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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF626 Gene

protein-coding   GIFtS: 43
GCID: GC19M020802

Zinc Finger Protein 626

  Search for ZNF626
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 6261 2

External Ids:    HGNC: 304611   Entrez Gene: 1997772   Ensembl: ENSG000001881717   UniProtKB: Q68DY13   

Export aliases for ZNF626 gene to outside databases

Previous GC identifers: GC19M020619 GC19M020294


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF626 Gene: 
ZNF626 (zinc finger protein 626) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot: ZN626_HUMAN, Q68DY1
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF626 gene promoter:
         AREB6   p53   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF626 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF626

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF626


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p13.11

ZNF626 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF626 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M020802:  view genomic region     (about GC identifiers)

Start:
20,802,745 bp from pter      End:
20,844,402 bp from pter
Size:
41,658 bases      Orientation:
minus strand

1 alternative location:
Chr19-,NW_003571053 537,192-578,849     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN626_HUMAN, Q68DY1 (See protein sequence)
Recommended Name: Zinc finger protein 626  
Size: 528 amino acids; 60893 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAC04729.1; Type=Miscellaneous discrepancy; Note=Intron-exon boundaries of the last
intron are not canonical, they have a CT-AG boundary; Sequence=CAH18089.1; Type=Miscellaneous discrepancy;
Note=Intron-exon boundaries of the last intron are not canonical, they have a CT-AG boundary;
Secondary accessions: Q8N8T4 Q96QM1
Alternative splicing: 3 isoforms:  Q68DY1-1   Q68DY1-2   Q68DY1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF626: NX_Q68DY1

Explore proteomics data for ZNF626 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q68DY1

  • ZNF626 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF626 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001070143.1  NP_660340.1  

    ENSEMBL proteins: 
     ENSP00000469958   ENSP00000469566   ENSP00000291750  
    Reactome Protein details: Q68DY1
    Human Recombinant Protein Products for ZNF626: 
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    Cloud-Clone Corp. Proteins for ZNF626 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF626 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q68DY1

    ProtoNet protein and cluster: Q68DY1

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN626_HUMAN, Q68DY1
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF626 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN626_HUMAN, Q68DY1
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF626 for ontologies           About GeneDecksing


    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF626 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF626
        Generic Transcription Pathway
    Gene Expression



    ZNF626 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF626

    2 Interacting proteins for ZNF626 (Q68DY13) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FHL2Q141923I2D: score=1 
    ID3Q025353I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF626 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF626 (ZN626)

    Search CenterWatch for drugs/clinical trials and news about ZNF626 / ZN626

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF626 gene (2 alternative transcripts): 
    NM_001076675.2  NM_145297.3  

    Unigene Cluster for ZNF626:

    Zinc finger protein 626
    Hs.657001  [show with all ESTs]
    Unigene Representative Sequence: NM_001076675
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000601440 ENST00000595405 ENST00000291750(uc002npd.1)
    miRNA
    Products:
         
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF626
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF626
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF626
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF626
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF626

    Additional mRNA sequence: 

    AK091329.1 AK096221.1 BC007116.1 BC107803.1 BC150651.1 BX648764.1 CR749233.1 

    9 DOTS entries:

    DT.450351  DT.99969921  DT.306919  DT.121496520  DT.101961053  DT.121496658  DT.100775080  DT.121496453 
    DT.302998 

    4 AceView cDNA sequences:

    AA281609 AI335597 BX281683 AA281646 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF626 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTGAGAA
    ZNF626 Expression
    About this image


    See ZNF626 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF626

    SOURCE GeneReport for Unigene cluster: Hs.657001
        SABiosciences Custom PCR Arrays for ZNF626
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF626

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF626 gene from 1/3 species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    24(a)
    1 → many
    GL343733.1(125230-159240)
            Species with no ortholog for ZNF626

