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Aliases for ZNF641 Gene

Aliases for ZNF641 Gene

  • Zinc Finger Protein 641 2 3

External Ids for ZNF641 Gene

Previous GeneCards Identifiers for ZNF641 Gene

  • GC12M047023
  • GC12M048733
  • GC12M045767

Summaries for ZNF641 Gene

GeneCards Summary for ZNF641 Gene

ZNF641 (Zinc Finger Protein 641) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity. An important paralog of this gene is ZNF202.

UniProtKB/Swiss-Prot for ZNF641 Gene

  • Transcriptional activator. Activates transcriptional activities of SRE and AP-1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF641 Gene

Genomics for ZNF641 Gene

Regulatory Elements for ZNF641 Gene

Genomic Location for ZNF641 Gene

Start:
48,335,282 bp from pter
End:
48,351,414 bp from pter
Size:
16,133 bases
Orientation:
Minus strand

Genomic View for ZNF641 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF641 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF641 Gene

Proteins for ZNF641 Gene

  • Protein details for ZNF641 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96N77-ZN641_HUMAN
    Recommended name:
    Zinc finger protein 641
    Protein Accession:
    Q96N77
    Secondary Accessions:
    • B3KS43
    • B4DNU5
    • Q8TCQ7
    • Q8WVE1

    Protein attributes for ZNF641 Gene

    Size:
    438 amino acids
    Molecular mass:
    49528 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF641 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF641 Gene

Proteomics data for ZNF641 Gene at MOPED

Post-translational modifications for ZNF641 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF641 Gene

Domains for ZNF641 Gene

Gene Families for ZNF641 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF641 Gene

Graphical View of Domain Structure for InterPro Entry

Q96N77

UniProtKB/Swiss-Prot:

ZN641_HUMAN :
  • Q96N77
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF641: view

Function for ZNF641 Gene

Molecular function for ZNF641 Gene

UniProtKB/Swiss-Prot Function: Transcriptional activator. Activates transcriptional activities of SRE and AP-1.

Gene Ontology (GO) - Molecular Function for ZNF641 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF641: view

Phenotypes for ZNF641 Gene

GenomeRNAi human phenotypes for ZNF641:
genes like me logo Genes that share phenotypes with ZNF641: view

miRNA for ZNF641 Gene

miRTarBase miRNAs that target ZNF641

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF641 Gene

Localization for ZNF641 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF641 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF641 Gene COMPARTMENTS Subcellular localization image for ZNF641 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF641 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZNF641: view

Pathways for ZNF641 Gene

SuperPathways for ZNF641 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF641: view

Pathways by source for ZNF641 Gene

2 Reactome pathways for ZNF641 Gene

Gene Ontology (GO) - Biological Process for ZNF641 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ZNF641: view

Transcripts for ZNF641 Gene

Unigene Clusters for ZNF641 Gene

Zinc finger protein 641:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF641 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d
SP1: - - - - -
SP2: - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: -
SP7:
SP8:

Relevant External Links for ZNF641 Gene

GeneLoc Exon Structure for
ZNF641
ECgene alternative splicing isoforms for
ZNF641

Expression for ZNF641 Gene

mRNA expression in normal human tissues for ZNF641 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF641 Gene

SOURCE GeneReport for Unigene cluster for ZNF641 Gene Hs.23492

mRNA Expression by UniProt/SwissProt for ZNF641 Gene

Q96N77-ZN641_HUMAN
Tissue specificity: Highly expressed in skeletal muscle, moderate expression in heart, liver, and pancreas, lower expression in placenta, no expression seen in brain, lung, and kidney.
genes like me logo Genes that share expressions with ZNF641: view

No data available for mRNA differential expression in normal tissues for ZNF641 Gene

Orthologs for ZNF641 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF641 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF641 35
  • 99.62 (n)
  • 99.54 (a)
ZNF641 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF641 35
  • 92.53 (n)
  • 95.52 (a)
ZNF641 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF641 35
  • 93.44 (n)
  • 96.53 (a)
ZNF641 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp641 35
  • 84.44 (n)
  • 82.7 (a)
Zfp641 16
Zfp641 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF641 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF641 36
  • 41 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp641 35
  • 85.27 (n)
  • 83.85 (a)
Species with no ortholog for ZNF641:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF641 Gene

ENSEMBL:
Gene Tree for ZNF641 (if available)
TreeFam:
Gene Tree for ZNF641 (if available)

Paralogs for ZNF641 Gene

Paralogs for ZNF641 Gene

genes like me logo Genes that share paralogs with ZNF641: view

Variants for ZNF641 Gene

Sequence variations from dbSNP and Humsavar for ZNF641 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs751315 -- 48,340,492(+) CTTGT(C/T)GTAAT utr-variant-3-prime, intron-variant
rs751316 -- 48,340,726(+) AGTGC(A/G)TTTCT utr-variant-3-prime, intron-variant
rs901962 -- 48,347,436(-) AGAAG(A/T)TGTGA intron-variant
rs901963 -- 48,340,826(-) TGACA(C/T)TTCTT utr-variant-3-prime, intron-variant
rs1061986 -- 48,342,656(-) AGTCT(A/G)TGCTA utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF641 Gene

Variant ID Type Subtype PubMed ID
dgv509e1 CNV Complex 17122850
nsv8971 CNV Gain+Loss 18304495
esv34439 CNV Gain 17911159
dgv510e1 CNV Complex 17122850
nsv832402 CNV Gain 17160897
nsv826362 CNV Gain 20364138
nsv437752 CNV Loss 16327808
nsv438208 CNV Loss 16468122

Relevant External Links for ZNF641 Gene

HapMap Linkage Disequilibrium report
ZNF641

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF641 Gene

Disorders for ZNF641 Gene

No disorders were found for ZNF641 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF641 Gene

Publications for ZNF641 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Activation of transcriptional activities of AP-1 and SRE by a new zinc-finger protein ZNF641. (PMID: 16343441) Qi X. … Wu X. (Biochem. Biophys. Res. Commun. 2006) 3 4
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3

Products for ZNF641 Gene

Sources for ZNF641 Gene

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