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Aliases for ZNF618 Gene

Aliases for ZNF618 Gene

  • Zinc Finger Protein 618 2 3 5
  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 10 2 3
  • KIAA1952 4
  • FP13169 3
  • NEDD10 3

External Ids for ZNF618 Gene

Previous GeneCards Identifiers for ZNF618 Gene

  • GC09P112015
  • GC09P113718
  • GC09P115678
  • GC09P116638
  • GC09P086337

Summaries for ZNF618 Gene

GeneCards Summary for ZNF618 Gene

ZNF618 (Zinc Finger Protein 618) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZNF618 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF618 Gene

Genomics for ZNF618 Gene

Regulatory Elements for ZNF618 Gene

Enhancers for ZNF618 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G113906 0.9 Ensembl ENCODE 9.2 +30.5 30481 1.3 RFX1 ZBTB21 ATF2 ATF3 ZNF692 ZNF629 ZNF24 PRDM10 ZXDB SP7 ZNF618 GC09P114396
GH09G113885 1 Ensembl ENCODE 7.1 +10.4 10424 2.2 ATF1 IRF2 ZNF664 ZFHX2 ZNF316 STAT2 ADNP IKZF2 MAFK STAT1 ZNF618 GC09P114396
GH09G113952 1.2 Ensembl ENCODE dbSUPER 5.8 +79.4 79366 6.8 JUN YY1 ZNF23 ZNF316 GATA2 NFE2 FOS MAFK MAFG ATF2 ZNF618 GC09P114396
GH09G113929 1.1 Ensembl ENCODE 6.3 +53.9 53869 1.6 PKNOX1 FEZF1 ZBTB40 YY1 RARA GATA2 ZSCAN5C FOS JUNB PRDM6 ZNF618 GC09P114396
GH09G113673 1.6 FANTOM5 Ensembl ENCODE 4.3 -200.8 -200760 3.3 PKNOX1 ATF1 ARNT SIN3A TCF12 ZNF766 ELK1 GATA2 FOS ZNF263 BSPRY ZNF618 LOC105376223 LOC100288542
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF618 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF618 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000240169 519 2400 CTCF ZNF384 CHD7 ZNF2 RAD21 YY1 FOXM1 GLIS2 ZNF316 POLR2A

Genomic Location for ZNF618 Gene

113,876,282 bp from pter
114,056,595 bp from pter
180,314 bases
Plus strand

Genomic View for ZNF618 Gene

Genes around ZNF618 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF618 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF618 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF618 Gene

Proteins for ZNF618 Gene

  • Protein details for ZNF618 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 618
    Protein Accession:
    Secondary Accessions:
    • B9EG82
    • Q4G0X6
    • Q5T7W1
    • Q6ZT53
    • Q7Z6B9
    • Q8TF49
    • Q96E49

    Protein attributes for ZNF618 Gene

    954 amino acids
    Molecular mass:
    104956 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH36039.1; Type=Erroneous termination; Positions=241; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=AAH53892.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB85538.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF618 Gene


neXtProt entry for ZNF618 Gene

Post-translational modifications for ZNF618 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF618 Gene

Domains & Families for ZNF618 Gene

Gene Families for ZNF618 Gene

Protein Domains for ZNF618 Gene

Suggested Antigen Peptide Sequences for ZNF618 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF618: view

Function for ZNF618 Gene

Molecular function for ZNF618 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF618 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF618: view

Phenotypes for ZNF618 Gene

GenomeRNAi human phenotypes for ZNF618:
genes like me logo Genes that share phenotypes with ZNF618: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF618 Gene

Localization for ZNF618 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF618 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF618 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF618 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF618: view

Pathways & Interactions for ZNF618 Gene

SuperPathways for ZNF618 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF618 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF618: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF618 Gene

Drugs & Compounds for ZNF618 Gene

No Compound Related Data Available

Transcripts for ZNF618 Gene

Unigene Clusters for ZNF618 Gene

Zinc finger protein 618:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF618 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - -
SP2: -
SP4: -
SP5: - - -

Relevant External Links for ZNF618 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF618 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF618 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF618 Gene

This gene is overexpressed in Platelet (66.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF618 Gene

Protein tissue co-expression partners for ZNF618 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF618 Gene:


SOURCE GeneReport for Unigene cluster for ZNF618 Gene:


Evidence on tissue expression from TISSUES for ZNF618 Gene

  • Eye(4.3)
  • Nervous system(4.3)
  • Kidney(4.2)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with ZNF618: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF618 Gene

Orthologs for ZNF618 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF618 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF618 35
  • 100 (a)
(Bos Taurus)
Mammalia ZNF618 35
  • 89 (a)
(Mus musculus)
Mammalia Zfp618 34 16 35
  • 88.26 (n)
(Canis familiaris)
Mammalia ZNF618 35
  • 87 (a)
(Monodelphis domestica)
Mammalia ZNF618 35
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF618 35
  • 80 (a)
(Gallus gallus)
Aves ZNF618 34 35
  • 80.21 (n)
(Anolis carolinensis)
Reptilia ZNF618 35
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13236 34
(Danio rerio)
Actinopterygii znf618 34
  • 62.36 (n)
ZNF618 35
  • 54 (a)
Species where no ortholog for ZNF618 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF618 Gene

Gene Tree for ZNF618 (if available)
Gene Tree for ZNF618 (if available)

Paralogs for ZNF618 Gene

No data available for Paralogs for ZNF618 Gene

Variants for ZNF618 Gene

Sequence variations from dbSNP and Humsavar for ZNF618 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000001308 -- 114,053,722(+) TGGCA(C/T)AGTTC utr-variant-3-prime
rs1000013461 -- 113,992,290(+) GACAA(A/G)GCCTG intron-variant, utr-variant-5-prime
rs1000015881 -- 113,970,507(+) CTCTG(C/T)CAGTA intron-variant
rs1000041080 -- 114,030,918(+) GTCCT(C/G)CATAG intron-variant
rs1000046537 -- 113,906,209(+) TTGGC(C/G)CTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF618 Gene

Variant ID Type Subtype PubMed ID
dgv12855n54 CNV gain 21841781
dgv33e196 CNV duplication 17116639
dgv945n27 CNV gain 19166990
esv1406827 CNV insertion 17803354
esv2738960 CNV deletion 23290073
esv2761285 CNV gain 21179565
esv3621549 CNV gain 21293372
esv3621551 CNV loss 21293372
nsv1075670 CNV deletion 25765185
nsv1144288 CNV deletion 24896259
nsv415373 CNV deletion 16902084
nsv471319 CNV gain 18288195
nsv521361 CNV gain 19592680
nsv521362 CNV loss 19592680
nsv522429 CNV gain 19592680
nsv523823 CNV loss 19592680
nsv528822 CNV gain 19592680
nsv825055 CNV gain 20364138
nsv825056 CNV gain 20364138

Variation tolerance for ZNF618 Gene

Residual Variation Intolerance Score: 3.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF618 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF618 Gene

Disorders for ZNF618 Gene

Relevant External Links for ZNF618

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF618 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF618 Gene

Publications for ZNF618 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 46 64
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 46 64
  4. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PMID: 20583170) Letra A. … Vieira A.R. (Am. J. Med. Genet. A 2010) 3 46 64
  5. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PMID: 19724895) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2009) 3 46 64

Products for ZNF618 Gene

Sources for ZNF618 Gene

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