ZNF627 Gene
protein-coding GIFtS: 49
GCID: GC19P011674
|
|
zinc finger protein 627
| |
Aliases
for ZNF627 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 6271 2 | | FLJ903651 |
Export aliases for ZNF627 gene to outside databasesPrevious GC identifers: GC19P011559 GC19P011570 GC19P011709 GC19P011282 |
Summaries
for ZNF627 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN627_HUMAN, Q7L945Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF627 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF627 gene promoter:
GCNF STAT5A CREB deltaCREB GCNF-1 FOXJ2 (long isoform) FOXJ2 GCNF-2 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF627
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF627 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2ZNF627 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P011674: view genomic region
(about GC identifiers)
Start:
|
11,670,189 bp from pter |
End:
|
11,729,974 bp from pter |
Size:
|
59,786 bases |
Orientation:
|
plus strand |
|
Proteins
for ZNF627 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN627_HUMAN, Q7L945 (See
protein sequence)Recommended Name: Zinc finger protein 627 Size: 461 amino acids; 52853 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH06279.2; Type=Erroneous initiation; Sequence=AAH98416.1; Type=Erroneous initiation;
Secondary accessions: O14846 Q4KMP9 Q6NT81 Q9BRG4Explore the universe of human proteins at neXtProt for ZNF627: NX_Q7L945
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7L945
ZNF627 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_660338.1
ENSEMBL proteins: ENSP00000464997 ENSP00000354414 ENSP00000466068 ENSP00000465841 Reactome Protein details: Q7L945
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF627 for ontologies About GeneDecksing
ZNF627 Antibody Products:
Assay Products for ZNF627: |
Protein
Domains /
Families
for ZNF627 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF627 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7L945ProtoNet protein and cluster: Q7L945 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN627_HUMAN, Q7L945Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 11 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF627 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN627_HUMAN, Q7L945Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF627 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF627
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF627 (NM_145295) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF627 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF627 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF627 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF627 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF627 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF627
ZNF627 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF627
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF627 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF627 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF627
Search CenterWatch for drugs/clinical trials and news about ZNF627 / ZN627
|
Transcripts
for ZNF627 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF627 gene: NM_145295.3 Unigene Cluster for ZNF627: Zinc finger protein 627 Hs.526665 [show with all ESTs]Unigene Representative Sequence: NM_1452956 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000593279 ENST00000585493 ENST00000588651 ENST00000361113(uc002msk.2)
ENST00000587939 ENST00000588174
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF627 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF627
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF627 (NM_145295) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF627 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF627 |
Additional cDNA sequence: AF024694.1 AK074846.1 AK075063.1 AK095639.1 BC006279.2 BC069232.1 BC098416.1 BX537936.1 8 DOTS entries: DT.415409 DT.97786887 DT.101976974 DT.91758109 DT.121463066 DT.121463070 DT.91918363 DT.91853808 24/108 AceView cDNA sequences (see all 108): BU167761 BM783750 AV654123 F02900 NM_145295 CA311262 R49757 BE350110 F03094 AA305054 AI863968 AK074846 AA860092 BC069232 AA888763 BM747175 BX431145 AA453251 BM740151 BU607571 BU855842 BM745218 AI862977 BM747939
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF627 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | - | | | | | |
ECgene alternative splicing isoforms for ZNF627
|
Expression
for ZNF627 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF627 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCACAAAAA
About this image
See ZNF627 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF627
SOURCE GeneReport for Unigene cluster: Hs.526665
SABiosciences Custom PCR Arrays for ZNF627
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF627
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF627 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF627 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF627 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF627 |
Orthologs
for ZNF627 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF627 (if available)
TreeFam Gene Tree for ZNF627 (if available) |
Paralogs
for ZNF627 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF627 gene
- ZNF6692 ZNF4902 ZNF5642 ZNF4412 ZNF8782 ENSG000002671792 ZNF142 ENSG000001968262
- ZNF7002 ZNF692 ZNF4402 ZNF4432 ZNF442 ZNF4392 ZNF8232 ZNF4912
- ENSG000001884742 ZNF5552 ZNF7092 ZNF6252 ZNF7992 ZNF202 ZNF1012 ZNF7912
- ZNF4422 ZNF4332 ZNF572 ZNF5632 ENSG000002573552 ZNF1362 ZNF5562 ZNF6702
- ZNF7632 ZNF1242 ZNF6992 ZNF8442 ZNF772
18/462 SIMAP similar genes for ZNF627 using alignment to 4 protein entries: ZN627_HUMAN (see all proteins)
(see all similar genes):ZNF625 ZNF669 KRBOX4 ZNF624 ZNF235 ZNF596
ZFP90 MGC12518 ZNF69 HZF36 ZNF124 ZNF136
ZNF224 ZNF688 ZNF195 ZNF573 ZNF84 ZNF230
ZNF627 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF627
PGOHUM00000234541
|
Genomic Variants
for ZNF627 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF627 (11670189 - 11729974 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF627
1 Indel: 102787
Human Gene Mutation Database (HGMD): ZNF627
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF627 |
|
Disorders
/ Diseases
for ZNF627 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF627 for disorders About GeneDecksing
OMIM gene information: 612248
OMIM disorders: --
1  disease for ZNF627: About MalaCardsmyocardial infarction
Human Genome Epidemiology (HuGE) Navigator: ZNF627 (3 documents)
Export disorders for ZNF627 gene to outside databases
|
Publications
for ZNF627 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF627 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF627) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Isolation of novel expression sequences of C2H2 type zinc finger protein gene from human brain tissue according to the conservation of zinc finger motif. (PubMed id 12016960)1, 2 Sun X.Y.... Zhao S.Y. (1998)
- Genetic risk for myocardial infarction determined by polymorphisms of candidate genes in a Japanese population. (PubMed id 18077766)1, 9 Yamada Y....Nozawa Y. (2008)
- Variations of specific non-candidate genes and risk o f myocardial infarction: A replication study. (PubMed id 19709766)1 Koch W....Kastrati A. (2009)
- Associations with myocardial infarction of six polymorphisms selected from a three-stage genome-wide association study. (PubMed id 17967605)1 Horne B.D....Anderson J.L. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for ZNF627 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF627 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF627 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF627 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF627 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF627 gene:
Search GeneIP for patents involving ZNF627
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF627 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF627 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF627 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF627 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF627 | | OriGene 3'-UTR Clone for ZNF627 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF627 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF627 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF627 | | OriGene Custom Protein Services for ZNF627 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF627 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF627 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF627 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF627 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF627 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF627 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ZNF627 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ZNF627 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF627 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF627 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF627 |
|
|
|
|
