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Aliases for ZNF626 Gene

Aliases for ZNF626 Gene

  • Zinc Finger Protein 626 2 3
  • CTC-513N18.7 3

External Ids for ZNF626 Gene

Previous GeneCards Identifiers for ZNF626 Gene

  • GC19M020619
  • GC19M020802
  • GC19M020294
  • GC19M020772

Summaries for ZNF626 Gene

GeneCards Summary for ZNF626 Gene

ZNF626 (Zinc Finger Protein 626) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF253.

UniProtKB/Swiss-Prot for ZNF626 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF626 Gene

Genomics for ZNF626 Gene

Regulatory Elements for ZNF626 Gene

Genomic Location for ZNF626 Gene

Chromosome:
19
Start:
20,544,571 bp from pter
End:
20,863,281 bp from pter
Size:
318,711 bases
Orientation:
Minus strand

Genomic View for ZNF626 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF626 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF626 Gene

Proteins for ZNF626 Gene

  • Protein details for ZNF626 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68DY1-ZN626_HUMAN
    Recommended name:
    Zinc finger protein 626
    Protein Accession:
    Q68DY1
    Secondary Accessions:
    • Q8N8T4
    • Q96QM1

    Protein attributes for ZNF626 Gene

    Size:
    528 amino acids
    Molecular mass:
    60893 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04729.1; Type=Miscellaneous discrepancy; Note=Intron-exon boundaries of the last intron are not canonical, they have a CT-AG boundary.; Evidence={ECO:0000305}; Sequence=CAH18089.1; Type=Miscellaneous discrepancy; Note=Intron-exon boundaries of the last intron are not canonical, they have a CT-AG boundary.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF626 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF626 Gene

Proteomics data for ZNF626 Gene at MOPED

Post-translational modifications for ZNF626 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF626 Gene

No data available for DME Specific Peptides for ZNF626 Gene

Domains & Families for ZNF626 Gene

Gene Families for ZNF626 Gene

Protein Domains for ZNF626 Gene

Suggested Antigen Peptide Sequences for ZNF626 Gene

Graphical View of Domain Structure for InterPro Entry

Q68DY1

UniProtKB/Swiss-Prot:

ZN626_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF626: view

Function for ZNF626 Gene

Molecular function for ZNF626 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF626 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF626: view

Phenotypes for ZNF626 Gene

genes like me logo Genes that share phenotypes with ZNF626: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF626

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF626 Gene

Localization for ZNF626 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF626 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF626 Gene COMPARTMENTS Subcellular localization image for ZNF626 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF626 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF626: view

Pathways & Interactions for ZNF626 Gene

SuperPathways for ZNF626 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF626: view

Pathways by source for ZNF626 Gene

2 Reactome pathways for ZNF626 Gene

Interacting Proteins for ZNF626 Gene

Gene Ontology (GO) - Biological Process for ZNF626 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF626: view

No data available for SIGNOR curated interactions for ZNF626 Gene

Drugs & Compounds for ZNF626 Gene

No Compound Related Data Available

Transcripts for ZNF626 Gene

mRNA/cDNA for ZNF626 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF626 Gene

Zinc finger protein 626:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF626

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF626 Gene

No ASD Table

Relevant External Links for ZNF626 Gene

GeneLoc Exon Structure for
ZNF626
ECgene alternative splicing isoforms for
ZNF626

Expression for ZNF626 Gene

mRNA expression in normal human tissues for ZNF626 Gene

Protein differential expression in normal tissues from HIPED for ZNF626 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF626 Gene



SOURCE GeneReport for Unigene cluster for ZNF626 Gene Hs.657001

genes like me logo Genes that share expression patterns with ZNF626: view

Protein tissue co-expression partners for ZNF626 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF626 Gene

Orthologs for ZNF626 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF626 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 51 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 36 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp386 36
  • 35 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 63 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
Species with no ortholog for ZNF626:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF626 Gene

ENSEMBL:
Gene Tree for ZNF626 (if available)
TreeFam:
Gene Tree for ZNF626 (if available)

Paralogs for ZNF626 Gene

(541) SIMAP similar genes for ZNF626 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF626 Gene

genes like me logo Genes that share paralogs with ZNF626: view

Variants for ZNF626 Gene

Sequence variations from dbSNP and Humsavar for ZNF626 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs274797 -- 20,662,960(+) tctgt(A/G)caggg upstream-variant-2KB
rs274801 -- 20,659,959(+) aaaaa(A/C)taaca intron-variant
rs274802 -- 20,659,743(+) tctaa(C/T)attct intron-variant
rs274803 -- 20,659,472(+) ctgac(C/T)tgcgg intron-variant
rs274804 -- 20,658,760(+) tagag(A/T)cagca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF626 Gene

Variant ID Type Subtype PubMed ID
dgv550e201 CNV Deletion 23290073
dgv3794n71 CNV Loss 21882294
dgv3795n71 CNV Loss 21882294
dgv1063e1 CNV Complex 17122850
nsv458377 CNV Gain 19166990
dgv3804n71 CNV Loss 21882294
nsv911405 CNV Loss 21882294
esv2751781 CNV Gain 17911159
dgv3805n71 CNV Loss 21882294
nsv9676 CNV Gain 18304495
esv1003988 OTHER Inversion 20482838
dgv71e19 OTHER Inversion 19470904
esv2573650 OTHER Inversion 19546169
nsv436702 OTHER Inversion 17901297
esv2718318 CNV Deletion 23290073
esv1010023 CNV Deletion 20482838
esv1100051 CNV Deletion 17803354
nsv510470 CNV Loss 20534489
esv2751782 CNV Gain 17911159
nsv458512 CNV Gain 19166990
nsv911409 CNV Gain 21882294
dgv404n27 CNV Gain 19166990
nsv517256 CNV Gain 19592680

Variation tolerance for ZNF626 Gene

Residual Variation Intolerance Score: 80.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.00; 68.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF626 Gene

HapMap Linkage Disequilibrium report
ZNF626

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF626 Gene

Disorders for ZNF626 Gene

Relevant External Links for ZNF626

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF626
genes like me logo Genes that share disorders with ZNF626: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF626 Gene

Publications for ZNF626 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PMID: 23400010) Del-Aguila J.L. … Boerwinkle E. (Pharmacogenomics J. 2013) 67
  3. A protein-protein interaction network of transcription factors acting during liver cell proliferation. (PMID: 18255255) Gao J. … Yu Y. (Genomics 2008) 67
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for ZNF626 Gene

Sources for ZNF626 Gene

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