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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF629 Gene

protein-coding   GIFtS: 40
GCID: GC16M030789

Zinc Finger Protein 629

(Previous name: zinc finger protein 65)
(Previous symbol: ZNF65)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 6291 2
Zinc Finger Protein 651 2 3
ZNF651 2 3
ZNF2
DNA-Binding Protein2
KIAA03263

External Ids:    HGNC: 290081   Entrez Gene: 233612   Ensembl: ENSG000001028707   UniProtKB: Q9UEG43   

Export aliases for ZNF629 gene to outside databases

Previous GC identifers: GC16M030830 GC16M030700 GC16M030697 GC16M028352


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF629 Gene: 
ZNF629 (zinc finger protein 629) is a protein-coding gene. Diseases associated with ZNF629 include enamel erosion. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF48.

UniProtKB/Swiss-Prot: ZN629_HUMAN, Q9UEG4
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF629 gene promoter:
         Bach2   Olf-1   LCR-F1   NF-E2 p45   HEN1   RORalpha1   MRF-2   NF-E2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZNF629

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF629


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

ZNF629 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF629 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M030789:  view genomic region     (about GC identifiers)

Start:
30,789,770 bp from pter      End:
30,798,523 bp from pter
Size:
8,754 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN629_HUMAN, Q9UEG4 (See protein sequence)
Recommended Name: Zinc finger protein 629  
Size: 869 amino acids; 96620 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAA20784.1; Type=Erroneous initiation;
Secondary accessions: Q15938

Explore the universe of human proteins at neXtProt for ZNF629: NX_Q9UEG4

Explore proteomics data for ZNF629 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UEG4

  • ZNF629 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF629 Protein Expression
    REFSEQ proteins: NP_001073886.1  
    ENSEMBL proteins: 
     ENSP00000262525  

    Human Recombinant Protein Products for ZNF629: 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--

    ZNF629 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UEG4

    ProtoNet protein and cluster: Q9UEG4

    UniProtKB/Swiss-Prot: ZN629_HUMAN, Q9UEG4
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 19 C2H2-type zinc fingers


    ZNF629 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN629_HUMAN, Q9UEG4
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF629 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF629

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF629 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZNF629 (ZN629)

    Search CenterWatch for drugs/clinical trials and news about ZNF629 / ZN629

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF629 gene: 
    NM_001080417.1  

    Unigene Cluster for ZNF629:

    Zinc finger protein 629
    Hs.301094  [show with all ESTs]
    Unigene Representative Sequence: NM_001080417
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000262525(uc002dzs.1)
    miRNA
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    hsa-miR-3938 hsa-miR-15a hsa-miR-1224-3p hsa-miR-200a hsa-miR-1260b hsa-miR-1273d hsa-miR-155* hsa-miR-3649
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Additional mRNA sequence: 

    AB002324.1 AK026115.1 BC015676.2 BC047041.1 BC063520.1 BC080594.1 

    2 DOTS entries:

    DT.313763  DT.91926972 

    24/111 AceView cDNA sequences (see all 111):

    BX643362 BU542127 AI924293 Z41004 BM564352 BE883524 BQ428180 Z45297 
    AB002324 BG823125 CA426124 F03007 BQ928892 BU543072 T89182 BC063520 
    BU542770 C02488 BU543566 BG392937 BC047041 AL044847 CA429849 AU121767 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF629 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCTTAGTT
    ZNF629 Expression
    About this image


    See ZNF629 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF629

    SOURCE GeneReport for Unigene cluster: Hs.301094
        SABiosciences Custom PCR Arrays for ZNF629
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF629

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF629 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp6291 , 5 zinc finger protein 6291, 5 86.08(n)1
    89.16(a)1
      7 (69.62 cM)5
    3206831  NM_177226.51  NP_796200.11 
     1276070315 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    40(a)
    possible ortholog
    GL344516.1(3581-57538)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkeyp-53d3.36
    si:dkeyp-53d3.3
    44(a)
    possible ortholog
    22(2605686-2617104)
    fruit fly
    (Drosophila melanogaster)
    Insecta Meics6
    Meiotic central spindle
    22(a)
    1 → many
    3L(13955758-13957802)


    ENSEMBL Gene Tree for ZNF629 (if available)
    TreeFam Gene Tree for ZNF629 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF629 gene
    ZNF482  
    18/476 SIMAP similar genes for ZNF629 using alignment to 1 protein entry:     ZN629_HUMAN(see all similar genes):
    ZNF78L1    DKFZp666C237    ZFS-4    ZNF24    ZNF818P    HZF36
    ZKSCAN7    ZNF250    ZNF852    kr-znf3    ZNF    ZNF286A
    ZNF568    ZNF696    ZNF774    zf30    ZNF146    ZNF180

    ZNF629 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/192 SNPs in ZNF629 are shown (see all 192)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1910602741,2
    --30789328(+) ACCTCC/TCCCAG 1 -- ds50010--------
    rs1807518411,2
    --30789411(+) TTGCGC/GGTATG 1 -- ds50010--------
    rs1400882361,2
    --30789573(+) CTTTCC/TGCACC 1 -- ds50010--------
    rs1119540991,2
    C,F--30789623(+) CCCACA/GAGCCA 1 -- ds50012Minor allele frequency- G:0.09NA 122
    rs1861377331,2
    --30789857(+) CACTCA/GAAAAT 1 -- ut310--------
    rs1380915121,2
    --30789881(+) ACTCCA/TTGGGG 1 -- ut310--------
    rs1422211901,2
    C--30790046(+) CTCCAC/TGTCCA 1 -- ut310--------
    rs1459977061,2
    --30790123(+) GTTGGC/GCTCCT 1 -- ut310--------
    rs1911082381,2
    C--30790164(+) GGGCCC/TGCATG 1 -- ut310--------
    rs1833751401,2
    --30790205(+) GCCTTC/TCAGAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF629 (30789770 - 30798523 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ZNF629:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv905733CNV Loss21882294
    nsv905729CNV Loss21882294
    nsv469724CNV Loss16826518
    nsv905728CNV Loss21882294
    nsv905732CNV Loss21882294
    nsv833188CNV Loss17160897
    nsv9438CNV Gain18304495

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZNF629:    About MalaCards
    enamel erosion    


    ZNF629 for disorders           About GeneDecksing


    Export disorders for ZNF629 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF629 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF629)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
    2. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PubMed id 1505991)1, 2 Lichter P....Ward D.C. (1992)
    3. Characterization and mapping of human genes encoding zinc finger proteins. (PubMed id 1946370)1, 2 Bray P.L.... Dawid I.B. (1991)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23361 HGNC: 29008 AceView: ZNF629 Ensembl:ENSG00000102870 euGenes: HUgn23361
    ECgene: ZNF629 H-InvDB: ZNF629

    (According to HUGE)
    About This Section
    HUGE: KIAA0326

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF629 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF629 gene:
    Search GeneIP for patents involving ZNF629

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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