequencing identifies ZNF644 mutations in high myopia. (PubMed id 21695231)1, 2 Shi Y.... Yang Z. (2011)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Study of a US cohort supports the role of ZNF644 and h igh-grade myopia susceptibility. (PubMed id 22539872)1 Tran-Viet K.N....Young T.L. (2012)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84146 HGNC: 29222 AceView: Zep-2 Ensembl:ENSG00000122482 euGenes: HUgn84146
    ECgene: ZNF644 H-InvDB: ZNF644

    (According to HUGE)
    About This Section
    HUGE: KIAA1221

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF644 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF644 gene:
    Search GeneIP for patents involving ZNF644

    GeneCards and IP:
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