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Aliases for ZNF638 Gene

Aliases for ZNF638 Gene

  • Zinc Finger Protein 638 2 3 5
  • Cutaneous T-Cell Lymphoma-Associated Antigen Se33-1 3 4
  • Zinc Finger Matrin-Like Protein 3 4
  • CTCL-Associated Antigen Se33-1 3 4
  • Nuclear Protein 220 3 4
  • NP220 3 4
  • ZFML 3 4
  • CTCL Tumor Antigen Se33-1 3
  • Zinc Finger, Matrin-Like 2
  • NP220 Nuclear Protein 3
  • Zfp638 3

External Ids for ZNF638 Gene

Previous HGNC Symbols for ZNF638 Gene

  • ZFML

Previous GeneCards Identifiers for ZNF638 Gene

  • GC02P071470
  • GC02P071412

Summaries for ZNF638 Gene

Entrez Gene Summary for ZNF638 Gene

  • The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded DNA. This protein has three types of domains: MH1, MH2 (repeated three times) and MH3. It is associated with packaging, transferring, or processing transcripts. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF638 Gene

ZNF638 (Zinc Finger Protein 638) is a Protein Coding gene. Diseases associated with ZNF638 include cutaneous t cell lymphoma. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is MATR3.

UniProtKB/Swiss-Prot for ZNF638 Gene

  • Early regulator of adipogenesis that works as a transcription cofactor of CEBPs, controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). Binds to cytidine clusters in double-stranded DNA (PubMed:8647861). May also regulate alternative splicing of target genes during adipogenesis (By similarity).

Gene Wiki entry for ZNF638 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF638 Gene

Genomics for ZNF638 Gene

Regulatory Elements for ZNF638 Gene

Promoters for ZNF638 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF638 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF638 Gene

Chromosome:
2
Start:
71,276,561 bp from pter
End:
71,435,069 bp from pter
Size:
158,509 bases
Orientation:
Plus strand

Genomic View for ZNF638 Gene

Genes around ZNF638 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF638 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF638 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF638 Gene

Proteins for ZNF638 Gene

  • Protein details for ZNF638 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14966-ZN638_HUMAN
    Recommended name:
    Zinc finger protein 638
    Protein Accession:
    Q14966
    Secondary Accessions:
    • B5MDV1
    • B7ZLD1
    • Q53R34
    • Q5XJ05
    • Q68DP3
    • Q6P2H2
    • Q7Z3T7
    • Q8NF92
    • Q8TCA1
    • Q9H2G1
    • Q9NP37

    Protein attributes for ZNF638 Gene

    Size:
    1978 amino acids
    Molecular mass:
    220625 Da
    Quaternary structure:
    • Interacts with FHL2 (PubMed:11813260). Interacts with CEBPA, CEBPD and CEBPG (By similarity).
    Miscellaneous:
    • Isoform 5 is a tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and in particular in mycosis fungoides patients and in Sezary syndrome patients.
    SequenceCaution:
    • Sequence=AAH64530.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF638 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF638 Gene

Proteomics data for ZNF638 Gene at MOPED

Post-translational modifications for ZNF638 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ZNF638 Gene

Domains & Families for ZNF638 Gene

Gene Families for ZNF638 Gene

Protein Domains for ZNF638 Gene

Suggested Antigen Peptide Sequences for ZNF638 Gene

Graphical View of Domain Structure for InterPro Entry

Q14966

UniProtKB/Swiss-Prot:

ZN638_HUMAN :
  • The matrin-type zinc finger domain is required for localization to nuclear speckles.
  • Contains 1 matrin-type zinc finger.
Domain:
  • The matrin-type zinc finger domain is required for localization to nuclear speckles.
  • Contains 2 RRM (RNA recognition motif) domains.
Similarity:
  • Contains 1 matrin-type zinc finger.
genes like me logo Genes that share domains with ZNF638: view

Function for ZNF638 Gene

Molecular function for ZNF638 Gene

UniProtKB/Swiss-Prot Function:
Early regulator of adipogenesis that works as a transcription cofactor of CEBPs, controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). Binds to cytidine clusters in double-stranded DNA (PubMed:8647861). May also regulate alternative splicing of target genes during adipogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for ZNF638 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003690 double-stranded DNA binding TAS 8647861
GO:0003723 RNA binding TAS 8647861
genes like me logo Genes that share ontologies with ZNF638: view

