ZNF622 Gene

Aliases
for ZNF622 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC05M016505 GC05M016506 GC05M016507

Summaries
for ZNF622 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for ZNF622 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000005.9  NC_018916.2  NT_006576.17  

SwitchGear Promoter luciferase reporter plasmid: ZNF622 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF622

ZNF622 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M016451:  view genomic region     (about GC identifiers)

Proteins
for ZNF622 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for ZNF622: NX_Q969S3

Explore proteomics data for ZNF622 at MOPED

Post-translational modifications: 

ZNF622 Human Recombinant Protein Products:

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Domains /
Families
for ZNF622 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q969S3

Find genes that share domains with ZNF622           About GenesLikeMe

Function
for ZNF622 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 4 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for ZNF622

miRNA Products:		miRTarBase miRNAs that target ZNF622: hsa-mir-1 (MIRT023928), hsa-mir-92a-3p (MIRT049311), hsa-mir-16-5p (MIRT001395), hsa-mir-103a-3p (MIRT027111)
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		hsa-miR-562 hsa-miR-15a hsa-miR-503 hsa-miR-497 hsa-miR-545 hsa-miR-646 hsa-miR-424 hsa-miR-16
		Browse SwitchGear 3'UTR luciferase reporter plasmids

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Gene Editing Products:

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF622

Localization
for ZNF622 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	5
golgi apparatus	4
cytosol	3

About this image

Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for ZNF622 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 5 biological process terms:    About this table

Drugs & Compounds
for ZNF622 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for ZNF622 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for ZNF622 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF622 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CAGTATGTCC

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for ZNF622 OriGene qSTAR qPCR primer pairs in human, mouse for ZNF622
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF622
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF622

Orthologs
for ZNF622 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for ZNF622 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for ZNF622 gene

Find genes that share paralogs with ZNF622           About GenesLikeMe


1 Pseudogenes.org Pseudogene for ZNF622
PGOHUM00000241619

Genomic Variants
for ZNF622 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF622 (see all 340)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1835478281,2		--	16451152(+)	CTAAGC/TATTTT	1	--	int1		0	--	--	--	--
rs4662051,2	C,F,O,A,H	--	16451188(+)	TGCACC/TACTGG	1	--	int1		21		EA NS NA WA	3834
rs274541,2	C,F,A,H	--	16451246(-)	GTTTTC/ATATTT	1	--	int1		28		NA PA EA NS WA CSA	4020
rs1180362331,2	F	--	16451267(+)	AGCTAT/CTGATG	1	--	int1		1		EA	120
rs1160285691,2	C,F	--	16451286(+)	AACTTA/GGCCTG	1	--	int1		1		NA	120
rs1899757021,2		--	16451288(+)	CTTAGC/TCTGGA	1	--	int1		0	--	--	--	--
rs1438367241,2	C	--	16451306(+)	CAAGCA/GCCCAG	1	--	int1		0	--	--	--	--
rs1481341901,2		--	16451404(+)	GGTCCA/CAGTGC	1	--	int1		0	--	--	--	--
rs260171,2	C,F,A,H	--	16451431(-)	ACTTTC/GAGAGT	1	--	int1		30		NS EA NA WA CSA	2777
rs1812368671,2		--	16451515(+)	TGAGGC/TGATGA	1	--	int1		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF622 (16451628 - 16465901 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for ZNF622:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv269198	CNV	Insertion	20981092

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ZNF622

DNA2.0 Custom Variant and Variant Library Synthesis for ZNF622

Disorders / Diseases
for ZNF622 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for ZNF622 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38). (PubMed id 11802789)^{1, 2, 3, 9} Seong H.-A.... Ha H. (Biochem. J. 2002)
2. Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein. (PubMed id 12645566)^{1, 2, 3} Seong H.A.... Ha H. (J. Biol. Chem. 2003)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
4. Thioredoxin inhibits MPK38-induced ASK1, TGF-I^, and p53 function in a phosphorylation-dependent manner. (PubMed id 23747528)¹ Manoharan R....Ha H. (amp 2013)
5. A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (Sci Signal 2012)
7. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)² Bienvenut W.V....Giglione C. (amp 2012)
8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (Nat. Methods 2012)
9. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)¹ Li S.... Dorf M.E. (Immunity 2011)
10. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

External Searches for ZNF622 gene

Genome Databases showing ZNF622 gene

Other Databases showing ZNF622 gene

Specialized Databases showing ZNF622 gene

Products
for ZNF622 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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