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ZNF622 Gene

protein-coding GIFtS: 50
GCID: GC05M016451

Zinc Finger Protein 622

See related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Zinc Finger Protein 622¹ ²
Zinc Finger-Like Protein 9² ³
ZPR9² ³

External Ids:	HGNC: 30958¹	Entrez Gene: 90441²	Ensembl: ENSG00000173545⁷	OMIM: 608694⁵	UniProtKB: Q969S3³

Export aliases for ZNF622 gene to outside databases

Previous GC identifers: GC05M016505 GC05M016506 GC05M016507

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF622 Gene:

ZNF622 (zinc finger protein 622) is a protein-coding gene. Diseases associated with ZNF622 include malaria. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot: ZN622_HUMAN, Q969S3

Function: May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic

development

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000005.10 NC_018916.2 NT_006576.17

Regulatory elements:

Regulatory transcription factor binding sites in the ZNF622 gene promoter:
USF1 AML1a HFH-1 HOXA5 Pax-6 ITF-2 Tal-1beta C/EBPalpha GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF622 promoter sequence

Search Chromatin IP Primers for ZNF622

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF622

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.1 Ensembl cytogenetic band: 5p15.1 HGNC cytogenetic band: 5p15.1

ZNF622 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF622 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M016451: view genomic region (about GC identifiers)

Start:	16,451,628 bp from pter	End:	16,465,901 bp from pter
Size:	14,274 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN622_HUMAN, Q969S3 (See protein sequence)

Recommended Name: Zinc finger protein 622

Size: 477 amino acids; 54272 Da

Subunit: Homo- and heterodimer. Interacts with MELK and MYBL2

Explore the universe of human proteins at neXtProt for ZNF622: NX_Q969S3

Explore proteomics data for ZNF622 at MOPED

Post-translational modifications:

Phosphorylated by MELK. The phosphorylation may redirect the protein to the nucleus¹

Ubiquitination² at Lys75, Lys116

Modification sites at PhosphoSitePlus

See ZNF622 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_219482.1

ENSEMBL proteins:

ENSP00000310042

ZNF622 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:

IPR003604 Znf_U1

IPR015880 Znf_C2H2-like

IPR007087 Znf_C2H2

IPR022755 Znf_C2H2_jaz

Graphical View of Domain Structure for InterPro Entry Q969S3

ProtoNet protein and cluster: Q969S3

1 Blocks protein domain: IPB003604 Zn-finger

UniProtKB/Swiss-Prot: ZN622_HUMAN, Q969S3

Similarity: Contains 2 U1-type zinc fingers

ZNF622 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: ZN622_HUMAN, Q969S3

Function: May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic

development

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0005515	protein binding	IPI	--
GO:0008270	zinc ion binding	IEA	--
GO:0044822	poly(A) RNA binding	IDA	--

ZNF622 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ZNF622:

Decreased viability with pacli

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF622

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miRNA Products:		miRTarBase miRNAs that target ZNF622: hsa-mir-1 (MIRT023928), hsa-mir-92a-3p (MIRT049311), hsa-mir-16-5p (MIRT001395), hsa-mir-103a-3p (MIRT027111)

		Block miRNA regulation of human, mouse, rat ZNF622 using miScript Target Protectors
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		Browse SwitchGear 3'UTR luciferase reporter plasmids

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Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF622

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

ZN622_HUMAN, Q969S3: Cytoplasm. Nucleus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
golgi apparatus	4
cytosol	3

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Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005730	nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005794	Golgi apparatus	IDA	--

ZNF622 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for ZNF622
Interactions:

Search GeneGlobe Interaction Network for ZNF622

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for ZNF622 (Q969S3^{1, 2, 3} ENSP00000310042⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 140)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

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Gene Ontology (GO): 5 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	IDA	--
GO:0033674	positive regulation of kinase activity	IDA	--
GO:0043065	positive regulation of apoptotic process	IDA	--
GO:0043410	positive regulation of MAPK cascade	IDA	--
GO:0046330	positive regulation of JNK cascade	IMP	--

ZNF622 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for ZNF622 (ZN622)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ZNF622 gene:

NM_033414.2

Unigene Cluster for ZNF622:

Zinc finger protein 622

Hs.60300 [show with all ESTs]

Unigene Representative Sequence: BC008752

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000308683(uc003jfq.3)

miRNA Products:		Block miRNA regulation of human, mouse, rat ZNF622 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate ZNF622 (see all 10):
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		QuantiFast Probe-based Assays in human, mouse, rat ZNF622

Additional mRNA sequence:

AY046059.1 BC008752.2 BC010545.1

7 DOTS entries:

DT.214516 DT.100803408 DT.97833608 DT.214515 DT.100803409 DT.91759562 DT.99956964

Selected AceView cDNA sequences (see all 192):

BM975670 BQ000939 CR624583 BM674316 BU857013 BQ070666 CR599167 BF724659

CR626791 CA448449 CR624161 BM810137 AI753794 AI086084 AI334423 CR609231

BG742804 AA493406 AV708897 BE275770 BQ051792 BF437635 BF059722 AW070786

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF622 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CAGTATGTCC

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ZNF622 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ZNF622 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.60300

