ZNF639 Gene
protein-coding GIFtS: 45
GCID: GC03P179040
|
|
zinc finger protein 639
| |
Aliases
for ZNF639 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 6391 2 | | Zinc Finger Protein ZASC12 3 | | ZASC11 2 3 | | 6230400O18Rik2 | | ANC-2H011 2 | | ANC_2H012 | | Zinc Finger Protein ANC_2H012 3 | | Zinc Finger Amplified In Esophageal Squamous Cell Carcinomas 12 |
Export aliases for ZNF639 gene to outside databasesPrevious GC identifers: GC03P180524 GC03P176444 |
Summaries
for ZNF639 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN639_HUMAN, Q9UID6Function: Binds DNA and may function as a transcriptional repressor
|
Genomic Views
for ZNF639 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF639 gene promoter:
C/EBPbeta HNF-4alpha2 Cdc5 LCR-F1 HNF-4alpha1 CREB Nkx6-1 deltaCREB FOXJ2 (long isoform) FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF639
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF639 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q26.33 Ensembl cytogenetic band: 3q26.33 HGNC cytogenetic band: 3q27.1ZNF639 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P179040: view genomic region
(about GC identifiers)
Start:
|
179,040,779 bp from pter |
End:
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179,053,323 bp from pter |
Size:
|
12,545 bases |
Orientation:
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plus strand |
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Proteins
for ZNF639 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN639_HUMAN, Q9UID6 (See
protein sequence)Recommended Name: Zinc finger protein 639 Size: 485 amino acids; 56054 Da
Subunit: Interacts with CTNNA2
Subcellular location: Nucleus
Secondary accessions: A9X3Z9 D3DNR3Explore the universe of human proteins at neXtProt for ZNF639: NX_Q9UID6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UID6
ZNF639 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057415.1
ENSEMBL proteins: ENSP00000417740 ENSP00000418870 ENSP00000418628 ENSP00000325634 ENSP00000419650 ENSP00000418766 ENSP00000417232
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
ZNF639 for ontologies About GeneDecksing
ZNF639 Antibody Products:
Assay Products for ZNF639: |
Protein
Domains /
Families
for ZNF639 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF639 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UID6ProtoNet protein and cluster: Q9UID6 UniProtKB/Swiss-Prot: ZN639_HUMAN, Q9UID6Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 8 C2H2-type zinc fingers |
Function
for ZNF639 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN639_HUMAN, Q9UID6Function: Binds DNA and may function as a transcriptional repressor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF639 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF639 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ZNF639 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF639 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF639 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
ZNF639 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for ZNF639:
|
Pathways & Interactions
for ZNF639 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF639
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for ZNF639 (Q9UID62, 3 ENSP000003256344) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0019059 | initiation of viral infection |
-- | -- | | GO:0030307 | positive regulation of cell growth |
IMP | 14522885 | | GO:0043922 | negative regulation by host of viral transcription |
IMP | -- | | GO:0043923 | positive regulation by host of viral transcription |
IMP | -- |
ZNF639 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF639 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF639
Search CenterWatch for drugs/clinical trials and news about ZNF639 / ZN639
|
Transcripts
for ZNF639 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF639 gene: NM_016331.1 Unigene Cluster for ZNF639: Zinc finger protein 639 Hs.632578 [show with all ESTs]Unigene Representative Sequence: AB0978629 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000496856 ENST00000491818 ENST00000481587 ENST00000326361(uc003fjq.1 uc003fjr.1)
ENST00000466264 ENST00000484866 ENST00000494234 ENST00000483460 ENST00000466663
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF639 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF639 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF639 (NM_016331) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF639 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF639 |
Additional cDNA sequence: AB097862.1 AF003924.1 AK122884.1 BC020500.1 BC026181.1 DQ323613.1 10 DOTS entries: DT.413725 DT.100781910 DT.99989754 DT.120919697 DT.97774246 DT.100781906 DT.75104261 DT.95089974 DT.100781908 DT.95101752 24/143 AceView cDNA sequences (see all 143): BM676599 AI521739 BU789647 BM974833 Z43037 AI148470 CR616193 AV717781 BU194794 BM693693 CB134329 Z39583 BU753241 AI355794 F02513 BC020500 CR617398 BQ022595 AI139321 CA435254 C02065 AA358286 AA908795 BM797456
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF639 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b |
|---|
|
| SP1: | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF639
|
Expression
for ZNF639 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF639 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGACAACTTG
About this image
See ZNF639 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF639
SOURCE GeneReport for Unigene cluster: Hs.632578
SABiosciences Custom PCR Arrays for ZNF639
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF639
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF639 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF639 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF639 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF639 |
Orthologs
for ZNF639 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF639 gene from 4/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Zfp6391 , 5 |
zinc finger protein 6391, 5 |
87.01(n)1
92.99(a)1 |
|
3 (15.75 cM)5
677781 NM_001161818.11 NP_001155290.11
325152955 |
chicken
(Gallus gallus) |
Aves |
ZNF6391 |
zinc finger protein 639 |
72.15(n)
72.5(a) |
|
425280 XM_423061.3 XP_423061.3 |
lizard
(Anolis carolinensis) |
Reptilia |
ZNF6396 |
-- |
70(a) |
1 ↔ 1 |
3(2281464-2288327) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.56242 |
Xenopus laevis transcribed sequence with moderate similarity to protein refNP_057415.1 (H.sapiens) zinc finger protein ANC_2H01 [Homo sapiens] less |
80.64(n) |
|
48029645 |
ENSEMBL Gene Tree for ZNF639 (if available)
TreeFam Gene Tree for ZNF639 (if available) |
Paralogs
for ZNF639 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF639 gene
- ZFY2 ZNF7112 ZFX2
ZNF639 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF639 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF639 (179040779 - 179053323 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF639: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF639 |
|
Disorders
/ Diseases
for ZNF639 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF639 for disorders About GeneDecksing
5  diseases for ZNF639: About MalaCardsesophageal squamous cell carcinoma squamous cell carcinoma esophagitis carcinoma
ataxia
Export disorders for ZNF639 gene to outside databases
|
Publications
for ZNF639 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF639 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with ZNF639) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of ZASC1 encoding a Kruppel-like zinc finger protein as a novel target for 3q26 amplification in esophageal squamous cell carcinomas. (PubMed id 14522885)1, 2, 3 Imoto I....Inazawa J. (2003)
- Nuclear translocation of alphaN-catenin by the novel zinc finger transcriptional repressor ZASC1. (PubMed id 16182284)1, 2 Bogaerts S.... van Roy F. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Increase of ZASC1 gene copy number in recurrent oral carcinoma. (PubMed id 20646234)1 Chiang W.F....Lin S.C. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Functional persistence of exonized mammalian-wide interspersed repeat elements (MIRs). (PubMed id 17623809)2 Krull M.... Schmitz J. (2007)
|
External Searches for ZNF639 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF639 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF639 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF639 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF639 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF639 gene:
Search GeneIP for patents involving ZNF639
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF639 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF639 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF639 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF639 | | | OriGene Protein Over-expression Lysate for ZNF639 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF639 | | OriGene 3'-UTR Clone for ZNF639 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF639 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF639 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF639 | | OriGene Custom Protein Services for ZNF639 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF639 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF639 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF639 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF639 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF639 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF639 |
| |
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| | | | Search Tocris compounds for ZNF639 |
| |  |  |  |  | | | | |
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 | | | ZNF639 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF639 |
|  |  |  | | | | ThermoFisher Antibody for ZNF639 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF639 |
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