Aliases for ZNF622 Gene
External Ids for ZNF622 Gene
- HGNC: 30958
- Entrez Gene: 90441
- Ensembl: ENSG00000173545
- OMIM: 608694
- UniProtKB: Q969S3
Previous GeneCards Identifiers for ZNF622 Gene
- GC05M016505
- GC05M016506
- GC05M016507
Summaries for ZNF622 Gene
GeneCards Summary for ZNF622 Gene
ZNF622 (Zinc Finger Protein 622) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.
UniProtKB/Swiss-Prot for ZNF622 Gene
-
May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development.
Additional gene information for ZNF622 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF622 Gene
Genomics for ZNF622 Gene
GeneHancer (GH) Regulatory Elements for ZNF622 Gene
Promoters and enhancers for ZNF622 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH05I016460 | Promoter/Enhancer | 2.3 | EPDnew Ensembl ENCODE dbSUPER | 550.4 | +5.9 | 5858 | 7.8 | HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B | GC05P016465 ZNF622 LINC02150 FBXL7 GC05P016453 | |
GH05I016468 | Enhancer | 0.3 | dbSUPER | 550.8 | +0.9 | 918 | 1.1 | ZNF362 | ZNF622 ENSG00000250415 RETREG1 LINC02150 GC05P016465 | |
GH05I016470 | Enhancer | 0.2 | dbSUPER | 550.8 | -1.0 | -952 | 1.1 | ZNF622 LINC02150 ENSG00000250415 RETREG1 LOC101929524 | ||
GH05I016491 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE dbSUPER | 17.5 | -22.6 | -22632 | 2.6 | RFX1 NFIB ZNF384 DPF2 E2F1 GATA3 JUND SCRT2 NFE2 FOS | ZNF622 RETREG1 LOC101929524 | |
GH05I016505 | Promoter/Enhancer | 1.7 | EPDnew Ensembl ENCODE dbSUPER | 11.3 | -38.0 | -37950 | 4.6 | FOXA2 KLF17 RAD21 RFX5 YY1 ZNF335 RCOR1 ELK4 SMARCC1 NFYA | RETREG1 ZNF622 LOC101929524 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ZNF622 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ZNF622 Gene
Genomic Locations for ZNF622 Gene
- chr5:16,451,519-16,470,327
- (GRCh38/hg38)
- Size:
- 18,809 bases
- Orientation:
- Minus strand
- chr5:16,451,628-16,465,901
- (GRCh37/hg19)
Genomic View for ZNF622 Gene
Genes around ZNF622 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5p15.1 by Ensembl
- 5p15.1 by Entrez Gene
- 5p15.1 by HGNC
ZNF622 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)


RefSeq DNA sequence for ZNF622 Gene
Proteins for ZNF622 Gene
-
Protein details for ZNF622 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q969S3-ZN622_HUMAN
- Recommended name:
- Zinc finger protein 622
- Protein Accession:
- Q969S3
Protein attributes for ZNF622 Gene
- Size:
- 477 amino acids
- Molecular mass:
- 54272 Da
- Quaternary structure:
-
- Homo- and heterodimer. Interacts with MELK and MYBL2 (PubMed:11802789, PubMed:12645566). Interacts with DNAJC21 (PubMed:27346687).
Protein Expression for ZNF622 Gene
Post-translational modifications for ZNF622 Gene
- Phosphorylated by MELK. The phosphorylation may redirect the protein to the nucleus.
- Ubiquitination at posLast=7575 and isoforms=116
Other Protein References for ZNF622 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
Abcam antibodies for ZNF622
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-
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Protein Products
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Abcam proteins for ZNF622
Assay Products
No data available for DME Specific Peptides for ZNF622 Gene
Domains & Families for ZNF622 Gene
Gene Families for ZNF622 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ZNF622 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF622 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ZNF622 Gene
Function for ZNF622 Gene
Molecular function for ZNF622 Gene
- UniProtKB/Swiss-Prot Function:
- May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development.
Phenotypes From GWAS Catalog for ZNF622 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | HDA,IDA | 22658674 |
GO:0005515 | protein binding | IPI | 21771788 |
GO:0008270 | zinc ion binding | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZNF622 Gene
- GenomeRNAi human phenotypes for ZNF622:
Animal Model Products
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CRISPR Products
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OriGene CRISPR knockouts for ZNF622
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-
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miRNA for ZNF622 Gene
- miRTarBase miRNAs that target ZNF622
-
- hsa-mir-16-5p (MIRT001395)
- hsa-mir-1-3p (MIRT023928)
- hsa-mir-103a-3p (MIRT027111)
- hsa-mir-92a-3p (MIRT049311)
- hsa-mir-4524b-5p (MIRT500303)
- hsa-mir-6895-3p (MIRT500304)
- hsa-mir-4524a-5p (MIRT500305)
- hsa-mir-548x-5p (MIRT500306)
- hsa-mir-548g-5p (MIRT500307)
- hsa-mir-548f-5p (MIRT500308)
- hsa-mir-5585-5p (MIRT500309)
- hsa-mir-548aj-5p (MIRT500310)
- hsa-mir-548ax (MIRT500311)
- hsa-mir-6845-3p (MIRT500312)
- hsa-mir-548ao-5p (MIRT500313)
- hsa-mir-545-3p (MIRT500314)
- hsa-mir-589-3p (MIRT500315)
- hsa-mir-1182 (MIRT500316)
- hsa-mir-646 (MIRT500317)
- hsa-mir-548p (MIRT500318)
- hsa-mir-562 (MIRT500319)
- hsa-mir-503-5p (MIRT500320)
- hsa-mir-15a-5p (MIRT500321)
- hsa-mir-15b-5p (MIRT500322)
- hsa-mir-195-5p (MIRT500323)
- hsa-mir-424-5p (MIRT500324)
- hsa-mir-497-5p (MIRT500325)
- hsa-mir-6838-5p (MIRT500326)
- hsa-mir-6888-3p (MIRT519684)
- hsa-mir-202-5p (MIRT519685)
- hsa-mir-3120-5p (MIRT519686)
miRNA Products
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Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF622 Gene
Localization for ZNF622 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF622 Gene
- Cytoplasm. Nucleus.
