ZNF622 Gene
protein-coding GIFtS: 50
GCID: GC05M016451
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Zinc Finger Protein 622
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Aliases
for ZNF622 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 6221 2 | | Zinc Finger-Like Protein 92 3 | | ZPR92 3 |
Export aliases for ZNF622 gene to outside databasesPrevious GC identifers: GC05M016505 GC05M016506 GC05M016507 |
Summaries
for ZNF622 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
GeneCards Summary for ZNF622 Gene: 
ZNF622 (zinc finger protein 622) is a protein-coding gene. GO annotations related to this gene include zinc ion binding and nucleic acid binding.
UniProtKB/Swiss-Prot: ZN622_HUMAN, Q969S3Function: May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic
development
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Genomic Views
for ZNF622 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.2 NT_006576.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF622 gene promoter:
USF1 AML1a HFH-1 HOXA5 Pax-6 ITF-2 Tal-1beta C/EBPalpha GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF622
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF622 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5p15.1 Ensembl cytogenetic band: 5p15.1 HGNC cytogenetic band: 5p15.1ZNF622 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M016451: view genomic region
(about GC identifiers)
Start:
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16,451,628 bp from pter |
End:
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16,465,901 bp from pter |
Size:
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14,274 bases |
Orientation:
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minus strand |
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Proteins
for ZNF622 gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
|
UniProtKB/Swiss-Prot: ZN622_HUMAN, Q969S3 (See
protein sequence)Recommended Name: Zinc finger protein 622 Size: 477 amino acids; 54272 Da
Subunit: Homo- and heterodimer. Interacts with MELK and MYBL2
Subcellular location: Cytoplasm. NucleusExplore the universe of human proteins at neXtProt for ZNF622: NX_Q969S3
Explore proteomics data for ZNF622 at MOPED
Post-translational modifications:
UniProtKB: Phosphorylated by MELK. The phosphorylation may redirect the protein to the nucleus
View modification sites using PhosphoSitePlusView neXtProt modification sites for NX_Q969S3
ZNF622 Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : About this image 
REFSEQ proteins: NP_219482.1
ENSEMBL proteins: ENSP00000310042
Human Recombinant Protein Products for ZNF622:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ZNF622 for ontologies About GeneDecksing
ZNF622 Antibody Products:
Assay Products for ZNF622: |
Protein
Domains /
Families
for ZNF622 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| 4 InterPro protein domains:Graphical View of Domain Structure for InterPro Entry Q969S3 ProtoNet protein and cluster: Q969S3 1 Blocks protein domain: IPB003604 Zn-finger
UniProtKB/Swiss-Prot: ZN622_HUMAN, Q969S3Similarity: Contains 2 U1-type zinc fingers
ZNF622 for domains About GeneDecksing
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Function
for ZNF622 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
Vector BioLabs,
and Sirion Biotech,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZN622_HUMAN, Q969S3Function: May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic
development Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF622 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for ZNF622:
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for ZNF622 | |  | Search LifeMap BioReagents cell lines for ZNF622 | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF622 |
Pathways & Interactions
for ZNF622 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF622
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/92 Interacting proteins for ZNF622 (Q969S31, 2, 3 ENSP000003100424) via UniProtKB, MINT, STRING, and/or I2D (see all 92)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress |
IDA | -- | | GO:0033674 | positive regulation of kinase activity |
IDA | -- | | GO:0043065 | positive regulation of apoptotic process |
IDA | -- | | GO:0043410 | positive regulation of MAPK cascade |
IDA | -- | | GO:0046330 | positive regulation of JNK cascade |
IMP | -- |
ZNF622 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF622 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF622 (ZN622)
Search CenterWatch for drugs/clinical trials and news about ZNF622 / ZN622
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Transcripts
for ZNF622 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Sirion Biotech,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF622 gene: NM_033414.2 Unigene Cluster for ZNF622: Zinc finger protein 622 Hs.60300 [show with all ESTs]Unigene Representative Sequence: BC0087521 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000308683(uc003jfq.3)
Primer
Products: |  | OriGene qPCR primer pairs and template standards for ZNF622
OriGene qSTAR qPCR primer pairs in human, mouse for ZNF622
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF622 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF622 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF622 |
Additional mRNA sequence: AY046059.1 BC008752.2 BC010545.1 7 DOTS entries: DT.214516 DT.100803408 DT.97833608 DT.214515 DT.100803409 DT.91759562 DT.99956964 24/192 AceView cDNA sequences (see all 192): BE794037 BQ070666 CA448449 CR624583 AI624462 AV708897 CR591618 BC008752 BM701410 BF724659 BU627856 AW009850 BQ000939 BM674316 CR599167 BF437635 AI478351 CR604339 BM975670 AV708572 BM824811 BM810137 CB108210 CA417235
GeneLoc Exon Structure
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Expression
for ZNF622 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF622 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CAGTATGTCC
About this image
See ZNF622 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF622
SOURCE GeneReport for Unigene cluster: Hs.60300
UniProtKB/Swiss-Prot: ZN622_HUMAN, Q969S3Tissue specificity: Expressed in lung, kidney, spleen, liver and brain with lowest expression in kidney
SABiosciences Custom PCR Arrays for ZNF622
Primer
Products: | | OriGene qPCR primer pairs and template standards for ZNF622
OriGene qSTAR qPCR primer pairs in human, mouse for ZNF622
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF622 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF622 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF622 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF622 |
Orthologs
for ZNF622 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZNF622 gene from 10/23 species (see all 23) About this table
ENSEMBL Gene Tree for ZNF622 (if available)
TreeFam Gene Tree for ZNF622 (if available) |
Paralogs
for ZNF622 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF622 gene
ZNF622 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF622
PGOHUM00000241619
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Genomic Variants
for ZNF622 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF622 (16451628 - 16465901 bp)
Structural Variations
Database of Genomic Variants (DGV) 1 variation for ZNF622: About this table
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF622 |
|
Disorders
/ Diseases
for ZNF622 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF622 for disorders About MalaCards
OMIM gene information: 608694
OMIM disorders: --
ZNF622 for disorders About GeneDecksing
Genetic Association Database (GAD): ZNF622
Export disorders for ZNF622 gene to outside databases
|
Publications
for ZNF622 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF622 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with ZNF622) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38). (PubMed id 11802789)1, 2, 3, 9 Seong H.-A.... Ha H. (2002)
- Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein. (PubMed id 12645566)1, 2, 3 Seong H.A.... Ha H. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Thioredoxin inhibits MPK38-induced ASK1, TGF-b, and p5 3 function in a phosphorylation-dependent manner. (PubMed id 23747528)1 Manoharan R....Ha H. (2013)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Positive regulation of apoptosis signal-regulating ki nase 1 signaling by ZPR9 protein, a zinc finger protein. (PubMed id 21771788)1 Seong H.A....Ha H. (2011)
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External Searches for ZNF622 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ZNF622 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF622 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF622 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF622 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ZNF622 gene:
Search GeneIP for patents involving ZNF622
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF622 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF622 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF622 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF622 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF622 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF622 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF622 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF622 |
|  |  |  |  | | | | ThermoFisher Antibodies for ZNF622 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF622 |
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