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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF619 Gene

protein-coding GIFtS: 45
GCID: GC03P040518

zinc finger protein 619

Search for ZNF619
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 619¹ ²
FLJ90764¹

External Ids:	HGNC: 26910¹	Entrez Gene: 285267²	Ensembl: ENSG00000177873⁷	UniProtKB: Q8N2I2³

ORGUL members:
	NONCODE:n407275

Export aliases for ZNF619 gene to outside databases

Previous GC identifers: GC03P040480 GC03P040493

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN619_HUMAN, Q8N2I2

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF619 gene promoter:
AhR C/EBPbeta Nkx5-1 Arnt HEN1 PPAR-gamma1 E2F-1 E2F PPAR-gamma2 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF619 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF619

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF619

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.1 Ensembl cytogenetic band: 3p22.1 HGNC cytogenetic band: 3p21.33

ZNF619 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF619 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P040518: view genomic region (about GC identifiers)

Start:	40,518,604 bp from pter	End:	40,531,728 bp from pter
Size:	13,125 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN619_HUMAN, Q8N2I2 (See protein sequence)

Recommended Name: Zinc finger protein 619

Size: 560 amino acids; 63322 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: B4E271

Alternative splicing: 2 isoforms: Q8N2I2-1 Q8N2I2-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF619: NX_Q8N2I2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N2I2

ZNF619 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001138554.1 NP_001138555.1 NP_001138565.1

ENSEMBL proteins:

ENSP00000322529 ENSP00000430574 ENSP00000428004 ENSP00000430705 ENSP00000388710

ENSP00000397232 ENSP00000411132 ENSP00000398024

Reactome Protein details: Q8N2I2
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZNF619 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF619 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q8N2I2

ProtoNet protein and cluster: Q8N2I2

UniProtKB/Swiss-Prot: ZN619_HUMAN, Q8N2I2

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 10 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN619_HUMAN, Q8N2I2

Function: May be involved in transcriptional regulation

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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF619 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZNF619

	Generic Transcription Pathway
	Gene Expression

ZNF619 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF619

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF619 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF619
Search CenterWatch for drugs/clinical trials and news about ZNF619 / ZN619

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for ZNF619 gene (5 alternative transcripts):

NM_001145094.1 NM_173656.2 NM_001145082.2 NM_001145083.1 NM_001145093.2

Unigene Cluster for ZNF619:

Zinc finger protein 619

Hs.407159 [show with all ESTs]

Unigene Representative Sequence: NR_026746

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000314686 ENST00000462961 ENST00000520737 ENST00000494154 ENST00000522736

ENST00000521353 ENST00000432264 ENST00000456778 ENST00000447116(uc011azb.2 uc011aza.2)

ENST00000429348(uc011azc.2 uc011azd.2 uc003ckj.3 uc021wwh.1)

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Additional cDNA sequence:

AK075245.1 AK304139.1 AK304741.1 AK304793.1 BC117169.1 BC143304.1 BC143306.1 BC143331.1

BC143332.1 NR_026746.2

4 DOTS entries:

DT.100016590 DT.99998001 DT.100767153 DT.40217820

24/32 AceView cDNA sequences (see all 32):

BG289896 NM_173656 BU167504 BE866874 NM_175888 AK075245 AK131232 AW103006

BM922232 BC044953 AI948629 CO250062 AX748220 AK093599 BQ222863 CO250237

AW748345 AI696883 CO247771 W20056 CD236827 BE973643 BE019346 CO247840

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF619 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b
SP1:
SP2:							-

ECgene alternative splicing isoforms for ZNF619

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF619 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGTGGTACT

About this image
See ZNF619 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF619

SOURCE GeneReport for Unigene cluster: Hs.407159

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZNF619 gene from 1/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
honey bee (Apis mellifera)	Insecta	--	--	20(a)	1 → many	GroupUn.197(18775-21878)

ENSEMBL Gene Tree for ZNF619 (if available)
TreeFam Gene Tree for ZNF619 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF619 gene

ZNF621² ZNF19² ZNF620² ENSG00000261611² ZNF662²

18/509 SIMAP similar genes for ZNF619 using alignment to 5 protein entries: ZN619_HUMAN (see all proteins) (see all similar genes):

ZNF78L1 ZNF688 ZNF707 kr-znf3 HZF36 ZNF232

ZNF818P ZSCAN23 ZNF501 HZF30 ZNF808 DKFZp666C237

GLI4 ZFP3 ZFS-5 ZNF345 ZNF56 ZNF826P

ZNF619 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for ZNF619
PGOHUM00000257067 PGOHUM00000233223 PGOHUM00000234005

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183402315^1,2		--	40516639(+)	`AAGGAA/GGGACA`	4	--	us2k¹		0	--	--	--	--
rs114226037^1,2	F,	--	40516648(+)	`CAACTC/GGAAGT`	4	--	us2k¹		1		WA	118
rs78597970^1,2	F,	--	40516649(+)	`AACTCG/AAAGTG`	4	--	us2k¹		1		WA	118
rs56298591^1,2	C,	--	40516718(+)	`CCTTT-/TTCCTTT`	4	--	us2k¹		0	--	--	--	--
rs199735361^1,2		--	40516748(+)	`CCTTT-/CCTTTC`	3	--	us2k¹		0	--	--	--	--
rs7633091^1,2	C,A	--	40516759(+)	`CTTTCC/TTTTCT`	3	--	us2k¹ tfbs³ trp³		0	--	--	--	--
rs7640785^1,2	C,A,H,	--	40516825(+)	`CTCACT/GCCTGT`	3	--	us2k¹		7		NA WA CSA	14
rs34847987^1,2	C	--	40517086(+)	`AAAAAA/-GTTAT`	3	--	us2k¹		1		NA	2
rs148078315^1,2		--	40517163(+)	`ATAAGA/GGGTTT`	3	--	us2k¹		0	--	--	--	--
rs12630072^1,2	C,F,H,	--	40517190(+)	`TATTAT/GGCAGA`	3	--	us2k¹		10		NS EA NA CSA	626

HapMap Linkage Disequilibrium report for ZNF619 (40518604 - 40531728 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF619
1 CNV: 9992

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF619 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF619)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)² Muzny D.M....Gibbs R.A. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 285267	HGNC: 26910	AceView: ZNF619andZNF620	Ensembl:ENSG00000177873	euGenes: HUgn285267
ECgene: ZNF619	H-InvDB: ZNF619

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF619	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF619 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF619 gene:
Search GeneIP for patents involving ZNF619

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF619 gene at Home site.

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ZNF619 Gene

zinc finger protein 619

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ZNF619 Gene

zinc finger protein 619

Aliasesfor ZNF619 gene

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