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Aliases for ZNF616 Gene

Aliases for ZNF616 Gene

  • Zinc Finger Protein 616 2 3 5

External Ids for ZNF616 Gene

Previous GeneCards Identifiers for ZNF616 Gene

  • GC19M057310
  • GC19M057314
  • GC19M052617
  • GC19M048948

Summaries for ZNF616 Gene

GeneCards Summary for ZNF616 Gene

ZNF616 (Zinc Finger Protein 616) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF841.

UniProtKB/Swiss-Prot for ZNF616 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF616 Gene

Genomics for ZNF616 Gene

Regulatory Elements for ZNF616 Gene

Enhancers for ZNF616 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZNF616 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF616 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF616 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF616 Gene

Chromosome:
19
Start:
52,113,091 bp from pter
End:
52,139,938 bp from pter
Size:
26,848 bases
Orientation:
Minus strand

Genomic View for ZNF616 Gene

Genes around ZNF616 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF616 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF616 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF616 Gene

Proteins for ZNF616 Gene

  • Protein details for ZNF616 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08AN1-ZN616_HUMAN
    Recommended name:
    Zinc finger protein 616
    Protein Accession:
    Q08AN1
    Secondary Accessions:
    • B3KRV1
    • Q0P658
    • Q658V7

    Protein attributes for ZNF616 Gene

    Size:
    781 amino acids
    Molecular mass:
    90273 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF616 Gene

Post-translational modifications for ZNF616 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF616 Gene

No data available for DME Specific Peptides for ZNF616 Gene

Domains & Families for ZNF616 Gene

Gene Families for ZNF616 Gene

Protein Domains for ZNF616 Gene

Suggested Antigen Peptide Sequences for ZNF616 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q08AN1

UniProtKB/Swiss-Prot:

ZN616_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 21 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 21 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF616: view

Function for ZNF616 Gene

Molecular function for ZNF616 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF616 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF616: view
genes like me logo Genes that share phenotypes with ZNF616: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF616 Gene

Localization for ZNF616 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF616 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF616 Gene COMPARTMENTS Subcellular localization image for ZNF616 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF616 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF616: view

Pathways & Interactions for ZNF616 Gene

SuperPathways for ZNF616 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF616: view

Pathways by source for ZNF616 Gene

2 Reactome pathways for ZNF616 Gene

Interacting Proteins for ZNF616 Gene

Gene Ontology (GO) - Biological Process for ZNF616 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF616: view

No data available for SIGNOR curated interactions for ZNF616 Gene

Drugs & Compounds for ZNF616 Gene

No Compound Related Data Available

Transcripts for ZNF616 Gene

Unigene Clusters for ZNF616 Gene

Zinc finger protein 616:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF616 Gene

No ASD Table

Relevant External Links for ZNF616 Gene

GeneLoc Exon Structure for
ZNF616
ECgene alternative splicing isoforms for
ZNF616

Expression for ZNF616 Gene

mRNA expression in normal human tissues for ZNF616 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF616 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF616 Gene:

ZNF616

SOURCE GeneReport for Unigene cluster for ZNF616 Gene:

Hs.645225
genes like me logo Genes that share expression patterns with ZNF616: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF616 Gene

Orthologs for ZNF616 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF616 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC617476 34
  • 66.9 (n)
  • 52.43 (a)
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm13247 34
  • 69.37 (n)
  • 57.14 (a)
Zfp992 16
Zfp51 35
  • 39 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia ZNF616 34
  • 99.02 (n)
  • 97.95 (a)
ZNF616 35
  • 98 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
CSA.1668 35
  • 33 (a)
ManyToMany
Species where no ortholog for ZNF616 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF616 Gene

ENSEMBL:
Gene Tree for ZNF616 (if available)
TreeFam:
Gene Tree for ZNF616 (if available)

Paralogs for ZNF616 Gene

(517) SIMAP similar genes for ZNF616 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF616: view

Variants for ZNF616 Gene

Sequence variations from dbSNP and Humsavar for ZNF616 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3764537 - 52,115,812(-) TTCAC(A/G)TCTTG reference, missense
rs35582075 - 52,117,016(+) TTTAG(A/G)AGAGA reference, missense
rs11084145 -- 52,123,459(+) AGCCT(A/G)AGTGA intron-variant
rs17779542 -- 52,127,660(+) TATAG(A/C)GTCCT intron-variant
rs17779578 -- 52,130,217(+) ACCAC(A/G)GGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF616 Gene

Variant ID Type Subtype PubMed ID
dgv1067e212 CNV gain 25503493
dgv143e55 CNV gain 17911159
dgv3626n100 CNV gain 25217958
dgv6523n54 CNV gain 21841781
esv2718780 CNV deletion 23290073
esv3644684 CNV gain 21293372
nsv1140251 OTHER inversion 24896259
nsv2535 CNV deletion 18451855
nsv833872 CNV loss 17160897
nsv960859 CNV duplication 23825009

Variation tolerance for ZNF616 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF616 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF616

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF616 Gene

Disorders for ZNF616 Gene

Relevant External Links for ZNF616

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF616

No disorders were found for ZNF616 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF616 Gene

Publications for ZNF616 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3 65
  4. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3 65
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65

Products for ZNF616 Gene

Sources for ZNF616 Gene

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