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ZNF622 Gene

protein-coding   GIFtS: 50
GCID: GC05M016451

Zinc Finger Protein 622

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 6221 2
Zinc Finger-Like Protein 92 3
ZPR92 3

External Ids:    HGNC: 309581   Entrez Gene: 904412   Ensembl: ENSG000001735457   OMIM: 6086945   UniProtKB: Q969S33   

Export aliases for ZNF622 gene to outside databases

Previous GC identifers: GC05M016505 GC05M016506 GC05M016507


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF622 Gene:
ZNF622 (zinc finger protein 622) is a protein-coding gene. Diseases associated with ZNF622 include malaria. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot: ZN622_HUMAN, Q969S3
Function: May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic
development




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_006576.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF622 gene promoter:
         USF1   AML1a   HFH-1   HOXA5   Pax-6   ITF-2   Tal-1beta   C/EBPalpha   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF622 promoter sequence
   Search Chromatin IP Primers for ZNF622

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF622


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.1   Ensembl cytogenetic band:  5p15.1   HGNC cytogenetic band: 5p15.1

ZNF622 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF622 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M016451:  view genomic region     (about GC identifiers)

Start:
16,451,628 bp from pter      End:
16,465,901 bp from pter
Size:
14,274 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN622_HUMAN, Q969S3 (See protein sequence)
Recommended Name: Zinc finger protein 622  
Size: 477 amino acids; 54272 Da
Subunit: Homo- and heterodimer. Interacts with MELK and MYBL2

Explore the universe of human proteins at neXtProt for ZNF622: NX_Q969S3

Explore proteomics data for ZNF622 at MOPED

Post-translational modifications: 

  • Phosphorylated by MELK. The phosphorylation may redirect the protein to the nucleus1
  • Ubiquitination2 at Lys75, Lys116
  • Modification sites at PhosphoSitePlus

  • See ZNF622 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_219482.1  
    ENSEMBL proteins: 
     ENSP00000310042  

    ZNF622 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for ZNF622


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR003604 Znf_U1
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2
     IPR022755 Znf_C2H2_jaz

    Graphical View of Domain Structure for InterPro Entry Q969S3

    ProtoNet protein and cluster: Q969S3

    1 Blocks protein domain: IPB003604 Zn-finger

    UniProtKB/Swiss-Prot: ZN622_HUMAN, Q969S3
    Similarity: Contains 2 U1-type zinc fingers


    ZNF622 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN622_HUMAN, Q969S3
    Function: May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic
    development

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    ZNF622 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF622:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF622
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    miRNA
    Products:
        
    miRTarBase miRNAs that target ZNF622:
    hsa-mir-1 (MIRT023928), hsa-mir-92a-3p (MIRT049311), hsa-mir-16-5p (MIRT001395), hsa-mir-103a-3p (MIRT027111)

    Block miRNA regulation of human, mouse, rat ZNF622 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF622 (see all 10):
    hsa-miR-562 hsa-miR-15a hsa-miR-503 hsa-miR-497 hsa-miR-545 hsa-miR-646 hsa-miR-424 hsa-miR-16
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN622_HUMAN, Q969S3: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus4
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--

    ZNF622 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF622
    Interactions:

        Search GeneGlobe Interaction Network for ZNF622

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZNF622 (Q969S31, 2, 3 ENSP000003100424) via UniProtKB, MINT, STRING, and/or I2D (see all 140)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008631intrinsic apoptotic signaling pathway in response to oxidative stress IDA--
    GO:0033674positive regulation of kinase activity IDA--
    GO:0043065positive regulation of apoptotic process IDA--
    GO:0043410positive regulation of MAPK cascade IDA--
    GO:0046330positive regulation of JNK cascade IMP--

    ZNF622 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF622 (ZN622)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF622 gene: 
    NM_033414.2  

    Unigene Cluster for ZNF622:

    Zinc finger protein 622
    Hs.60300  [show with all ESTs]
    Unigene Representative Sequence: BC008752
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000308683(uc003jfq.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZNF622 (see all 10):
    hsa-miR-562 hsa-miR-15a hsa-miR-503 hsa-miR-497 hsa-miR-545 hsa-miR-646 hsa-miR-424 hsa-miR-16
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for ZNF622
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF622
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF622
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF622
      QuantiFast Probe-based Assays in human, mouse, rat ZNF622

    Additional mRNA sequence: 

    AY046059.1 BC008752.2 BC010545.1 

    7 DOTS entries:

    DT.214516  DT.100803408  DT.97833608  DT.214515  DT.100803409  DT.91759562  DT.99956964 

    Selected AceView cDNA sequences (see all 192):

