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ZNF621 Gene

protein-coding   GIFtS: 46
GCID: GC03P040566

Zinc Finger Protein 621

  Search for ZNF621
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 6211 2

External Ids:    HGNC: 247871   Entrez Gene: 2852682   Ensembl: ENSG000001728887   UniProtKB: Q6ZSS33   
ORGUL members:         

Export aliases for ZNF621 gene to outside databases

Previous GC identifers: GC03P040527 GC03P040541


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF621 Gene:
ZNF621 (zinc finger protein 621) is a protein-coding gene. An important paralog of this gene is ZNF19.

UniProtKB/Swiss-Prot: ZN621_HUMAN, Q6ZSS3
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF621 gene promoter:
         AREB6   C/EBPbeta   Ik-2   Ik-3   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF621 promoter sequence
   Search Chromatin IP Primers for ZNF621

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF621


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.1   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p21.33

ZNF621 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF621 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P040566:  view genomic region     (about GC identifiers)

Start:
40,566,369 bp from pter      End:
40,616,176 bp from pter
Size:
49,808 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN621_HUMAN, Q6ZSS3 (See protein sequence)
Recommended Name: Zinc finger protein 621  
Size: 439 amino acids; 49205 Da
Secondary accessions: Q14DC7 Q8TE91
Alternative splicing: 2 isoforms:  Q6ZSS3-1   Q6ZSS3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF621: NX_Q6ZSS3

Explore proteomics data for ZNF621 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF621 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001091884.1  NP_001274174.1  NP_940886.1  

    ENSEMBL proteins: 
     ENSP00000386051   ENSP00000340841   ENSP00000413236   ENSP00000408779   ENSP00000312144  
    Reactome Protein details: Q6ZSS3

    ZNF621 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZNF621

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    Cloud-Clone Corp. ELISAs for ZNF621
    Cloud-Clone Corp. CLIAs for ZNF621


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6ZSS3

    ProtoNet protein and cluster: Q6ZSS3

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN621_HUMAN, Q6ZSS3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 7 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF621 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN621_HUMAN, Q6ZSS3
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    ZNF621 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF621
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF621
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF621

    miRNA
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    miRTarBase miRNAs that target ZNF621:
    hsa-mir-149-5p (MIRT045546)

    Block miRNA regulation of human, mouse, rat ZNF621 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF621 (see all 10):
    hsa-miR-196a* hsa-miR-548o hsa-miR-3133 hsa-miR-335 hsa-miR-1912 hsa-miR-548m hsa-miR-629* hsa-miR-1323
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF621

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF621


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN621_HUMAN, Q6ZSS3: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF621 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF621 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF621
        Generic Transcription Pathway



    ZNF621 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF621
    Interactions:

        Search GeneGlobe Interaction Network for ZNF621

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    ZNF621 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF621 (ZN621)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF621 gene (3 alternative transcripts): 
    NM_001098414.2  NM_001287245.1  NM_198484.4  

    Unigene Cluster for ZNF621:

    Zinc finger protein 621
    Hs.19977  [show with all ESTs]
    Unigene Representative Sequence: NM_198484
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000403205 ENST00000339296(uc003ckm.2 uc003ckn.2 uc003cko.2 uc011aze.1)
    ENST00000431278 ENST00000490457 ENST00000462161 ENST00000453351 ENST00000492098
    ENST00000310898
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZNF621 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF621 (see all 10):
    hsa-miR-196a* hsa-miR-548o hsa-miR-3133 hsa-miR-335 hsa-miR-1912 hsa-miR-548m hsa-miR-629* hsa-miR-1323
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): ZNF621 (NM_198484)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF621
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF621
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF621
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF621
      QuantiFast Probe-based Assays in human, mouse, rat ZNF621

    Additional mRNA sequence: 

    AK074366.1 BC101619.1 BC113415.1 CR749268.1 

    5 DOTS entries:

    DT.101981767  DT.91865015  DT.120853231  DT.92042620  DT.100019783 

    Selected AceView cDNA sequences (see all 104):

    BU188973 BX457201 BX091128 AA029153 AK127181 AI094286 AI375136 AA430479 
    BQ677703 R40398 N41962 BX951154 AI672426 BQ718780 NM_198484 AI263441 
    BX503658 AW166946 AK074366 AA641212 BE467374 AI032215 N33233 AA373115 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF621 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
    SP1:                                -     -                 -                                             
    SP2:                                      -                 -                                             
    SP3:                                -     -           -                                                   
    SP4:                                                        -                                             
    SP5:                                      -           -     -                                             


    ECgene alternative splicing isoforms for ZNF621

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF621 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTACAGATAA
    ZNF621 Expression
    About this image

    ZNF621 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF621 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.19977
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF621

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF621 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF6216
    zinc finger protein 621
    87(a)
    1 ↔ 1
    23(9966661-9979936)


    ENSEMBL Gene Tree for ZNF621 (if available)
    TreeFam Gene Tree for ZNF621 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF621 gene
    ZNF192  ZNF6202  ZNF6192  ZNF6622  ENSG000002616112  
    Selected SIMAP similar genes for ZNF621 using alignment to 3 protein entries:     ZN621_HUMAN (see all proteins) (see all similar genes):
    ZNF818P    POM121C    ZSCAN23    kr-znf3    FIK    ZNF674
    ZNF283    ZNF300P1    ZNF551    ZNF78L1    ZNF81    ZNF826P
    ZNF23    ZNF271    ZNF510    ZNF70    ZNF761    ZNF211

    ZNF621 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF621 (see all 330)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894446001,2
    --40564391(+) CACCCA/GGCGCA 2 -- us2k10--------
    rs1814130301,2
    --40564447(+) TGTGAA/GTGAGT 2 -- us2k10--------
    rs1141817311,2
    F--40564647(+) TGATTC/TATAGA 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1481408161,2
    C--40564878(+) ATTCCC/TCTTTA 2 -- us2k10--------
    rs801736541,2
    C,F--40564906(+) GTGGTG/CAGGAG 2 -- us2k12Minor allele frequency- C:0.06CSA WA 120
    rs1849915721,2
    --40565068(+) TGGCTA/GACACG 2 -- us2k10--------
    rs1904313211,2
    --40565070(+) GCTAAC/TACGGT 2 -- us2k10--------
    rs728664551,2
    C,F--40565139(+) GTAGTT/CCCAGC 2 -- us2k14Minor allele frequency- C:0.29WA NA CSA 7
    rs76295761,2
    C,F--40565213(+) gattgC/Tgccat 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs97586541,2
    A--40565260(+) tcaaaA/Caaaca 2 -- us2k1 tfbs30--------

    HapMap Linkage Disequilibrium report for ZNF621 (40566369 - 40616176 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF621:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876716CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF621
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF621

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF621 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF621)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 285268 HGNC: 24787 AceView: ZNF621 Ensembl:ENSG00000172888 euGenes: HUgn285268
    ECgene: ZNF621 H-InvDB: ZNF621

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF621 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF621 gene:
    Search GeneIP for patents involving ZNF621

    GeneCards and IP:
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