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Aliases for ZNF627 Gene

Aliases for ZNF627 Gene

  • Zinc Finger Protein 627 2 3

External Ids for ZNF627 Gene

Summaries for ZNF627 Gene

GeneCards Summary for ZNF627 Gene

ZNF627 (Zinc Finger Protein 627) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF709.

UniProtKB/Swiss-Prot for ZNF627 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF627 Gene

Genomics for ZNF627 Gene

Genomic Location for ZNF627 Gene

Start:
11,559,374 bp from pter
End:
11,619,159 bp from pter
Size:
59,786 bases
Orientation:
Plus strand

Genomic View for ZNF627 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF627 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF627 Gene

Regulatory Elements for ZNF627 Gene

Proteins for ZNF627 Gene

  • Protein details for ZNF627 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L945-ZN627_HUMAN
    Recommended name:
    Zinc finger protein 627
    Protein Accession:
    Q7L945
    Secondary Accessions:
    • O14846
    • Q4KMP9
    • Q6NT81
    • Q9BRG4

    Protein attributes for ZNF627 Gene

    Size:
    461 amino acids
    Molecular mass:
    52853 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH06279.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH98416.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF627 Gene

Proteomics data for ZNF627 Gene at MOPED

Post-translational modifications for ZNF627 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF627 Gene

No data available for DME Specific Peptides for ZNF627 Gene

Domains for ZNF627 Gene

Gene Families for ZNF627 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF627 Gene

UniProtKB/Swiss-Prot:

ZN627_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q7L945
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q7L945
Similarity:
  • Contains 11 C2H2-type zinc fingers.:
    • Q7L945
genes like me logo Genes that share domains with ZNF627: view

Function for ZNF627 Gene

Molecular function for ZNF627 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF627 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF627: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF627 Gene

Localization for ZNF627 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF627 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF627 Gene COMPARTMENTS Subcellular localization image for ZNF627 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF627 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF627: view

Pathways for ZNF627 Gene

SuperPathways for ZNF627 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF627: view

Pathways by source for ZNF627 Gene

2 Reactome pathways for ZNF627 Gene

Gene Ontology (GO) - Biological Process for ZNF627 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF627: view

Transcripts for ZNF627 Gene

Unigene Clusters for ZNF627 Gene

Zinc finger protein 627:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF627 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c
SP1:
SP2: -

Relevant External Links for ZNF627 Gene

GeneLoc Exon Structure for
ZNF627
ECgene alternative splicing isoforms for
ZNF627

Expression for ZNF627 Gene

mRNA expression in normal human tissues for ZNF627 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF627 Gene

SOURCE GeneReport for Unigene cluster for ZNF627 Gene Hs.526665

genes like me logo Genes that share expressions with ZNF627: view

Orthologs for ZNF627 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF627 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF627 36
  • 99.64 (n)
  • 99.57 (a)
ZNF627 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 52 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp867 36
  • 68.25 (n)
  • 60.43 (a)
Zfp867 16
rat
(Rattus norvegicus)
Mammalia Zfp867 36
  • 69.9 (n)
  • 61.02 (a)
Species with no ortholog for ZNF627:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF627 Gene

ENSEMBL:
Gene Tree for ZNF627 (if available)
TreeFam:
Gene Tree for ZNF627 (if available)

Paralogs for ZNF627 Gene

Selected SIMAP similar genes for ZNF627 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ZNF627 Gene

genes like me logo Genes that share paralogs with ZNF627: view

Variants for ZNF627 Gene

Sequence variations from dbSNP and Humsavar for ZNF627 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7531 -- 11,618,890(-) TGTCT(C/T)AACAA utr-variant-3-prime
rs1128133 -- 11,618,618(+) CCAGA(A/G)GGGAG utr-variant-3-prime
rs1263689 -- 11,606,018(+) tccag(C/T)agggc intron-variant
rs1263690 -- 11,596,530(+) TTggc(C/T)gggca upstream-variant-2KB
rs1471110 -- 11,608,952(+) CTGCA(A/G)TCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF627 Gene

Variant ID Type Subtype PubMed ID
nsv911062 CNV Loss 21882294
nsv509721 CNV Insertion 20534489
nsv513515 CNV Insertion 21212237
esv2464355 CNV Insertion 19546169

Relevant External Links for ZNF627 Gene

HapMap Linkage Disequilibrium report
ZNF627
Human Gene Mutation Database (HGMD)
ZNF627

Disorders for ZNF627 Gene

Relevant External Links for ZNF627

Genetic Association Database (GAD)
ZNF627
Human Genome Epidemiology (HuGE) Navigator
ZNF627
genes like me logo Genes that share disorders with ZNF627: view

No data available for UniProtKB/Swiss-Prot for ZNF627 Gene

Publications for ZNF627 Gene

  1. Genetic risk for myocardial infarction determined by polymorphisms of candidate genes in a Japanese population. (PMID: 18077766) Yamada Y. … Nozawa Y. (J. Med. Genet. 2008) 3 23 49
  2. Isolation of novel expression sequences of C2H2 type zinc finger protein gene from human brain tissue according to the conservation of zinc finger motif. (PMID: 12016960) Sun X.Y. … Zhao S.Y. (Shi Yan Sheng Wu Xue Bao 1998) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ZNF627 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF627
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF627
    • Block miRNA regulation of ZNF627 using miScript Target Protectors

    Sources for ZNF627 Gene

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