    ENSEMBL Gene Tree for ZNF626 (if available)
    TreeFam Gene Tree for ZNF626 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF626 gene
    ZNF852  ZNF4862  ZNF1952  ZNF7272  ZNF922  ZNF1002  ZNF7322  ZNF6752  
    ZNF1382  ZNF5062  ZNF662  ZNF2732  ZNF6952  ZNF6802  ZNF4792  ZNF2532  
    ZNF6822  ZNF4922  ZNF6762  ZNF6812  ZNF1412  ZNF7362  ZNF6792  ZNF2572  
    ZNF2672  ZNF2542  ZNF7372  ZNF982  ZNF7162  ZNF7142  ZNF5192  ZNF4302  
    ZNF7302  ZNF7082  ZNF1172  ZNF4312  ZNF902  ZNF7262  ZNF7282  
    18/540 SIMAP similar genes for ZNF626 using alignment to 3 protein entries:     ZN626_HUMAN (see all proteins) (see all similar genes):
    MGC12518    ZNF273    ZNF738    ZNF66    ZNF818P    DKFZp762K012
    ZNF492    ZNF730    ZNF93    ZNF98    HZF30    ZFS-1
    ZNF737    ZNF429    ZNF676    ZNF253    ZNF486    ZNF100

    ZNF626 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ZNF626
    PGOHUM00000250563 PGOHUM00000234562 PGOHUM00000234568


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1254 SNPs in ZNF626 are shown (see all 1254)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0298364
    ----see VAR_0298362 N D mis40--------
    rs711747241,2
    C--20767567(+) TAGCA-/TTAG  
            
    TTAGA
    1 -- int11Minor allele frequency- TTAG:0.00NA 2
    rs1995269191,2
    --20802258(+) GGTGA-/TTTATT 1 -- ds50010--------
    rs678513791,2
    C--20802292(+) TTTTT-/CCCCTC 1 -- ds50012Minor allele frequency- C:0.25NA CSA 4
    rs116730831,2
    C,H--20802346(+) GAAGGT/CAGGAA 1 -- ds50016Minor allele frequency- C:0.00NA WA 14
    rs116731521,2
    C,H--20802349(+) GGCAGA/GAATGA 1 -- ds50016Minor allele frequency- G:0.00NA WA 12
    rs116730601,2
    C,F,A,H--20802357(+) TGATGA/GCAATA 1 -- ds50019Minor allele frequency- G:0.02NS EA NA 420
    rs713321961,2
    C--20802361(+) GACAAG/TAAACA 1 -- ds50012Minor allele frequency- T:0.00NA 4
    rs104021301,2
    C,H--20802363(+) CAATAT/AACAAA 1 -- ds50014Minor allele frequency- A:0.00NA 8
    rs1920836611,2
    --20802555(+) GTAACA/GTAATT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ZNF626 (20802745 - 20844402 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/23 variations for ZNF626 (see all 23):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1100051CNV Deletion17803354
    esv2718318CNV Deletion23290073
    esv1010023CNV Deletion20482838
    dgv550e201CNV Deletion23290073
    nsv510470CNV Loss20534489
    dgv3805n71CNV Loss21882294
    dgv3804n71CNV Loss21882294
    dgv3794n71CNV Loss21882294
    nsv911405CNV Loss21882294
    dgv3795n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): ZNF626
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF626
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF626

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF626 for disorders           About MalaCards

    ZNF626 for disorders           About GeneDecksing


    Export disorders for ZNF626 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF626 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF626)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Genome-wide association analyses suggest NELL1 influen ces adverse metabolic response to HCTZ in African Americans. (PubMed id 23400010)1 Del-Aguila J.L....Boerwinkle E. (2013)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. A protein-protein interaction network of transcription factors acting during liver cell proliferation. (PubMed id 18255255)1 Gao J....Yu Y. (2008)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 199777 HGNC: 30461 AceView: ZNF626 Ensembl:ENSG00000188171 euGenes: HUgn199777
    ECgene: ZNF626 H-InvDB: ZNF626

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF626 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF626 gene:
    Search GeneIP for patents involving ZNF626

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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