- Cytosol (4)
- Nucleus (4)
- Nucleoli (3)
- Golgi apparatus (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | -- |
GO:0005730 | nucleolus | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005794 | Golgi apparatus | IDA | -- |
GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for ZNF622 Gene
No Data Available
Interacting Proteins for ZNF622 Gene
Selected Interacting proteins:
ENSP00000310042
Q969S3-ZN622_HUMAN
for ZNF622 Gene via
STRING
IID
UniProtKB
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress | IDA | 21771788 |
GO:0033674 | positive regulation of kinase activity | IDA | 21771788 |
GO:0042273 | ribosomal large subunit biogenesis | IBA | -- |
GO:0043065 | positive regulation of apoptotic process | IDA | 21771788 |
GO:0043410 | positive regulation of MAPK cascade | IDA | 21771788 |
No data available for Pathways by source for ZNF622 Gene
Transcripts for ZNF622 Gene
mRNA/cDNA for ZNF622 Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (192) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZNF622 Gene
CRISPR Products
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OriGene CRISPR knockouts for ZNF622
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF622
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Inhibitory RNA Products
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-
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Clone Products
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- Applied Biological Materials Clones for ZNF622
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ZNF622 Gene
This gene is overexpressed in Lung (65.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF622 Gene
NURSA nuclear receptor signaling pathways regulating expression of ZNF622 Gene:
ZNF622SOURCE GeneReport for Unigene cluster for ZNF622 Gene:
Hs.60300mRNA Expression by UniProt/SwissProt for ZNF622 Gene:
Q969S3-ZN622_HUMAN
Tissue specificity:
Expressed in lung, kidney, spleen, liver and brain with lowest expression in kidney.
Evidence on tissue expression from TISSUES for ZNF622 Gene
- Skin(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for ZNF622
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OriGene qPCR primer pairs for ZNF622
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF622 Gene
Orthologs for ZNF622 Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ZNF622 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Zfp622 33 |
|
||
cow (Bos Taurus) |
Mammalia | ZNF622 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Zfp622 33 16 34 |
|
||
dog (Canis familiaris) |
Mammalia | ZNF622 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | ZNF622 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | ZNF622 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | ZNF622 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | ZNF622 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | znf622 33 |
|
||
Str.10152 33 |
|
||||
zebrafish (Danio rerio) |
Actinopterygii | znf622 33 34 |
|
||
wufb64b07 33 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | CG6769 33 34 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002118 33 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | C16A3.4 33 34 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | REI1 34 |
|
OneToMany | |
REH1 34 36 |
|
OneToMany | |||
thale cress (Arabidopsis thaliana) |
eudicotyledons | FZF 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os06g0693500 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8710 34 |
|
OneToOne |
- Species where no ortholog for ZNF622 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ZNF622 Gene
Pseudogenes.org Pseudogenes for ZNF622 Gene
No data available for Paralogs for ZNF622 Gene
Variants for ZNF622 Gene
SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000081874 | -- | 16,456,032(-) | G/A | intron_variant | |
rs1000254191 | -- | 16,454,157(-) | A/G | intron_variant | |
rs1000909423 | -- | 16,461,826(-) | G/C | intron_variant | |
rs1000950932 | -- | 16,455,011(-) | A/T | intron_variant | |
rs1001085413 | -- | 16,454,765(-) | T/C | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3430353 | CNV | insertion | 20981092 |
Residual Variation Intolerance Score:
14.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.02;
37.16% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF622 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZNF622
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF622 Gene
Disorders for ZNF622 Gene
Additional Disease Information for ZNF622
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for ZNF622 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF622 Gene
Publications for ZNF622 Gene
- Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38). (PMID: 11802789) Seong HA … Ha H (The Biochemical journal 2002) 2 3 4 22 58
- Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein. (PMID: 12645566) Seong HA … Ha H (The Journal of biological chemistry 2003) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- DNAJC21 Mutations Link a Cancer-Prone Bone Marrow Failure Syndrome to Corruption in 60S Ribosome Subunit Maturation. (PMID: 27346687) Tummala H … Vulliamy T (American journal of human genetics 2016) 4 58
Products for ZNF622 Gene
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Sources for ZNF622 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
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