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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF624 Gene

protein-coding   GIFtS: 47
GCID: GC17M016524

Zinc Finger Protein 624

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 6241 2
KIAA13493

External Ids:    HGNC: 292541   Entrez Gene: 575472   Ensembl: ENSG000001975667   UniProtKB: Q9P2J83   

Export aliases for ZNF624 gene to outside databases

Previous GC identifers: GC17M016724 GC17M016464 GC17M016390


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF624 Gene: 
ZNF624 (zinc finger protein 624) is a protein-coding gene. Diseases associated with ZNF624 include esophageal adenocarcinoma, and esophagitis, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF616.

UniProtKB/Swiss-Prot: ZN624_HUMAN, Q9P2J8
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF624 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   Evi-1   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF624 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF624

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF624


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

ZNF624 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF624 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M016524:  view genomic region     (about GC identifiers)

Start:
16,524,048 bp from pter      End:
16,557,170 bp from pter
Size:
33,123 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN624_HUMAN, Q9P2J8 (See protein sequence)
Recommended Name: Zinc finger protein 624  
Size: 865 amino acids; 99929 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAA92587.1; Type=Erroneous initiation;
Secondary accessions: Q3SY62 Q3SY63 Q6ZN27
Alternative splicing: 2 isoforms:  Q9P2J8-1   Q9P2J8-2   

Explore the universe of human proteins at neXtProt for ZNF624: NX_Q9P2J8

Explore proteomics data for ZNF624 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P2J8

  • ZNF624 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF624 Protein Expression
    REFSEQ proteins: NP_065838.2  
    ENSEMBL proteins: 
     ENSP00000310472   ENSP00000463295   ENSP00000406525  
    Reactome Protein details: Q9P2J8
    Human Recombinant Protein Products for ZNF624: 
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    Novus Biologicals ZNF624 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF624 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF624 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9P2J8

    ProtoNet protein and cluster: Q9P2J8

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZN624_HUMAN, Q9P2J8
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 21 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF624 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN624_HUMAN, Q9P2J8
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF624 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF624 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF624 
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    miRNA
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    hsa-miR-579 hsa-miR-125a-5p hsa-miR-373* hsa-miR-188-3p hsa-miR-125b hsa-miR-670 hsa-miR-3662 hsa-miR-616*
    SwitchGear 3'UTR luciferase reporter plasmidZNF624 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF624


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF624 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF624
        Generic Transcription Pathway
    Gene Expression



    ZNF624 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF624

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF624 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF624 (ZN624)

    Search CenterWatch for drugs/clinical trials and news about ZNF624 / ZN624

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF624 gene: 
    NM_020787.3  

    Unigene Cluster for ZNF624:

    Zinc finger protein 624
    Hs.128078  [show with all ESTs]
    Unigene Representative Sequence: NM_020787
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311331(uc010cpi.2) ENST00000579528(uc021tre.1) ENST00000579983
    ENST00000583766 ENST00000423860
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF624
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF624 (see all 9):
    hsa-miR-579 hsa-miR-125a-5p hsa-miR-373* hsa-miR-188-3p hsa-miR-125b hsa-miR-670 hsa-miR-3662 hsa-miR-616*
    SwitchGear 3'UTR luciferase reporter plasmidZNF624 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF624
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF624
    Clone
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    OriGene clones in human, mouse for ZNF624 (see all 5)
    OriGene ORF clones in mouse, rat for ZNF624
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    GenScript: all cDNA clones in your preferred vector: ZNF624 (NM_020787)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF624
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF624
    Sirion Biotech Customized lentivirus for stable overexpression of ZNF624 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF624 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF624
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF624
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF624
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF624

    Additional mRNA sequence: 

