Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF626 Gene

Aliases for ZNF626 Gene

  • Zinc Finger Protein 626 2 3 5
  • CTC-513N18.7 3

External Ids for ZNF626 Gene

Previous GeneCards Identifiers for ZNF626 Gene

  • GC19M020802
  • GC19M020294
  • GC19M020772
  • GC19M021063

Summaries for ZNF626 Gene

GeneCards Summary for ZNF626 Gene

ZNF626 (Zinc Finger Protein 626) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF93.

UniProtKB/Swiss-Prot for ZNF626 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF626 Gene

Genomics for ZNF626 Gene

Regulatory Elements for ZNF626 Gene

Enhancers for ZNF626 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G020660 0.9 ENCODE 9 +0.4 399 2.1 HDAC1 ELF3 TBP PKNOX1 FOXA2 CREB3L1 NFRKB ARID4B ZBTB40 DNMT3B ENSG00000269779 RPL7AP10 ZNF431 ZNF626 ENSG00000269110 GC19M021962
GH19G020663 0.9 Ensembl ENCODE 8.2 -3.4 -3390 2.0 ELF3 SOX5 SOX13 DRAP1 SAP130 MLX CEBPG ZGPAT POLR2A SMARCA4 ENSG00000269779 ZNF626 GC19M021960
GH19G020610 0.5 ENCODE 8 +49.0 49033 3.4 PKNOX1 SCRT2 ZNF652 ZNF626 LOC105372318 ENSG00000267419 ENSG00000268416 GC19P020618
GH19G020564 0.9 ENCODE 4.1 +96.1 96058 2.2 ELF3 TBP PKNOX1 ARID4B SIN3A DMAP1 ZNF48 RAD21 ZBTB40 ELK1 ZNF737 ZNF626 GC19M021949
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF626 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF626 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108310 496 1800 ELF3 TBP PKNOX1 FOXA2 ARID4B ZBTB40 DNMT3B ZNF48 YY1 FOS

Genomic Location for ZNF626 Gene

Chromosome:
19
Start:
20,619,939 bp from pter
End:
20,661,596 bp from pter
Size:
41,658 bases
Orientation:
Minus strand

Genomic View for ZNF626 Gene

Genes around ZNF626 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF626 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF626 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF626 Gene

Proteins for ZNF626 Gene

  • Protein details for ZNF626 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68DY1-ZN626_HUMAN
    Recommended name:
    Zinc finger protein 626
    Protein Accession:
    Q68DY1
    Secondary Accessions:
    • Q8N8T4
    • Q96QM1

    Protein attributes for ZNF626 Gene

    Size:
    528 amino acids
    Molecular mass:
    60893 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04729.1; Type=Miscellaneous discrepancy; Note=Intron-exon boundaries of the last intron are not canonical, they have a CT-AG boundary.; Evidence={ECO:0000305}; Sequence=CAH18089.1; Type=Miscellaneous discrepancy; Note=Intron-exon boundaries of the last intron are not canonical, they have a CT-AG boundary.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF626 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF626 Gene

Post-translational modifications for ZNF626 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF626 Gene

No data available for DME Specific Peptides for ZNF626 Gene

Domains & Families for ZNF626 Gene

Gene Families for ZNF626 Gene

Protein Domains for ZNF626 Gene

Suggested Antigen Peptide Sequences for ZNF626 Gene

Graphical View of Domain Structure for InterPro Entry

Q68DY1

UniProtKB/Swiss-Prot:

ZN626_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF626: view

Function for ZNF626 Gene

Molecular function for ZNF626 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF626 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF626: view
genes like me logo Genes that share phenotypes with ZNF626: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF626 Gene

Localization for ZNF626 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF626 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF626 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF626 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF626: view

Pathways & Interactions for ZNF626 Gene

SuperPathways for ZNF626 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF626: view

Pathways by source for ZNF626 Gene

2 Reactome pathways for ZNF626 Gene

Interacting Proteins for ZNF626 Gene

Gene Ontology (GO) - Biological Process for ZNF626 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF626: view

