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ZNF639 Gene

protein-coding   GIFtS: 49
GCID: GC03P179040

Zinc Finger Protein 639

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 6391 2     ZASC12 3
Zinc Finger Amplified In Esophageal Squamous Cell Carcinomas 11 2     6230400O18Rik2
Zinc Finger Protein ANC_2H012 3     ANC-2H012
Zinc Finger Protein ZASC12 3     ANC_2H012

External Ids:    HGNC: 309501   Entrez Gene: 511932   Ensembl: ENSG000001218647   UniProtKB: Q9UID63   

Export aliases for ZNF639 gene to outside databases

Previous GC identifers: GC03P180524 GC03P176444


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF639 Gene:
ZNF639 (zinc finger protein 639) is a protein-coding gene. Diseases associated with ZNF639 include esophageal squamous cell carcinoma, and esophagitis. GO annotations related to this gene include protein self-association and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZFY.

UniProtKB/Swiss-Prot: ZN639_HUMAN, Q9UID6
Function: Binds DNA and may function as a transcriptional repressor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF639 gene promoter:
         C/EBPbeta   HNF-4alpha2   Cdc5   LCR-F1   HNF-4alpha1   CREB   Nkx6-1   deltaCREB   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF639 promoter sequence
   Search Chromatin IP Primers for ZNF639

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF639


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.33   Ensembl cytogenetic band:  3q26.33   HGNC cytogenetic band: 3q27.1

ZNF639 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF639 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P179040:  view genomic region     (about GC identifiers)

Start:
179,040,779 bp from pter      End:
179,053,323 bp from pter
Size:
12,545 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN639_HUMAN, Q9UID6 (See protein sequence)
Recommended Name: Zinc finger protein 639  
Size: 485 amino acids; 56054 Da
Subunit: Interacts with CTNNA2
Secondary accessions: A9X3Z9 D3DNR3

Explore the universe of human proteins at neXtProt for ZNF639: NX_Q9UID6

Explore proteomics data for ZNF639 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys263
  • Modification sites at PhosphoSitePlus

  • See ZNF639 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057415.1  
    ENSEMBL proteins: 
     ENSP00000417740   ENSP00000418870   ENSP00000418628   ENSP00000325634   ENSP00000419650  
     ENSP00000418766   ENSP00000417232  

    ZNF639 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UID6

    ProtoNet protein and cluster: Q9UID6

    UniProtKB/Swiss-Prot: ZN639_HUMAN, Q9UID6
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 8 C2H2-type zinc fingers


    ZNF639 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN639_HUMAN, Q9UID6
    Function: Binds DNA and may function as a transcriptional repressor

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IDA16182284
    GO:0005515protein binding IPI16182284
    GO:0043621protein self-association IPI--
    GO:0044212transcription regulatory region DNA binding IDA--
    GO:0046872metal ion binding IEA--
         
    ZNF639 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ZNF639:
     Decreased viability of wild-ty  Increased S DNA content  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF639
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    7 qRT-PCR Assays for microRNAs that regulate ZNF639:
    hsa-miR-194* hsa-miR-433 hsa-miR-4311 hsa-miR-489 hsa-miR-3908 hsa-miR-1252 hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF639 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF639

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN639_HUMAN, Q9UID6: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA14522885

    ZNF639 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF639
    Interactions:

        GeneGlobe Interaction Network for ZNF639

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for ZNF639 (Q9UID62, 3 ENSP000003256344) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APTXQ7Z2E32, 3, ENSP000004008064MINT-2873030 MINT-2873049 I2D: score=3 STRING: ENSP00000400806
    CREBBPQ927933, ENSP000002623674I2D: score=2 STRING: ENSP00000262367
    WDR48Q8TAF33, ENSP000003074914I2D: score=2 STRING: ENSP00000307491
    SREBF2Q127723I2D: score=2 
    L3MBTL2ENSP000002162374STRING: ENSP00000216237
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0030307positive regulation of cell growth IMP14522885
    GO:0043922negative regulation by host of viral transcription IMP--
    GO:0043923positive regulation by host of viral transcription IMP--
    GO:0045892negative regulation of transcription, DNA-templated IDA16182284

    ZNF639 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF639 (ZN639)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF639 gene: 
    NM_016331.1  

    Unigene Cluster for ZNF639:

    Zinc finger protein 639
    Hs.632578  [show with all ESTs]
    Unigene Representative Sequence: AB097862
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496856 ENST00000491818 ENST00000481587 ENST00000326361(uc003fjq.1 uc003fjr.1)
    ENST00000466264 ENST00000484866 ENST00000494234 ENST00000483460 ENST00000466663

