Aliases for ZNF622 Gene
External Ids for ZNF622 Gene
- HGNC: 30958
- Entrez Gene: 90441
- Ensembl: ENSG00000173545
- OMIM: 608694
- UniProtKB: Q969S3
Previous GeneCards Identifiers for ZNF622 Gene
- GC05M016505
- GC05M016506
- GC05M016507
Summaries for ZNF622 Gene
GeneCards Summary for ZNF622 Gene
ZNF622 (Zinc Finger Protein 622) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and poly(A) RNA binding.
UniProtKB/Swiss-Prot for ZNF622 Gene
-
May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development.
No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF622 Gene
Genomics for ZNF622 Gene
Regulatory Elements for ZNF622 Gene
Enhancers for ZNF622 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around ZNF622 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ZNF622 gene promoter:
Regulatory Element Products
Genomic Location for ZNF622 Gene
- Chromosome:
- 5
- Start:
- 16,451,519 bp from pter
- End:
- 16,470,327 bp from pter
- Size:
- 18,809 bases
- Orientation:
- Minus strand
Genomic View for ZNF622 Gene
Genes around ZNF622 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5p15.1 by Ensembl
- 5p15.1 by Entrez Gene
- 5p15.1 by HGNC
ZNF622 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF622 Gene
Proteins for ZNF622 Gene
-
Protein details for ZNF622 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q969S3-ZN622_HUMAN
- Recommended name:
- Zinc finger protein 622
- Protein Accession:
- Q969S3
Protein attributes for ZNF622 Gene
- Size:
- 477 amino acids
- Molecular mass:
- 54272 Da
- Quaternary structure:
-
- Homo- and heterodimer. Interacts with MELK and MYBL2.
Protein Expression for ZNF622 Gene
Post-translational modifications for ZNF622 Gene
- Phosphorylated by MELK. The phosphorylation may redirect the protein to the nucleus.
- Ubiquitination at Lys 75 and Lys 116
- Modification sites at PhosphoSitePlus
Other Protein References for ZNF622 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ZNF622
- antibodies-online Antibodies for ZNF622: See all 42
- Search GeneTex for Antibodies for ZNF622
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZNF622
Protein Products
-
OriGene Purified Proteins for ZNF622
- Search Origene for MassSpec and Protein Over-expression Lysates for ZNF622
- Origene Custom Protein Services for ZNF622
- antibodies-online Proteins for ZNF622: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ZNF622
Assay Products
- antibodies-online Kits for ZNF622: See all 10
No data available for DME Specific Peptides for ZNF622 Gene
Domains & Families for ZNF622 Gene
Protein Domains for ZNF622 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF622 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q969S3- Similarity:
-
- Contains 2 U1-type zinc fingers.
No data available for Gene Families for ZNF622 Gene
Function for ZNF622 Gene
Molecular function for ZNF622 Gene
- UniProtKB/Swiss-Prot Function:
- May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development.
Phenotypes for ZNF622 Gene
- GenomeRNAi human phenotypes for ZNF622:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for ZNF622 gene
-
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- Search ViGene Biosciences for ZNF622
CRISPR Products
-
OriGene CRISPR knockouts for ZNF622
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF622
- GenScript: Design CRISPR guide RNA sequences for ZNF622
miRNA for ZNF622 Gene
- miRTarBase miRNAs that target ZNF622
-
- hsa-mir-16-5p (MIRT001395)
- hsa-mir-1-3p (MIRT023928)
- hsa-mir-103a-3p (MIRT027111)
- hsa-mir-92a-3p (MIRT049311)
- hsa-mir-4524b-5p (MIRT500303)
- hsa-mir-6895-3p (MIRT500304)
- hsa-mir-4524a-5p (MIRT500305)
- hsa-mir-548x-5p (MIRT500306)
- hsa-mir-548g-5p (MIRT500307)
- hsa-mir-548f-5p (MIRT500308)
- hsa-mir-5585-5p (MIRT500309)
- hsa-mir-548aj-5p (MIRT500310)
- hsa-mir-548ax (MIRT500311)
- hsa-mir-6845-3p (MIRT500312)
- hsa-mir-548ao-5p (MIRT500313)
- hsa-mir-545-3p (MIRT500314)
- hsa-mir-589-3p (MIRT500315)
- hsa-mir-1182 (MIRT500316)
- hsa-mir-646 (MIRT500317)
- hsa-mir-548p (MIRT500318)
- hsa-mir-562 (MIRT500319)
- hsa-mir-503-5p (MIRT500320)
- hsa-mir-15a-5p (MIRT500321)
- hsa-mir-15b-5p (MIRT500322)
- hsa-mir-195-5p (MIRT500323)
- hsa-mir-424-5p (MIRT500324)
- hsa-mir-497-5p (MIRT500325)
- hsa-mir-6838-5p (MIRT500326)
- hsa-mir-6888-3p (MIRT519684)
- hsa-mir-202-5p (MIRT519685)
- hsa-mir-3120-5p (MIRT519686)
miRNA Products
- Search ViGene Biosciences for ZNF622
Inhibitory RNA Products
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for ZNF622
- Browse OriGene Inhibitory RNA Products For ZNF622
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF622 gene
Clone Products
- OriGene clones in human for ZNF622
- OriGene ORF clones in human for ZNF622
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for ZNF622 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ZNF622 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF622 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF622 Gene
Localization for ZNF622 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF622 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| nucleus | 5 |
| cytosol | 4 |
No data available for Gene Ontology (GO) - Cellular Components for ZNF622 Gene
Pathways & Interactions for ZNF622 Gene
More details on SuperPathways for ZNF622
No Data Available
Interacting Proteins for ZNF622 Gene
Selected Interacting proteins:
Q969S3-ZN622_HUMAN
ENSP00000310042
for ZNF622 Gene via
MINT
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0033674 | positive regulation of kinase activity | IDA | 21771788 |
