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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF625 Gene

protein-coding GIFtS: 43
GCID: GC19M012242

zinc finger protein 625

Search for ZNF625
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 625¹ ²

External Ids:	HGNC: 30571¹	Entrez Gene: 90589²	Ensembl: ENSG00000213297⁷	UniProtKB: Q96I27³

ORGUL members:
	NONCODE:n410563

Export aliases for ZNF625 gene to outside databases

Previous GC identifers: GC19M012117 GC19M012104 GC19M012121 GC19M012122 GC19M011830

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN625_HUMAN, Q96I27

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF625 gene promoter:
RORalpha1 PPAR-gamma1 GCNF-1 GCNF p300 PPAR-gamma2 GCNF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF625 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF625

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF625

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2

ZNF625 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF625 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M012242: view genomic region (about GC identifiers)

Start:	12,242,932 bp from pter	End:	12,267,546 bp from pter
Size:	24,615 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN625_HUMAN, Q96I27 (See protein sequence)

Recommended Name: Zinc finger protein 625

Size: 306 amino acids; 34746 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: A4FU45 I3L0E9

Alternative splicing: 2 isoforms: Q96I27-1 Q96I27-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF625: NX_Q96I27

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96I27

ZNF625 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_660276.2

ENSEMBL proteins:

ENSP00000457423 ENSP00000457791

Reactome Protein details: Q96I27
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZNF625 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF625 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q96I27

ProtoNet protein and cluster: Q96I27

1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN625_HUMAN, Q96I27

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 9 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN625_HUMAN, Q96I27

Function: May be involved in transcriptional regulation

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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF625 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZNF625

	Generic Transcription Pathway
	Gene Expression

ZNF625 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF625

1 Interacting protein for ZNF625 (Q96I27³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MDFI	Q99750³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF625 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF625
Search CenterWatch for drugs/clinical trials and news about ZNF625 / ZN625

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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About This Section

REFSEQ mRNAs for ZNF625 gene:

NM_145233.3

Unigene Cluster for ZNF625:

Zinc finger protein 625

Hs.732736 [show with all ESTs]

Unigene Representative Sequence: NM_145233

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000430024 ENST00000434822

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Additional cDNA sequence:

BC007868.2 BC101589.1 BC101591.1 BC143563.1 NR_037801.1

3 DOTS entries:

DT.202017 DT.92049687 DT.100018881

24/78 AceView cDNA sequences (see all 78):

BX100736 AI085836 AK096560 BC045814 AA860133 AI968718 AU133067 AI936844

BC036714 AL080125 BF062327 CB152168 X52344 BE551497 BE219250 BX440069

AI695854 W32055 CB961080 CA336606 AW341477 BE408214 BE877366 AA148578

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF625 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAACCATCG

About this image
See ZNF625 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF625

SOURCE GeneReport for Unigene cluster: Hs.732736

SABiosciences Custom PCR Arrays for ZNF625

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for ZNF625 (if available)
TreeFam Gene Tree for ZNF625 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF625 gene

ZNF669² ZNF490² ZNF564² ZNF441² ZNF878² ENSG00000267179² ZNF14² ENSG00000196826²

ZNF700² ZNF69² ZNF440² ZNF443² ZNF44² ZNF439² ZNF823² ZNF491²

ENSG00000188474² ZNF555² ZNF709² ZNF799² ZNF20² ZNF101² ZNF791² ZNF442²

ZNF433² ZNF57² ZNF563² ZNF627² ENSG00000257355² ZNF136² ZNF556² ZNF670²

ZNF763² ZNF124² ZNF699² ZNF844² ZNF77²

18/522 SIMAP similar genes for ZNF625 using alignment to 3 protein entries: ZN625_HUMAN (see all proteins) (see all similar genes):

ZNF433 ZNF124 ZNF878 ZNF596 ZFP90 ZNF669

ZNF627 ZNF763 ZNF709 ZNF235 ZNF624 ZNF559

ZNF84 ZNF20 ZNF850 ZNF439 ZNF844 ZNF846

ZNF625 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10414949^1,2	C,F,H,	--	12255493(+)	`ACCTTC/TCTGTA`	3	--	int¹		11		NS EA NA WA CSA	1294
rs143452366^1,2		--	12255498(+)	`CCTGTA/GTATAT`	3	--	int¹		0	--	--	--	--
rs113436902^1,2		--	12255594(+)	`AGTGGC/TGCAAT`	3	--	int¹		1		CSA	2
rs147636418^1,2		--	12255595(+)	`GTGGCA/GCAATC`	3	--	int¹		0	--	--	--	--
rs142300995^1,2		--	12255712(+)	`TTTTAA/GTAGAG`	3	--	ut3¹ nc-transcript-variantint¹		0	--	--	--	--
rs77446672^1,2	C	--	12255723(+)	`ATGGGG/TTTTCA`	3	--	ut3¹ int¹ nc-transcript-variant		0	--	--	--	--
rs191469429^1,2		--	12255764(+)	`GACCTC/TGTGGT`	3	--	int¹ nc-transcript-variantut3¹		0	--	--	--	--
rs183668710^1,2		--	12255781(+)	`GCCTCA/GGCCTC`	3	--	ut3¹ int¹ nc-transcript-variant		0	--	--	--	--
rs149597664^1,2		--	12255977(+)	`TACTGA/GCATTT`	3	--	int¹ nc-transcript-variantut3¹		0	--	--	--	--
rs115447016^1,2		--	12256139(+)	`CCTTTC/TGAAGT`	4	S	nc-transcript-variantint¹ syn¹		1		WA	216

HapMap Linkage Disequilibrium report for ZNF625 (12242932 - 12267546 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF625: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF625 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF625)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)¹ Nozawa R.S....Obuse C. (2010)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 90589	HGNC: 30571	AceView: ZNF20andZNF625andLOC388508	Ensembl:ENSG00000213297	euGenes: HUgn90589
ECgene: ZNF625	H-InvDB: ZNF625

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF625	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF625 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF625 gene:
Search GeneIP for patents involving ZNF625

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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Hot genes Disease genes ZNF625 gene at Home site.

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ZNF625 Gene

zinc finger protein 625

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ZNF625 Gene

zinc finger protein 625

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for ZNF625 gene

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for ZNF625 gene

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for ZNF625 gene

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for ZNF625 gene

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for ZNF625 gene

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