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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF619 Gene

protein-coding   GIFtS: 44
GCID: GC03P040518

Zinc Finger Protein 619

  Search for ZNF619
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 6191 2

External Ids:    HGNC: 269101   Entrez Gene: 2852672   Ensembl: ENSG000001778737   UniProtKB: Q8N2I23   
ORGUL members:         
NONCODE14:n407275      

Export aliases for ZNF619 gene to outside databases

Previous GC identifers: GC03P040480 GC03P040493


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF619 Gene: 
ZNF619 (zinc finger protein 619) is a protein-coding gene, and is affiliated with the lncRNA class. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF621.

UniProtKB/Swiss-Prot: ZN619_HUMAN, Q8N2I2
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF619 gene promoter:
         AhR   C/EBPbeta   Nkx5-1   Arnt   HEN1   PPAR-gamma1   E2F-1   E2F   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF619 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF619

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF619


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.1   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p21.33

ZNF619 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF619 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P040518:  view genomic region     (about GC identifiers)

Start:
40,518,604 bp from pter      End:
40,531,728 bp from pter
Size:
13,125 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN619_HUMAN, Q8N2I2 (See protein sequence)
Recommended Name: Zinc finger protein 619  
Size: 560 amino acids; 63322 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B4E271
Alternative splicing: 2 isoforms:  Q8N2I2-1   Q8N2I2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF619: NX_Q8N2I2

Explore proteomics data for ZNF619 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N2I2

  • ZNF619 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF619 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001138554.1  NP_001138555.1  NP_001138565.1  

    ENSEMBL proteins: 
     ENSP00000322529   ENSP00000430574   ENSP00000428004   ENSP00000430705   ENSP00000388710  
     ENSP00000397232   ENSP00000411132   ENSP00000398024  
    Reactome Protein details: Q8N2I2
    Human Recombinant Protein Products for ZNF619: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF619 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N2I2

    ProtoNet protein and cluster: Q8N2I2

    UniProtKB/Swiss-Prot: ZN619_HUMAN, Q8N2I2
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers


    ZNF619 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN619_HUMAN, Q8N2I2
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF619 for ontologies           About GeneDecksing


    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF619 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF619
        Generic Transcription Pathway
    Gene Expression



    ZNF619 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF619

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF619 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF619 (ZN619)

    Search CenterWatch for drugs/clinical trials and news about ZNF619 / ZN619

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF619 gene (5 alternative transcripts): 
    NM_001145094.1  NM_173656.2  NM_001145082.2  NM_001145083.1  NM_001145093.2  

    Unigene Cluster for ZNF619:

    Zinc finger protein 619
    Hs.407159  [show with all ESTs]
    Unigene Representative Sequence: NR_026746
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314686 ENST00000462961 ENST00000520737 ENST00000494154 ENST00000522736
    ENST00000521353 ENST00000432264 ENST00000456778 ENST00000447116(uc011azb.2 uc011aza.2)
    ENST00000429348(uc011azc.2 uc011azd.2 uc003ckj.3 uc021wwh.1)

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF619:
    hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidZNF619 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF619
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    Additional mRNA sequence: 

    AK075245.1 AK304139.1 AK304741.1 AK304793.1 BC117169.1 BC143304.1 BC143306.1 BC143331.1 
    BC143332.1 NR_026746.2 

    4 DOTS entries:

    DT.100016590  DT.99998001  DT.100767153  DT.40217820 

    24/32 AceView cDNA sequences (see all 32):

    NM_175888 BG289896 NM_173656 BU167504 BE866874 BM922232 AK075245 AK131232 
    AW103006 AI948629 BC044953 CO250062 AX748220 AK093599 BQ222863 CO250237 
    AI696883 CO247840 CO247771 CD236827 AW748345 CO250098 W20056 BE019346 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF619    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:                    -               


    ECgene alternative splicing isoforms for ZNF619

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF619 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTGGTACT
    ZNF619 Expression
    About this image


    See ZNF619 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF619

    SOURCE GeneReport for Unigene cluster: Hs.407159
        SABiosciences Custom PCR Arrays for ZNF619
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF619

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF619 gene from 1/3 species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF6196
    zinc finger protein 619
    70(a)
    1 ↔ 1
    23(9923607-9932189)


    ENSEMBL Gene Tree for ZNF619 (if available)
    TreeFam Gene Tree for ZNF619 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF619 gene
    ZNF6212  ZNF192  ZNF6202  ZNF6622  ENSG000002616112  
    18/519 SIMAP similar genes for ZNF619 using alignment to 5 protein entries:     ZN619_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    FIK    ZNF688    ZNF707    kr-znf3    HZF36
    ZNF232    ZNF818P    ZSCAN23    ZNF501    HZF30    ZNF808
    DKFZp666C237    GLI4    ZFP3    ZFS-5    ZNF274    ZNF345

    ZNF619 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ZNF619
    PGOHUM00000257067 PGOHUM00000233223 PGOHUM00000234005


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/343 SNPs in ZNF619 are shown (see all 343)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1834023151,2
    --40448926(+) AAGGAA/GGGACA 4 -- us2k10--------
    rs1142260371,2
    F--40448935(+) CAACTC/GGAAGT 4 -- us2k11Minor allele frequency- G:0.02WA 118
    rs785979701,2
    C,F--40448936(+) AACTCG/AAAGTG 4 -- us2k11Minor allele frequency- A:0.13WA 118
    rs562985911,2
    C--40449005(+) CCTTTTT/-CCTTT 4 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs720339361,2
    C--40449016(+) TTTCC-/CTTTC 
    CTTTC
    /TT
    TTTCC
    4 -- us2k10--------
    rs1997353611,2
    --40449035(+) CCTTT-/CCTTTC 4 -- us2k10--------
    rs583075681,2
    C--40449045(+) CTTTC-/CTTTCCTTTC/CTTTCC
    TTTCCTTTCCTTTCCTTTC
    TTTTC
    4 -- us2k11NA 2
    rs76330911,2
    C,A--40449046(+) ctttcC/Ttttct 4 -- us2k1 tfbs3 trp30--------
    rs76407851,2
    C,A,H--40449112(+) ctcacT/Gcctgt 4 -- us2k17Minor allele frequency- G:0.07NA WA CSA 14
    rs348479871,2
    C--40449395(+) AAAAAA/-GTTAT 4 -- us2k11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for ZNF619 (40518604 - 40531728 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF619:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv818137CNV Loss17921354
    nsv876717CNV Loss21882294
    nsv876716CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF619 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF619)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    4. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 285267 HGNC: 26910 AceView: ZNF619andZNF620 Ensembl:ENSG00000177873 euGenes: HUgn285267
    ECgene: ZNF619 H-InvDB: ZNF619

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF619 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF619 gene:
    Search GeneIP for patents involving ZNF619

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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