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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF639 Gene

protein-coding   GIFtS: 48
GCID: GC03P179040

Zinc Finger Protein 639

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 6391 2     ZASC12 3
Zinc Finger Amplified In Esophageal Squamous Cell Carcinomas 11 2     6230400O18Rik2
Zinc Finger Protein ANC_2H012 3     ANC-2H012
Zinc Finger Protein ZASC12 3     ANC_2H012

External Ids:    HGNC: 309501   Entrez Gene: 511932   Ensembl: ENSG000001218647   UniProtKB: Q9UID63   

Export aliases for ZNF639 gene to outside databases

Previous GC identifers: GC03P180524 GC03P176444


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF639 Gene: 
ZNF639 (zinc finger protein 639) is a protein-coding gene. Diseases associated with ZNF639 include esophageal squamous cell carcinoma, and squamous cell carcinoma. GO annotations related to this gene include protein self-association and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZFY.

UniProtKB/Swiss-Prot: ZN639_HUMAN, Q9UID6
Function: Binds DNA and may function as a transcriptional repressor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF639 gene promoter:
         C/EBPbeta   HNF-4alpha2   Cdc5   LCR-F1   HNF-4alpha1   CREB   Nkx6-1   deltaCREB   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF639 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF639

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF639


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.33   Ensembl cytogenetic band:  3q26.33   HGNC cytogenetic band: 3q27.1

ZNF639 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF639 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P179040:  view genomic region     (about GC identifiers)

Start:
179,040,779 bp from pter      End:
179,053,323 bp from pter
Size:
12,545 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN639_HUMAN, Q9UID6 (See protein sequence)
Recommended Name: Zinc finger protein 639  
Size: 485 amino acids; 56054 Da
Subunit: Interacts with CTNNA2
Subcellular location: Nucleus
Secondary accessions: A9X3Z9 D3DNR3

Explore the universe of human proteins at neXtProt for ZNF639: NX_Q9UID6

Explore proteomics data for ZNF639 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UID6

  • ZNF639 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF639 Protein Expression
    REFSEQ proteins: NP_057415.1  
    ENSEMBL proteins: 
     ENSP00000417740   ENSP00000418870   ENSP00000418628   ENSP00000325634   ENSP00000419650  
     ENSP00000418766   ENSP00000417232  

    Human Recombinant Protein Products for ZNF639: 
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    Cloud-Clone Corp. Proteins for ZNF639 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA14522885

    ZNF639 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UID6

    ProtoNet protein and cluster: Q9UID6

    UniProtKB/Swiss-Prot: ZN639_HUMAN, Q9UID6
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 8 C2H2-type zinc fingers


    ZNF639 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN639_HUMAN, Q9UID6
    Function: Binds DNA and may function as a transcriptional repressor

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IDA16182284
    GO:0005515protein binding IPI16182284
    GO:0008270zinc ion binding ----
    GO:0043621protein self-association IPI--
    GO:0044212transcription regulatory region DNA binding IDA--
         
    ZNF639 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ZNF639:
     Decreased viability of wild-ty  Increased S DNA content  Increased number of mitotic ce 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidZNF639 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF639

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for ZNF639 (Q9UID62, 3 ENSP000003256344) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APTXQ7Z2E32, 3, ENSP000004008064MINT-2873030 MINT-2873049 I2D: score=3 STRING: ENSP00000400806
    CREBBPQ927933, ENSP000002623674I2D: score=2 STRING: ENSP00000262367
    WDR48Q8TAF33, ENSP000003074914I2D: score=2 STRING: ENSP00000307491
    SREBF2Q127723I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0030307positive regulation of cell growth IMP14522885
    GO:0043922negative regulation by host of viral transcription IMP--
    GO:0043923positive regulation by host of viral transcription IMP--
    GO:0045892negative regulation of transcription, DNA-dependent IDA16182284

    ZNF639 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF639 (ZN639)

    Search CenterWatch for drugs/clinical trials and news about ZNF639 / ZN639

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF639 gene: 
    NM_016331.1  

    Unigene Cluster for ZNF639:

    Zinc finger protein 639
    Hs.632578  [show with all ESTs]
    Unigene Representative Sequence: AB097862
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496856 ENST00000491818 ENST00000481587 ENST00000326361(uc003fjq.1 uc003fjr.1)
    ENST00000466264 ENST00000484866 ENST00000494234 ENST00000483460 ENST00000466663

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF639:
    hsa-miR-194* hsa-miR-433 hsa-miR-4311 hsa-miR-489 hsa-miR-3908 hsa-miR-1252 hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF639 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF639

