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Aliases for ZNF644 Gene

Aliases for ZNF644 Gene

  • Zinc Finger Protein 644 2 3 5
  • ZEP-2 3 4
  • Zinc Finger Motif Enhancer Binding Protein 2 3
  • Zinc Finger Motif Enhancer-Binding Protein 2 4
  • KIAA1221 4
  • BM-005 3
  • MYP21 3
  • NatF 3
  • ZEP2 4

External Ids for ZNF644 Gene

Previous GeneCards Identifiers for ZNF644 Gene

  • GC01M091093
  • GC01M091153
  • GC01M091380
  • GC01M089499

Summaries for ZNF644 Gene

Entrez Gene Summary for ZNF644 Gene

  • The protein encoded by this gene is a zinc finger transcription factor that may play a role in eye development. Defects in this gene have been associated with high myopia. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for ZNF644 Gene

ZNF644 (Zinc Finger Protein 644) is a Protein Coding gene. Diseases associated with ZNF644 include Myopia 21, Autosomal Dominant and Myopia. An important paralog of this gene is WIZ.

UniProtKB/Swiss-Prot for ZNF644 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF644 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF644 Gene

Genomics for ZNF644 Gene

Regulatory Elements for ZNF644 Gene

Enhancers for ZNF644 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF644 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF644 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF644 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF644 Gene

Chromosome:
1
Start:
90,915,298 bp from pter
End:
91,022,272 bp from pter
Size:
106,975 bases
Orientation:
Minus strand

Genomic View for ZNF644 Gene

Genes around ZNF644 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF644 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF644 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF644 Gene

Proteins for ZNF644 Gene

  • Protein details for ZNF644 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H582-ZN644_HUMAN
    Recommended name:
    Zinc finger protein 644
    Protein Accession:
    Q9H582
    Secondary Accessions:
    • A2RU71
    • Q2TAM0
    • Q5TCC0
    • Q6BEP7
    • Q6P446
    • Q6PI06
    • Q7LG67
    • Q9ULJ9

    Protein attributes for ZNF644 Gene

    Size:
    1327 amino acids
    Molecular mass:
    149565 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF644 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF644 Gene

Proteomics data for ZNF644 Gene at MOPED

Post-translational modifications for ZNF644 Gene

  • Ubiquitination at Lys 843 and Lys 1110
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF644 Gene

No data available for DME Specific Peptides for ZNF644 Gene

Domains & Families for ZNF644 Gene

Protein Domains for ZNF644 Gene

Suggested Antigen Peptide Sequences for ZNF644 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H582

UniProtKB/Swiss-Prot:

ZN644_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 7 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF644: view

No data available for Gene Families for ZNF644 Gene

Function for ZNF644 Gene

Molecular function for ZNF644 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF644 Gene

genes like me logo Genes that share phenotypes with ZNF644: view

Human Phenotype Ontology for ZNF644 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for ZNF644 Gene

miRTarBase miRNAs that target ZNF644

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF644 Gene

Localization for ZNF644 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF644 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF644 Gene COMPARTMENTS Subcellular localization image for ZNF644 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF644 Gene

Pathways & Interactions for ZNF644 Gene

SuperPathways for ZNF644 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF644 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF644: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF644 Gene

Drugs & Compounds for ZNF644 Gene

No Compound Related Data Available

Transcripts for ZNF644 Gene

Unigene Clusters for ZNF644 Gene

Zinc finger protein 644:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF644 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b
SP1: - - - - -
SP2: - - - - - - - -
SP3:
SP4: - - - - - -
SP5: - - - - -
SP6: - - -
SP7: -
SP8: - - -
SP9: - - - - -

Relevant External Links for ZNF644 Gene

GeneLoc Exon Structure for
ZNF644
ECgene alternative splicing isoforms for
ZNF644

Expression for ZNF644 Gene

mRNA expression in normal human tissues for ZNF644 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF644 Gene

This gene is overexpressed in Plasma (23.8), Lung (21.9), and Liver (21.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF644 Gene



SOURCE GeneReport for Unigene cluster for ZNF644 Gene Hs.173001

mRNA Expression by UniProt/SwissProt for ZNF644 Gene

Q9H582-ZN644_HUMAN
Tissue specificity: Expressed in liver, placenta, retina and retinal pigment epithelium.
genes like me logo Genes that share expression patterns with ZNF644: view

Protein tissue co-expression partners for ZNF644 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for ZNF644 Gene

Orthologs for ZNF644 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF644 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF644 35
  • 93.42 (n)
  • 92.54 (a)
ZNF644 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF644 35
  • 93.44 (n)
  • 93.82 (a)
ZNF644 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp644 35
  • 86.26 (n)
  • 85.13 (a)
Zfp644 16
Zfp644 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF644 35
  • 99.45 (n)
  • 99.4 (a)
ZNF644 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp644 35
  • 82.8 (n)
  • 81.82 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF644 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF644 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF644 35
  • 80.78 (n)
  • 81.12 (a)
ZNF644 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF644 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf644 35
  • 68.43 (n)
  • 61.27 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8927 35
zebrafish
(Danio rerio)
Actinopterygii znf644b 36
  • 28 (a)
OneToOne
Species with no ortholog for ZNF644:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF644 Gene

ENSEMBL:
Gene Tree for ZNF644 (if available)
TreeFam:
Gene Tree for ZNF644 (if available)

Paralogs for ZNF644 Gene

Paralogs for ZNF644 Gene

genes like me logo Genes that share paralogs with ZNF644: view

Variants for ZNF644 Gene

Sequence variations from dbSNP and Humsavar for ZNF644 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035593 A breast cancer sample
rs17131242 - 90,939,688(+) GACCA(C/T)AGGGC intron-variant, reference, missense
rs10922938 - 90,938,973(+) TTTTG(A/G)CGTCA intron-variant, reference, missense
rs146936371 Myopia 21, autosomal dominant (MYP21) 90,939,595(+) ACATA(C/T)GTAGG intron-variant, reference, missense
VAR_066390 Myopia 21, autosomal dominant (MYP21)

Structural Variations from Database of Genomic Variants (DGV) for ZNF644 Gene

Variant ID Type Subtype PubMed ID
nsv159370 CNV Loss 16902084

Variation tolerance for ZNF644 Gene

Residual Variation Intolerance Score: 32.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.29; 62.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF644 Gene

Human Gene Mutation Database (HGMD)
ZNF644

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF644 Gene

Disorders for ZNF644 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ZNF644 Gene - From: OMIM, ClinVar, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
myopia 21, autosomal dominant
  • myp21
myopia
  • near vision
refractive error
  • refractive errors
degenerative myopia
  • degenerative progressive high myopia
spermatocele
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ZN644_HUMAN
  • Myopia 21, autosomal dominant (MYP21) [MIM:614167]: A refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far. {ECO:0000269 PubMed:21695231, ECO:0000269 PubMed:22539872, ECO:0000269 PubMed:24991186, ECO:0000269 PubMed:25525168}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ZNF644

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF644
genes like me logo Genes that share disorders with ZNF644: view

No data available for Genatlas for ZNF644 Gene

Publications for ZNF644 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. Detection of mutations in LRPAP1, CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2 in 298 families with early-onset high myopia by exome sequencing. (PMID: 25525168) Jiang D. … Zhang Q. (Invest. Ophthalmol. Vis. Sci. 2015) 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. The zinc finger proteins ZNF644 and WIZ regulate the G9a/GLP complex for gene repression. (PMID: 25789554) Bian C. … Yu X. (Elife 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ZNF644 Gene

Sources for ZNF644 Gene

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