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ZNF627 Gene

protein-coding   GIFtS: 51
GCID: GC19P011674

Zinc Finger Protein 627

  Search for ZNF627
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 6271 2

External Ids:    HGNC: 305701   Entrez Gene: 1996922   Ensembl: ENSG000001985517   OMIM: 6122485   UniProtKB: Q7L9453   
ORGUL members:         

Export aliases for ZNF627 gene to outside databases

Previous GC identifers: GC19P011559 GC19P011570 GC19P011709 GC19P011282


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF627 Gene:
ZNF627 (zinc finger protein 627) is a protein-coding gene. An important paralog of this gene is ZNF669.

UniProtKB/Swiss-Prot: ZN627_HUMAN, Q7L945
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF627 gene promoter:
         GCNF   STAT5A   CREB   deltaCREB   GCNF-1   FOXJ2 (long isoform)   FOXJ2   GCNF-2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF627 promoter sequence
   Search Chromatin IP Primers for ZNF627

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF627


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF627 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF627 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P011674:  view genomic region     (about GC identifiers)

Start:
11,670,189 bp from pter      End:
11,729,974 bp from pter
Size:
59,786 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN627_HUMAN, Q7L945 (See protein sequence)
Recommended Name: Zinc finger protein 627  
Size: 461 amino acids; 52853 Da
Sequence caution: Sequence=AAH06279.2; Type=Erroneous initiation; Sequence=AAH98416.1; Type=Erroneous initiation;
Secondary accessions: O14846 Q4KMP9 Q6NT81 Q9BRG4

Explore the universe of human proteins at neXtProt for ZNF627: NX_Q7L945

Explore proteomics data for ZNF627 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF627 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001277012.1  NP_001277013.1  NP_001277014.1  NP_660338.1  

    ENSEMBL proteins: 
     ENSP00000464997   ENSP00000354414   ENSP00000466068   ENSP00000465841  
    Reactome Protein details: Q7L945

    ZNF627 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q7L945

    ProtoNet protein and cluster: Q7L945

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN627_HUMAN, Q7L945
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF627           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN627_HUMAN, Q7L945
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF627           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF627
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF627
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN627_HUMAN, Q7L945: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF627           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF627 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF627           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF627
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF627
    Interactions:

        Search GeneGlobe Interaction Network for ZNF627

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF627           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF627 (ZN627)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF627 gene (4 alternative transcripts): 
    NM_001290083.1  NM_001290084.1  NM_001290085.1  NM_145295.3  

    Unigene Cluster for ZNF627:

    Zinc finger protein 627
    Hs.526665  [show with all ESTs]
    Unigene Representative Sequence: NM_145295
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000593279 ENST00000585493 ENST00000588651 ENST00000361113(uc002msk.2)
    ENST00000587939 ENST00000588174
    miRNA
    Products:
         
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF627
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF627
      QuantiFast Probe-based Assays in human, mouse, rat ZNF627

    Additional mRNA sequence: 

    AF024694.1 AK074846.1 AK075063.1 AK095639.1 BC006279.2 BC069232.1 BC098416.1 BX537936.1 

    8 DOTS entries:

    DT.415409  DT.97786887  DT.101976974  DT.91758109  DT.121463066  DT.121463070  DT.91918363  DT.91853808 

    Selected AceView cDNA sequences (see all 108):

    BX441638 AA888763 BC006279 BX431145 BM747175 AA453251 BM783750 Z39909 
    AA305054 AA860092 AK074846 AA708124 NM_145295 AI863968 F02900 BC069232 
    F03094 BM740151 BU855842 AV654123 BU607571 BM747939 BU167761 BE350110 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF627    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for ZNF627

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF627 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCACAAAAA
    ZNF627 Expression
    About this image

    ZNF627 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF627 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.526665
        Custom PCR Arrays for ZNF627
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF627

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF627 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp8671 , 5 zinc finger protein 8671, 5 68.25(n)1
    60.43(a)1
      11 (37.71 cM)5
    2377751  NM_178417.31  NP_848504.21 
     594611975 


