Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF628 Gene

Aliases for ZNF628 Gene

  • Zinc Finger Protein 628 2 3 5
  • Zinc Finger Expressed In Embryonal Cells And Certain Adult Organs 2
  • Zinc Finger Protein Zec 3
  • Zfp628 3
  • ZEC 3

External Ids for ZNF628 Gene

Previous GeneCards Identifiers for ZNF628 Gene

  • GC19P060681
  • GC19P060492
  • GC19P055987
  • GC19P052302

Summaries for ZNF628 Gene

Entrez Gene Summary for ZNF628 Gene

  • Zinc finger proteins (ZNFs), which bind nucleic acids, perform many key functions, the most important of which is regulating transcription. See ZNF91 (MIM 603971) for general information on ZNFs.[supplied by OMIM, Mar 2008]

GeneCards Summary for ZNF628 Gene

ZNF628 (Zinc Finger Protein 628) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF784.

UniProtKB/Swiss-Prot for ZNF628 Gene

  • Transcription activator. Binds DNA on GT-box consensus sequence 5-TTGGTT-3 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF628 Gene

Genomics for ZNF628 Gene

Regulatory Elements for ZNF628 Gene

Enhancers for ZNF628 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F055215 1.2 ENCODE 36.1 -259.6 -259628 2.9 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 U2AF2 LENG8-AS1 ENSG00000235681 ENSG00000267523 ZNF581 ZNF628 ZNF580 ENSG00000267096 KMT5C RFPL4AP1
GH19F054747 1.2 Ensembl 25.2 -728.4 -728443 1.4 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 MEF2D ZNF628 LENG1 LENG8-AS1 MIR519A2 PRPF31 ZNF784 SBK3 ENSG00000269275 ENSG00000235681 KIR2DL3
GH19F055158 1.3 Ensembl ENCODE 16.4 -316.0 -315977 3.9 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A ZNF2 ZNF143 ZNF263 SP3 SP5 TNNI3 ZNF628 LENG8-AS1 ENSG00000235681 ENSG00000267523 ZNF581 U2AF2 DNAAF3 NAT14 ENSG00000267110
GH19F055337 1.5 FANTOM5 ENCODE 13.8 -136.5 -136505 4.0 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 LENG8-AS1 HSPBP1 FAM71E2 KMT5C PPP6R1 ZNF628 U2AF2 TMEM238 IL11 TMEM190
GH19F055246 1.2 ENCODE 17 -222.5 -222474 14.5 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 HSPBP1 TMEM86B ZNF628 RFPL4AP1 RPL13P13 PPP6R1 BRSK1 MIR6805 RPL28 TMEM238
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF628 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF628 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000218052 568 1801 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for ZNF628 Gene

Chromosome:
19
Start:
55,476,332 bp from pter
End:
55,484,487 bp from pter
Size:
8,156 bases
Orientation:
Plus strand

Genomic View for ZNF628 Gene

Genes around ZNF628 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF628 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF628 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF628 Gene

Proteins for ZNF628 Gene

  • Protein details for ZNF628 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5EBL2-ZN628_HUMAN
    Recommended name:
    Zinc finger protein 628
    Protein Accession:
    Q5EBL2
    Secondary Accessions:
    • Q86X34

    Protein attributes for ZNF628 Gene

    Size:
    1059 amino acids
    Molecular mass:
    110887 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH89449.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNF628 Gene

Post-translational modifications for ZNF628 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF628 Gene

No data available for DME Specific Peptides for ZNF628 Gene

Domains & Families for ZNF628 Gene

Gene Families for ZNF628 Gene

Protein Domains for ZNF628 Gene

Suggested Antigen Peptide Sequences for ZNF628 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5EBL2

UniProtKB/Swiss-Prot:

ZN628_HUMAN :
  • Contains 16 C2H2-type zinc fingers.
Similarity:
  • Contains 16 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF628: view

Function for ZNF628 Gene

Molecular function for ZNF628 Gene

UniProtKB/Swiss-Prot Function:
Transcription activator. Binds DNA on GT-box consensus sequence 5-TTGGTT-3 (By similarity).

