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Aliases for ZNF623 Gene

Aliases for ZNF623 Gene

  • Zinc Finger Protein 623 2 3 5
  • KIAA0628 4

External Ids for ZNF623 Gene

Previous GeneCards Identifiers for ZNF623 Gene

  • GC08U900475
  • GC08P144804
  • GC08P144789
  • GC08P144718
  • GC08P139969

Summaries for ZNF623 Gene

GeneCards Summary for ZNF623 Gene

ZNF623 (Zinc Finger Protein 623) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF70.

UniProtKB/Swiss-Prot for ZNF623 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF623 Gene

Genomics for ZNF623 Gene

Regulatory Elements for ZNF623 Gene

Promoters for ZNF623 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF623 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF623 Gene

Chromosome:
8
Start:
143,636,013 bp from pter
End:
143,656,418 bp from pter
Size:
20,406 bases
Orientation:
Plus strand

Genomic View for ZNF623 Gene

Genes around ZNF623 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF623 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF623 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF623 Gene

Proteins for ZNF623 Gene

  • Protein details for ZNF623 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75123-ZN623_HUMAN
    Recommended name:
    Zinc finger protein 623
    Protein Accession:
    O75123
    Secondary Accessions:
    • A4FU80
    • B4DGP3
    • E7ENV5

    Protein attributes for ZNF623 Gene

    Size:
    536 amino acids
    Molecular mass:
    61392 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA31603.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG57854.1; Type=Frameshift; Positions=467; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF623 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF623 Gene

Proteomics data for ZNF623 Gene at MOPED

Post-translational modifications for ZNF623 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF623 Gene

No data available for DME Specific Peptides for ZNF623 Gene

Domains & Families for ZNF623 Gene

Gene Families for ZNF623 Gene

Protein Domains for ZNF623 Gene

Suggested Antigen Peptide Sequences for ZNF623 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75123

UniProtKB/Swiss-Prot:

ZN623_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF623: view

Function for ZNF623 Gene

Molecular function for ZNF623 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF623: view

Animal Model Products

CRISPR Products

miRNA for ZNF623 Gene

miRTarBase miRNAs that target ZNF623

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF623 Gene

Localization for ZNF623 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF623 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF623 Gene COMPARTMENTS Subcellular localization image for ZNF623 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF623 Gene

Pathways & Interactions for ZNF623 Gene

SuperPathways for ZNF623 Gene

No Data Available

Interacting Proteins for ZNF623 Gene

Gene Ontology (GO) - Biological Process for ZNF623 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF623 Gene

Drugs & Compounds for ZNF623 Gene

No Compound Related Data Available

Transcripts for ZNF623 Gene

mRNA/cDNA for ZNF623 Gene

(5) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF623 Gene

Zinc finger protein 623:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF623 Gene

No ASD Table

Relevant External Links for ZNF623 Gene

GeneLoc Exon Structure for
ZNF623
ECgene alternative splicing isoforms for
ZNF623

Expression for ZNF623 Gene

mRNA expression in normal human tissues for ZNF623 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ZNF623 Gene



SOURCE GeneReport for Unigene cluster for ZNF623 Gene Hs.694018

genes like me logo Genes that share expression patterns with ZNF623: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF623 Gene

Orthologs for ZNF623 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF623 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF623 35
  • 99.44 (n)
  • 99.07 (a)
ZNF623 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF623 36
  • 79 (a)
OneToOne
ZNF623 35
  • 78.93 (n)
  • 81.3 (a)
dog
(Canis familiaris)
Mammalia ZNF623 35
  • 85.31 (n)
  • 84.91 (a)
ZNF623 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp623 16
Zfp623 36
  • 82 (a)
OneToOne
Zfp623 35
  • 80.82 (n)
  • 83.27 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 42 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC102547932 35
  • 80.61 (n)
  • 82.04 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii BX927130.1 36
  • 39 (a)
OneToMany
Species with no ortholog for ZNF623:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF623 Gene

ENSEMBL:
Gene Tree for ZNF623 (if available)
TreeFam:
Gene Tree for ZNF623 (if available)

Paralogs for ZNF623 Gene

(508) SIMAP similar genes for ZNF623 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF623: view

Variants for ZNF623 Gene

Sequence variations from dbSNP and Humsavar for ZNF623 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs4874084 - 143,650,248(+) CTTGC(A/G)ATATC reference, missense
rs896936 -- 143,643,299(-) CAAAG(A/C)TGCAA intron-variant
rs896937 -- 143,643,149(-) agccg(C/T)cccta intron-variant
rs921669 -- 143,653,177(-) CCACT(A/G)TCCAT utr-variant-3-prime
rs2384928 -- 143,637,410(-) GGGGA(A/T)ATTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF623 Gene

Variant ID Type Subtype PubMed ID
nsv891676 CNV Loss 21882294
dgv7932n71 CNV Loss 21882294
dgv7934n71 CNV Loss 21882294
dgv7935n71 CNV Loss 21882294
nsv466004 CNV Loss 19166990
nsv831488 CNV Loss 17160897
nsv6439 CNV Loss 18451855
esv4725 CNV Deletion 18987735
esv5538 CNV Loss 19470904
esv1406298 CNV Deletion 17803354
esv2738024 CNV Deletion 23290073
nsv6440 CNV Insertion 18451855

Variation tolerance for ZNF623 Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF623 Gene

HapMap Linkage Disequilibrium report
ZNF623

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF623 Gene

Disorders for ZNF623 Gene

Relevant External Links for ZNF623

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF623

No disorders were found for ZNF623 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF623 Gene

Publications for ZNF623 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. MxA interacts with and is modified by the SUMOylation machinery. (PMID: 25447205) Brantis-de-Carvalho C.E. … Valentini S.R. (Exp. Cell Res. 2015) 3
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ZNF623 Gene

Sources for ZNF623 Gene

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