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate ZNF639:
    hsa-miR-194* hsa-miR-433 hsa-miR-4311 hsa-miR-489 hsa-miR-3908 hsa-miR-1252 hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmidZNF639 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF639
      QuantiFast Probe-based Assays in human, mouse, rat ZNF639

    Additional mRNA sequence: 

    AB097862.1 AF003924.1 AK122884.1 BC020500.1 BC026181.1 DQ323613.1 

    10 DOTS entries:

    DT.413725  DT.100781910  DT.99989754  DT.120919697  DT.97774246  DT.100781906  DT.75104261  DT.95089974 
    DT.100781908  DT.95101752 

    Selected AceView cDNA sequences (see all 143):

    BC020500 BM454714 BE048866 AW169703 AV717781 BF001614 AA235044 BM714217 
    BM670843 AI370775 CB134329 AI355794 CR614635 CD723842 AI348505 BE878565 
    BM069587 CR617398 BU789647 BU194794 CA435254 CR616193 AA908795 AA128266 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF639    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
    SP1:                    -                     
    SP2:                                          


    ECgene alternative splicing isoforms for ZNF639

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF639 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACAACTTG
    ZNF639 Expression
    About this image

    ZNF639 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF639 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632578
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF639 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp6391 , 5 zinc finger protein 6391, 5 87.01(n)1
    92.99(a)1
      3 (15.75 cM)5
    677781  NM_144519.41  NP_653102.11 
     325152955 
    chicken
    (Gallus gallus)
    Aves ZNF6391 zinc finger protein 639 72.14(n)
    72.35(a)
      425280  NM_001277480.1  NP_001264409.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF6396
    zinc finger protein 639
    68(a)
    1 ↔ 1
    3(2278885-2295325)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.56242 Xenopus laevis transcribed sequence with moderate similarity more 80.64(n)    48029645 


    ENSEMBL Gene Tree for ZNF639 (if available)
    TreeFam Gene Tree for ZNF639 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF639 gene
    ZFY2  ZNF7112  ZFX2  

    ZNF639 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF639 (see all 339)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs773262641,2
    C--179039591(+) CTGTGC/TTAGAT 1 -- us2k10--------
    rs1173359791,2
    F--179039719(+) TAAAAA/TCTGAG 1 -- us2k11Minor allele frequency- T:0.02EA 120
    rs789407461,2
    C,F--179039731(+) CTCACA/GAACAA 1 -- us2k11Minor allele frequency- G:0.04NA 120
    rs1461658501,2
    --179039750(+) TCTTTC/GAAATA 1 -- us2k10--------
    rs38066851,2
    C,F,H--179039751(+) CTTTCA/GAATAT 1 -- us2k123Minor allele frequency- G:0.20EA NS NA WA CSA 2536
    rs1927059401,2
    --179039814(+) TACTTC/TCCAGC 1 -- us2k10--------
    rs1160841551,2
    C,F--179039819(+) TCCAGC/TGATTG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1399954961,2
    --179039930(+) TCCACA/GTGGCT 1 -- us2k10--------
    rs20327001,2
    C,F,A,H--179040177(+) GCTCAA/GAGAAA 1 -- us2k123Minor allele frequency- G:0.08EA NS NA 2494
    rs1498123361,2
    C--179040527(+) CTCCCA/GGTTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF639 (179040779 - 179053323 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF639:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv471116CNV Gain18288195
    nsv829806CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF639
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for ZNF639:    
    About MalaCards
    esophageal squamous cell carcinoma    esophagitis    squamous cell carcinoma    ataxia


    ZNF639 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF639

    Export disorders for ZNF639 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF639 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with ZNF639)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of ZASC1 encoding a Kruppel-like zinc finger protein as a novel target for 3q26 amplification in esophageal squamous cell carcinomas. (PubMed id 14522885)1, 2, 3 Imoto I....Inazawa J. (Cancer Res. 2003)
    2. Nuclear translocation of alphaN-catenin by the novel zinc finger transcriptional repressor ZASC1. (PubMed id 16182284)1, 2 Bogaerts S.... van Roy F. (Exp. Cell Res. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Increase of ZASC1 gene copy number in recurrent oral carcinoma. (PubMed id 20646234)1 Chiang W.F....Lin S.C. (Oral Dis 2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    9. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51193 HGNC: 30950 AceView: ZNF639 Ensembl:ENSG00000121864 euGenes: HUgn51193
    ECgene: ZNF639 H-InvDB: ZNF639

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF639 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF639 gene:
    Search GeneIP for patents involving ZNF639

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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