ZNF641 Gene
protein-coding GIFtS: 49
GCID: GC12M048733
|
|
zinc finger protein 641
| |
Aliases
for ZNF641 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 6411 2 | | FLJ312951 |
Export aliases for ZNF641 gene to outside databasesPrevious GC identifers: GC12M047023 GC12M045767 |
Summaries
for ZNF641 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN641_HUMAN, Q96N77Function: Transcriptional activatior. Activates transcriptional activities of SRE and AP-1
|
Genomic Views
for ZNF641 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF641 gene promoter:
NF-1 RFX1 USF1 AP-1 ATF-2 LCR-F1 Evi-1 USF-1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF641
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF641 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.11 Ensembl cytogenetic band: 12q13.11 HGNC cytogenetic band: 12q13.11ZNF641 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M048733: view genomic region
(about GC identifiers)
Start:
|
48,733,791 bp from pter |
End:
|
48,745,197 bp from pter |
Size:
|
11,407 bases |
Orientation:
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minus strand |
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Proteins
for ZNF641 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN641_HUMAN, Q96N77 (See
protein sequence)Recommended Name: Zinc finger protein 641 Size: 438 amino acids; 49528 Da
Subcellular location: Nucleus
Secondary accessions: B3KS43 B4DNU5 Q8TCQ7 Q8WVE1Alternative splicing: 4 isoforms: Q96N77-1 Q96N77-2 Q96N77-3 Q96N77-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF641: NX_Q96N77
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96N77
ZNF641 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001166152.1 NP_001166153.1 NP_689533.2
ENSEMBL proteins: ENSP00000437832 ENSP00000394627 ENSP00000449974 ENSP00000448025 ENSP00000448140 ENSP00000448810 ENSP00000447381 ENSP00000446625 ENSP00000301042 Reactome Protein details: Q96N77
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
ZNF641 for ontologies About GeneDecksing
ZNF641 Antibody Products:
Assay Products for ZNF641: |
Protein
Domains /
Families
for ZNF641 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF641 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96N77ProtoNet protein and cluster: Q96N77 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN641_HUMAN, Q96N77Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 5 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF641 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN641_HUMAN, Q96N77Function: Transcriptional activatior. Activates transcriptional activities of SRE and AP-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF641 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF641 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): ZNF641 (NM_152320) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF641 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF641 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF641 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF641 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZNF641:
|
Pathways & Interactions
for ZNF641 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF641
ZNF641 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF641
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for ZNF641 (Q96N773 ENSP000003010424) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF641 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF641 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF641
Search CenterWatch for drugs/clinical trials and news about ZNF641 / ZN641
|
Transcripts
for ZNF641 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF641 gene (3 alternative transcripts): NM_001172681.1 NM_001172682.1 NM_152320.2 Unigene Cluster for ZNF641: Zinc finger protein 641 Hs.23492 [show with all ESTs]Unigene Representative Sequence: AY84228510 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000544117 ENST00000448928 ENST00000547026 ENST00000549512 ENST00000546874
ENST00000549125 ENST00000548932 ENST00000550181 ENST00000550342 ENST00000301042(uc001rrn.2 uc001rro.2 uc010sls.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF641 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF641 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): ZNF641 (NM_152320) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF641 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF641 |
Additional cDNA sequence: AF086127.1 AK055857.1 AK092740.1 AK127710.1 AK298064.1 AL713659.1 AY842285.1 BC018090.1 11 DOTS entries: DT.110775 DT.408833 DT.100763500 DT.95083958 DT.97858537 DT.100734385 DT.87015609 DT.100809546 DT.121147718 DT.40131146 DT.95260013 17 AceView cDNA sequences: AF086127 AK092740 AX747699 AA548635 AA662552 AK055857 BC018090 NM_152320 AL713659 AK127710 AK054984 BF747290 BX420623 BE062008 BE062148 BX413683 BF899105
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF641 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | | | | | | | - | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | - | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF641
|
Expression
for ZNF641 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF641 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGTCTAAGG
About this image
See ZNF641 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF641
SOURCE GeneReport for Unigene cluster: Hs.23492
UniProtKB/Swiss-Prot: ZN641_HUMAN, Q96N77Tissue specificity: Highly expressed in skeletal muscle, moderate expression in heart, liver, and pancreas, lowerexpression in placenta, no expression seen in brain, lung, and kidney
SABiosciences Custom PCR Arrays for ZNF641
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF641
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF641 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF641 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF641 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF641 |
Orthologs
for ZNF641 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF641 gene from 1/7 species (see all 7) About this table
ENSEMBL Gene Tree for ZNF641 (if available)
TreeFam Gene Tree for ZNF641 (if available) |
Paralogs
for ZNF641 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ZNF641 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF641 (48733791 - 48745197 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ZNF641
4 CNVs: 30600 2983 8729 3888 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF641 |
|
Disorders
/ Diseases
for ZNF641 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF641 for disorders About MalaCards
ZNF641 for disorders About GeneDecksing
OMIM gene information: 613906
OMIM disorders: --
Export disorders for ZNF641 gene to outside databases
|
Publications
for ZNF641 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF641 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF641) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Activation of transcriptional activities of AP-1 and SRE by a new zinc-finger protein ZNF641. (PubMed id 16343441)1, 2 Qi X.... Wu X. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF641 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF641 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF641 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF641 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF641 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF641 gene:
Search GeneIP for patents involving ZNF641
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF641 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF641 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF641 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF641 | | | OriGene Protein Over-expression Lysate for ZNF641 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF641 | | OriGene 3'-UTR Clone for ZNF641 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF641 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF641 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF641 | | OriGene Custom Protein Services for ZNF641 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF641 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF641 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF641 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF641 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF641 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF641 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ZNF641 |
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 | | | ZNF641 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF641 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF641 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF641 |
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