Gene Ontology (GO) - Molecular Function for ZNF628 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF628: view
genes like me logo Genes that share phenotypes with ZNF628: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF628 Gene

Localization for ZNF628 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF628 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF628 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF628 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF628: view

Pathways & Interactions for ZNF628 Gene

SuperPathways for ZNF628 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF628 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF628: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF628 Gene

Transcripts for ZNF628 Gene

mRNA/cDNA for ZNF628 Gene

Unigene Clusters for ZNF628 Gene

Zinc finger protein 628:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF628 Gene

No ASD Table

Relevant External Links for ZNF628 Gene

GeneLoc Exon Structure for
ZNF628
ECgene alternative splicing isoforms for
ZNF628

Expression for ZNF628 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF628 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF628 Gene

This gene is overexpressed in Testis (x5.4).

Protein differential expression in normal tissues from HIPED for ZNF628 Gene

This gene is overexpressed in Spinal cord (66.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF628 Gene



Protein tissue co-expression partners for ZNF628 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF628 Gene:

ZNF628

SOURCE GeneReport for Unigene cluster for ZNF628 Gene:

Hs.525209
genes like me logo Genes that share expression patterns with ZNF628: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF628 Gene

Orthologs for ZNF628 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF628 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF628 34 35
  • 89.58 (n)
cow
(Bos Taurus)
Mammalia ZNF628 34 35
  • 85.6 (n)
dog
(Canis familiaris)
Mammalia ZNF628 34 35
  • 85.52 (n)
mouse
(Mus musculus)
Mammalia Zfp628 34 16 35
  • 81.38 (n)
rat
(Rattus norvegicus)
Mammalia Zfp628 34
  • 80.1 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF628 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF628 34 35
  • 65.1 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF628 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf628 34
  • 53.27 (n)
zebrafish
(Danio rerio)
Actinopterygii ZNF628 35
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7153 35
  • 24 (a)
OneToMany
Species where no ortholog for ZNF628 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF628 Gene

ENSEMBL:
Gene Tree for ZNF628 (if available)
TreeFam:
Gene Tree for ZNF628 (if available)

Paralogs for ZNF628 Gene

Paralogs for ZNF628 Gene

(248) SIMAP similar genes for ZNF628 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNF628 Gene

genes like me logo Genes that share paralogs with ZNF628: view

Variants for ZNF628 Gene

Sequence variations from dbSNP and Humsavar for ZNF628 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10417633 -- 55,476,804(+) GGGCC(A/G)CAGGT utr-variant-5-prime
rs10423355 -- 55,482,509(+) CCCCG(C/T)CCCGC reference, missense
rs10426126 -- 55,477,756(+) GACCC(C/T)GTCTC intron-variant
rs10432286 -- 55,477,358(+) GTTTT(G/T)TTTTT intron-variant
rs10432287 -- 55,477,364(+) TTTTT(G/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF628 Gene

Variant ID Type Subtype PubMed ID
nsv2552 CNV insertion 18451855
nsv458833 CNV loss 19166990
nsv580343 CNV loss 21841781
nsv953624 CNV deletion 24416366

Variation tolerance for ZNF628 Gene

Residual Variation Intolerance Score: 23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.83; 67.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF628 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF628

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF628 Gene

Disorders for ZNF628 Gene

Relevant External Links for ZNF628

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF628

No disorders were found for ZNF628 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF628 Gene

Publications for ZNF628 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  4. ZEC, a zinc finger protein with novel binding specificity and transcription regulatory activity. (PMID: 15556296) Chen G.Y. … Muramatsu T. (Gene 2004) 3 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64

Products for ZNF628 Gene

Sources for ZNF628 Gene

Content
Loading form....