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Aliases for ZNF621 Gene

Aliases for ZNF621 Gene

  • Zinc Finger Protein 621 2 3 5

External Ids for ZNF621 Gene

Previous GeneCards Identifiers for ZNF621 Gene

  • GC03P040527
  • GC03P040541

Summaries for ZNF621 Gene

GeneCards Summary for ZNF621 Gene

ZNF621 (Zinc Finger Protein 621) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ENSG00000261611.

UniProtKB/Swiss-Prot for ZNF621 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF621 Gene

Genomics for ZNF621 Gene

Regulatory Elements for ZNF621 Gene

Enhancers for ZNF621 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF621 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF621 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF621 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF621 Gene

40,524,316 bp from pter
40,574,685 bp from pter
50,370 bases
Plus strand

Genomic View for ZNF621 Gene

Genes around ZNF621 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF621 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF621 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF621 Gene

Proteins for ZNF621 Gene

  • Protein details for ZNF621 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 621
    Protein Accession:
    Secondary Accessions:
    • Q14DC7
    • Q8TE91

    Protein attributes for ZNF621 Gene

    439 amino acids
    Molecular mass:
    49205 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF621 Gene


neXtProt entry for ZNF621 Gene

Proteomics data for ZNF621 Gene at MOPED

Post-translational modifications for ZNF621 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF621 Gene

No data available for DME Specific Peptides for ZNF621 Gene

Domains & Families for ZNF621 Gene

Gene Families for ZNF621 Gene

Protein Domains for ZNF621 Gene

Suggested Antigen Peptide Sequences for ZNF621 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 7 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF621: view

Function for ZNF621 Gene

Molecular function for ZNF621 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF621: view

Animal Model Products

CRISPR Products

miRNA for ZNF621 Gene

miRTarBase miRNAs that target ZNF621

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF621 Gene

Localization for ZNF621 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF621 Gene

Subcellular locations from

Jensen Localization Image for ZNF621 Gene COMPARTMENTS Subcellular localization image for ZNF621 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF621 Gene

Pathways & Interactions for ZNF621 Gene

SuperPathways for ZNF621 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF621: view

Pathways by source for ZNF621 Gene

2 Reactome pathways for ZNF621 Gene

Interacting Proteins for ZNF621 Gene

Gene Ontology (GO) - Biological Process for ZNF621 Gene


No data available for SIGNOR curated interactions for ZNF621 Gene

Drugs & Compounds for ZNF621 Gene

No Compound Related Data Available

Transcripts for ZNF621 Gene

Unigene Clusters for ZNF621 Gene

Zinc finger protein 621:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF621 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6: - - -

Relevant External Links for ZNF621 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF621 Gene

mRNA expression in normal human tissues for ZNF621 Gene

Protein differential expression in normal tissues from HIPED for ZNF621 Gene

This gene is overexpressed in Monocytes (34.3) and Blymphocyte (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF621 Gene

SOURCE GeneReport for Unigene cluster for ZNF621 Gene Hs.19977

genes like me logo Genes that share expression patterns with ZNF621: view

Protein tissue co-expression partners for ZNF621 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF621 Gene

Orthologs for ZNF621 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF621 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100849024 35
  • 84.6 (n)
  • 83.14 (a)
(Pan troglodytes)
Mammalia ZNF621 35
  • 99.62 (n)
  • 99.09 (a)
ZNF621 36
  • 99 (a)
(Canis familiaris)
Mammalia ZNF621 36
  • 87 (a)
Species with no ortholog for ZNF621:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF621 Gene

Gene Tree for ZNF621 (if available)
Gene Tree for ZNF621 (if available)

Paralogs for ZNF621 Gene

Paralogs for ZNF621 Gene

(498) SIMAP similar genes for ZNF621 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF621: view

Variants for ZNF621 Gene

Sequence variations from dbSNP and Humsavar for ZNF621 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs12520 -- 40,538,896(-) TCCAC(C/T)GAAGT utr-variant-3-prime
rs1142464 -- 40,539,522(+) TAGGT(A/G)CTGGA utr-variant-3-prime
rs6599108 -- 40,524,103(+) GAAAA(A/G)TAAGT upstream-variant-2KB
rs10222477 -- 40,531,271(+) CTGCA(A/T)GACCT intron-variant
rs4602359 -- 40,537,866(+) tagct(A/G)agtta intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF621 Gene

Variant ID Type Subtype PubMed ID
nsv876716 CNV Gain 21882294

Variation tolerance for ZNF621 Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.44% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF621 Gene

Disorders for ZNF621 Gene

Relevant External Links for ZNF621

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF621 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF621 Gene

Publications for ZNF621 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF621 Gene

Sources for ZNF621 Gene