ZNF616 Gene
protein-coding GIFtS: 44
GCID: GC19M052617
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zinc finger protein 616
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Aliases
for ZNF616 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 6161 2 | | MGC455561 |
Export aliases for ZNF616 gene to outside databasesPrevious GC identifers: GC19M057310 GC19M057314 GC19M048948 |
Summaries
for ZNF616 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN616_HUMAN, Q08AN1Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF616 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF616 gene promoter:
Egr-3 HTF Pax-2 Pax-2a IRF-1 C/EBPalpha AREB6 NRF-2 Pax-2b ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF616
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF616 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.41ZNF616 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M052617: view genomic region
(about GC identifiers)
Start:
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52,617,653 bp from pter |
End:
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52,643,191 bp from pter |
Size:
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25,539 bases |
Orientation:
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minus strand |
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Proteins
for ZNF616 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN616_HUMAN, Q08AN1 (See
protein sequence)Recommended Name: Zinc finger protein 616 Size: 781 amino acids; 90273 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B3KRV1 Q0P658 Q658V7Explore the universe of human proteins at neXtProt for ZNF616: NX_Q08AN1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q08AN1
ZNF616 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_848618.2
ENSEMBL proteins: ENSP00000328722 Reactome Protein details: Q08AN1
Human Recombinant Protein Products for ZNF616:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF616 for ontologies About GeneDecksing
ZNF616 Antibody Products:
Assay Products for ZNF616: |
Protein
Domains /
Families
for ZNF616 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF616 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q08AN1ProtoNet protein and cluster: Q08AN1 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN616_HUMAN, Q08AN1Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 21 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF616 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZN616_HUMAN, Q08AN1Function: May be involved in transcriptional regulation Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF616 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for ZNF616:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF616 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF616
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF616 (NM_178523) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF616 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF616 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF616 |
|
Pathways & Interactions
for ZNF616 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF616
ZNF616 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF616
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF616 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF616 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF616
Search CenterWatch for drugs/clinical trials and news about ZNF616 / ZN616
|
Transcripts
for ZNF616 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF616 gene: NM_178523.3 Unigene Clusters for ZNF616: Zinc finger protein 616 Hs.645225 [show with all ESTs], Hs.731969 [show with all ESTs]Unigene Representative Sequences: BM544555, NM_1785231 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000330123(uc002pym.3 uc002pyn.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF616 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF616
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF616 (NM_178523) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF616 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF616 |
Additional cDNA sequence: AK025434.1 AK092266.1 AL832969.1 BC033199.1 BC125099.1 BC125100.1 6 DOTS entries: DT.210730 DT.40128514 DT.100745264 DT.121500795 DT.100829903 DT.100829904 24/57 AceView cDNA sequences (see all 57): BC033199 AA024577 AX747442 BU156163 BX117464 AA219288 BX951264 AL832969 NM_178523 AK092266 AA243787 AI434799 BF971059 AW196816 AI014727 CA311374 AA400326 BG149442 AI829044 AI091121 BX109081 AA076467 AA243569 BF224062
GeneLoc Exon Structure
|
Expression
for ZNF616 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF616 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGAAAATG
About this image
See ZNF616 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF616
SOURCE GeneReport for Unigene clusters: Hs.645225 Hs.731969
SABiosciences Custom PCR Arrays for ZNF616
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF616
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF616 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF616 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF616 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF616 |
Orthologs
for ZNF616 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNF616 gene from 3/15 species (see all 15) About this table
ENSEMBL Gene Tree for ZNF616 (if available)
TreeFam Gene Tree for ZNF616 (if available) |
Paralogs
for ZNF616 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF616 gene
- ZNF1602 ZNF8502 ZNF992 ZNF5462 ZNF6652 ZNF8362 ZNF7212 ZNF8412
- ZNF912 ZNF432 ZNF780B2 ZNF1972 ZNF585A2 ZNF8082 ZNF7292 ZNF3472
- ZNF8452 ZNF1842 ZNF585B2 ZNF6582 ZNF6242 ZNF2082
18/476 SIMAP similar genes for ZNF616 using alignment to 5 protein entries: ZN616_HUMAN (see all proteins)
(see all similar genes):ZNF738 ZNF78L1 MGC12518 DKFZp686M04222 DKFZp762K012 ZFS-1
ZFS-6 ZNF232 kr-znf3 DKFZp686B16128 ZFS-4 ZNF397
ZNF818P smap-7 ZNF160 DKFZp313M0722 DKFZp666M039 HZF30
ZNF616 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF616 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF616 (52617653 - 52643191 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF616
1 CNV: 8875 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF616 |
|
Disorders
/ Diseases
for ZNF616 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF616 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF616 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF616) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF616 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF616 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF616 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF616 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF616 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF616 gene:
Search GeneIP for patents involving ZNF616
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF616 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF616 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF616 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF616 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF616 | | OriGene 3'-UTR Clone for ZNF616 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF616 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF616 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | ZNF616 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF616 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for ZNF616 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF616 |
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