ZNF618 Gene
protein-coding GIFtS: 44
GCID: GC09P116638
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|
zinc finger protein 618
| |
Aliases
for ZNF618 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 6181 2 | | NEDD101 2 | | KIAA19521 3 | | FP131692 | | Neural Precursor Cell Expressed, Developmentally Down-Regulated 102 |
Export aliases for ZNF618 gene to outside databasesPrevious GC identifers: GC09P112015 GC09P113718 GC09P115678 GC09P086337 |
Summaries
for ZNF618 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN618_HUMAN, Q5T7W0Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF618 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF618 gene promoter:
TBP C/EBPbeta POU2F1 POU2F1a Cart-1 NF-E2 NF-E2 p45 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF618
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF618 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q32 Ensembl cytogenetic band: 9q32 HGNC cytogenetic band: 9q33.1ZNF618 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P116638: view genomic region
(about GC identifiers)
Start:
|
116,638,562 bp from pter |
End:
|
116,818,875 bp from pter |
Size:
|
180,314 bases |
Orientation:
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plus strand |
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Proteins
for ZNF618 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN618_HUMAN, Q5T7W0 (See
protein sequence)Recommended Name: Zinc finger protein 618 Size: 954 amino acids; 104956 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH36039.1; Type=Erroneous termination; Positions=241; Note=Translated as Glu;Sequence=AAH53892.1; Type=Erroneous initiation; Sequence=BAB85538.1; Type=Erroneous initiation;
Secondary accessions: Q4G0X6 Q5T7W1 Q6ZT53 Q7Z6B9 Q8TF49 Q96E49Alternative splicing: 3 isoforms: Q5T7W0-1 Q5T7W0-2 Q5T7W0-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF618: NX_Q5T7W0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T7W0
ZNF618 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_588615.2
ENSEMBL proteins: ENSP00000363241 ENSP00000395400 ENSP00000363239 ENSP00000288466
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF618 for ontologies About GeneDecksing
ZNF618 Antibody Products:
Assay Products for ZNF618: |
Protein
Domains /
Families
for ZNF618 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF618 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5T7W0ProtoNet protein and cluster: Q5T7W0 UniProtKB/Swiss-Prot: ZN618_HUMAN, Q5T7W0Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 4 C2H2-type zinc fingers |
Function
for ZNF618 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN618_HUMAN, Q5T7W0Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF618 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF618
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF618 (NM_133374) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF618 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF618 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF618 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF618 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF618 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF618
1 Interacting protein for ZNF618 (Q5T7W03) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF618 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF618 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF618
Search CenterWatch for drugs/clinical trials and news about ZNF618 / ZN618
|
Transcripts
for ZNF618 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF618 gene (2 alternative transcripts): NM_001040063.1 NM_133374.2 Unigene Cluster for ZNF618: Zinc finger protein 618 Hs.349208 [show with all ESTs]Unigene Representative Sequence: NM_1333746 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374126(uc004bib.1) ENST00000452710 ENST00000374124 ENST00000481558
ENST00000470105 ENST00000288466(uc004bic.3 uc004bid.3 uc011lxi.2 uc011lxj.2 uc010mvb.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF618 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF618
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF618 (NM_133374) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF618 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF618 |
Additional cDNA sequence: AF147430.1 AF495724.1 AJ420454.1 AK126896.1 BC012922.1 BC036039.1 BC053892.1 BC130642.1 BC130644.1 BC136287.1 BC143826.1 8 DOTS entries: DT.415103 DT.100745728 DT.40215883 DT.75103656 DT.91743422 DT.305664 DT.40115051 DT.100752221 23 AceView cDNA sequences: T11471 CD675830 BI713105 BC053892 BI195298 AI820911 BU187769 BI712152 AK126896 BX095476 AA293099 BM853663 AB075832 BE261402 BU855071 BE798689 CD673771 AA293753 AL530784 BF317252 T11484 AL530785 BM856986
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF618 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF618
|
Expression
for ZNF618 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF618 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAGTGTTGT
About this image
See ZNF618 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF618
SOURCE GeneReport for Unigene cluster: Hs.349208
SABiosciences Custom PCR Arrays for ZNF618
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF618
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF618 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF618 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF618 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF618 |
Orthologs
for ZNF618 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF618 gene from 5/10 species (see all 10) About this table
ENSEMBL Gene Tree for ZNF618 (if available)
TreeFam Gene Tree for ZNF618 (if available) |
Paralogs
for ZNF618 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ZNF618 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF618 (116638562 - 116818875 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for ZNF618
4 CNVs: 29802 5263 53913 5264
1 Indel: 13197 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF618 |
|
Disorders
/ Diseases
for ZNF618 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF618 for disorders About GeneDecksing
3  diseases for ZNF618: About MalaCardscleft lip/palate cleft lip kidney disease
Human Genome Epidemiology (HuGE) Navigator: ZNF618 (4 documents)
Export disorders for ZNF618 gene to outside databases
|
Publications
for ZNF618 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF618 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF618) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2, 3 Nagase T.... Ohara O. (2001)
- Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1 Oguri M....Yamada Y. (2010)
- Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PubMed id 20583170)1 Letra A....Vieira A.R. (2010)
- Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1 Yoshida T....Yamada Y. (2010)
- Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PubMed id 19724895)1 Yoshida T....Yamada Y. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF618 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF618 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF618 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZNF618 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF618 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF618 gene:
Search GeneIP for patents involving ZNF618
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF618 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF618 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF618 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF618 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF618 | | OriGene 3'-UTR Clone for ZNF618 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF618 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF618 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF618 | | OriGene Custom Protein Services for ZNF618 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF618 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF618 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF618 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF618 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF618 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF618 |
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 | | | ZNF618 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF618 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF618 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF618 |
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