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Aliases for ZNF638 Gene

Aliases for ZNF638 Gene

  • Zinc Finger Protein 638 2 3 5
  • Cutaneous T-Cell Lymphoma-Associated Antigen Se33-1 3 4
  • Zinc Finger Matrin-Like Protein 3 4
  • CTCL-Associated Antigen Se33-1 3 4
  • Nuclear Protein 220 3 4
  • NP220 3 4
  • ZFML 3 4
  • CTCL Tumor Antigen Se33-1 3
  • Zinc Finger, Matrin-Like 2
  • NP220 Nuclear Protein 3
  • Zfp638 3

External Ids for ZNF638 Gene

Previous HGNC Symbols for ZNF638 Gene

  • ZFML

Previous GeneCards Identifiers for ZNF638 Gene

  • GC02P071470
  • GC02P071412

Summaries for ZNF638 Gene

Entrez Gene Summary for ZNF638 Gene

  • The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded DNA. This protein has three types of domains: MH1, MH2 (repeated three times) and MH3. It is associated with packaging, transferring, or processing transcripts. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF638 Gene

ZNF638 (Zinc Finger Protein 638) is a Protein Coding gene. Diseases associated with ZNF638 include Cutaneous T Cell Lymphoma. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Developmental Biology. GO annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot for ZNF638 Gene

  • Early regulator of adipogenesis that works as a transcription cofactor of CEBPs, controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). Binds to cytidine clusters in double-stranded DNA (PubMed:8647861). May also regulate alternative splicing of target genes during adipogenesis (By similarity).

Gene Wiki entry for ZNF638 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF638 Gene

Genomics for ZNF638 Gene

Regulatory Elements for ZNF638 Gene

Enhancers for ZNF638 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F071448 1.5 FANTOM5 Ensembl ENCODE 18.2 +177.5 177541 10.3 CBX3 PKNOX1 RAD21 ETS1 YY1 SCRT2 RCOR1 FOS CREM ZNF263 DYSF ZNF638 RNU6-105P PAIP2B OR7E91P NAGK GC02P071578
GH02F071416 0.9 Ensembl ENCODE 19.4 +140.9 140944 1.5 STAT1 CHD1 ZNF384 DPF2 REST CTBP1 CBX1 POLR2A ZNF341 ZNF638 RNU6-105P OR7E91P PAIP2B DYSF GC02M071380
GH02F071331 1.1 ENCODE 8 +56.1 56126 3.2 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 CD207 TEX261 CLEC4F ZNF638 PAIP2B OR7E91P ZNF638-IT1
GH02F071303 0.5 ENCODE 11.7 +27.5 27485 0.1 CTCF ARNT REST ZNF638 ZNF638-IT1
GH02F071336 0.6 Ensembl 7.6 +60.3 60340 1.4 KLF1 HLF CEBPB CEBPG FOSL1 CEBPA SCRT2 FOXP2 SPI1 ZNF638 PAIP2B ZNF638-IT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF638 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF638 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000013916 839 2401 ARID4B SIN3A GLI4 ZNF48 ZNF2 ZNF121 SLC30A9 GLIS2 ZNF143 ZNF263

Genomic Location for ZNF638 Gene

Chromosome:
2
Start:
71,276,561 bp from pter
End:
71,435,069 bp from pter
Size:
158,509 bases
Orientation:
Plus strand

Genomic View for ZNF638 Gene

Genes around ZNF638 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF638 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF638 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF638 Gene

Proteins for ZNF638 Gene

  • Protein details for ZNF638 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14966-ZN638_HUMAN
    Recommended name:
    Zinc finger protein 638
    Protein Accession:
    Q14966
    Secondary Accessions:
    • B5MDV1
    • B7ZLD1
    • Q53R34
    • Q5XJ05
    • Q68DP3
    • Q6P2H2
    • Q7Z3T7
    • Q8NF92
    • Q8TCA1
    • Q9H2G1
    • Q9NP37

    Protein attributes for ZNF638 Gene

    Size:
    1978 amino acids
    Molecular mass:
    220625 Da
    Quaternary structure:
    • Interacts with FHL2 (PubMed:11813260). Interacts with CEBPA, CEBPD and CEBPG (By similarity).
    Miscellaneous:
    • Isoform 5 is a tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and in particular in mycosis fungoides patients and in Sezary syndrome patients.
    SequenceCaution:
    • Sequence=AAH64530.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF638 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF638 Gene

Post-translational modifications for ZNF638 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF638 Gene

Domains & Families for ZNF638 Gene

Gene Families for ZNF638 Gene

Suggested Antigen Peptide Sequences for ZNF638 Gene

Graphical View of Domain Structure for InterPro Entry

Q14966

UniProtKB/Swiss-Prot:

ZN638_HUMAN :
  • The matrin-type zinc finger domain is required for localization to nuclear speckles.
  • Contains 1 matrin-type zinc finger.
Domain:
  • The matrin-type zinc finger domain is required for localization to nuclear speckles.
  • Contains 2 RRM (RNA recognition motif) domains.
Similarity:
  • Contains 1 matrin-type zinc finger.
genes like me logo Genes that share domains with ZNF638: view

