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ZNF628 Gene

protein-coding   GIFtS: 40
GCID: GC19P055987

Zinc Finger Protein 628

  Search for ZNF628
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 6281 2
ZEC2 5
Zinc Finger Expressed In Embryonal Cells And Certain Adult Organs1
Zfp6282
Zinc Finger Protein Zec2

External Ids:    HGNC: 280541   Entrez Gene: 898872   Ensembl: ENSG000001974837   OMIM: 6106715   UniProtKB: Q5EBL23   

Export aliases for ZNF628 gene to outside databases

Previous GC identifers: GC19P060681 GC19P060492 GC19P052302


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF628 Gene:
Zinc finger proteins (ZNFs), which bind nucleic acids, perform many key functions, the most important of which is
regulating transcription. See ZNF91 (MIM 603971) for general information on ZNFs.(supplied by OMIM, Mar 2008)

GeneCards Summary for ZNF628 Gene:
ZNF628 (zinc finger protein 628) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF784.

UniProtKB/Swiss-Prot: ZN628_HUMAN, Q5EBL2
Function: Transcription activator. Binds DNA on GT-box consensus sequence 5'-TTGGTT-3' (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF628 gene promoter:
         RFX1   AML1a   RREB-1   Lmo2   Roaz   GATA-1   E47   AREB6   Msx-1   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZNF628 promoter sequence
   Search Chromatin IP Primers for ZNF628

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF628


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.43

ZNF628 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF628 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055987:  view genomic region     (about GC identifiers)

Start:
55,987,699 bp from pter      End:
55,995,854 bp from pter
Size:
8,156 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN628_HUMAN, Q5EBL2 (See protein sequence)
Recommended Name: Zinc finger protein 628  
Size: 1059 amino acids; 110887 Da
Caution: It is uncertain whether Met-1 or Met-5 is the initiator
Sequence caution: Sequence=AAH89449.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q86X34

Explore the universe of human proteins at neXtProt for ZNF628: NX_Q5EBL2

Explore proteomics data for ZNF628 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF628 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_149104.3  
    ENSEMBL proteins: 
     ENSP00000469591   ENSP00000465905   ENSP00000375598  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q5EBL2

    ProtoNet protein and cluster: Q5EBL2

    UniProtKB/Swiss-Prot: ZN628_HUMAN, Q5EBL2
    Similarity: Contains 16 C2H2-type zinc fingers


    Find genes that share domains with ZNF628           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN628_HUMAN, Q5EBL2
    Function: Transcription activator. Binds DNA on GT-box consensus sequence 5'-TTGGTT-3' (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF628           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN628_HUMAN, Q5EBL2: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF628           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF628
    Interactions:

        Search GeneGlobe Interaction Network for ZNF628

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----

    Find genes that share ontologies with ZNF628           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF628 (ZN628)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF628 gene: 
    NM_033113.2  

    Unigene Cluster for ZNF628:

    Zinc finger protein 628
    Hs.525209  [show with all ESTs]
    Unigene Representative Sequence: NM_033113
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000598519 ENST00000591164 ENST00000391718(uc002qld.2)
    miRNA
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    Additional mRNA sequence: 

    AF367249.1 BC016036.2 BC047332.1 BC089449.1 

    1 DOTS entry:

    DT.208341 

    Selected AceView cDNA sequences (see all 35):

    AI912315 BU944663 CF552749 BC016036 AW615682 BC047332 BF724583 BQ877992 
    D60780 BU183527 BE207234 BU196853 BQ215062 BG290052 BU163321 BQ686745 
    BE266530 BG681196 BE891963 BU190227 BG913938 BU166694 AA827434 BX284088 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF628 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGCCGGCCT
    ZNF628 Expression
    About this image

    ZNF628 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF628 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525209
        Custom PCR Arrays for ZNF628
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF628

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF628 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp6281 , 5 zinc finger protein 6281, 5 81.38(n)1
    86.64(a)1
      7 (2.84 cM)5
    2328161  NM_170759.21  NP_739565.21 
     49152175 
    chicken
    (Gallus gallus)
    Aves ZNF6281 zinc finger protein 628 65.1(n)
    60.02(a)
      100857228  XM_004949787.1  XP_004949844.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF6286
    zinc finger protein 628
    49(a)
    1 ↔ 1
    GL343253.1(1357918-1361529)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia znf6281 zinc finger protein 628 53.27(n)
    52.04(a)
      100489381  XM_002941887.2  XP_002941933.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ZNF6286
    zinc finger protein 628
    29(a)
    1 ↔ 1
    16(14372406-14380323) ENSDARG00000087439


    ENSEMBL Gene Tree for ZNF628 (if available)
    TreeFam Gene Tree for ZNF628 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF628 gene
    ZNF7842  
    Selected SIMAP similar genes for ZNF628 using alignment to 2 protein entries:     ZN628_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    DKFZp666C237    kr-znf3    ZNF620    ZNF818P    ZNF22
    ZNF323    ZNF514    ZNF708    ZNF    HZF36    ZIC1
    ZKSCAN1    ZNF124    ZNF56    DKFZp686M04222    ZNF554    ZNF664

    Find genes that share paralogs with ZNF628           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF628
    PGOHUM00000242933


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF628 (see all 195)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1390858451,2
    --55985718(+) GTTCCA/GGGGGG 1 -- us2k10--------
    rs800745171,2
    C--55985738(+) AACCCC/GACCTC 1 -- us2k12Minor allele frequency- G:0.10CSA WA 120
    rs621282561,2
    C,F--55985786(+) AGTGCT/CGGACA 1 -- us2k15Minor allele frequency- C:0.14NA WA 244
    rs1128688601,2
    C--55985815(+) CCTCCG/CGTCAC 1 -- us2k13Minor allele frequency- C:0.06CSA WA NA 240
    rs1429903981,2
    --55985817(+) TCCGGA/TCACTG 1 -- us2k10--------
    rs779045261,2
    C,F--55985820(+) GGTCAC/GTGTCT 1 -- us2k13Minor allele frequency- G:0.06CSA WA NA 240
    rs1858620991,2
    --55985838(+) GCTGCA/GAGGCT 1 -- us2k10--------
    rs2017299841,2
    --55985999(+) CTTTC-/TTTTTT 1 -- us2k10--------
    rs1122487921,2
    C,F--55986032(+) TGTCCA/GGGCTG 1 -- us2k12Minor allele frequency- G:0.10CSA WA 119
    rs1474469481,2
    --55986103(+) CTCACC/TTCAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF628 (55987699 - 55995854 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF628 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2552CNV Insertion18451855
    dgv4024n71CNV Loss21882294
    nsv912478CNV Loss21882294
    nsv912489CNV Loss21882294
    dgv4023n71CNV Loss21882294
    nsv912463CNV Loss21882294
    dgv4025n71CNV Loss21882294
    nsv912457CNV Loss21882294
    nsv912473CNV Loss21882294
    nsv458833CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610671    OMIM disorders: --


    Find genes that share disorders with ZNF628           About GenesLikeMe


    Export disorders for ZNF628 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF628 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF628)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. ZEC, a zinc finger protein with novel binding specificity and transcription regulatory activity. (PubMed id 15556296)1 Chen G.Y....Muramatsu T. (Gene 2004)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 89887 HGNC: 28054 AceView: ZEC Ensembl:ENSG00000197483 euGenes: HUgn89887
    ECgene: ZNF628 H-InvDB: ZNF628

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF628 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF628 gene:
    Search GeneIP for patents involving ZNF628

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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