    AB037770.1 AK131401.1 BC103943.1 BC103944.1 BC103945.1 BC103946.1 

    4 DOTS entries:

    DT.300111  DT.102821245  DT.120946069  DT.439688 

    9 AceView cDNA sequences:

    AK131401 BP873144 BF435259 NM_020787 AA455629 BF436167 AI913542 AA455682 
    AA455709 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF624 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF624 Expression
    About this image


    See ZNF624 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF624

    SOURCE GeneReport for Unigene cluster: Hs.128078
        SABiosciences Custom PCR Arrays for ZNF624
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF624

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF624 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp261 , 5 zinc finger protein 261, 5 58.74(n)1
    49.14(a)1
      9 (7.55 cM)5
    226881  NM_011753.31  NP_035883.21 
     204329725 
    lizard
    (Anolis carolinensis)
    Reptilia --
    ZNF486
    Uncharacterized protein
    45(a)
    44(a)
    possible ortholog
    1 ↔ many
    2(194885249-194899810)
    GL343516.1(205193-231700)


    ENSEMBL Gene Tree for ZNF624 (if available)
    TreeFam Gene Tree for ZNF624 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF624 gene
    ZNF6162  ZNF4732  ZNF1602  ZNF5462  ZNF992  ZNF8362  ZNF7172  ZNF5942  
    ZNF6002  ZFP622  ZNF8412  ZNF780B2  ZNF1972  ZNF585A2  ZNF1072  ZNF8082  
    ZNF8452  ZNF6582  ZNF2682  
    18/526 SIMAP similar genes for ZNF624 using alignment to 3 protein entries:     ZN624_HUMAN (see all proteins) (see all similar genes):
    MGC12518    ZNF66    ZNF83    ZNF525    ZNF721    ZNF761
    ZNF527    ZNF273    ZNF155    ZNF616    ZNF257    ZNF320
    ZFP90    ZNF519    ZNF813    ZNF267    ZNF506    ZNF140

    ZNF624 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/673 SNPs in ZNF624 are shown (see all 673)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355924
    A colorectal cancer sample4--see VAR_0355922 C S mis40--------
    rs169598701,2
    C,F--16512954(+) CACAAC/TGAAAA 1 -- ut3113Minor allele frequency- T:0.34NA WA CSA EA 512
    rs1878451781,2
    --16523617(+) TTCCAA/TGCCCT 1 -- ds50010--------
    rs1929549511,2
    --16523696(+) TTACAC/TGGCCT 1 -- ds50010--------
    rs72253371,2
    C,F,H--16523746(+) CTTTGG/ATGGCA 1 -- ds500124Minor allele frequency- A:0.11NA NS EA WA CSA 2490
    rs124524941,2
    H--16523747(+) TTTGGT/AGGCAT 1 -- ds50014Minor allele frequency- A:0.00NS EA 410
    rs169598691,2
    C,F,H--16523910(+) AGTAAC/ATTTTT 1 -- ds500123Minor allele frequency- A:0.21NA EA NS WA CSA 2558
    rs1426284801,2
    --16524040(+) TAAAAC/TGCACA 1 -- ds50010--------
    rs1826297761,2
    --16524082(+) TACAGA/GTTCAT 1 -- ut310--------
    rs1468900731,2
    --16524171(+) ACCATA/CATTAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF624 (16524048 - 16557170 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF624:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2715702CNV Deletion23290073
    dgv928e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): ZNF624
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF624
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF624

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for ZNF624:    About MalaCards
    esophageal adenocarcinoma    esophagitis    adenocarcinoma


    ZNF624 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF624
    Human Genome Epidemiology (HuGE) Navigator: ZNF624 (1 document)

    Export disorders for ZNF624 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF624 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF624)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57547 HGNC: 29254 AceView: ZNF624 Ensembl:ENSG00000197566 euGenes: HUgn57547
    ECgene: ZNF624 H-InvDB: ZNF624

    (According to HUGE)
    About This Section
    HUGE: KIAA1349

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF624 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF624 gene:
    Search GeneIP for patents involving ZNF624

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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