Function for ZNF638 Gene

Molecular function for ZNF638 Gene

UniProtKB/Swiss-Prot Function:
Early regulator of adipogenesis that works as a transcription cofactor of CEBPs, controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). Binds to cytidine clusters in double-stranded DNA (PubMed:8647861). May also regulate alternative splicing of target genes during adipogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for ZNF638 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003690 double-stranded DNA binding TAS 8647861
GO:0003723 RNA binding TAS 8647861
genes like me logo Genes that share ontologies with ZNF638: view

Phenotypes for ZNF638 Gene

GenomeRNAi human phenotypes for ZNF638:
genes like me logo Genes that share phenotypes with ZNF638: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF638 Gene

Localization for ZNF638 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF638 Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF638 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF638 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm TAS 8647861
GO:0016607 nuclear speck IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ZNF638: view

Pathways & Interactions for ZNF638 Gene

genes like me logo Genes that share pathways with ZNF638: view

Pathways by source for ZNF638 Gene

Gene Ontology (GO) - Biological Process for ZNF638 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with ZNF638: view

No data available for SIGNOR curated interactions for ZNF638 Gene

Drugs & Compounds for ZNF638 Gene

(1) Drugs for ZNF638 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine Experimental Pharma 0
genes like me logo Genes that share compounds with ZNF638: view

Transcripts for ZNF638 Gene

Unigene Clusters for ZNF638 Gene

Zinc finger protein 638:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF638 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1:
SP2:
SP3:
SP4:
SP5: - -
SP6: -
SP7: - - -
SP8: - -
SP9: -
SP10:
SP11:
SP12:

ExUns: 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b
SP1: - - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ZNF638 Gene

GeneLoc Exon Structure for
ZNF638
ECgene alternative splicing isoforms for
ZNF638

Expression for ZNF638 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF638 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF638 Gene

This gene is overexpressed in Fetal Brain (13.9), Peripheral blood mononuclear cells (12.1), and Pancreas (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF638 Gene



Protein tissue co-expression partners for ZNF638 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF638 Gene:

ZNF638

SOURCE GeneReport for Unigene cluster for ZNF638 Gene:

Hs.434401
genes like me logo Genes that share expression patterns with ZNF638: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF638 Gene

Orthologs for ZNF638 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF638 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF638 34 35
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia ZNF638 34 35
  • 90.59 (n)
cow
(Bos Taurus)
Mammalia ZNF638 34 35
  • 89.61 (n)
rat
(Rattus norvegicus)
Mammalia Zfp638 34
  • 85.45 (n)
mouse
(Mus musculus)
Mammalia Zfml 34 35
  • 85.12 (n)
Zfp638 16
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 75 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 47 (a)
OneToMany
-- 35
  • 43 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZNF638 35
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF638 35
  • 38 (a)
OneToOne
Species where no ortholog for ZNF638 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF638 Gene

ENSEMBL:
Gene Tree for ZNF638 (if available)
TreeFam:
Gene Tree for ZNF638 (if available)

Paralogs for ZNF638 Gene

(1) SIMAP similar genes for ZNF638 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ZNF638: view

No data available for Paralogs for ZNF638 Gene

Variants for ZNF638 Gene

Sequence variations from dbSNP and Humsavar for ZNF638 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10165298 -- 71,383,832(+) CCTAA(A/C)CTTAA intron-variant
rs10169693 -- 71,307,498(+) gagat(C/G)gtgcc intron-variant
rs10171071 -- 71,420,879(+) ATTTG(A/G)AAAGA intron-variant
rs10173072 -- 71,433,674(+) CTTTT(C/T)TAAAT intron-variant, downstream-variant-500B
rs10175747 -- 71,379,774(+) cctaa(C/T)gaata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF638 Gene

Variant ID Type Subtype PubMed ID
nsv526102 CNV gain 19592680
nsv521345 CNV loss 19592680
nsv519545 CNV loss 19592680
nsv1146116 CNV insertion 26484159
nsv1125212 CNV insertion 24896259
nsv1117243 CNV tandem duplication 24896259
nsv1010266 CNV gain 25217958
esv3591228 CNV gain 21293372
esv3591226 CNV gain 21293372
dgv3864n100 CNV loss 25217958
dgv3863n100 CNV gain 25217958

Variation tolerance for ZNF638 Gene

Residual Variation Intolerance Score: 2.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.31; 96.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF638 Gene

Human Gene Mutation Database (HGMD)
ZNF638
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF638

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF638 Gene

Disorders for ZNF638 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF638 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF638

Genetic Association Database (GAD)
ZNF638
Human Genome Epidemiology (HuGE) Navigator
ZNF638
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF638
genes like me logo Genes that share disorders with ZNF638: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF638 Gene

Publications for ZNF638 Gene

  1. A large DNA-binding nuclear protein with RNA recognition motif and serine/arginine-rich domain. (PMID: 8647861) Inagaki H. … Kitagawa Y. (J. Biol. Chem. 1996) 2 3 4 22 64
  2. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G. … White R.L. (Alcohol. Clin. Exp. Res. 2010) 3 46 64
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64

Products for ZNF638 Gene

Sources for ZNF638 Gene

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