Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ZNF638 Gene

protein-coding   GIFtS: 55
GCID: GC02P071412

Zinc Finger Protein 638

(Previous names: zinc finger, matrin-like)
(Previous symbol: ZFML)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Zinc Finger Protein 6381 2     CTCL-Associated Antigen Se33-12 3
ZFML1 2 3     Zinc Finger, Matrin-Like1
NP2202 3 5     Zfp6382
Cutaneous T-Cell Lymphoma-Associated Antigen Se33-12 3     CTCL Tumor Antigen Se33-12
Nuclear Protein 2202 3     NP220 Nuclear Protein2
Zinc Finger Matrin-Like Protein2 3     

External Ids:    HGNC: 178941   Entrez Gene: 273322   Ensembl: ENSG000000752927   OMIM: 6143495   UniProtKB: Q149663   

Export aliases for ZNF638 gene to outside databases

Previous GC identifers: GC02P071470 GC02P071357


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ZNF638 Gene:
The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded
DNA. This protein has three types of domains: MH1, MH2 (repeated three times) and MH3. It is associated with
packaging, transferring, or processing transcripts. Multiple alternatively spliced transcript variants have been
found for this gene, but the biological validity of some variants has not been determined. (provided by RefSeq,
Jul 2008)

GeneCards Summary for ZNF638 Gene:
ZNF638 (zinc finger protein 638) is a protein-coding gene. GO annotations related to this gene include double-stranded DNA binding and RNA binding.

UniProtKB/Swiss-Prot: ZN638_HUMAN, Q14966
Function: Early regulator of adipogenesis that works as a transcription cofactor of CEBPs, controlling the
expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). Binds to cytidine
clusters in double-stranded DNA

Gene Wiki entry for ZNF638 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF638 gene promoter:
         Sox5   Pax-5   NF-kappaB   C/EBPalpha   Roaz   AREB6   Cart-1   TGIF   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF638 promoter sequence
   Search Chromatin IP Primers for ZNF638

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF638


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.1   Ensembl cytogenetic band:  2p13.2   HGNC cytogenetic band: 2p13.1

ZNF638 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF638 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P071412:  view genomic region     (about GC identifiers)

Start:
71,503,691 bp from pter      End:
71,662,199 bp from pter
Size:
158,509 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ZN638_HUMAN, Q14966 (See protein sequence)
Recommended Name: Zinc finger protein 638  
Size: 1978 amino acids; 220625 Da
Subunit: Interacts with FHL2. Interacts with CEBPA, CEBPD and CEBPG (By similarity)
Miscellaneous: Isoform 5 is a tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and in
particular in mycosis fungoides patients and in Sezary syndrome patients
Sequence caution: Sequence=AAH64530.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: B5MDV1 B7ZLD1 Q53R34 Q5XJ05 Q68DP3 Q6P2H2 Q7Z3T7 Q8NF92 Q8TCA1 Q9H2G1
Q9NP37
Alternative splicing: 5 isoforms:  Q14966-1   Q14966-2   Q14966-3   Q14966-4   Q14966-5   (Broadly expressed)

Explore the universe of human proteins at neXtProt for ZNF638: NX_Q14966

Explore proteomics data for ZNF638 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF638 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001014972.1  NP_001239541.1  NP_001239542.1  NP_055312.2  

    ENSEMBL proteins: 
     ENSP00000388164   ENSP00000264447   ENSP00000386433   ENSP00000408557   ENSP00000402875  
     ENSP00000396909   ENSP00000409647   ENSP00000469295   ENSP00000386813   ENSP00000348066  
     ENSP00000367033  

    ZNF638 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ZNF638
    GenScript Custom Purified and Recombinant Proteins Services for ZNF638
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF638

     
    Search eBioscience for Proteins for ZNF638 

    ZNF638 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ZNF638
    OriGene Custom Antibody Services for ZNF638
    Novus Biologicals ZNF638 Antibodies
    Abcam antibodies for ZNF638
    Cloud-Clone Corp. Antibodies for ZNF638
    Search ThermoFisher Antibodies for ZNF638
    LSBio Antibodies in human, mouse, rat for ZNF638