| GO:0046330 | positive regulation of JNK cascade | IMP | 21771788 |
No data available for Pathways by source for ZNF622 Gene
Transcripts for ZNF622 Gene
mRNA/cDNA for ZNF622 Gene
- (2) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (192) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZNF622 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZNF622
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF622
- GenScript: Design CRISPR guide RNA sequences for ZNF622
miRNA Products
- Search ViGene Biosciences for ZNF622
Inhibitory RNA Products
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for ZNF622
- Browse OriGene Inhibitory RNA Products For ZNF622
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF622 gene
Clone Products
- OriGene clones in human for ZNF622
- OriGene ORF clones in human for ZNF622
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for ZNF622 Gene
This gene is overexpressed in Lung (65.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF622 Gene
SOURCE GeneReport for Unigene cluster for ZNF622 Gene Hs.60300
mRNA Expression by UniProt/SwissProt for ZNF622 Gene
Q969S3-ZN622_HUMAN
Tissue specificity:
Expressed in lung, kidney, spleen, liver and brain with lowest expression in kidney.
Primer Products
-
OriGene qPCR primer pairs for ZNF622
-
OriGene qPCR primer pairs and template standards for ZNF622
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF622 Gene
Orthologs for ZNF622 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | ZNF622 35 |
|
||
| ZNF622 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | ZNF622 35 |
|
||
| ZNF622 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Zfp622 35 |
|
||
| Zfp622 16 |
|
||||
| Zfp622 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | ZNF622 35 |
|
||
| ZNF622 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Zfp622 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ZNF622 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ZNF622 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ZNF622 35 |
|
||
| ZNF622 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | ZNF622 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.10152 35 |
|
||
| znf622 35 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | wufb64b07 35 |
|
||
| znf622 35 |
|
||||
| znf622 36 |
|
OneToOne | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002118 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG6769 35 |
|
||
| CG6769 36 |
|
OneToOne | |||
| worm (Caenorhabditis elegans) |
Secernentea | C16A3.4 35 |
|
||
| C16A3.4 36 |
|
OneToOne | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | REH1 36 |
|
OneToMany | |
| REI1 36 |
|
OneToMany | |||
| REH1 38 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | FZF 35 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os06g0693500 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8710 36 |
|
OneToOne |
- Species with no ortholog for ZNF622:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ZNF622 Gene
Pseudogenes.org Pseudogenes for ZNF622 Gene
No data available for Paralogs for ZNF622 Gene
Variants for ZNF622 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs26013 | -- | 16,464,040(+) | TCCTA(C/T)CTGCC | intron-variant | |
| rs26014 | -- | 16,471,296(+) | CCACA(A/G)AATCA | upstream-variant-2KB | |
| rs26017 | -- | 16,451,322(-) | ACTTT(C/G)AGAGT | downstream-variant-500B | |
| rs26018 | -- | 16,454,261(-) | atccg(C/T)ccacc | intron-variant | |
| rs26019 | -- | 16,454,380(-) | ctccc(A/G)agtag | intron-variant |
Residual Variation Intolerance Score:
14.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.02;
37.16% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF622 Gene
Disorders for ZNF622 Gene
Relevant External Links for ZNF622
No disorders were found for ZNF622 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF622 Gene
Publications for ZNF622 Gene
- Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38). (PMID: 11802789) Seong H.-A. … Ha H. (Biochem. J. 2002) 2 3 4 23 67
- Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc finger protein. (PMID: 12645566) Seong H.A. … Ha H. (J. Biol. Chem. 2003) 2 3
- Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
- A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
Products for ZNF622 Gene
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- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- OriGene qPCR primer pairs for ZNF622
- OriGene qPCR primer pairs and template standards for ZNF622
- OriGene CRISPR knockouts for ZNF622
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for ZNF622: See all 42
- antibodies-online Kits for ZNF622: See all 10
- antibodies-online Proteins for ZNF622: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for ZNF622
- Search GeneTex for Proteins for ZNF622
- ViGene Biosciences adenoviral particle packaged cDNA for ZNF622 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ZNF622 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ZNF622 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ZNF622 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ZNF622 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ZNF622 gene
- Search ViGene Biosciences for ZNF622
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- Santa Cruz Biotechnology (SCBT) Antibodies for ZNF622
- Search Santa Cruz Biotechnology (SCBT) for ZNF622 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ZNF622
Sources for ZNF622 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon