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Aliases for ZNF622 Gene

Aliases for ZNF622 Gene

  • Zinc Finger Protein 622 2 3
  • Zinc Finger-Like Protein 9 3 4
  • ZPR9 3 4

External Ids for ZNF622 Gene

Previous GeneCards Identifiers for ZNF622 Gene

  • GC05M016505
  • GC05M016506
  • GC05M016507

Summaries for ZNF622 Gene

GeneCards Summary for ZNF622 Gene

ZNF622 (Zinc Finger Protein 622) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and poly(A) RNA binding.

UniProtKB/Swiss-Prot for ZNF622 Gene

  • May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF622 Gene

Genomics for ZNF622 Gene

Regulatory Elements for ZNF622 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF622 Gene

Chromosome:
5
Start:
16,451,519 bp from pter
End:
16,470,327 bp from pter
Size:
18,809 bases
Orientation:
Minus strand

Genomic View for ZNF622 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF622 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF622 Gene

Proteins for ZNF622 Gene

  • Protein details for ZNF622 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969S3-ZN622_HUMAN
    Recommended name:
    Zinc finger protein 622
    Protein Accession:
    Q969S3

    Protein attributes for ZNF622 Gene

    Size:
    477 amino acids
    Molecular mass:
    54272 Da
    Quaternary structure:
    • Homo- and heterodimer. Interacts with MELK and MYBL2.

neXtProt entry for ZNF622 Gene

Proteomics data for ZNF622 Gene at MOPED

Post-translational modifications for ZNF622 Gene

  • Phosphorylated by MELK. The phosphorylation may redirect the protein to the nucleus.
  • Ubiquitination at Lys 75 and Lys 116
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF622 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF622 Gene

Domains & Families for ZNF622 Gene

Protein Domains for ZNF622 Gene

Suggested Antigen Peptide Sequences for ZNF622 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969S3

UniProtKB/Swiss-Prot:

ZN622_HUMAN :
  • Contains 2 U1-type zinc fingers.
Similarity:
  • Contains 2 U1-type zinc fingers.
genes like me logo Genes that share domains with ZNF622: view

No data available for Gene Families for ZNF622 Gene

Function for ZNF622 Gene

Molecular function for ZNF622 Gene

UniProtKB/Swiss-Prot Function:
May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development

Gene Ontology (GO) - Molecular Function for ZNF622 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 21771788
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNF622: view

Phenotypes for ZNF622 Gene

GenomeRNAi human phenotypes for ZNF622:
genes like me logo Genes that share phenotypes with ZNF622: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF622 Gene

Localization for ZNF622 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF622 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF622 Gene COMPARTMENTS Subcellular localization image for ZNF622 gene
Compartment Confidence
golgi apparatus 4
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF622 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0022625 cytosolic large ribosomal subunit IBA --
GO:0030687 preribosome, large subunit precursor IBA --
genes like me logo Genes that share ontologies with ZNF622: view

Pathways & Interactions for ZNF622 Gene

SuperPathways for ZNF622 Gene

No Data Available

SIGNOR curated interactions for ZNF622 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ZNF622 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IDA 21771788
GO:0033674 positive regulation of kinase activity IDA 21771788
GO:0042273 ribosomal large subunit biogenesis IBA --
GO:0043065 positive regulation of apoptotic process IDA 21771788
GO:0043410 positive regulation of MAPK cascade IDA 21771788
genes like me logo Genes that share ontologies with ZNF622: view

No data available for Pathways by source for ZNF622 Gene

Drugs & Compounds for ZNF622 Gene

No Compound Related Data Available

Transcripts for ZNF622 Gene

mRNA/cDNA for ZNF622 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(192) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF622 Gene

Zinc finger protein 622:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF622

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF622 Gene

No ASD Table

Relevant External Links for ZNF622 Gene

GeneLoc Exon Structure for
ZNF622
ECgene alternative splicing isoforms for
ZNF622

Expression for ZNF622 Gene

mRNA expression in normal human tissues for ZNF622 Gene

Protein differential expression in normal tissues from HIPED for ZNF622 Gene

This gene is overexpressed in Lung (65.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF622 Gene



SOURCE GeneReport for Unigene cluster for ZNF622 Gene Hs.60300

mRNA Expression by UniProt/SwissProt for ZNF622 Gene

Q969S3-ZN622_HUMAN
Tissue specificity: Expressed in lung, kidney, spleen, liver and brain with lowest expression in kidney.
genes like me logo Genes that share expression patterns with ZNF622: view

Protein tissue co-expression partners for ZNF622 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF622 Gene

Orthologs for ZNF622 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZNF622 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF622 35
  • 85.53 (n)
  • 85.32 (a)
ZNF622 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF622 35
  • 84.87 (n)
  • 81.29 (a)
ZNF622 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp622 35
  • 85.04 (n)
  • 84.04 (a)
Zfp622 16
Zfp622 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF622 35
  • 97.55 (n)
  • 96.85 (a)
ZNF622 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp622 35
  • 86.38 (n)
  • 87.87 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF622 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF622 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF622 35
  • 72.76 (n)
  • 72.76 (a)
ZNF622 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF622 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10152 35
znf622 35
  • 68.63 (n)
  • 71.9 (a)
zebrafish
(Danio rerio)
Actinopterygii wufb64b07 35
znf622 35
  • 67.04 (n)
  • 67.12 (a)
znf622 36
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002118 35
  • 53.86 (n)
  • 50.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6769 35
  • 55.62 (n)
  • 49.57 (a)
CG6769 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C16A3.4 35
  • 48.21 (n)
  • 42.62 (a)
C16A3.4 36
  • 37 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes REH1 36
  • 27 (a)
OneToMany
REI1 36
  • 31 (a)
OneToMany
REH1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons FZF 35
  • 48.42 (n)
  • 40.98 (a)
rice
(Oryza sativa)
Liliopsida Os06g0693500 35
  • 50.16 (n)
  • 38.34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8710 36
  • 42 (a)
OneToOne
Species with no ortholog for ZNF622:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF622 Gene

ENSEMBL:
Gene Tree for ZNF622 (if available)
TreeFam:
Gene Tree for ZNF622 (if available)

Paralogs for ZNF622 Gene

Pseudogenes.org Pseudogenes for ZNF622 Gene

genes like me logo Genes that share paralogs with ZNF622: view

No data available for Paralogs for ZNF622 Gene

Variants for ZNF622 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF622 Gene

Variant ID Type Subtype PubMed ID
esv269198 CNV Insertion 20981092

Variation tolerance for ZNF622 Gene

Residual Variation Intolerance Score: 14.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF622 Gene

HapMap Linkage Disequilibrium report
ZNF622

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for ZNF622 Gene

Disorders for ZNF622 Gene

Relevant External Links for ZNF622

Genetic Association Database (GAD)
ZNF622
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF622
genes like me logo Genes that share disorders with ZNF622: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF622 Gene

Publications for ZNF622 Gene

  1. Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38). (PMID: 11802789) Seong H.-A. … Ha H. (Biochem. J. 2002) 2 23 67
  2. Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein. (PMID: 12645566) Seong H.A. … Ha H. (J. Biol. Chem. 2003) 2 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 67
  5. Thioredoxin inhibits MPK38-induced ASK1, TGF-I^, and p53 function in a phosphorylation-dependent manner. (PMID: 23747528) Manoharan R. … Ha H. (Free Radic. Biol. Med. 2013) 67

Products for ZNF622 Gene

Sources for ZNF622 Gene

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