    ZNF638 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZNF638
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZNF638
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZNF638
    Cloud-Clone Corp. CLIAs for ZNF638
    Search eBioscience for ELISAs for ZNF638 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    Selected InterPro protein domains (see all 6):
     IPR003604 Znf_U1
     IPR012677 Nucleotide-bd_a/b_plait
     IPR015880 Znf_C2H2-like
     IPR000690 Znf_C2H2_matrin
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q14966

    ProtoNet protein and cluster: Q14966

    UniProtKB/Swiss-Prot: ZN638_HUMAN, Q14966
    Similarity: Contains 1 matrin-type zinc finger
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Find genes that share domains with ZNF638           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN638_HUMAN, Q14966
    Function: Early regulator of adipogenesis that works as a transcription cofactor of CEBPs, controlling the
    expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). Binds to cytidine
    clusters in double-stranded DNA

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003690double-stranded DNA binding TAS8647861
    GO:0003723RNA binding TAS8647861
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ZNF638           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF638:
     Proliferating cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF638
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZNF638

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF638
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF638

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZNF638:
    hsa-mir-16-5p (MIRT051090), hsa-mir-30a-5p (MIRT028626), hsa-mir-27a-3p (MIRT050029), hsa-mir-106b-3p (MIRT038582), hsa-mir-1 (MIRT024068)

    Block miRNA regulation of human, mouse, rat ZNF638 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate ZNF638:
    hsa-miR-1273d hsa-miR-3654 hsa-miR-548c-3p hsa-let-7f-2*
    SwitchGear 3'UTR luciferase reporter plasmidZNF638 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZNF638
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF638

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZNF638

    Clone
    Products:
         
    OriGene clones in human, mouse for ZNF638 (see all 10)
    OriGene ORF clones in mouse, rat for ZNF638
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZNF638 (NM_001014972)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF638
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF638

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ZNF638
    Browse ESI BIO Cell Lines and PureStem Progenitors for ZNF638 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF638


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ZN638_HUMAN, Q14966: Nucleus speckle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS8647861
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm TAS8647861
    GO:0016607nuclear speck IEA--

    Find genes that share ontologies with ZNF638           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF638
    Interactions:

        Search GeneGlobe Interaction Network for ZNF638

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for ZNF638 (Q149662, 3 ENSP000002644474) via UniProtKB, MINT, STRING, and/or I2D (see all 795)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRRM1Q8IYB32, 3, ENSP000003262614MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000326261
    HOOK2Q96ED92, 3, ENSP000003807854MINT-68395 I2D: score=5 STRING: ENSP00000380785
    KRT15P190122, 3, ENSP000002540434MINT-68063 I2D: score=5 STRING: ENSP00000254043
    KRT19P087272, 3, ENSP000003551244MINT-67324 I2D: score=5 STRING: ENSP00000355124
    KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-67102 I2D: score=5 STRING: ENSP00000377582
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0008380RNA splicing TAS8647861

    Find genes that share ontologies with ZNF638           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF638 (ZN638)

    1 HMDB Compound for ZNF638    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cytidine1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine (see all 20)65-46-3--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ZNF638 gene (4 alternative transcripts): 
    NM_001014972.2  NM_001252612.1  NM_001252613.1  NM_014497.4  

    Unigene Cluster for ZNF638:

    Zinc finger protein 638
    Hs.434401  [show with all ESTs]
    Unigene Representative Sequence: CR749322
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000494621 ENST00000466975 ENST00000410075 ENST00000466330 ENST00000437658
    ENST00000464375 ENST00000475743 ENST00000264447(uc010yqw.1 uc002shx.3 uc002shz.3 uc002shy.3)
    ENST00000409544(uc002sia.3) ENST00000455226 ENST00000454278 ENST00000487707
    ENST00000417778 ENST00000454122 ENST00000601581 ENST00000434786 ENST00000486494
    ENST00000491843
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZNF638 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate ZNF638:
    hsa-miR-1273d hsa-miR-3654 hsa-miR-548c-3p hsa-let-7f-2*
    SwitchGear 3'UTR luciferase reporter plasmidZNF638 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF638
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF638
    Clone
    Products:
         
