ZNF630 Gene
protein-coding GIFtS: 43
GCID: GC0XM047842
|
|
zinc finger protein 630
| |
Aliases
for ZNF630 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 6301 2 | | DJ54B20.21 | | BC0373161 | | FLJ205731 | | MGC1383441 | | DJ54B20.2 (Novel KRAB Box Containing C2H2 Type Zinc Finger Protein)2 |
Export aliases for ZNF630 gene to outside databasesPrevious GC identifers: GC0XM046964 GC0XM047673 GC0XM047802 GC0XM045632 |
Summaries
for ZNF630 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZNF630:
This gene encodes a zinc finger protein with an N-terminal Kruppel-associated box-containing (KRAB) domain and 13Kruppel-type C2H2 zinc finger domains. Like other zinc finger proteins, this gene may function as a transcriptionfactor. This gene resides on an area of chromosome X that has been implicated in nonsyndromic X-linked mentalretardation. (provided by RefSeq, Jul 2010)
UniProtKB/Swiss-Prot: ZN630_HUMAN, Q2M218Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF630 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_079573.4
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ZNF630
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF630
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF630 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.3-p11.1 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.3-p11.1ZNF630 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM047842: view genomic region
(about GC identifiers)
Start:
|
47,842,756 bp from pter |
End:
|
47,931,025 bp from pter |
Size:
|
88,270 bases |
Orientation:
|
minus strand |
|
Proteins
for ZNF630 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN630_HUMAN, Q2M218 (See
protein sequence)Recommended Name: Zinc finger protein 630 Size: 657 amino acids; 76094 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q5H8Z5Explore the universe of human proteins at neXtProt for ZNF630: NX_Q2M218
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q2M218
ZNF630 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001032824.2 NP_001177184.1
ENSEMBL proteins: ENSP00000400030 ENSP00000354683 ENSP00000386393 ENSP00000407278 ENSP00000408054 ENSP00000393163
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF630 for ontologies About GeneDecksing
ZNF630 Antibody Products:
Assay Products for ZNF630: |
Protein
Domains /
Families
for ZNF630 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF630 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q2M218ProtoNet protein and cluster: Q2M218 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN630_HUMAN, Q2M218Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 14 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF630 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN630_HUMAN, Q2M218Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF630 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF630 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF630 (NM_001037735) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF630 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF630 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF630 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF630 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF630 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF630
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF630 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF630 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF630
Search CenterWatch for drugs/clinical trials and news about ZNF630 / ZN630
|
Transcripts
for ZNF630 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF630 gene (2 alternative transcripts): NM_001037735.2 NM_001190255.1 Unigene Cluster for ZNF630: Zinc finger protein 630 Hs.650883 [show with all ESTs]Unigene Representative Sequence: NR_0337306 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000428463(uc010nhz.1) ENST00000276054(uc022bvs.1) ENST00000409324(uc004div.4)
ENST00000428686 ENST00000421903 ENST00000442455(uc022bvr.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF630 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF630 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF630 (NM_001037735) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF630 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF630 |
Additional cDNA sequence: AK000580.1 AK307979.1 BC037316.1 BC112139.1 NR_033730.1 3 DOTS entries: DT.95291766 DT.121299545 DT.100781947 7 AceView cDNA sequences: BG436394 BX419623 BC037316 BX116378 AK000580 R67493 BI545533
GeneLoc Exon Structure
|
Expression
for ZNF630 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF630 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTACCCTTC
About this image
See ZNF630 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF630
SOURCE GeneReport for Unigene cluster: Hs.650883
SABiosciences Custom PCR Arrays for ZNF630
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF630
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF630 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF630 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF630 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF630 |
Orthologs
for ZNF630 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF630 gene from 1/6 species (see all 6) About this table
ENSEMBL Gene Tree for ZNF630 (if available)
TreeFam Gene Tree for ZNF630 (if available) |
Paralogs
for ZNF630 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF630 gene
- ZNF1752 ZNF6742 LOC1002875152 ZNF6142 ZNF4322 ZNF6132 ZNF262 ZNF3502
- ZNF812 ZNF6492 ZNF6052 ZNF5772 ZNF842 ZFP372 ZNF4842 ENSG000002296312
- ZNF1822 ZNF412 ZNF2682 LOC1009964642 ZNF6152 ZNF3002
18/540 SIMAP similar genes for ZNF630 using alignment to 6 protein entries: ZN630_HUMAN (see all proteins)
(see all similar genes):kr-znf3 POM121C ZNF818P ZNF78L1 ZFP90 ZNF81
HZF36 MGC12518 ZFP41 zf30 ZNF300 ZNF3
ZNF300P1 ZNF283 DKFZp666M039 KRBOX4 ZFS-5 ZNF213
ZNF630 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF630
PGOHUM00000235424
|
Genomic Variants
for ZNF630 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF630 (47842756 - 47931025 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 35 variations for ZNF630
15/35 CNVs (see all 35): 83493 34416 4149 67975 0822 83492 8912 53004 53002 37578 8305 1847 83491 37638 53006
Locus Specific Mutation Databases (LSDB): ZNF630
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF630 |
|
Disorders
/ Diseases
for ZNF630 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF630 for disorders About MalaCards
ZNF630 for disorders About GeneDecksing
OMIM gene information: 300819
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: ZNF630 (1 document)
Export disorders for ZNF630 gene to outside databases
|
Publications
for ZNF630 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF630 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF630) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Recurrent deletion of ZNF630 at Xp11.23 is not associ ated with mental retardation. (PubMed id 20186789)1 Lugtenberg D....de Brouwer A.P. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF630 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF630 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF630 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF630 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF630 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF630 gene:
Search GeneIP for patents involving ZNF630
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF630 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF630 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF630 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF630 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF630 | | OriGene 3'-UTR Clone for ZNF630 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF630 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF630 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF630 | | OriGene Custom Protein Services for ZNF630 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF630 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF630 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF630 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF630 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF630 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF630 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ZNF630 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ZNF630 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF630 |
|  |  |  | | | | ThermoFisher Antibodies for ZNF630 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF630 |
|
|
|
|
