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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF641 Gene

protein-coding   GIFtS: 49
GCID: GC12M048733

Zinc Finger Protein 641

  Search for ZNF641
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 6411 2

External Ids:    HGNC: 318341   Entrez Gene: 1212742   Ensembl: ENSG000001675287   OMIM: 6139065   UniProtKB: Q96N773   

Export aliases for ZNF641 gene to outside databases

Previous GC identifers: GC12M047023 GC12M045767


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF641 Gene: 
ZNF641 (zinc finger protein 641) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF263.

UniProtKB/Swiss-Prot: ZN641_HUMAN, Q96N77
Function: Transcriptional activatior. Activates transcriptional activities of SRE and AP-1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF641 gene promoter:
         NF-1   RFX1   USF1   AP-1   ATF-2   LCR-F1   Evi-1   USF-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF641 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF641

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF641


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.11   Ensembl cytogenetic band:  12q13.11   HGNC cytogenetic band: 12q13.11

ZNF641 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF641 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M048733:  view genomic region     (about GC identifiers)

Start:
48,733,791 bp from pter      End:
48,745,197 bp from pter
Size:
11,407 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN641_HUMAN, Q96N77 (See protein sequence)
Recommended Name: Zinc finger protein 641  
Size: 438 amino acids; 49528 Da
Subcellular location: Nucleus
Secondary accessions: B3KS43 B4DNU5 Q8TCQ7 Q8WVE1
Alternative splicing: 4 isoforms:  Q96N77-1   Q96N77-2   Q96N77-3   Q96N77-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF641: NX_Q96N77

Explore proteomics data for ZNF641 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96N77

  • ZNF641 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF641 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001166152.1  NP_001166153.1  NP_689533.2  

    ENSEMBL proteins: 
     ENSP00000437832   ENSP00000394627   ENSP00000449974   ENSP00000448025   ENSP00000448140  
     ENSP00000448810   ENSP00000447381   ENSP00000446625   ENSP00000301042  
    Reactome Protein details: Q96N77
    Human Recombinant Protein Products for ZNF641: 
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    Cloud-Clone Corp. Proteins for ZNF641 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    ZNF641 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96N77

    ProtoNet protein and cluster: Q96N77

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN641_HUMAN, Q96N77
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF641 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN641_HUMAN, Q96N77
    Function: Transcriptional activatior. Activates transcriptional activities of SRE and AP-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF641 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF641:
     Increased cell number in G1, a 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidZNF641 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF641 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF641
        Generic Transcription Pathway
    Gene Expression



    ZNF641 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF641

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for ZNF641 (Q96N773 ENSP000003010424) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BARX1Q9HBU13I2D: score=1 
    ZNF524Q96C553I2D: score=1 
    SQLEENSP000002658964STRING: ENSP00000265896
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
    GO:0006366transcription from RNA polymerase II promoter IBA--

    ZNF641 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF641 (ZN641)

    Search CenterWatch for drugs/clinical trials and news about ZNF641 / ZN641

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF641 gene (3 alternative transcripts): 
    NM_001172681.1  NM_001172682.1  NM_152320.2  

    Unigene Cluster for ZNF641:

    Zinc finger protein 641
    Hs.23492  [show with all ESTs]
    Unigene Representative Sequence: AY842285
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000544117 ENST00000448928 ENST00000547026 ENST00000549512 ENST00000546874
    ENST00000549125 ENST00000548932 ENST00000550181 ENST00000550342 ENST00000301042(uc001rrn.2 uc001rro.2 uc010sls.2)

    miRNA
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    hsa-miR-124* hsa-miR-4291 hsa-miR-582-3p hsa-let-7d hsa-let-7a-2* hsa-miR-3074-3p hsa-miR-507 hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF641 3' UTR sequence
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    Additional mRNA sequence: 

    AF086127.1 AK055857.1 AK092740.1 AK127710.1 AK298064.1 AL713659.1 AY842285.1 BC018090.1 

    11 DOTS entries:

    DT.110775  DT.408833  DT.100763500  DT.95083958  DT.97858537  DT.100734385  DT.87015609  DT.100809546 
    DT.121147718  DT.40131146  DT.95260013 

    17 AceView cDNA sequences:

    AX747699 AF086127 AK092740 AA662552 AL713659 BC018090 AA548635 NM_152320 
    AK055857 AK127710 AK054984 BF747290 BE062008 BX420623 BE062148 BX413683 
    BF899105 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF641 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d
    SP1:                          -     -     -                       -                 -                                 
    SP2:                                                              -                 -                                 
    SP3:                          -     -     -                       -     -     -     -                                 
    SP4:        -     -     -     -     -     -                       -                                                   
    SP5:                          -     -     -                                                                           


    ECgene alternative splicing isoforms for ZNF641

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF641 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTCTAAGG
    ZNF641 Expression
    About this image


    See ZNF641 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF641

    SOURCE GeneReport for Unigene cluster: Hs.23492

    UniProtKB/Swiss-Prot: ZN641_HUMAN, Q96N77
    Tissue specificity: Highly expressed in skeletal muscle, moderate expression in heart, liver, and pancreas, lower
    expression in placenta, no expression seen in brain, lung, and kidney

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF641 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp6411 , 5 zinc finger protein 6411, 5 84.44(n)1
    82.7(a)1
      15 (54.29 cM)5
    2396521  NM_173769.31  NP_776130.11 
     982861225 


    ENSEMBL Gene Tree for ZNF641 (if available)
    TreeFam Gene Tree for ZNF641 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF641 gene
    ZNF2632  ZNF4962  ZNF2022  ZSCAN252  ZKSCAN52  
    18/68 SIMAP similar genes for ZNF641 using alignment to 6 protein entries:     ZN641_HUMAN (see all proteins) (see all similar genes):
    POM121C    ZNF28    ZNF761    ZNF133    ZNF81    ZNF720
    ZNF331    ZNF33B    ZNF78L1    kr-znf3    ZNF251    ZNF248
    ZNF254    DKFZp434J0650    MGC12518    ZNF273    ZNF718    ZNF169

    ZNF641 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/241 SNPs in ZNF641 are shown (see all 241)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs24509921,2
    C,F,A,H--48579678(-) CAGGCG/ATGAGA 2 -- us2k19Minor allele frequency- A:0.44NA WA CSA 137
    rs1438725841,2
    --48579729(+) AGGTCA/GGGAGT 2 -- us2k10--------
    rs1397735121,2
    --48733480(+) CCCTTA/GATGGA 3 -- ds50010--------
    rs571750551,2
    C--48733695(+) TTTGAA/GAGATA 3 -- ds50012Minor allele frequency- G:0.04WA 120
    rs781978171,2
    C,F--48733753(+) CCAGAT/CGGAAA 3 -- ds50011Minor allele frequency- C:0.12NA 120
    rs1130242931,2
    C--48733859(+) TGAACAT/-TTGAG 3 -- ut311Minor allele frequency- -:0.50CSA 2
    rs1810764531,2
    --48733947(+) AGAGAA/GGTGGT 3 -- ut310--------
    rs1452706111,2
    C--48733973(+) AGAAGA/GCAGTG 3 -- ut310--------
    rs1476201451,2
    --48734048(+) TTCAGC/TTGGGT 3 -- ut310--------
    rs1852788001,2
    C--48734052(+) GCTGGA/GTGCTA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF641 (48733791 - 48745197 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ZNF641:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv437752CNV Loss16327808
    nsv438208CNV Loss16468122
    esv34439CNV Gain17911159
    nsv826362CNV Gain20364138
    nsv832402CNV Gain17160897
    nsv8971CNV Gain+Loss18304495
    dgv510e1CNV Complex17122850
    dgv509e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF641 for disorders           About MalaCards
    OMIM gene information: 613906    OMIM disorders: --


    ZNF641 for disorders           About GeneDecksing


    Export disorders for ZNF641 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF641 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF641)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of transcriptional activities of AP-1 and SRE by a new zinc-finger protein ZNF641. (PubMed id 16343441)1, 2 Qi X.... Wu X. (2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    4. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 121274 HGNC: 31834 AceView: FLJ31295 Ensembl:ENSG00000167528 euGenes: HUgn121274
    ECgene: ZNF641 H-InvDB: ZNF641

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF641 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF641 gene:
    Search GeneIP for patents involving ZNF641

    GeneCards and IP:
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