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Aliases for ZNF623 Gene

Aliases for ZNF623 Gene

  • Zinc Finger Protein 623 2 3 5
  • KIAA0628 4

External Ids for ZNF623 Gene

Previous GeneCards Identifiers for ZNF623 Gene

  • GC08U900475
  • GC08P144804
  • GC08P144789
  • GC08P144718
  • GC08P139969

Summaries for ZNF623 Gene

GeneCards Summary for ZNF623 Gene

ZNF623 (Zinc Finger Protein 623) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for ZNF623 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF623 Gene

Genomics for ZNF623 Gene

Regulatory Elements for ZNF623 Gene

Enhancers for ZNF623 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F144455 1.4 Ensembl ENCODE 117.4 +820.4 820434 1.6 PKNOX1 ARNT CREB3L1 ZFP64 SIN3A ZNF2 ZNF416 ZNF207 ZNF548 FOS ZNF623 ZNF251 ZNF250 VPS28 GPAA1 LRRC14 LOC105375803 ZNF517 ZNF34 PPP1R16A
GH08F143021 1.9 FANTOM5 Ensembl ENCODE 51 -610.4 -610438 8.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF143 ZNF416 ZNF623 LOC100133669 ENSG00000253728 ENSG00000254574 LY6D ENSG00000253715 AK3P2 SLURP1 JRK TOP1MT
GH08F144101 1.2 ENCODE 60.4 +467.9 467899 4.0 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 ZNF623 ZNF250 ZNF251 ZNF517 LRRC14 TMED10P1 ENSG00000255164 WDR97 ZNF696 VPS28
GH08F143914 1.9 FANTOM5 Ensembl ENCODE 33.1 +301.1 301118 45.2 MLX CREB3L1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZNF251 ZNF250 ZNF517 LRRC14 PLEC LOC105375803 ZNF696 ZNF623 VPS28 COMMD5
GH08F143460 1.2 Ensembl ENCODE 46.2 -173.8 -173761 3.6 HDGF TBP PKNOX1 TBL1XR1 ZNF493 THRB RAD21 RARA ZNF207 CREM ZNF623 VPS28 JRK SLC52A2 GPAA1 ADCK5 TIGD5 ZNF696 LOC105375798 MINCR
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF623 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF623 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001404195 -13 1601 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 FOS KLF13 ZNF263

Genomic Location for ZNF623 Gene

Chromosome:
8
Start:
143,636,013 bp from pter
End:
143,656,418 bp from pter
Size:
20,406 bases
Orientation:
Plus strand

Genomic View for ZNF623 Gene

Genes around ZNF623 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF623 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF623 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF623 Gene

Proteins for ZNF623 Gene

  • Protein details for ZNF623 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75123-ZN623_HUMAN
    Recommended name:
    Zinc finger protein 623
    Protein Accession:
    O75123
    Secondary Accessions:
    • A4FU80
    • B4DGP3
    • E7ENV5

    Protein attributes for ZNF623 Gene

    Size:
    536 amino acids
    Molecular mass:
    61392 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA31603.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG57854.1; Type=Frameshift; Positions=467; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF623 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF623 Gene

Post-translational modifications for ZNF623 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF623 Gene

No data available for DME Specific Peptides for ZNF623 Gene

Domains & Families for ZNF623 Gene

Gene Families for ZNF623 Gene

Protein Domains for ZNF623 Gene

Suggested Antigen Peptide Sequences for ZNF623 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75123

UniProtKB/Swiss-Prot:

ZN623_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF623: view

Function for ZNF623 Gene

Molecular function for ZNF623 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF623 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF623: view
genes like me logo Genes that share phenotypes with ZNF623: view

Animal Model Products

miRNA for ZNF623 Gene

miRTarBase miRNAs that target ZNF623

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF623 Gene

Localization for ZNF623 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF623 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF623 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF623 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF623: view

Pathways & Interactions for ZNF623 Gene

SuperPathways for ZNF623 Gene

No Data Available

Interacting Proteins for ZNF623 Gene

Selected Interacting proteins: O75123-ZN623_HUMAN for ZNF623 Gene via IID

Gene Ontology (GO) - Biological Process for ZNF623 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF623: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF623 Gene

Transcripts for ZNF623 Gene

mRNA/cDNA for ZNF623 Gene

(4) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF623 Gene

Zinc finger protein 623:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF623 Gene

No ASD Table

Relevant External Links for ZNF623 Gene

GeneLoc Exon Structure for
ZNF623
ECgene alternative splicing isoforms for
ZNF623

Expression for ZNF623 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF623 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF623 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF623 Gene:

ZNF623

SOURCE GeneReport for Unigene cluster for ZNF623 Gene:

Hs.694018
genes like me logo Genes that share expression patterns with ZNF623: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF623 Gene

Orthologs for ZNF623 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF623 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF623 34 35
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia ZNF623 34 35
  • 85.31 (n)
mouse
(Mus musculus)
Mammalia Zfp623 34 16 35
  • 80.82 (n)
rat
(Rattus norvegicus)
Mammalia LOC102547932 34
  • 80.61 (n)
cow
(Bos Taurus)
Mammalia ZNF623 34 35
  • 78.93 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 42 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 40 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii BX927130.1 35
  • 39 (a)
OneToMany
Species where no ortholog for ZNF623 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF623 Gene

ENSEMBL:
Gene Tree for ZNF623 (if available)
TreeFam:
Gene Tree for ZNF623 (if available)

Paralogs for ZNF623 Gene

(508) SIMAP similar genes for ZNF623 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF623: view

No data available for Paralogs for ZNF623 Gene

Variants for ZNF623 Gene

Sequence variations from dbSNP and Humsavar for ZNF623 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10097092 -- 143,634,985(+) TTGAG(C/T)GTCGG nc-transcript-variant, upstream-variant-2KB
rs10098662 -- 143,648,286(+) AGGCT(A/G)TCCCA intron-variant, upstream-variant-2KB
rs10107353 -- 143,642,560(+) catgc(C/G)ttcct intron-variant
rs10112400 -- 143,634,996(+) CTGGG(A/C)ACAGC nc-transcript-variant, upstream-variant-2KB
rs10112632 -- 143,635,201(+) gagcc(A/G)taggt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF623 Gene

Variant ID Type Subtype PubMed ID
nsv957688 CNV deletion 24416366
nsv831488 CNV loss 17160897
nsv6440 CNV insertion 18451855
nsv6439 CNV deletion 18451855
nsv466004 CNV loss 19166990
nsv1161814 CNV deletion 26073780
nsv1150215 CNV deletion 26484159
nsv1077073 CNV deletion 25765185
esv5538 CNV loss 19470904
esv4725 CNV loss 18987735
esv3584899 CNV loss 24956385
esv3573036 CNV loss 25503493
esv3544392 CNV deletion 23714750
esv3269385 CNV deletion 24192839
esv2738024 CNV deletion 23290073
esv1406298 CNV deletion 17803354
dgv3930n106 CNV deletion 24896259
dgv271n111 CNV deletion 26073780
dgv2118e212 CNV loss 25503493
dgv12429n54 CNV loss 21841781
dgv12419n54 CNV loss 21841781

Variation tolerance for ZNF623 Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF623 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF623

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF623 Gene

Disorders for ZNF623 Gene

Relevant External Links for ZNF623

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF623

No disorders were found for ZNF623 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF623 Gene

Publications for ZNF623 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. MxA interacts with and is modified by the SUMOylation machinery. (PMID: 25447205) Brantis-de-Carvalho C.E. … Valentini S.R. (Exp. Cell Res. 2015) 3 64
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64

Products for ZNF623 Gene

Sources for ZNF623 Gene

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