    ENSEMBL Gene Tree for ZNF627 (if available)
    TreeFam Gene Tree for ZNF627 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF627 gene
    ZNF6692  ZNF5642  ZNF4902  ZNF4412  ZNF625-ZNF202  ZNF8782  ENSG000002671792  ZNF142  
    ENSG000002697552  ENSG000001968262  ZNF7002  ZNF692  ZNF4402  ZNF4432  ZNF670-ZNF6952  ZNF442  
    ZNF4392  ZNF8232  ENSG000001884742  ZNF4912  ZNF5552  ENSG000002688702  ZNF7092  ZNF6252  
    ZNF7992  ZNF202  ZNF7882  ZNF1012  ZNF7912  ZNF4422  ZNF4332  ZNF572  
    ZNF5632  ENSG000002573552  ZNF1362  ZNF5562  ZNF7632  ENSG000002687442  ZNF8442  ZNF772  
    Selected SIMAP similar genes for ZNF627 using alignment to 4 protein entries:     ZN627_HUMAN (see all proteins) (see all similar genes):
    ZNF625-ZNF20    LOC101928664    ZNF669    ZNF625    FIK    KRBOX4
    ZNF624    ZNF235    ZFP90    MGC12518    ZNF75A    ZNF177
    ZNF20    ZNF69    HZF36    ZNF136    ZNF224    ZNF596

    Find genes that share paralogs with ZNF627           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF627
    PGOHUM00000234541


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF627 (see all 586)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs104092421,2
    C,F,H--11706373(+) aatggT/Cgtgat 1 -- us2k14Minor allele frequency- C:0.38NA WA CSA 8
    rs1508840811,2
    --11706437(+) CCTCCC/TGAGTA 1 -- us2k10--------
    rs1842009951,2
    --11706486(+) TTTGTA/GTTTTT 1 -- us2k10--------
    rs1882800151,2
    --11706508(+) TATTTA/TATTTT 1 -- us2k10--------
    rs1925650011,2
    --11706639(+) CTCCCG/TAGTAG 1 -- us2k10--------
    rs104033991,2
    C,F--11706658(+) ACAGGC/GGCCCA 1 -- us2k15Minor allele frequency- G:0.40NA WA 10
    rs1848676181,2
    --11706682(+) CTAATG/TTTTTG 1 -- us2k10--------
    rs1890439971,2
    --11706696(+) TTTTAA/GTAGAG 1 -- us2k10--------
    rs1404114321,2
    C--11706703(+) AGAGAC/TGGGGT 1 -- us2k10--------
    rs1453992031,2
    C--11706704(+) GAGATA/GGGGTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF627 (11670189 - 11729974 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZNF627:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2464355CNV Insertion19546169
    nsv513515CNV Insertion21212237
    nsv509721CNV Insertion20534489
    nsv911062CNV Loss21882294

    Human Gene Mutation Database (HGMD): ZNF627
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF627
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF627

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612248    OMIM disorders: --


    Find genes that share disorders with ZNF627           About GenesLikeMe

    Genetic Association Database (GAD): ZNF627
    Human Genome Epidemiology (HuGE) Navigator: ZNF627 (3 documents)

    Export disorders for ZNF627 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF627 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF627)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic risk for myocardial infarction determined by polymorphisms of candidate genes in a Japanese population. (PubMed id 18077766)1, 4, 9 Yamada Y....Nozawa Y. (J. Med. Genet. 2008)
    2. Variations of specific non-candidate genes and risk of myocardial infarction: a replication study. (PubMed id 19709766)1, 4 Koch W....Kastrati A. (Int. J. Cardiol. 2011)
    3. Associations with myocardial infarction of six polymorphisms selected from a three-stage genome-wide association study. (PubMed id 17967605)1, 4 Horne B.D....Anderson J.L. (Am. Heart J. 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Isolation of novel expression sequences of C2H2 type zinc finger protein gene from human brain tissue according to the conservation of zinc finger motif. (PubMed id 12016960)1, 2 Sun X.Y.... Zhao S.Y. (Shi Yan Sheng Wu Xue Bao 1998)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 199692 HGNC: 30570 AceView: ZNF627 Ensembl:ENSG00000198551 euGenes: HUgn199692
    ECgene: ZNF627 H-InvDB: ZNF627

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF627 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF627 gene:
    Search GeneIP for patents involving ZNF627

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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