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ZNF619 Gene

protein-coding   GIFtS: 43
GCID: GC03P040518

Zinc Finger Protein 619

  Search for ZNF619
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 6191 2

External Ids:    HGNC: 269101   Entrez Gene: 2852672   Ensembl: ENSG000001778737   UniProtKB: Q8N2I23   

Export aliases for ZNF619 gene to outside databases

Previous GC identifers: GC03P040480 GC03P040493


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF619 Gene:
ZNF619 (zinc finger protein 619) is a protein-coding gene. An important paralog of this gene is ZNF621.

UniProtKB/Swiss-Prot: ZN619_HUMAN, Q8N2I2
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF619 gene promoter:
         AhR   C/EBPbeta   Nkx5-1   Arnt   HEN1   PPAR-gamma1   E2F-1   E2F   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF619 promoter sequence
   Search Chromatin IP Primers for ZNF619

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF619


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.1   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p21.33

ZNF619 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF619 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P040518:  view genomic region     (about GC identifiers)

Start:
40,518,604 bp from pter      End:
40,531,728 bp from pter
Size:
13,125 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN619_HUMAN, Q8N2I2 (See protein sequence)
Recommended Name: Zinc finger protein 619  
Size: 560 amino acids; 63322 Da
Secondary accessions: B4E271
Alternative splicing: 2 isoforms:  Q8N2I2-1   Q8N2I2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF619: NX_Q8N2I2

Explore proteomics data for ZNF619 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF619 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138554.1  NP_001138555.1  NP_001138565.1  

    ENSEMBL proteins: 
     ENSP00000322529   ENSP00000430574   ENSP00000428004   ENSP00000430705   ENSP00000388710  
     ENSP00000397232   ENSP00000411132   ENSP00000398024  
    Reactome Protein details: Q8N2I2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N2I2

    ProtoNet protein and cluster: Q8N2I2

    UniProtKB/Swiss-Prot: ZN619_HUMAN, Q8N2I2
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers


    ZNF619 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN619_HUMAN, Q8N2I2
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF619 for ontologies           About GeneDecksing


    Animal Models:
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN619_HUMAN, Q8N2I2: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF619 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF619 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF619
        Generic Transcription Pathway



    ZNF619 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF619
    Interactions:

        Search GeneGlobe Interaction Network for ZNF619

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF619 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF619 (ZN619)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF619 gene (5 alternative transcripts): 
    NM_001145094.1  NM_173656.2  NM_001145082.2  NM_001145083.1  NM_001145093.2  

    Unigene Cluster for ZNF619:

    Zinc finger protein 619
    Hs.407159  [show with all ESTs]
    Unigene Representative Sequence: NR_026746
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314686 ENST00000462961 ENST00000520737 ENST00000494154 ENST00000522736
    ENST00000521353 ENST00000432264 ENST00000456778 ENST00000447116(uc011azb.2 uc011aza.2)
    ENST00000429348(uc011azc.2 uc011azd.2 uc003ckj.3 uc021wwh.1)

    miRNA
    Products:
         
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    1 qRT-PCR Assays for microRNA that regulate ZNF619:
    hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidZNF619 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF619

    Additional mRNA sequence: 

    AK075245.1 AK304139.1 AK304741.1 AK304793.1 BC117169.1 BC143304.1 BC143306.1 BC143331.1 
    BC143332.1 NR_026746.2 

    4 DOTS entries:

    DT.100016590  DT.99998001  DT.100767153  DT.40217820 

    Selected AceView cDNA sequences (see all 32):

    BG289896 AK075245 NM_173656 NM_175888 AK131232 BE866874 BM922232 BU167504 
    AW103006 AK093599 CO250062 AX748220 AI948629 BC044953 CO250237 BQ222863 
    CO247771 CO247840 AI696883 BE973643 CO250098 W20056 AW748345 CD236827 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF619    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:                    -               


    ECgene alternative splicing isoforms for ZNF619

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF619 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTGGTACT
    ZNF619 Expression
    About this image

    ZNF619 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF619 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.407159
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF619 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF6191 zinc finger protein 619 80.62(n)
    72.44(a)
      102155269  XM_005634275.1  XP_005634332.1 


    ENSEMBL Gene Tree for ZNF619 (if available)
    TreeFam Gene Tree for ZNF619 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF619 gene
    ZNF6212  ZNF192  ZNF6202  ZNF6622  ENSG000002616112  
    Selected SIMAP similar genes for ZNF619 using alignment to 5 protein entries:     ZN619_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    FIK    ZNF688    ZNF707    kr-znf3    HZF36
    ZNF232    ZNF818P    ZSCAN23    ZNF501    HZF30    ZNF808
    DKFZp666C237    GLI4    ZFP3    ZFS-5    ZNF274    ZNF345

    ZNF619 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ZNF619
    PGOHUM00000257067 PGOHUM00000233223 PGOHUM00000234005


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF619 (see all 343)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1834023151,2
    --40448926(+) AAGGAA/GGGACA 4 -- us2k10--------
    rs1142260371,2
    F--40448935(+) CAACTC/GGAAGT 4 -- us2k11Minor allele frequency- G:0.02WA 118
    rs785979701,2
    C,F--40448936(+) AACTCG/AAAGTG 4 -- us2k11Minor allele frequency- A:0.13WA 118
    rs562985911,2
    C--40449005(+) CCTTTTT/-CCTTT 4 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs720339361,2
    C--40449016(+) TTTCC-/CTTTC 
    CTTTC
    /TT
    TTTCC
    4 -- us2k10--------
    rs1997353611,2
    --40449035(+) CCTTT-/CCTTTC 4 -- us2k10--------
    rs583075681,2
    C--40449045(+) CTTTC-/CTTTCCTTTC/CTTTCC
    TTTCCTTTCCTTTCCTTTC
    TTTTC
    4 -- us2k11NA 2
    rs76330911,2
    C,A--40449046(+) ctttcC/Ttttct 4 -- us2k1 tfbs3 trp30--------
    rs76407851,2
    C,A,H--40449112(+) ctcacT/Gcctgt 4 -- us2k17Minor allele frequency- G:0.07NA WA CSA 14
    rs348479871,2
    C--40449395(+) AAAAAA/-GTTAT 4 -- us2k11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for ZNF619 (40518604 - 40531728 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF619:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv818137CNV Loss17921354
    nsv876717CNV Loss21882294
    nsv876716CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF619 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF619)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 285267 HGNC: 26910 AceView: ZNF619andZNF620 Ensembl:ENSG00000177873 euGenes: HUgn285267
    ECgene: ZNF619 H-InvDB: ZNF619

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF619 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF619 gene:
    Search GeneIP for patents involving ZNF619

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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