Phenotypes for ZNF638 Gene

GenomeRNAi human phenotypes for ZNF638:
genes like me logo Genes that share phenotypes with ZNF638: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF638 Gene

Localization for ZNF638 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF638 Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF638 Gene COMPARTMENTS Subcellular localization image for ZNF638 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF638 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 8647861
genes like me logo Genes that share ontologies with ZNF638: view

Pathways & Interactions for ZNF638 Gene

SuperPathways for ZNF638 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF638 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF638 Gene

Drugs & Compounds for ZNF638 Gene

(1) Drugs for ZNF638 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine Experimental Pharma 0
genes like me logo Genes that share compounds with ZNF638: view

Transcripts for ZNF638 Gene

Unigene Clusters for ZNF638 Gene

Zinc finger protein 638:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF638 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1:
SP2:
SP3:
SP4:
SP5: - -
SP6: -
SP7: - - -
SP8: - -
SP9: -
SP10:
SP11:
SP12:

ExUns: 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b
SP1: - - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ZNF638 Gene

GeneLoc Exon Structure for
ZNF638
ECgene alternative splicing isoforms for
ZNF638

Expression for ZNF638 Gene

mRNA expression in normal human tissues for ZNF638 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF638 Gene

This gene is overexpressed in Fetal Brain (13.9), Peripheral blood mononuclear cells (12.1), and Pancreas (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF638 Gene



SOURCE GeneReport for Unigene cluster for ZNF638 Gene Hs.434401

genes like me logo Genes that share expression patterns with ZNF638: view

Protein tissue co-expression partners for ZNF638 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF638 Gene

Orthologs for ZNF638 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF638 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF638 36
  • 99 (a)
OneToOne
ZNF638 35
  • 99.53 (n)
  • 99.14 (a)
cow
(Bos Taurus)
Mammalia ZNF638 35
  • 89.61 (n)
  • 84.26 (a)
ZNF638 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF638 36
  • 86 (a)
OneToOne
ZNF638 35
  • 90.59 (n)
  • 86.14 (a)
mouse
(Mus musculus)
Mammalia Zfp638 16
Zfml 36
  • 78 (a)
OneToOne
Zfml 35
  • 85.12 (n)
  • 77.84 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 59 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp638 35
  • 85.45 (n)
  • 78.98 (a)
chicken
(Gallus gallus)
Aves ZNF638 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF638 36
  • 38 (a)
OneToOne
Species with no ortholog for ZNF638:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF638 Gene

ENSEMBL:
Gene Tree for ZNF638 (if available)
TreeFam:
Gene Tree for ZNF638 (if available)

Paralogs for ZNF638 Gene

Paralogs for ZNF638 Gene

(1) SIMAP similar genes for ZNF638 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ZNF638 Gene

genes like me logo Genes that share paralogs with ZNF638: view

Variants for ZNF638 Gene

Sequence variations from dbSNP and Humsavar for ZNF638 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs12612365 - 71,349,282(+) CTCAT(A/G)TATCT intron-variant, nc-transcript-variant, reference, missense
rs3732235 - 71,403,979(-) TCATG(C/T)TTTCA nc-transcript-variant, reference, missense
rs1804020 - 71,427,045(+) CTCAG(A/G)TGCCC nc-transcript-variant, reference, missense
rs11542286 - 71,431,411(-) CAGAC(A/G)CCACT nc-transcript-variant, reference, missense
rs10427371 - 71,423,899(+) GAGCA(A/G)TCTTA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF638 Gene

Variant ID Type Subtype PubMed ID
nsv521345 CNV Loss 19592680
nsv519545 CNV Loss 19592680
nsv526102 CNV Gain 19592680

Variation tolerance for ZNF638 Gene

Residual Variation Intolerance Score: 2.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.31; 96.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF638 Gene

HapMap Linkage Disequilibrium report
ZNF638
Human Gene Mutation Database (HGMD)
ZNF638

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF638 Gene

Disorders for ZNF638 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF638 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF638

Genetic Association Database (GAD)
ZNF638
Human Genome Epidemiology (HuGE) Navigator
ZNF638
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF638
genes like me logo Genes that share disorders with ZNF638: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF638 Gene

Publications for ZNF638 Gene

  1. A large DNA-binding nuclear protein with RNA recognition motif and serine/arginine-rich domain. (PMID: 8647861) Inagaki H. … Kitagawa Y. (J. Biol. Chem. 1996) 2 3 4 23 67
  2. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 3

Products for ZNF638 Gene

Sources for ZNF638 Gene

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