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Aliases for ZNF639 Gene

Aliases for ZNF639 Gene

  • Zinc Finger Protein 639 2 3
  • Zinc Finger Amplified In Esophageal Squamous Cell Carcinomas 1 2 3
  • ZASC1 3 4
  • Zinc Finger Protein ANC_2H01 4
  • Zinc Finger Protein ZASC1 4
  • ANC-2H01 3
  • ANC_2H01 3

External Ids for ZNF639 Gene

Summaries for ZNF639 Gene

Entrez Gene Summary for ZNF639 Gene

  • This gene encodes a member of the Kruppel-like zinc finger family of proteins. Amplification and overexpression of this gene have been observed in esophageal squamous cell carcinoma. The encoded protein has been shown to bind DNA in a sequence-specific manner and may regulate HIV-1 gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for ZNF639 Gene

ZNF639 (Zinc Finger Protein 639) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein self-association. An important paralog of this gene is ZFY.

UniProtKB/Swiss-Prot for ZNF639 Gene

  • Binds DNA and may function as a transcriptional repressor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF639 Gene

Genomics for ZNF639 Gene

Genomic Location for ZNF639 Gene

Start:
179,322,991 bp from pter
End:
179,338,583 bp from pter
Size:
15,593 bases
Orientation:
Plus strand

Genomic View for ZNF639 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF639 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF639 Gene

Proteins for ZNF639 Gene

  • Protein details for ZNF639 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UID6-ZN639_HUMAN
    Recommended name:
    Zinc finger protein 639
    Protein Accession:
    Q9UID6
    Secondary Accessions:
    • A9X3Z9
    • D3DNR3

    Protein attributes for ZNF639 Gene

    Size:
    485 amino acids
    Molecular mass:
    56054 Da
    Quaternary structure:
    • Interacts with CTNNA2.

neXtProt entry for ZNF639 Gene

Proteomics data for ZNF639 Gene at MOPED

Post-translational modifications for ZNF639 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys263

No data available for DME Specific Peptides for ZNF639 Gene

Domains for ZNF639 Gene

Gene Families for ZNF639 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF639 Gene

Suggested Antigen Peptide Sequences for ZNF639 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UID6

UniProtKB/Swiss-Prot:

ZN639_HUMAN
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q9UID6
Similarity:
  • Contains 8 C2H2-type zinc fingers.:
    • Q9UID6
genes like me logo Genes that share domains with ZNF639: view

Function for ZNF639 Gene

Molecular function for ZNF639 Gene

UniProtKB/Swiss-Prot Function: Binds DNA and may function as a transcriptional repressor.

Gene Ontology (GO) - Molecular Function for ZNF639 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 20484494
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 20484494
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 16182284
GO:0005515 protein binding IPI 16182284
GO:0043621 protein self-association IPI 20484494
genes like me logo Genes that share ontologies with ZNF639: view
genes like me logo Genes that share phenotypes with ZNF639: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF639 Gene

Localization for ZNF639 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF639 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF639 Gene COMPARTMENTS Subcellular localization image for ZNF639 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF639 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 14522885
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF639: view

Pathways for ZNF639 Gene

SuperPathways for ZNF639 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF639 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0030307 positive regulation of cell growth IMP 14522885
GO:0043922 negative regulation by host of viral transcription IMP 20484494
GO:0043923 positive regulation by host of viral transcription IMP 20484494
GO:0045892 negative regulation of transcription, DNA-templated IDA 16182284
genes like me logo Genes that share ontologies with ZNF639: view

No data available for Pathways by source for ZNF639 Gene

Transcripts for ZNF639 Gene

Unigene Clusters for ZNF639 Gene

Zinc finger protein 639:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF639 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2:

Relevant External Links for ZNF639 Gene

GeneLoc Exon Structure for
ZNF639
ECgene alternative splicing isoforms for
ZNF639

Expression for ZNF639 Gene

mRNA expression in normal human tissues for ZNF639 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF639 Gene

SOURCE GeneReport for Unigene cluster for ZNF639 Gene Hs.632578

genes like me logo Genes that share expressions with ZNF639: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF639 Gene

Orthologs for ZNF639 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF639 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF639 35
  • 99.38 (n)
  • 99.59 (a)
ZNF639 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF639 35
  • 95.19 (n)
  • 98.35 (a)
ZNF639 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF639 35
  • 95.05 (n)
  • 98.14 (a)
ZNF639 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp639 35
  • 87.01 (n)
  • 92.99 (a)
Zfp639 16
Zfp639 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF639 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF639 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp639 35
  • 87.49 (n)
  • 92.78 (a)
chicken
(Gallus gallus)
Aves ZNF639 35
  • 72.14 (n)
  • 72.35 (a)
ZNF639 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF639 36
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5624 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19246 35
znf639 35
  • 68.97 (n)
  • 68.44 (a)
Species with no ortholog for ZNF639:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF639 Gene

ENSEMBL:
Gene Tree for ZNF639 (if available)
TreeFam:
Gene Tree for ZNF639 (if available)

Paralogs for ZNF639 Gene

Paralogs for ZNF639 Gene

genes like me logo Genes that share paralogs with ZNF639: view

Variants for ZNF639 Gene

Sequence variations from dbSNP and Humsavar for ZNF639 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs14182 -- 179,334,554(-) AAAAT(C/T)TTATA utr-variant-3-prime
rs1045860 -- 179,333,733(+) ATGAA(C/G)AGGAT missense, reference
rs1592652 -- 179,331,424(+) tctgc(A/G)ctcct intron-variant
rs1895025 -- 179,330,460(+) AAAAA(C/T)TTTTT intron-variant
rs5854829 -- 179,330,723(+) AGAAC(-/AG)AGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF639 Gene

Variant ID Type Subtype PubMed ID
nsv829806 CNV Gain 17160897
nsv471116 CNV Gain 18288195

Relevant External Links for ZNF639 Gene

HapMap Linkage Disequilibrium report
ZNF639

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF639 Gene

Disorders for ZNF639 Gene

Relevant External Links for ZNF639

Genetic Association Database (GAD)
ZNF639
genes like me logo Genes that share disorders with ZNF639: view

No data available for UniProtKB/Swiss-Prot for ZNF639 Gene

Publications for ZNF639 Gene

  1. Identification of ZASC1 encoding a Kruppel-like zinc finger protein as a novel target for 3q26 amplification in esophageal squamous cell carcinomas. (PMID: 14522885) Imoto I. … Inazawa J. (Cancer Res. 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Nuclear translocation of alphaN-catenin by the novel zinc finger transcriptional repressor ZASC1. (PMID: 16182284) Bogaerts S. … van Roy F. (Exp. Cell Res. 2005) 3 4
  4. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3
  5. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3

Products for ZNF639 Gene

Sources for ZNF639 Gene

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