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Aliases for ZNF622 Gene

Aliases for ZNF622 Gene

  • Zinc Finger Protein 622 2 3
  • Zinc Finger-Like Protein 9 3 4
  • ZPR9 3 4

External Ids for ZNF622 Gene

Summaries for ZNF622 Gene

GeneCards Summary for ZNF622 Gene

ZNF622 (Zinc Finger Protein 622) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZNF622 Gene

  • May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF622 Gene

Genomics for ZNF622 Gene

Genomic Location for ZNF622 Gene

16,451,519 bp from pter
16,465,792 bp from pter
14,274 bases
Minus strand

Genomic View for ZNF622 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF622 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF622 Gene

Regulatory Elements for ZNF622 Gene

Proteins for ZNF622 Gene

  • Protein details for ZNF622 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 622
    Protein Accession:
    Secondary Accessions:

    Protein attributes for ZNF622 Gene

    477 amino acids
    Molecular mass:
    54272 Da
    Quaternary structure:
    • Homo- and heterodimer. Interacts with MELK and MYBL2.

neXtProt entry for ZNF622 Gene

Proteomics data for ZNF622 Gene at MOPED

Post-translational modifications for ZNF622 Gene

  • Phosphorylated by MELK. The phosphorylation may redirect the protein to the nucleus.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys75 and Lys116

Other Protein References for ZNF622 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF622 Gene

Domains for ZNF622 Gene

Protein Domains for ZNF622 Gene


  • Contains 2 U1-type zinc fingers.:
    • Q969S3
genes like me logo Genes that share domains with ZNF622: view

No data available for Gene Families for ZNF622 Gene

Function for ZNF622 Gene

Molecular function for ZNF622 Gene

UniProtKB/Swiss-Prot Function: May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development

Gene Ontology (GO) - Molecular Function for ZNF622 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 21771788
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ZNF622: view

Phenotypes for ZNF622 Gene

GenomeRNAi human phenotypes for ZNF622:
genes like me logo Genes that share phenotypes with ZNF622: view

miRNA for ZNF622 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF622 Gene

Localization for ZNF622 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF622 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for ZNF622 Gene COMPARTMENTS Subcellular localization image for ZNF622 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF622 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with ZNF622: view

Pathways for ZNF622 Gene

SuperPathways for ZNF622 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF622 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IDA 21771788
GO:0033674 positive regulation of kinase activity IDA 21771788
GO:0043065 positive regulation of apoptotic process IDA 21771788
GO:0043410 positive regulation of MAPK cascade IDA 21771788
GO:0046330 positive regulation of JNK cascade IMP 21771788
genes like me logo Genes that share ontologies with ZNF622: view

No data available for Pathways by source for ZNF622 Gene

Transcripts for ZNF622 Gene

mRNA/cDNA for ZNF622 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(192) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF622 Gene

Zinc finger protein 622:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF622 Gene

No ASD Table

Relevant External Links for ZNF622 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF622 Gene

mRNA expression in normal human tissues for ZNF622 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF622 Gene

SOURCE GeneReport for Unigene cluster for ZNF622 Gene Hs.60300

mRNA Expression by UniProt/SwissProt for ZNF622 Gene

Tissue specificity: Expressed in lung, kidney, spleen, liver and brain with lowest expression in kidney.
genes like me logo Genes that share expressions with ZNF622: view

Orthologs for ZNF622 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZNF622 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF622 36
  • 97.55 (n)
  • 96.85 (a)
ZNF622 37
  • 98 (a)
(Bos Taurus)
Mammalia ZNF622 36
  • 85.53 (n)
  • 85.32 (a)
ZNF622 37
  • 85 (a)
(Canis familiaris)
Mammalia ZNF622 36
  • 84.87 (n)
  • 81.29 (a)
ZNF622 37
  • 82 (a)
(Mus musculus)
Mammalia Zfp622 36
  • 85.04 (n)
  • 84.04 (a)
Zfp622 16
Zfp622 37
  • 83 (a)
(Monodelphis domestica)
Mammalia ZNF622 37
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF622 37
  • 80 (a)
(Rattus norvegicus)
Mammalia Zfp622 36
  • 86.38 (n)
  • 87.87 (a)
(Gallus gallus)
Aves ZNF622 36
  • 72.76 (n)
  • 72.76 (a)
ZNF622 37
  • 71 (a)
(Anolis carolinensis)
Reptilia ZNF622 37
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10152 36
znf622 36
  • 68.63 (n)
  • 71.9 (a)
(Danio rerio)
Actinopterygii wufb64b07 36
znf622 36
  • 67.04 (n)
  • 67.12 (a)
znf622 37
  • 65 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002118 36
  • 53.86 (n)
  • 50.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6769 36
  • 55.62 (n)
  • 49.57 (a)
CG6769 37
  • 45 (a)
(Caenorhabditis elegans)
Secernentea C16A3.4 36
  • 48.21 (n)
  • 42.62 (a)
C16A3.4 37
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes REH1 37
  • 27 (a)
REH1 39
REI1 37
  • 31 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons FZF 36
  • 48.42 (n)
  • 40.98 (a)
(Oryza sativa)
Liliopsida Os06g0693500 36
  • 50.16 (n)
  • 38.34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8710 37
  • 42 (a)
Species with no ortholog for ZNF622:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF622 Gene

Gene Tree for ZNF622 (if available)
Gene Tree for ZNF622 (if available)

Paralogs for ZNF622 Gene Pseudogenes for ZNF622 Gene

genes like me logo Genes that share paralogs with ZNF622: view

No data available for Paralogs for ZNF622 Gene

Variants for ZNF622 Gene

Sequence variations from dbSNP and Humsavar for ZNF622 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs26013 -- 16,464,040(+) TCCTA(C/T)CTGCC intron-variant
rs26017 -- 16,451,322(-) ACTTT(C/G)AGAGT downstream-variant-500B
rs26018 -- 16,454,261(-) atccg(C/T)ccacc intron-variant
rs26019 -- 16,454,380(-) ctccc(A/G)agtag intron-variant
rs26020 -- 16,455,157(+) GATAG(C/T)TGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF622 Gene

Variant ID Type Subtype PubMed ID
esv269198 CNV Insertion 20981092

Relevant External Links for ZNF622 Gene

HapMap Linkage Disequilibrium report

Disorders for ZNF622 Gene

Relevant External Links for ZNF622

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with ZNF622: view

No data available for UniProtKB/Swiss-Prot for ZNF622 Gene

Publications for ZNF622 Gene

  1. Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38). (PMID: 11802789) Seong H.-A. … Ha H. (Biochem. J. 2002) 2 3 4 23
  2. Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein. (PMID: 12645566) Seong H.A. … Ha H. (J. Biol. Chem. 2003) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Nucleolar proteome dynamics. (PMID: 15635413) Andersen J.S. … Mann M. (Nature 2005) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for ZNF622 Gene

Sources for ZNF622 Gene

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