    Additional mRNA sequence: 

    AB097862.1 AF003924.1 AK122884.1 BC020500.1 BC026181.1 DQ323613.1 

    10 DOTS entries:

    DT.413725  DT.100781910  DT.99989754  DT.120919697  DT.97774246  DT.100781906  DT.75104261  DT.95089974 
    DT.100781908  DT.95101752 

    24/143 AceView cDNA sequences (see all 143):

    AI139321 C02065 BE048866 AA358286 BM470306 BU194794 AI148470 AI355794 
    CR616193 BQ022595 CR617398 F02513 AI370775 AA908795 AA128266 CB134329 
    AA235044 AW169703 Z39583 AI521739 BE878565 BF001614 BQ924795 BM676599 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF639    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
    SP1:                    -                     
    SP2:                                          


    ECgene alternative splicing isoforms for ZNF639

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF639 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACAACTTG
    ZNF639 Expression
    About this image


    See ZNF639 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF639

    SOURCE GeneReport for Unigene cluster: Hs.632578
        SABiosciences Custom PCR Arrays for ZNF639
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF639

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF639 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp6391 , 5 zinc finger protein 6391, 5 87.01(n)1
    92.99(a)1
      3 (15.75 cM)5
    677781  NM_001161818.11  NP_001155290.11 
     325152955 
    chicken
    (Gallus gallus)
    Aves ZNF6391 zinc finger protein 639 72.15(n)
    72.5(a)
      425280  XM_423061.3  XP_423061.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF6396
    zinc finger protein 639
    67(a)
    1 ↔ 1
    3(2278885-2295325)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.56242 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_057415.1 (H.sapiens) zinc finger protein ANC_2H01 [Homo sapiens] less 80.64(n)    48029645 


    ENSEMBL Gene Tree for ZNF639 (if available)
    TreeFam Gene Tree for ZNF639 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF639 gene
    ZFY2  ZNF7112  ZFX2  

    ZNF639 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/339 SNPs in ZNF639 are shown (see all 339)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs773262641,2
    C--179039591(+) CTGTGC/TTAGAT 1 -- us2k10--------
    rs1173359791,2
    F--179039719(+) TAAAAA/TCTGAG 1 -- us2k11Minor allele frequency- T:0.02EA 120
    rs789407461,2
    C,F--179039731(+) CTCACA/GAACAA 1 -- us2k11Minor allele frequency- G:0.04NA 120
    rs1461658501,2
    --179039750(+) TCTTTC/GAAATA 1 -- us2k10--------
    rs38066851,2
    C,F,H--179039751(+) CTTTCA/GAATAT 1 -- us2k123Minor allele frequency- G:0.20EA NS NA WA CSA 2536
    rs1927059401,2
    --179039814(+) TACTTC/TCCAGC 1 -- us2k10--------
    rs1160841551,2
    C,F--179039819(+) TCCAGC/TGATTG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1399954961,2
    --179039930(+) TCCACA/GTGGCT 1 -- us2k10--------
    rs20327001,2
    C,F,A,H--179040177(+) GCTCAA/GAGAAA 1 -- us2k123Minor allele frequency- G:0.08EA NS NA 2494
    rs1498123361,2
    C--179040527(+) CTCCCA/GGTTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF639 (179040779 - 179053323 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF639:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv471116CNV Gain18288195
    nsv829806CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for ZNF639:    About MalaCards
    esophageal squamous cell carcinoma    squamous cell carcinoma    esophagitis


    ZNF639 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF639

    Export disorders for ZNF639 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF639 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with ZNF639)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of ZASC1 encoding a Kruppel-like zinc finger protein as a novel target for 3q26 amplification in esophageal squamous cell carcinomas. (PubMed id 14522885)1, 2, 3 Imoto I....Inazawa J. (2003)
    2. Nuclear translocation of alphaN-catenin by the novel zinc finger transcriptional repressor ZASC1. (PubMed id 16182284)1, 2 Bogaerts S.... van Roy F. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Increase of ZASC1 gene copy number in recurrent oral carcinoma. (PubMed id 20646234)1 Chiang W.F....Lin S.C. (2011)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    8. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. Functional persistence of exonized mammalian-wide interspersed repeat elements (MIRs). (PubMed id 17623809)2 Krull M.... Schmitz J. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51193 HGNC: 30950 AceView: ZNF639 Ensembl:ENSG00000121864 euGenes: HUgn51193
    ECgene: ZNF639 H-InvDB: ZNF639

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF639 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF639 gene:
    Search GeneIP for patents involving ZNF639

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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