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Aliases for ZNF627 Gene

Aliases for ZNF627 Gene

  • Zinc Finger Protein 627 2 3 5

External Ids for ZNF627 Gene

Previous GeneCards Identifiers for ZNF627 Gene

  • GC19P011559
  • GC19P011709
  • GC19P011282
  • GC19P011674

Summaries for ZNF627 Gene

GeneCards Summary for ZNF627 Gene

ZNF627 (Zinc Finger Protein 627) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000196826.

UniProtKB/Swiss-Prot for ZNF627 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF627 Gene

Genomics for ZNF627 Gene

Regulatory Elements for ZNF627 Gene

Promoters for ZNF627 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF627 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF627 Gene

Chromosome:
19
Start:
11,559,374 bp from pter
End:
11,619,159 bp from pter
Size:
59,786 bases
Orientation:
Plus strand

Genomic View for ZNF627 Gene

Genes around ZNF627 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF627 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF627 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF627 Gene

Proteins for ZNF627 Gene

  • Protein details for ZNF627 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L945-ZN627_HUMAN
    Recommended name:
    Zinc finger protein 627
    Protein Accession:
    Q7L945
    Secondary Accessions:
    • O14846
    • Q4KMP9
    • Q6NT81
    • Q9BRG4

    Protein attributes for ZNF627 Gene

    Size:
    461 amino acids
    Molecular mass:
    52853 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH06279.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH98416.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF627 Gene

Proteomics data for ZNF627 Gene at MOPED

Post-translational modifications for ZNF627 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF627 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF627 Gene

Domains & Families for ZNF627 Gene

Gene Families for ZNF627 Gene

Protein Domains for ZNF627 Gene

Suggested Antigen Peptide Sequences for ZNF627 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L945

UniProtKB/Swiss-Prot:

ZN627_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF627: view

Function for ZNF627 Gene

Molecular function for ZNF627 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF627 Gene

GenomeRNAi human phenotypes for ZNF627:
genes like me logo Genes that share phenotypes with ZNF627: view

Animal Model Products

miRNA for ZNF627 Gene

miRTarBase miRNAs that target ZNF627

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF627 Gene

Localization for ZNF627 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF627 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF627 Gene COMPARTMENTS Subcellular localization image for ZNF627 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF627 Gene

Pathways & Interactions for ZNF627 Gene

SuperPathways for ZNF627 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF627: view

Pathways by source for ZNF627 Gene

2 Reactome pathways for ZNF627 Gene

Gene Ontology (GO) - Biological Process for ZNF627 Gene

None

No data available for SIGNOR curated interactions for ZNF627 Gene

Drugs & Compounds for ZNF627 Gene

No Compound Related Data Available

Transcripts for ZNF627 Gene

Unigene Clusters for ZNF627 Gene

Zinc finger protein 627:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF627 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c
SP1:
SP2: -

Relevant External Links for ZNF627 Gene

GeneLoc Exon Structure for
ZNF627
ECgene alternative splicing isoforms for
ZNF627

Expression for ZNF627 Gene

mRNA expression in normal human tissues for ZNF627 Gene

Protein differential expression in normal tissues from HIPED for ZNF627 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF627 Gene



SOURCE GeneReport for Unigene cluster for ZNF627 Gene Hs.526665

genes like me logo Genes that share expression patterns with ZNF627: view

Protein tissue co-expression partners for ZNF627 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF627 Gene

Orthologs for ZNF627 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF627 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF627 35
  • 99.64 (n)
  • 99.57 (a)
ZNF627 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 52 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp867 16
Zfp867 35
  • 68.25 (n)
  • 60.43 (a)
rat
(Rattus norvegicus)
Mammalia Zfp867 35
  • 69.9 (n)
  • 61.02 (a)
Species with no ortholog for ZNF627:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF627 Gene

ENSEMBL:
Gene Tree for ZNF627 (if available)
TreeFam:
Gene Tree for ZNF627 (if available)

Paralogs for ZNF627 Gene

(470) SIMAP similar genes for ZNF627 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ZNF627 Gene

genes like me logo Genes that share paralogs with ZNF627: view

Variants for ZNF627 Gene

Sequence variations from dbSNP and Humsavar for ZNF627 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs889366 -- 11,587,323(+) AAGCA(A/G)TAAGG intron-variant
rs889367 -- 11,587,372(+) AAAAA(A/C)AAAAA intron-variant
rs1471110 -- 11,608,952(+) CTGCA(A/G)TCTCC intron-variant
rs1471111 -- 11,609,151(+) taggc(A/G)tgagc intron-variant
rs1128133 -- 11,618,618(+) CCAGA(A/G)GGGAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF627 Gene

Variant ID Type Subtype PubMed ID
nsv911062 CNV Loss 21882294
nsv509721 CNV Insertion 20534489
nsv513515 CNV Insertion 21212237
esv2464355 CNV Insertion 19546169

Variation tolerance for ZNF627 Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF627 Gene

HapMap Linkage Disequilibrium report
ZNF627
Human Gene Mutation Database (HGMD)
ZNF627

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF627 Gene

Disorders for ZNF627 Gene

Relevant External Links for ZNF627

Genetic Association Database (GAD)
ZNF627
Human Genome Epidemiology (HuGE) Navigator
ZNF627
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF627

No disorders were found for ZNF627 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF627 Gene

Publications for ZNF627 Gene

  1. Genetic risk for myocardial infarction determined by polymorphisms of candidate genes in a Japanese population. (PMID: 18077766) Yamada Y. … Nozawa Y. (J. Med. Genet. 2008) 3 23 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Variations of specific non-candidate genes and risk of myocardial infarction: a replication study. (PMID: 19709766) Koch W. … Kastrati A. (Int. J. Cardiol. 2011) 3

Products for ZNF627 Gene

Sources for ZNF627 Gene

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