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Aliases for ZNF621 Gene

Aliases for ZNF621 Gene

  • Zinc Finger Protein 621 2 3 5

External Ids for ZNF621 Gene

Previous GeneCards Identifiers for ZNF621 Gene

  • GC03P040527
  • GC03P040541

Summaries for ZNF621 Gene

GeneCards Summary for ZNF621 Gene

ZNF621 (Zinc Finger Protein 621) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF619.

UniProtKB/Swiss-Prot for ZNF621 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF621 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF621 Gene

Genomics for ZNF621 Gene

Regulatory Elements for ZNF621 Gene

Enhancers for ZNF621 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H041173 0.5 ENCODE 5.4 +651.3 651255 4 HLF ZIC2 TRIM28 ZNF621 ENSG00000233919 MRPS31P1
GH03H040523 1.1 ENCODE 0.7 +0.6 639 2 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZNF619 CTNNB1 ENTPD3-AS1 ZNF621 GC03M040586
GH03H040503 1.1 ENCODE 0.4 -18.9 -18887 2 PKNOX1 FOXA2 ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF143 FOS ZHX2 ZNF619 RPL14 ENTPD3-AS1 ZNF620 ZNF621
GH03H040584 1.1 Ensembl ENCODE 0.2 +60.7 60662 1 CTCF FOXA2 MXI1 RB1 MAX BATF RAD21 TEAD3 POLR2A SMC3 ENTPD3-AS1 CTNNB1 GC03M040586 ZNF621
GH03H040580 0.7 ENCODE 0.2 +56.4 56399 0 CTCF ZNF654 IRF2 ZSCAN26 NFIA SOX6 TRIM22 USF2 REST RAD21 ZNF620 CTNNB1 GC03M040586 ZNF621
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF621 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF621 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000151179 684 1601 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766

Genomic Location for ZNF621 Gene

Chromosome:
3
Start:
40,524,316 bp from pter
End:
40,574,685 bp from pter
Size:
50,370 bases
Orientation:
Plus strand

Genomic View for ZNF621 Gene

Genes around ZNF621 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF621 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF621 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF621 Gene

Proteins for ZNF621 Gene

  • Protein details for ZNF621 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZSS3-ZN621_HUMAN
    Recommended name:
    Zinc finger protein 621
    Protein Accession:
    Q6ZSS3
    Secondary Accessions:
    • Q14DC7
    • Q8TE91

    Protein attributes for ZNF621 Gene

    Size:
    439 amino acids
    Molecular mass:
    49205 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF621 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF621 Gene

Post-translational modifications for ZNF621 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF621 Gene

Domains & Families for ZNF621 Gene

Gene Families for ZNF621 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF621 Gene

Suggested Antigen Peptide Sequences for ZNF621 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZSS3

UniProtKB/Swiss-Prot:

ZN621_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF621: view

Function for ZNF621 Gene

Molecular function for ZNF621 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF621 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF621: view
genes like me logo Genes that share phenotypes with ZNF621: view

Animal Model Products

CRISPR Products

miRNA for ZNF621 Gene

miRTarBase miRNAs that target ZNF621

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF621
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF621 Gene

Localization for ZNF621 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF621 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF621 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF621 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with ZNF621: view

Pathways & Interactions for ZNF621 Gene

SuperPathways for ZNF621 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF621: view

Pathways by source for ZNF621 Gene

2 Reactome pathways for ZNF621 Gene

Gene Ontology (GO) - Biological Process for ZNF621 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF621: view

No data available for SIGNOR curated interactions for ZNF621 Gene

Drugs & Compounds for ZNF621 Gene

No Compound Related Data Available

Transcripts for ZNF621 Gene

Unigene Clusters for ZNF621 Gene

Zinc finger protein 621:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF621
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF621 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6: - - -

Relevant External Links for ZNF621 Gene

GeneLoc Exon Structure for
ZNF621
ECgene alternative splicing isoforms for
ZNF621

Expression for ZNF621 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF621 Gene

Protein differential expression in normal tissues from HIPED for ZNF621 Gene

This gene is overexpressed in Monocytes (34.3) and Blymphocyte (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF621 Gene



Protein tissue co-expression partners for ZNF621 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF621 Gene:

ZNF621

SOURCE GeneReport for Unigene cluster for ZNF621 Gene:

Hs.19977

Evidence on tissue expression from TISSUES for ZNF621 Gene

  • Nervous system(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ZNF621: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF621 Gene

Orthologs for ZNF621 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF621 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF621 33 34
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia ZNF621 34
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC100849024 33
  • 84.6 (n)
Species where no ortholog for ZNF621 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF621 Gene

ENSEMBL:
Gene Tree for ZNF621 (if available)
TreeFam:
Gene Tree for ZNF621 (if available)

Paralogs for ZNF621 Gene

Paralogs for ZNF621 Gene

(498) SIMAP similar genes for ZNF621 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF621: view

Variants for ZNF621 Gene

Sequence variations from dbSNP and Humsavar for ZNF621 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000094609 -- 40,539,779(+) TTTTG(A/G)CAATT utr-variant-3-prime
rs1000172178 -- 40,530,122(+) CCAAG(G/T)AGCCT intron-variant
rs1000205060 -- 40,529,863(+) ATTCT(G/T)TCTGG intron-variant
rs1000500391 -- 40,531,723(+) ATGCC(C/T)GGCTA intron-variant
rs1000530914 -- 40,531,487(+) TCCAG(C/G)CTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF621 Gene

Variant ID Type Subtype PubMed ID
esv2725188 CNV deletion 23290073
esv3595951 CNV loss 21293372

Variation tolerance for ZNF621 Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF621 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF621

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF621 Gene

Disorders for ZNF621 Gene

Relevant External Links for ZNF621

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF621

No disorders were found for ZNF621 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF621 Gene

Publications for ZNF621 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 60

Products for ZNF621 Gene

Sources for ZNF621 Gene

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