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Aliases for ZNF621 Gene

Aliases for ZNF621 Gene

  • Zinc Finger Protein 621 2 3

External Ids for ZNF621 Gene

Previous GeneCards Identifiers for ZNF621 Gene

  • GC03P040527
  • GC03P040541

Summaries for ZNF621 Gene

GeneCards Summary for ZNF621 Gene

ZNF621 (Zinc Finger Protein 621) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF662.

UniProtKB/Swiss-Prot for ZNF621 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF621 Gene

Genomics for ZNF621 Gene

Regulatory Elements for ZNF621 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF621 Gene

40,524,878 bp from pter
40,574,685 bp from pter
49,808 bases
Plus strand

Genomic View for ZNF621 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF621 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF621 Gene

Proteins for ZNF621 Gene

  • Protein details for ZNF621 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 621
    Protein Accession:
    Secondary Accessions:
    • Q14DC7
    • Q8TE91

    Protein attributes for ZNF621 Gene

    439 amino acids
    Molecular mass:
    49205 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF621 Gene


neXtProt entry for ZNF621 Gene

Proteomics data for ZNF621 Gene at MOPED

Post-translational modifications for ZNF621 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF621 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF621 Gene

Domains for ZNF621 Gene

Gene Families for ZNF621 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF621 Gene

Suggested Antigen Peptide Sequences for ZNF621 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6ZSS3
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF621: view

Function for ZNF621 Gene

Molecular function for ZNF621 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF621 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF621: view

Animal Model Products

CRISPR Products

miRNA for ZNF621 Gene

miRTarBase miRNAs that target ZNF621

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF621 Gene

Localization for ZNF621 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF621 Gene

Subcellular locations from

Jensen Localization Image for ZNF621 Gene COMPARTMENTS Subcellular localization image for ZNF621 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF621 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF621: view

Pathways for ZNF621 Gene

SuperPathways for ZNF621 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF621: view

Pathways by source for ZNF621 Gene

2 Reactome pathways for ZNF621 Gene

Interacting Proteins for ZNF621 Gene

Gene Ontology (GO) - Biological Process for ZNF621 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF621: view

Transcripts for ZNF621 Gene

Unigene Clusters for ZNF621 Gene

Zinc finger protein 621:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF621

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF621 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6: - - -

Relevant External Links for ZNF621 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF621 Gene

mRNA expression in normal human tissues for ZNF621 Gene

Protein differential expression in normal tissues for ZNF621 Gene

This gene is overexpressed in Monocytes (34.3) and Blymphocyte (20.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF621 Gene

SOURCE GeneReport for Unigene cluster for ZNF621 Gene Hs.19977

genes like me logo Genes that share expressions with ZNF621: view

Expression partners for ZNF621 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF621 Gene

Orthologs for ZNF621 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF621 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100849024 35
  • 84.6 (n)
  • 83.14 (a)
(Pan troglodytes)
Mammalia ZNF621 35
  • 99.62 (n)
  • 99.09 (a)
ZNF621 36
  • 99 (a)
(Canis familiaris)
Mammalia ZNF621 36
  • 87 (a)
Species with no ortholog for ZNF621:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF621 Gene

Gene Tree for ZNF621 (if available)
Gene Tree for ZNF621 (if available)

Paralogs for ZNF621 Gene

Paralogs for ZNF621 Gene

Selected SIMAP similar genes for ZNF621 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF621: view

Variants for ZNF621 Gene

Sequence variations from dbSNP and Humsavar for ZNF621 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs12520 -- 40,538,896(-) TCCAC(C/T)GAAGT utr-variant-3-prime
rs1142464 -- 40,539,522(+) TAGGT(A/G)CTGGA utr-variant-3-prime
rs3924444 -- 40,534,570(+) ATGTG(C/T)CTGAA utr-variant-3-prime, intron-variant
rs4264703 -- 40,534,405(+) GAACT(A/T)GAATT utr-variant-3-prime, intron-variant
rs4602359 -- 40,537,866(+) tagct(A/G)agtta utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF621 Gene

Variant ID Type Subtype PubMed ID
nsv876716 CNV Gain 21882294

Relevant External Links for ZNF621 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF621 Gene

Disorders for ZNF621 Gene

No disorders were found for ZNF621 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ZNF621 Gene

Publications for ZNF621 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF621 Gene

Sources for ZNF621 Gene

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