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Aliases for ZNF623 Gene

Aliases for ZNF623 Gene

  • Zinc Finger Protein 623 2 3 5
  • KIAA0628 4

External Ids for ZNF623 Gene

Previous GeneCards Identifiers for ZNF623 Gene

  • GC08U900475
  • GC08P144804
  • GC08P144789
  • GC08P144718
  • GC08P139969

Summaries for ZNF623 Gene

GeneCards Summary for ZNF623 Gene

ZNF623 (Zinc Finger Protein 623) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for ZNF623 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF623 Gene

Genomics for ZNF623 Gene

Regulatory Elements for ZNF623 Gene

Enhancers for ZNF623 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G144455 1.4 Ensembl ENCODE 120.9 +820.4 820434 1.6 HNRNPUL1 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ZFP64 SIN3A ZNF2 ZNF251 ZNF623 ZNF250 ZNF34 LRRC14 ZNF517 GPAA1 VPS28 TMED10P1 ENSG00000255164
GH08G143021 2.1 FANTOM5 Ensembl ENCODE dbSUPER 62.5 -610.9 -610928 7.1 CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF416 ZNF548 SP3 NFYC TBX21 ZNF623 LOC100133669 TIGD5 AK3P2 JRK TOP1MT MAFA PIR51584 GC08P143031
GH08G144101 1.2 ENCODE 60.4 +467.9 467899 4.0 CREB3L1 AGO1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 NFYC ZFP41 ZNF623 ZNF250 ZNF251 ZNF517 WDR97 ENSG00000255224 ZNF34 LRRC14 ZNF696 ENSG00000255164
GH08G143460 1.4 Ensembl ENCODE dbSUPER 28.3 -173.8 -173761 3.6 HDGF PKNOX1 ZNF493 ZNF207 ZNF202 JUNB REST TBX21 ZNF518A ZNF292 ZNF623 JRK VPS28 SLC52A2 GPAA1 ADCK5 LOC105375798 GSDMD ENSG00000253931 PIR44330
GH08G142725 1.7 FANTOM5 ENCODE dbSUPER 23 -908.8 -908785 3.2 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 LY6K JRK ZNF623 ZNF696 AK3P2 THEM6 LYNX1 PSCA ENSG00000253806
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF623 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF623 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZNF623 Gene

143,636,013 bp from pter
143,656,418 bp from pter
20,406 bases
Plus strand

Genomic View for ZNF623 Gene

Genes around ZNF623 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF623 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF623 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF623 Gene

Proteins for ZNF623 Gene

  • Protein details for ZNF623 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 623
    Protein Accession:
    Secondary Accessions:
    • A4FU80
    • B4DGP3
    • E7ENV5

    Protein attributes for ZNF623 Gene

    536 amino acids
    Molecular mass:
    61392 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA31603.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG57854.1; Type=Frameshift; Positions=467; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF623 Gene


neXtProt entry for ZNF623 Gene

Post-translational modifications for ZNF623 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF623 Gene

No data available for DME Specific Peptides for ZNF623 Gene

Domains & Families for ZNF623 Gene

Gene Families for ZNF623 Gene

Protein Domains for ZNF623 Gene

Suggested Antigen Peptide Sequences for ZNF623 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF623: view

Function for ZNF623 Gene

Molecular function for ZNF623 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF623 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF623: view
genes like me logo Genes that share phenotypes with ZNF623: view

Animal Model Products

CRISPR Products

miRNA for ZNF623 Gene

miRTarBase miRNAs that target ZNF623

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF623 Gene

Localization for ZNF623 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF623 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF623 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF623 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF623: view

Pathways & Interactions for ZNF623 Gene

SuperPathways for ZNF623 Gene

No Data Available

Interacting Proteins for ZNF623 Gene

Selected Interacting proteins: O75123-ZN623_HUMAN for ZNF623 Gene via IID

Gene Ontology (GO) - Biological Process for ZNF623 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
genes like me logo Genes that share ontologies with ZNF623: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF623 Gene

Drugs & Compounds for ZNF623 Gene

No Compound Related Data Available

Transcripts for ZNF623 Gene

mRNA/cDNA for ZNF623 Gene

(4) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF623 Gene

Zinc finger protein 623:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF623 Gene

No ASD Table

Relevant External Links for ZNF623 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF623 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF623 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF623 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF623 Gene:


SOURCE GeneReport for Unigene cluster for ZNF623 Gene:


Evidence on tissue expression from TISSUES for ZNF623 Gene

  • Nervous system(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ZNF623: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF623 Gene

Orthologs for ZNF623 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF623 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF623 34 35
  • 99.44 (n)
(Canis familiaris)
Mammalia ZNF623 34 35
  • 85.31 (n)
(Mus musculus)
Mammalia Zfp623 34 16 35
  • 80.82 (n)
(Rattus norvegicus)
Mammalia LOC102547932 34
  • 80.61 (n)
(Bos Taurus)
Mammalia ZNF623 34 35
  • 78.93 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 42 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 40 (a)
(Danio rerio)
Actinopterygii BX927130.1 35
  • 39 (a)
Species where no ortholog for ZNF623 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF623 Gene

Gene Tree for ZNF623 (if available)
Gene Tree for ZNF623 (if available)

Paralogs for ZNF623 Gene

(508) SIMAP similar genes for ZNF623 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF623: view

No data available for Paralogs for ZNF623 Gene

Variants for ZNF623 Gene

Sequence variations from dbSNP and Humsavar for ZNF623 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000014832 -- 143,642,877(+) GTGGT(A/C)TCTTA intron-variant
rs1000054712 -- 143,637,465(+) GGACA(C/G)CCCTA intron-variant
rs1000097853 -- 143,647,366(+) AGTGT(A/G)TTAGC intron-variant
rs1000107844 -- 143,650,807(+) GAGAA(G/T)TCACA reference, missense
rs1000387442 -- 143,642,666(+) TAATC(C/T)CAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF623 Gene

Variant ID Type Subtype PubMed ID
dgv12419n54 CNV loss 21841781
dgv12429n54 CNV loss 21841781
dgv2118e212 CNV loss 25503493
dgv271n111 CNV deletion 26073780
dgv3930n106 CNV deletion 24896259
esv1406298 CNV deletion 17803354
esv2738024 CNV deletion 23290073
esv3269385 CNV deletion 24192839
esv3544392 CNV deletion 23714750
esv3573036 CNV loss 25503493
esv3584899 CNV loss 24956385
esv4725 CNV loss 18987735
esv5538 CNV loss 19470904
nsv1077073 CNV deletion 25765185
nsv1150215 CNV deletion 26484159
nsv1161814 CNV deletion 26073780
nsv466004 CNV loss 19166990
nsv6439 CNV deletion 18451855
nsv6440 CNV insertion 18451855
nsv831488 CNV loss 17160897
nsv957688 CNV deletion 24416366

Variation tolerance for ZNF623 Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF623 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF623 Gene

Disorders for ZNF623 Gene

Relevant External Links for ZNF623

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF623 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF623 Gene

Publications for ZNF623 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. MxA interacts with and is modified by the SUMOylation machinery. (PMID: 25447205) Brantis-de-Carvalho C.E. … Valentini S.R. (Exp. Cell Res. 2015) 3 64
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64

Products for ZNF623 Gene

Sources for ZNF623 Gene

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