    OriGene clones in human, mouse for ZNF638 (see all 10)
    OriGene ORF clones in mouse, rat for ZNF638
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZNF638 (NM_001014972)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF638
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF638
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF638
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF638
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF638
      QuantiFast Probe-based Assays in human, mouse, rat ZNF638

    Additional mRNA sequence: 

    AF534078.1 AK093578.1 AK093684.1 AK098492.1 AK128706.1 AK291198.1 AK293938.1 AK303723.1 
    AK309221.1 BC010355.1 BC024000.1 BC064530.1 BC083513.1 BC143728.1 BX537425.1 CR749322.1 
    D83032.1 

    Selected DOTS entries (see all 29):

    DT.95203322  DT.95077570  DT.91739178  DT.100794578  DT.452337  DT.95132219  DT.316006  DT.100671521 
    DT.100794573  DT.99945122  DT.100794580  DT.120986191  DT.40110906  DT.70103391  DT.92014963  DT.97847163 
    DT.120986096  DT.120986170  DT.120986186  DT.120986210  DT.40211248  DT.91668418  DT.91720941  DT.91838684 

    Selected AceView cDNA sequences (see all 287):

    BQ721111 BQ575461 AK093578 NM_014497 BP348645 BQ006040 AA411994 BM503239 
    CK822046 BP349948 BX092185 CB130886 BM682958 BQ003580 AL047923 BX486385 
    AA421829 AA424987 BE670051 BE463960 AA625615 BU626229 BU622353 BQ216356 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF638 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                    -           -                                                                                                                           

    ExUns: 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b
    SP1:  -     -                                               -     -                           
    SP2:                    -     -                             -     -                           
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for ZNF638

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ZNF638 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAAATATC
    ZNF638 Expression
    About this image


    ZNF638 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)
             Telencephalon
    ZNF638 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF638 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.434401
        Custom PCR Arrays for ZNF638
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF638
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF638
    QuantiTect SYBR Green Assays in human, mouse, rat ZNF638
    QuantiFast Probe-based Assays in human, mouse, rat ZNF638
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF638

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF638 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfml1 , 5 zinc finger, matrin-like1, 5 85.12(n)1
    77.84(a)1
      6 (36.06 cM)5
    181391  NM_008717.31  NP_032743.21 
     839143535 
    chicken
    (Gallus gallus)
    Aves ZNF6386
    zinc finger protein 638
    49(a)
    1 ↔ 1
    JH376303.1(8287-21852)
    lizard
    (Anolis carolinensis)
    Reptilia ZNF6386
    zinc finger protein 638
    38(a)
    1 ↔ 1
    GL343831.1(18894-53668)


    ENSEMBL Gene Tree for ZNF638 (if available)
    TreeFam Gene Tree for ZNF638 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ZNF638 gene
    1 SIMAP similar gene for ZNF638 using alignment to 8 protein entries:     ZN638_HUMAN (see all proteins):
    NP220

    Find genes that share paralogs with ZNF638           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF638
    PGOHUM00000250459


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ZNF638 (see all 2526)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs357799821,2
    C--71556920(+) TTTGTA/-AGGGA 4 -- us2k12Minor allele frequency- -:0.25NA 4
    rs130287351,2
    F,A,H--71556922(+) TTGTAG/AGGAAA 4 -- us2k14Minor allele frequency- A:0.04NS EA 380
    rs105501831,2
    C--71556939(+) TTTTTTTT/-GAGAC 8 -- us2k1 cds11Minor allele frequency- -:0.50NA 2
    rs1492617521,2
    C--71556939(+) TTTTT-/TTTGAGAC 4 -- us2k10--------
    rs1139794901,2
    C--71556943(+) CTTTTC/TTTTTT 4 -- us2k11Minor allele frequency- T:0.50NA 2
    rs130051571,2
    A--71556944(+) tttttC/Tttttt 4 -- us2k1 trp30--------
    rs1501693191,2
    --71557241(+) TGCCTA/GTTTTC 4 -- us2k10--------
    rs1386703251,2
    --71557258(+) ATTTAC/GTGGAA 4 -- us2k10--------
    rs1851103931,2
    C--71557273(+) CACTTC/TGTAGA 4 -- us2k10--------
    rs130109751,2
    C,F,A,H--71557299(+) TTTTCT/CACAAC 4 -- us2k18Minor allele frequency- C:0.08NS EA NA WA 658