UniProtKB/Swiss-Prot: ZN622_HUMAN, Q969S3

Tissue specificity: Expressed in lung, kidney, spleen, liver and brain with lowest expression in kidney

Custom PCR Arrays for ZNF622

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF622

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for ZNF622 gene from Selected species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Zfp622^{1 , 5}	zinc finger protein 622^{1, 5}	85.04(n)¹ 84.04(a)¹		15 (9.71 cM)⁵ 52521¹ NM_144523.2¹ NP_653106.1¹ 25984366⁵
chicken (Gallus gallus)	Aves	ZNF622¹	zinc finger protein 622	72.76(n) 72.76(a)		373921 NM_204130.1 NP_989461.1
lizard (Anolis carolinensis)	Reptilia	ZNF622⁶	zinc finger protein 622	72(a)	1 ↔ 1	4(60242077-60255326)
African clawed frog (Xenopus laevis)	Amphibia	BC044053.1²	--	75.61(n)		BC044053.1
zebrafish (Danio rerio)	Actinopterygii	wufb64b07²	Danio rerio cDNA clone IMAGE6795513, partial cds	75.11(n)		BC055386.1
fruit fly (Drosophila melanogaster)	Insecta	CG6769¹	CG6769	55.62(n) 49.57(a)		32770 NM_001272734.1 NP_001259663.1
worm (Caenorhabditis elegans)	Secernentea	C16A3.4¹	C16A3.4	48.21(n) 42.62(a)		175905 NM_065996.4 NP_498397.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	REH1(YLR387C)⁴	Cytoplasmic 60S subunit biogenesis factor, associates more	--		12(897672-896374) 851103 NP_013491.1
thale cress (Arabidopsis thaliana)	eudicotyledons	FZF¹	FZF	48.42(n) 40.98(a)		816986 NM_128011.4 NP_180026.1
rice (Oryza sativa)	Liliopsida	Os06g0693500¹	Os06g0693500	50.16(n) 38.34(a)		4341920 NM_001064970.1 NP_001058435.1

ENSEMBL Gene Tree for ZNF622 (if available)
TreeFam Gene Tree for ZNF622 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ZNF622 gene

ZNF622 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ZNF622
PGOHUM00000241619

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183547828^1,2		--	16451152(+)	`CTAAGC/TATTTT`	1	--	int¹		0	--	--	--	--
rs466205^1,2	C,F,O,A,H	--	16451188(+)	`TGCACC/TACTGG`	1	--	int¹		21		EA NS NA WA	3834
rs27454^1,2	C,F,A,H	--	16451246(-)	`GTTTTC/ATATTT`	1	--	int¹		28		NA PA EA NS WA CSA	4020
rs118036233^1,2	F	--	16451267(+)	`AGCTAT/CTGATG`	1	--	int¹		1		EA	120
rs116028569^1,2	C,F	--	16451286(+)	`AACTTA/GGCCTG`	1	--	int¹		1		NA	120
rs189975702^1,2		--	16451288(+)	`CTTAGC/TCTGGA`	1	--	int¹		0	--	--	--	--
rs143836724^1,2	C	--	16451306(+)	`CAAGCA/GCCCAG`	1	--	int¹		0	--	--	--	--
rs148134190^1,2		--	16451404(+)	`GGTCCA/CAGTGC`	1	--	int¹		0	--	--	--	--
rs26017^1,2	C,F,A,H	--	16451431(-)	`ACTTTC/GAGAGT`	1	--	int¹		30		NS EA NA WA CSA	2777
rs181236867^1,2		--	16451515(+)	`TGAGGC/TGATGA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF622 (16451628 - 16465901 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for ZNF622: About this table

Variant ID	Type	Subtype	PubMed ID
esv269198	CNV	Insertion	20981092

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ZNF622

DNA2.0 Custom Variant and Variant Library Synthesis for ZNF622

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608694 OMIM disorders: --

1 disease for ZNF622:
About MalaCards

malaria

ZNF622 for disorders About GeneDecksing

Genetic Association Database (GAD): ZNF622

Export disorders for ZNF622 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ZNF622 gene, integrated from 10 sources (see all 21):
(articles sorted by number of sources associating them with ZNF622)

Utopia: connect your pdf to the dynamic
world of online information

Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38). (PubMed id 11802789)^{1, 2, 3, 9} Seong H.-A.... Ha H. (Biochem. J. 2002)
Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein. (PubMed id 12645566)^{1, 2, 3} Seong H.A.... Ha H. (J. Biol. Chem. 2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Thioredoxin inhibits MPK38-induced ASK1, TGF-I^, and p53 function in a phosphorylation-dependent manner. (PubMed id 23747528)¹ Manoharan R....Ha H. (amp 2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (Sci Signal 2012)
Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)² Bienvenut W.V....Giglione C. (amp 2012)
A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (Nat. Methods 2012)
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)¹ Li S.... Dorf M.E. (Immunity 2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 90441	HGNC: 30958	AceView: ZNF622	Ensembl:ENSG00000173545	euGenes: HUgn90441
ECgene: ZNF622	H-InvDB: ZNF622

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ZNF622	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF622 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ZNF622 gene:
Search GeneIP for patents involving ZNF622

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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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ZNF622 Gene

Zinc Finger Protein 622

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ZNF622 Gene

Zinc Finger Protein 622

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