No data available for SIGNOR curated interactions for ZNF626 Gene

Transcripts for ZNF626 Gene

mRNA/cDNA for ZNF626 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF626 Gene

Zinc finger protein 626:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF626 Gene

No ASD Table

Relevant External Links for ZNF626 Gene

GeneLoc Exon Structure for
ZNF626
ECgene alternative splicing isoforms for
ZNF626

Expression for ZNF626 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF626 Gene

Protein differential expression in normal tissues from HIPED for ZNF626 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF626 Gene



Protein tissue co-expression partners for ZNF626 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF626 Gene:

ZNF626

SOURCE GeneReport for Unigene cluster for ZNF626 Gene:

Hs.657001

Evidence on tissue expression from TISSUES for ZNF626 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with ZNF626: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF626 Gene

Orthologs for ZNF626 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF626 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 63 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 51 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 48 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 36 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp386 35
  • 35 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 50 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
Species where no ortholog for ZNF626 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF626 Gene

ENSEMBL:
Gene Tree for ZNF626 (if available)
TreeFam:
Gene Tree for ZNF626 (if available)

Paralogs for ZNF626 Gene

(541) SIMAP similar genes for ZNF626 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF626 Gene

genes like me logo Genes that share paralogs with ZNF626: view

Variants for ZNF626 Gene

Sequence variations from dbSNP and Humsavar for ZNF626 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000030527 -- 20,651,553(+) GAGGG(A/G)ATGAA intron-variant
rs1000140112 -- 20,645,642(+) ACCCC(A/T)TATCT intron-variant
rs1000221820 -- 20,657,752(+) GTGAG(A/C)CGAGG intron-variant
rs1000607368 -- 20,626,522(+) AGACC(A/G)GCCTG intron-variant
rs1000748233 -- 20,620,671(+) ACCTC(A/G)GCCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF626 Gene

Variant ID Type Subtype PubMed ID
dgv1028e212 CNV gain 25503493
dgv3465n100 CNV loss 25217958
dgv3467n100 CNV gain 25217958
dgv3468n100 CNV gain 25217958
dgv404n27 CNV gain 19166990
dgv509e201 CNV deletion 23290073
dgv6304n54 CNV loss 21841781
dgv6318n54 CNV gain 21841781
dgv6319n54 CNV gain 21841781
dgv81e19 OTHER inversion 19470904
esv1003988 OTHER inversion 20482838
esv1010023 CNV deletion 20482838
esv1100051 CNV deletion 17803354
esv2573650 OTHER inversion 19546169
esv2718318 CNV deletion 23290073
esv2751781 CNV gain 17911159
esv2751782 CNV gain 17911159
esv2758749 CNV loss 17122850
esv2763043 CNV gain 21179565
esv3643886 CNV loss 21293372
esv3643892 CNV loss 21293372
esv3643893 CNV gain 21293372
esv3893177 CNV gain 25118596
nsv1072340 CNV deletion 25765185
nsv1141886 OTHER inversion 24896259
nsv436702 OTHER inversion 17901297
nsv458377 CNV gain 19166990
nsv458512 CNV gain 19166990
nsv510470 OTHER sequence alteration 20534489
nsv517256 CNV gain 19592680
nsv578809 CNV gain 21841781
nsv578910 CNV gain 21841781
nsv578913 CNV loss 21841781
nsv578914 CNV loss 21841781
nsv954632 CNV deletion 24416366
nsv9676 CNV gain 18304495
nsv978786 CNV duplication 23825009

Variation tolerance for ZNF626 Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.00; 68.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF626 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF626

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF626 Gene

Disorders for ZNF626 Gene

Relevant External Links for ZNF626

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF626

No disorders were found for ZNF626 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF626 Gene

Publications for ZNF626 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PMID: 23400010) Del-Aguila J.L. … Boerwinkle E. (Pharmacogenomics J. 2013) 3 64
  4. A protein-protein interaction network of transcription factors acting during liver cell proliferation. (PMID: 18255255) Gao J. … Yu Y. (Genomics 2008) 3 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for ZNF626 Gene

Sources for ZNF626 Gene

Content
Loading form....