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Aliases for ZNF641 Gene

Aliases for ZNF641 Gene

  • Zinc Finger Protein 641 2 3 5

External Ids for ZNF641 Gene

Previous GeneCards Identifiers for ZNF641 Gene

  • GC12M047023
  • GC12M048733
  • GC12M045767

Summaries for ZNF641 Gene

GeneCards Summary for ZNF641 Gene

ZNF641 (Zinc Finger Protein 641) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF202.

UniProtKB/Swiss-Prot for ZNF641 Gene

  • Transcriptional activator. Activates transcriptional activities of SRE and AP-1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF641 Gene

Genomics for ZNF641 Gene

Regulatory Elements for ZNF641 Gene

Enhancers for ZNF641 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F048349 1.1 ENCODE 51.5 +0.7 674 2.9 PKNOX1 SIN3A FEZF1 BRCA1 ZNF2 YY1 GLIS2 GATA2 ELK1 ZNF263 ZNF641 RPL37P19 ENSG00000257735 ENSG00000258273
GH12F048278 0.8 Ensembl ENCODE 62.8 +71.5 71516 1.9 CTCF ZNF652 TRIM28 TCF7L2 ZNF641 RPL37P19 LOC102725258 H1FNT LOC105369753 OR10AD1
GH12F048282 0.6 Ensembl 62.8 +68.9 68914 0.6 DPF2 ZNF121 GATA3 GATA2 ZNF610 FOSL2 PRDM1 TCF7L2 ZNF641 LOC105369753 OR10AD1
GH12F048296 1.1 Ensembl ENCODE 32.8 +54.5 54535 1.5 TBP HDAC1 ATF1 CBX3 CREB3L1 ZNF76 ETS1 ZNF366 ZNF143 CREM ZNF641 RPL37P19 DDX23 CCNT1 LOC390314 SENP1 CCDC184 ASB8 LOC105369753 OR10AD1
GH12F048212 0.9 Ensembl ENCODE 35.3 +138.1 138126 1.8 TFDP1 ZNF766 L3MBTL2 ZNF740 NRF1 ZNF512 ZBTB40 MGA ZNF641 RPL37P19 H1FNT ASB8 CCDC184 OR10AD1 LOC105369753
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF641 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF641 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000172757 614 2401 PKNOX1 SIN3A FEZF1 BRCA1 ZNF2 YY1 GLIS2 ELK1 ZNF263 SP3

Genomic Location for ZNF641 Gene

Chromosome:
12
Start:
48,335,491 bp from pter
End:
48,351,414 bp from pter
Size:
15,924 bases
Orientation:
Minus strand

Genomic View for ZNF641 Gene

Genes around ZNF641 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF641 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF641 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF641 Gene

Proteins for ZNF641 Gene

  • Protein details for ZNF641 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96N77-ZN641_HUMAN
    Recommended name:
    Zinc finger protein 641
    Protein Accession:
    Q96N77
    Secondary Accessions:
    • B3KS43
    • B4DNU5
    • Q8TCQ7
    • Q8WVE1

    Protein attributes for ZNF641 Gene

    Size:
    438 amino acids
    Molecular mass:
    49528 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF641 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF641 Gene

Post-translational modifications for ZNF641 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF641 Gene

Domains & Families for ZNF641 Gene

Gene Families for ZNF641 Gene

Protein Domains for ZNF641 Gene

Graphical View of Domain Structure for InterPro Entry

Q96N77

UniProtKB/Swiss-Prot:

ZN641_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF641: view

Function for ZNF641 Gene

Molecular function for ZNF641 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator. Activates transcriptional activities of SRE and AP-1.

