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Aliases for ZNF615 Gene

Aliases for ZNF615 Gene

  • Zinc Finger Protein 615 2 3 5

External Ids for ZNF615 Gene

Previous GeneCards Identifiers for ZNF615 Gene

  • GC19M057188
  • GC19M057191
  • GC19M057193
  • GC19M057194
  • GC19M057195
  • GC19M057196
  • GC19M057197
  • GC19M057198
  • GC19M057199
  • GC19M052469
  • GC19M052494

Summaries for ZNF615 Gene

GeneCards Summary for ZNF615 Gene

ZNF615 (Zinc Finger Protein 615) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF432.

UniProtKB/Swiss-Prot for ZNF615 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF615 Gene

Genomics for ZNF615 Gene

Regulatory Elements for ZNF615 Gene

Enhancers for ZNF615 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G051687 1.8 FANTOM5 ENCODE dbSUPER 18.4 +317.7 317748 6.9 CREB3L1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D ZNF610 ZNF808 ZNF836 ZNF616 ZNF841 ZNF137P ENSG00000268970 ZNF766 ENSG00000269825 ZNF528 ZNF175
GH19G051016 1.2 Ensembl ENCODE 25.6 +990.9 990862 1.5 PKNOX1 ATF1 SIN3A GLI4 ZNF121 GLIS2 ZNF143 KLF7 SP3 REST ZNF175 ZNF615 KLK10 ZNF577 LRRC4B SPACA6 KLK13 KLK6 ZNF649 KLK14
GH19G051360 1.7 Ensembl ENCODE dbSUPER 13.5 +643.3 643295 8.5 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF175 VSIG10L ZNF836 ZNF615 LOC100419835 POLD1 ZNF616 ZNF766 SIGLEC8 RPL7P51
GH19G051766 1.1 FANTOM5 17.7 +241.6 241614 0.4 ATF1 CREB3L1 MLX E2F7 ARID4B SIN3A DMAP1 ZNF48 YY1 ELK1 FPR1 FPR2 ZNF615 ZNF175 ZNF528 SPACA6 LOC100419835 SPACA6P-AS SIGLEC10 ZNF528-AS1
GH19G051393 1.5 FANTOM5 ENCODE 11 +613.2 613191 2.8 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ZFP64 ARID4B SIN3A YY1 ZNF143 ZNF766 ZNF577 SPACA6P-AS ZNF836 C19orf84 ZNF432 ZNF616 ZNF880 ENSG00000268015 ZNF175
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF615 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF615 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111277 137 1799 HDGF FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 ZNF207 SP3

Transcription factor binding sites by QIAGEN in the ZNF615 gene promoter:

Genomic Location for ZNF615 Gene

Chromosome:
19
Start:
51,991,332 bp from pter
End:
52,008,238 bp from pter
Size:
16,907 bases
Orientation:
Minus strand

Genomic View for ZNF615 Gene

Genes around ZNF615 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF615 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF615 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF615 Gene

Proteins for ZNF615 Gene

  • Protein details for ZNF615 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8J6-ZN615_HUMAN
    Recommended name:
    Zinc finger protein 615
    Protein Accession:
    Q8N8J6
    Secondary Accessions:
    • B7ZKW9
    • Q2M2Y6
    • Q5CZB0
    • Q6ZMT7
    • Q6ZRB3

    Protein attributes for ZNF615 Gene

    Size:
    731 amino acids
    Molecular mass:
    83739 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC87399.1; Type=Miscellaneous discrepancy; Note=aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF615 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF615 Gene

Post-translational modifications for ZNF615 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF615 Gene

Domains & Families for ZNF615 Gene

Gene Families for ZNF615 Gene

Protein Domains for ZNF615 Gene

Suggested Antigen Peptide Sequences for ZNF615 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N8J6

UniProtKB/Swiss-Prot:

ZN615_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF615: view

Function for ZNF615 Gene

Molecular function for ZNF615 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF615 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF615: view

Phenotypes for ZNF615 Gene

GenomeRNAi human phenotypes for ZNF615:
genes like me logo Genes that share phenotypes with ZNF615: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF615 Gene

Localization for ZNF615 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF615 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF615 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF615 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF615: view

Pathways & Interactions for ZNF615 Gene

SuperPathways for ZNF615 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF615: view

Pathways by source for ZNF615 Gene

2 Reactome pathways for ZNF615 Gene

Interacting Proteins for ZNF615 Gene

Gene Ontology (GO) - Biological Process for ZNF615 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
genes like me logo Genes that share ontologies with ZNF615: view

No data available for SIGNOR curated interactions for ZNF615 Gene

Drugs & Compounds for ZNF615 Gene

No Compound Related Data Available

Transcripts for ZNF615 Gene

Unigene Clusters for ZNF615 Gene

Zinc finger protein 615:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF615 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d
SP1: - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - -
SP6: - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: - -
SP10:
SP11: -

Relevant External Links for ZNF615 Gene

GeneLoc Exon Structure for
ZNF615
ECgene alternative splicing isoforms for
ZNF615

Expression for ZNF615 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF615 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF615 Gene:

ZNF615

SOURCE GeneReport for Unigene cluster for ZNF615 Gene:

Hs.368355

Evidence on tissue expression from TISSUES for ZNF615 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with ZNF615: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF615 Gene

Orthologs for ZNF615 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF615 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF615 34 35
  • 99.18 (n)
dog
(Canis familiaris)
Mammalia ZNF615 34 35
  • 88.92 (n)
cow
(Bos Taurus)
Mammalia ZNF432 35
  • 60 (a)
OneToOne
Species where no ortholog for ZNF615 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF615 Gene

ENSEMBL:
Gene Tree for ZNF615 (if available)
TreeFam:
Gene Tree for ZNF615 (if available)

Paralogs for ZNF615 Gene

Paralogs for ZNF615 Gene

(556) SIMAP similar genes for ZNF615 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF615: view

Variants for ZNF615 Gene

Sequence variations from dbSNP and Humsavar for ZNF615 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000050007 -- 52,006,617(+) ACTTA(C/T)GTCTG intron-variant, upstream-variant-2KB
rs1000236821 -- 51,995,109(+) AAAAC(A/C)CTATT intron-variant
rs1000534207 -- 51,994,169(+) AATGA(A/G)CCGAC reference, missense
rs1001159209 -- 52,001,332(+) AAAAA(A/G)GTGGG intron-variant
rs1001224813 -- 52,006,911(+) TTATA(A/G)ATTAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF615 Gene

Variant ID Type Subtype PubMed ID
dgv1067e212 CNV gain 25503493
dgv143e55 CNV gain 17911159
dgv3626n100 CNV gain 25217958
dgv425n27 CNV gain 19166990
dgv6523n54 CNV gain 21841781
esv2758767 CNV gain+loss 17122850
nsv1109208 CNV deletion 24896259
nsv1140251 OTHER inversion 24896259
nsv580001 CNV gain 21841781
nsv580006 CNV loss 21841781
nsv833872 CNV loss 17160897
nsv963067 CNV duplication 23825009

Variation tolerance for ZNF615 Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.10; 92.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF615 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF615

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF615 Gene

Disorders for ZNF615 Gene

Relevant External Links for ZNF615

Genetic Association Database (GAD)
ZNF615
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF615

No disorders were found for ZNF615 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF615 Gene

Publications for ZNF615 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64

Products for ZNF615 Gene

Sources for ZNF615 Gene

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