Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF621 Gene

Aliases for ZNF621 Gene

  • Zinc Finger Protein 621 2 3 5

External Ids for ZNF621 Gene

Previous GeneCards Identifiers for ZNF621 Gene

  • GC03P040527
  • GC03P040541

Summaries for ZNF621 Gene

GeneCards Summary for ZNF621 Gene

ZNF621 (Zinc Finger Protein 621) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF619.

UniProtKB/Swiss-Prot for ZNF621 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF621 Gene

Genomics for ZNF621 Gene

Regulatory Elements for ZNF621 Gene

Enhancers for ZNF621 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F040523 0.6 ENCODE 13.7 +0.6 639 2.2 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3 ZNF621 ZNF619 ENTPD3-AS1 GC03M040586
GH03F040456 0.4 ENCODE 13.1 -66.5 -66515 3.1 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS ENTPD3-AS1 ZNF619 RPL14 ENSG00000234287 ZNF621 ENTPD3 PIR56082
GH03F040298 1.5 FANTOM5 Ensembl ENCODE 13 -224.3 -224339 2.0 PKNOX1 ATF1 ARNT CBX5 FOS NCOA1 CREB3 MBD2 MEF2D SMARCA4 ZNF621 ZNF619 EIF1B ENTPD3-AS1 GC03P040264
GH03F041173 0.9 ENCODE 5.4 +651.3 651255 4.3 ESRRA NCOR1 CEBPA HLF ZNF600 ZIC2 TRIM28 ZNF621 ENSG00000233919 MRPS31P1
GH03F040513 0.2 Ensembl 0.4 -10.3 -10278 0.3 ZBTB33 ZNF620 ZNF621
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF621 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF621 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001361768 784 2201 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3

Genomic Location for ZNF621 Gene

Chromosome:
3
Start:
40,524,316 bp from pter
End:
40,574,685 bp from pter
Size:
50,370 bases
Orientation:
Plus strand

Genomic View for ZNF621 Gene

Genes around ZNF621 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF621 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF621 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF621 Gene

Proteins for ZNF621 Gene

  • Protein details for ZNF621 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZSS3-ZN621_HUMAN
    Recommended name:
    Zinc finger protein 621
    Protein Accession:
    Q6ZSS3
    Secondary Accessions:
    • Q14DC7
    • Q8TE91

    Protein attributes for ZNF621 Gene

    Size:
    439 amino acids
    Molecular mass:
    49205 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF621 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF621 Gene

Post-translational modifications for ZNF621 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF621 Gene

Domains & Families for ZNF621 Gene

Gene Families for ZNF621 Gene

Protein Domains for ZNF621 Gene

Suggested Antigen Peptide Sequences for ZNF621 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZSS3

UniProtKB/Swiss-Prot:

ZN621_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 7 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF621: view

Function for ZNF621 Gene

Molecular function for ZNF621 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF621 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF621: view
genes like me logo Genes that share phenotypes with ZNF621: view

Animal Model Products

miRNA for ZNF621 Gene

miRTarBase miRNAs that target ZNF621

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF621 Gene

Localization for ZNF621 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF621 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF621 Gene COMPARTMENTS Subcellular localization image for ZNF621 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF621 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF621: view

Pathways & Interactions for ZNF621 Gene

SuperPathways for ZNF621 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF621: view

Pathways by source for ZNF621 Gene

2 Reactome pathways for ZNF621 Gene

Interacting Proteins for ZNF621 Gene

Gene Ontology (GO) - Biological Process for ZNF621 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF621: view

No data available for SIGNOR curated interactions for ZNF621 Gene

Transcripts for ZNF621 Gene

Unigene Clusters for ZNF621 Gene

Zinc finger protein 621:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF621 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6: - - -

Relevant External Links for ZNF621 Gene

GeneLoc Exon Structure for
ZNF621
ECgene alternative splicing isoforms for
ZNF621

Expression for ZNF621 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF621 Gene

Protein differential expression in normal tissues from HIPED for ZNF621 Gene

This gene is overexpressed in Monocytes (34.3) and Blymphocyte (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF621 Gene



Protein tissue co-expression partners for ZNF621 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF621 Gene:

ZNF621

SOURCE GeneReport for Unigene cluster for ZNF621 Gene:

Hs.19977
genes like me logo Genes that share expression patterns with ZNF621: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF621 Gene

Orthologs for ZNF621 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF621 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF621 34 35
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia ZNF621 35
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC100849024 34
  • 84.6 (n)
Species where no ortholog for ZNF621 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF621 Gene

ENSEMBL:
Gene Tree for ZNF621 (if available)
TreeFam:
Gene Tree for ZNF621 (if available)

Paralogs for ZNF621 Gene

(498) SIMAP similar genes for ZNF621 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF621: view

Variants for ZNF621 Gene

Sequence variations from dbSNP and Humsavar for ZNF621 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10222477 -- 40,531,271(+) CTGCA(A/T)GACCT intron-variant
rs111297789 -- 40,524,385(+) ATGTC(A/C/G)TGTGT upstream-variant-2KB, utr-variant-5-prime
rs111494189 -- 40,529,648(+) GACAG(A/G)GTCTC intron-variant
rs111662893 -- 40,531,661(+) GGGCT(G/T)AAGTG intron-variant
rs112083230 -- 40,522,105(+) GTAAA(A/C)ATGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF621 Gene

Variant ID Type Subtype PubMed ID
esv2725188 CNV deletion 23290073
esv3595951 CNV loss 21293372

Variation tolerance for ZNF621 Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF621 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF621

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF621 Gene

Disorders for ZNF621 Gene

Relevant External Links for ZNF621

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF621

No disorders were found for ZNF621 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF621 Gene

Publications for ZNF621 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for ZNF621 Gene

Sources for ZNF621 Gene

Content
Loading form....