Gene Ontology (GO) - Molecular Function for ZNF641 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF641: view
genes like me logo Genes that share phenotypes with ZNF641: view

Animal Model Products

miRNA for ZNF641 Gene

miRTarBase miRNAs that target ZNF641

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF641 Gene

Localization for ZNF641 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF641 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF641 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for ZNF641 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZNF641: view

Pathways & Interactions for ZNF641 Gene

SuperPathways for ZNF641 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF641: view

Pathways by source for ZNF641 Gene

2 Reactome pathways for ZNF641 Gene

Gene Ontology (GO) - Biological Process for ZNF641 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ZNF641: view

No data available for SIGNOR curated interactions for ZNF641 Gene

Transcripts for ZNF641 Gene

Unigene Clusters for ZNF641 Gene

Zinc finger protein 641:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF641 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d
SP1: - - - - -
SP2: - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: -
SP7:
SP8:

Relevant External Links for ZNF641 Gene

GeneLoc Exon Structure for
ZNF641
ECgene alternative splicing isoforms for
ZNF641

Expression for ZNF641 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF641 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF641 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF641 Gene



Protein tissue co-expression partners for ZNF641 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF641 Gene:

ZNF641

SOURCE GeneReport for Unigene cluster for ZNF641 Gene:

Hs.23492

mRNA Expression by UniProt/SwissProt for ZNF641 Gene:

Q96N77-ZN641_HUMAN
Tissue specificity: Highly expressed in skeletal muscle, moderate expression in heart, liver, and pancreas, lower expression in placenta, no expression seen in brain, lung, and kidney.
genes like me logo Genes that share expression patterns with ZNF641: view

Primer Products

No data available for mRNA differential expression in normal tissues for ZNF641 Gene

Orthologs for ZNF641 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF641 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF641 34 35
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia ZNF641 34 35
  • 93.44 (n)
cow
(Bos Taurus)
Mammalia ZNF641 34 35
  • 92.53 (n)
rat
(Rattus norvegicus)
Mammalia Zfp641 34
  • 85.27 (n)
mouse
(Mus musculus)
Mammalia Zfp641 34 16 35
  • 84.44 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF641 35
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF641 35
  • 41 (a)
OneToOne
Species where no ortholog for ZNF641 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF641 Gene

ENSEMBL:
Gene Tree for ZNF641 (if available)
TreeFam:
Gene Tree for ZNF641 (if available)

Paralogs for ZNF641 Gene

Paralogs for ZNF641 Gene

genes like me logo Genes that share paralogs with ZNF641: view

Variants for ZNF641 Gene

Sequence variations from dbSNP and Humsavar for ZNF641 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10083019 -- 48,334,821(+) gttct(C/G/T)gggag utr-variant-3-prime
rs1061986 -- 48,342,656(-) AGTCT(A/G)TGCTA intron-variant, utr-variant-3-prime
rs10875798 -- 48,339,101(+) AATCA(C/T)AGGAG intron-variant, utr-variant-3-prime
rs10875799 -- 48,347,096(+) AGGGT(A/C)TTATG intron-variant
rs111324025 -- 48,351,143(+) GCTTG(C/G)AGGGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF641 Gene

Variant ID Type Subtype PubMed ID
nsv8971 CNV gain+loss 18304495
nsv832402 CNV gain 17160897
nsv826362 CNV gain 20364138
nsv438208 CNV loss 16468122
nsv437752 CNV loss 16327808
nsv1045159 CNV gain 25217958
nsv1044444 CNV loss 25217958
esv3629436 CNV gain 21293372
esv34439 CNV gain 17911159
esv2759898 CNV gain+loss 17122850

Variation tolerance for ZNF641 Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.68; 82.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF641 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF641

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF641 Gene

Disorders for ZNF641 Gene

Relevant External Links for ZNF641

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF641

No disorders were found for ZNF641 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF641 Gene

Publications for ZNF641 Gene

  1. Activation of transcriptional activities of AP-1 and SRE by a new zinc-finger protein ZNF641. (PMID: 16343441) Qi X. … Wu X. (Biochem. Biophys. Res. Commun. 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3 64
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  5. Protein array based interactome analysis of amyloid-I^ indicates an inhibition of protein translation. (PMID: 21244100) Virok D.P. … FA1lAPp L. (J. Proteome Res. 2011) 3 64

Products for ZNF641 Gene

Sources for ZNF641 Gene

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