Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF618 Gene

Aliases for ZNF618 Gene

  • Zinc Finger Protein 618 2 3 5
  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 10 3
  • Developmentally Down-Regulated 10 2
  • Neural Precursor Cell Expressed 2
  • KIAA1952 4
  • FP13169 3
  • NEDD10 3

External Ids for ZNF618 Gene

Previous GeneCards Identifiers for ZNF618 Gene

  • GC09P112015
  • GC09P113718
  • GC09P115678
  • GC09P116638
  • GC09P086337

Summaries for ZNF618 Gene

GeneCards Summary for ZNF618 Gene

ZNF618 (Zinc Finger Protein 618) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for ZNF618 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF618 Gene

Genomics for ZNF618 Gene

Regulatory Elements for ZNF618 Gene

Promoters for ZNF618 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF618 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF618 Gene

113,876,282 bp from pter
114,056,595 bp from pter
180,314 bases
Plus strand

Genomic View for ZNF618 Gene

Genes around ZNF618 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF618 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF618 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF618 Gene

Proteins for ZNF618 Gene

  • Protein details for ZNF618 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 618
    Protein Accession:
    Secondary Accessions:
    • B9EG82
    • Q4G0X6
    • Q5T7W1
    • Q6ZT53
    • Q7Z6B9
    • Q8TF49
    • Q96E49

    Protein attributes for ZNF618 Gene

    954 amino acids
    Molecular mass:
    104956 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH36039.1; Type=Erroneous termination; Positions=241; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=AAH53892.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB85538.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF618 Gene


neXtProt entry for ZNF618 Gene

Proteomics data for ZNF618 Gene at MOPED

Post-translational modifications for ZNF618 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF618 Gene

No data available for DME Specific Peptides for ZNF618 Gene

Domains & Families for ZNF618 Gene

Gene Families for ZNF618 Gene

Protein Domains for ZNF618 Gene

Suggested Antigen Peptide Sequences for ZNF618 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 4 C2H2-type zinc fingers.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF618: view

Function for ZNF618 Gene

Molecular function for ZNF618 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF618 Gene

GenomeRNAi human phenotypes for ZNF618:
genes like me logo Genes that share phenotypes with ZNF618: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF618 Gene

Localization for ZNF618 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF618 Gene

Subcellular locations from

Jensen Localization Image for ZNF618 Gene COMPARTMENTS Subcellular localization image for ZNF618 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF618 Gene

Pathways & Interactions for ZNF618 Gene

SuperPathways for ZNF618 Gene

No Data Available

Interacting Proteins for ZNF618 Gene

Gene Ontology (GO) - Biological Process for ZNF618 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF618: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF618 Gene

Drugs & Compounds for ZNF618 Gene

No Compound Related Data Available

Transcripts for ZNF618 Gene

Unigene Clusters for ZNF618 Gene

Zinc finger protein 618:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF618 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - -
SP2: -
SP4: -
SP5: - - -

Relevant External Links for ZNF618 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF618 Gene

mRNA expression in normal human tissues for ZNF618 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF618 Gene

This gene is overexpressed in Platelet (66.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF618 Gene

SOURCE GeneReport for Unigene cluster for ZNF618 Gene Hs.349208

genes like me logo Genes that share expression patterns with ZNF618: view

Protein tissue co-expression partners for ZNF618 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF618 Gene

Orthologs for ZNF618 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF618 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Zfp618 35
  • 88.26 (n)
  • 95.12 (a)
Zfp618 16
Zfp618 36
  • 95 (a)
(Bos Taurus)
Mammalia ZNF618 36
  • 89 (a)
(Canis familiaris)
Mammalia ZNF618 36
  • 87 (a)
(Monodelphis domestica)
Mammalia ZNF618 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF618 36
  • 80 (a)
(Pan troglodytes)
Mammalia ZNF618 36
  • 100 (a)
(Gallus gallus)
Aves ZNF618 35
  • 80.21 (n)
  • 87.28 (a)
ZNF618 36
  • 78 (a)
(Anolis carolinensis)
Reptilia ZNF618 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13236 35
(Danio rerio)
Actinopterygii znf618 35
  • 62.36 (n)
  • 60.31 (a)
ZNF618 36
  • 54 (a)
Species with no ortholog for ZNF618:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF618 Gene

Gene Tree for ZNF618 (if available)
Gene Tree for ZNF618 (if available)

Paralogs for ZNF618 Gene

No data available for Paralogs for ZNF618 Gene

Variants for ZNF618 Gene

Sequence variations from dbSNP and Humsavar for ZNF618 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs140850 -- 114,033,847(+) TGGGC(-/ACT)ACTGC intron-variant
rs700124 -- 113,964,239(-) AGAAC(C/T)GAGCC intron-variant
rs700125 -- 114,001,625(+) AATGC(A/G)TTGAA intron-variant
rs860082 -- 113,980,055(+) gaagg(C/T)ggatc intron-variant
rs871806 -- 113,936,512(-) AAGGT(C/T)CCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF618 Gene

Variant ID Type Subtype PubMed ID
nsv893750 CNV Loss 21882294
nsv825055 CNV Gain 20364138
esv2738960 CNV Deletion 23290073
nsv415373 CNV Loss 16902084
esv1406827 CNV Insertion 17803354
nsv521361 CNV Gain 19592680
nsv825056 CNV Gain 20364138
nsv522429 CNV Gain 19592680
nsv523823 CNV Loss 19592680
nsv521362 CNV Loss 19592680
dgv33e196 CNV Duplication 17116639
dgv945n27 CNV Gain 19166990
nsv471319 CNV Gain 18288195
nsv528822 CNV Gain 19592680

Variation tolerance for ZNF618 Gene

Residual Variation Intolerance Score: 3.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF618 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF618 Gene

Disorders for ZNF618 Gene

Relevant External Links for ZNF618

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF618 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF618 Gene

Publications for ZNF618 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 67
  2. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3
  3. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3

Products for ZNF618 Gene

Sources for ZNF618 Gene

Back to Top