    HapMap Linkage Disequilibrium report for ZNF638 (71503691 - 71662199 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF638:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv521345CNV Loss19592680
    nsv519545CNV Loss19592680
    nsv526102CNV Gain19592680

    Human Gene Mutation Database (HGMD): ZNF638
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF638
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF638

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 614349    OMIM disorders: --


    Find genes that share disorders with ZNF638           About GenesLikeMe

    Genetic Association Database (GAD): ZNF638
    Human Genome Epidemiology (HuGE) Navigator: ZNF638 (2 documents)

    Export disorders for ZNF638 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ZNF638 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with ZNF638)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A large DNA-binding nuclear protein with RNA recognition motif and serine/arginine-rich domain. (PubMed id 8647861)1, 2, 3, 9 Inagaki H....Kitagawa Y. (J. Biol. Chem. 1996)
    2. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Interaction of the heart-specific LIM domain protein, FHL2, with DNA- binding nuclear protein, hNP220. (PubMed id 11813260)1, 2 Ng E.K.O.... Fung K.P. (J. Cell. Biochem. 2002)
    8. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PubMed id 11149944)1, 2 Eichmueller S....Schadendorf D. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    9. Genome-wide association study in Han Chinese identifies three novel loci for human height. (PubMed id 23456168)1 Hao Y....Gu D. (Hum. Genet. 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 27332 HGNC: 17894 AceView: ZNF638 Ensembl:ENSG00000075292 euGenes: HUgn27332
    ECgene: ZNF638 H-InvDB: ZNF638

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ZNF638 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ZNF638 gene:
    Search GeneIP for patents involving ZNF638

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ZNF638   OriGene RNAi products in human, mouse, rat for ZNF638  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ZNF638  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZNF638   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ZNF638   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZNF638   OriGene Custom Protein Services for ZNF638  

     
     
     Block miRNA regulation of human, mouse, rat ZNF638 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ZNF638
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF638 Predesigned siRNA for gene silencing in human, mouse, rat ZNF638
     QuantiFast Probe-based Assays in human, mouse, rat ZNF638 QuantiTect SYBR Green Assays in human, mouse, rat ZNF638
     Custom PCR Arrays for ZNF638 Search Chromatin IP Primers for ZNF638
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF638  Search GeneGlobe Interaction Network for ZNF638
     Regulatory tfbs in ZNF638 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ZNF638 GenScript cDNA clones with any tag delivered in your preferred vector for ZNF638
     GenScript Custom Assay Services for ZNF638 GenScript Custom overexpressing Cell Line Services for ZNF638
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ZNF638 (ZN638)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ZNF638 antibodies
     Antibodies for ZNF638
     See all of Abcam's Antibodies, Kits and Proteins for ZNF638
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ZNF638
     Antibodies for ZNF638
     ELISAs for ZNF638
     CLIAs for ZNF638



     Browse ESI BIO Cell Lines and PureStem Progenitors for ZNF638
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF638
     SwitchGear 3'UTR luciferase reporter plasmids for ZNF638
     SwitchGear Promoter luciferase reporter plasmids for ZNF638
     Search ThermoFisher Antibodies for ZNF638
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF638
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF638
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZNF638
     LSBio Antibodies in human, mouse, rat for ZNF638
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ZNF638
      Search eBioscience for proteins for ZNF638
      Search eBioscience for elisas for ZNF638
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ZNF638 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4