    BM975670 BQ000939 CR624583 BM674316 BU857013 BQ070666 CR599167 BF724659 
    CR626791 CA448449 CR624161 BM810137 AI753794 AI086084 AI334423 CR609231 
    BG742804 AA493406 AV708897 BE275770 BQ051792 BF437635 BF059722 AW070786 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF622 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTATGTCC
    ZNF622 Expression
    About this image

    ZNF622 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF622 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.60300

    UniProtKB/Swiss-Prot: ZN622_HUMAN, Q969S3
    Tissue specificity: Expressed in lung, kidney, spleen, liver and brain with lowest expression in kidney

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF622

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZNF622 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp6221 , 5 zinc finger protein 6221, 5 85.04(n)1
    84.04(a)1
      15 (9.71 cM)5
    525211  NM_144523.21  NP_653106.11 
     259843665 
    chicken
    (Gallus gallus)
    Aves ZNF6221 zinc finger protein 622 72.76(n)
    72.76(a)
      373921  NM_204130.1  NP_989461.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF6226
    zinc finger protein 622
    72(a)
    1 ↔ 1
    4(60242077-60255326)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044053.12   -- 75.61(n)    BC044053.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb64b072 Danio rerio cDNA clone IMAGE6795513, partial cds 75.11(n)    BC055386.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG67691 CG6769 55.62(n)
    49.57(a)
      32770  NM_001272734.1  NP_001259663.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C16A3.41 C16A3.4 48.21(n)
    42.62(a)
      175905  NM_065996.4  NP_498397.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes REH1(YLR387C)4 Cytoplasmic 60S subunit biogenesis factor, associates more   --   12(897672-896374) 851103  NP_013491.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons FZF1 FZF 48.42(n)
    40.98(a)
      816986  NM_128011.4  NP_180026.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g06935001 Os06g0693500 50.16(n)
    38.34(a)
      4341920  NM_001064970.1  NP_001058435.1 


    ENSEMBL Gene Tree for ZNF622 (if available)
    TreeFam Gene Tree for ZNF622 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF622 gene

    ZNF622 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF622
    PGOHUM00000241619


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF622 (see all 340)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1835478281,2
    --16451152(+) CTAAGC/TATTTT 1 -- int10--------
    rs4662051,2
    C,F,O,A,H--16451188(+) TGCACC/TACTGG 1 -- int121Minor allele frequency- T:0.37EA NS NA WA 3834
    rs274541,2
    C,F,A,H--16451246(-) GTTTTC/ATATTT 1 -- int128Minor allele frequency- A:0.31NA PA EA NS WA CSA 4020
    rs1180362331,2
    F--16451267(+) AGCTAT/CTGATG 1 -- int11Minor allele frequency- C:0.01EA 120
    rs1160285691,2
    C,F--16451286(+) AACTTA/GGCCTG 1 -- int11Minor allele frequency- G:0.02NA 120
    rs1899757021,2
    --16451288(+) CTTAGC/TCTGGA 1 -- int10--------
    rs1438367241,2
    C--16451306(+) CAAGCA/GCCCAG 1 -- int10--------
    rs1481341901,2
    --16451404(+) GGTCCA/CAGTGC 1 -- int10--------
    rs260171,2
    C,F,A,H--16451431(-) ACTTTC/GAGAGT 1 -- int130Minor allele frequency- G:0.22NS EA NA WA CSA 2777
    rs1812368671,2
    --16451515(+) TGAGGC/TGATGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF622 (16451628 - 16465901 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF622:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv269198CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF622
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608694    OMIM disorders: --

    1 disease for ZNF622:    
    About MalaCards
    malaria


    ZNF622 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF622

    Export disorders for ZNF622 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF622 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with ZNF622)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38). (PubMed id 11802789)1, 2, 3, 9 Seong H.-A.... Ha H. (Biochem. J. 2002)
    2. Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein. (PubMed id 12645566)1, 2, 3 Seong H.A.... Ha H. (J. Biol. Chem. 2003)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Thioredoxin inhibits MPK38-induced ASK1, TGF-I^, and p53 function in a phosphorylation-dependent manner. (PubMed id 23747528)1 Manoharan R....Ha H. (amp 2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    7. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90441 HGNC: 30958 AceView: ZNF622 Ensembl:ENSG00000173545 euGenes: HUgn90441
    ECgene: ZNF622 H-InvDB: ZNF622

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF622 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF622 gene:
    Search GeneIP for patents involving ZNF622

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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