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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF615 Gene

protein-coding   GIFtS: 46
GCID: GC19M052494

Zinc Finger Protein 615

  Search for ZNF615
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 6151 2

External Ids:    HGNC: 247401   Entrez Gene: 2843702   Ensembl: ENSG000001976197   UniProtKB: Q8N8J63   

Export aliases for ZNF615 gene to outside databases

Previous GC identifers: GC19M057188 GC19M057191 GC19M057193 GC19M057194 GC19M057195 GC19M057196 GC19M057197 GC19M057198 GC19M057199 GC19M052469


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF615 Gene: 
ZNF615 (zinc finger protein 615) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF420.

UniProtKB/Swiss-Prot: ZN615_HUMAN, Q8N8J6
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF615 gene promoter:
         Bach1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF615 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF615

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF615


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

ZNF615 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF615 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M052494:  view genomic region     (about GC identifiers)

Start:
52,494,585 bp from pter      End:
52,511,483 bp from pter
Size:
16,899 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN615_HUMAN, Q8N8J6 (See protein sequence)
Recommended Name: Zinc finger protein 615  
Size: 731 amino acids; 83739 Da
Subcellular location: Nucleus (Potential)
Caution: It is uncertain whether Met-1 or Met-2 is the initiator
Sequence caution: Sequence=BAC87399.1; Type=Miscellaneous discrepancy; Note=aberrant splicing;
Secondary accessions: B7ZKW9 Q2M2Y6 Q5CZB0 Q6ZMT7 Q6ZRB3
Alternative splicing: 3 isoforms:  Q8N8J6-1   Q8N8J6-2   Q8N8J6-3   (Contains a phosphoserine at position 85. Contains a phosphotyrosine at position 89)

Explore the universe of human proteins at neXtProt for ZNF615: NX_Q8N8J6

Explore proteomics data for ZNF615 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N8J6

  • ZNF615 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF615 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001186253.1  NP_940882.3  

    ENSEMBL proteins: 
     ENSP00000473089   ENSP00000471549   ENSP00000470475   ENSP00000365906   ENSP00000375672  
     ENSP00000471041   ENSP00000471202   ENSP00000470880   ENSP00000471608   ENSP00000470709  
     ENSP00000472341  
    Reactome Protein details: Q8N8J6
    Human Recombinant Protein Products for ZNF615: 
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    Cloud-Clone Corp. Proteins for ZNF615 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF615 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N8J6

    ProtoNet protein and cluster: Q8N8J6

    UniProtKB/Swiss-Prot: ZN615_HUMAN, Q8N8J6
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 19 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF615 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN615_HUMAN, Q8N8J6
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF615 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF615 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF615
        Generic Transcription Pathway
    Gene Expression



    ZNF615 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF615

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for ZNF615 (Q8N8J63 ENSP000003659064) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEK1Q96PY63, ENSP000004080204I2D: score=1 STRING: ENSP00000408020
    BRCA1ENSP000003502834STRING: ENSP00000350283
    RNF11ENSP000002427194STRING: ENSP00000242719
    TRIM28ENSP000002530244STRING: ENSP00000253024
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF615 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF615 (ZN615)

    Search CenterWatch for drugs/clinical trials and news about ZNF615 / ZN615

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF615 gene (2 alternative transcripts): 
    NM_001199324.1  NM_198480.3  

    Unigene Cluster for ZNF615:

    Zinc finger protein 615
    Hs.368355  [show with all ESTs]
    Unigene Representative Sequence: BC053884
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000602063 ENST00000594083 ENST00000599177 ENST00000376716(uc002pyf.2 uc002pye.2 uc002pyh.2 uc010epi.2 uc002pyg.2 uc010ydg.2)
    ENST00000391795 ENST00000598071 ENST00000593650 ENST00000599115 ENST00000601178
    ENST00000597747 ENST00000599631 ENST00000597905 ENST00000595114
    miRNA
    Products:
         
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF615:
    hsa-miR-433 hsa-miR-3145-3p
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF615

    Additional mRNA sequence: 

    AK091029.1 AK094071.1 AK096691.1 AK128361.1 AK131494.1 AK291734.1 AK294977.1 BC053884.1 
    BC105100.1 BC105102.1 BC112961.1 BC143429.1 BX647556.1 BX648594.1 CR936612.1 

    7 DOTS entries:

    DT.40238635  DT.100736776  DT.101982914  DT.101982915  DT.99984836  DT.100734734  DT.305751 

    24/45 AceView cDNA sequences (see all 45):

    BC053884 AA653611 AA385633 AI183853 AK094071 AK131494 CA447851 AX748441 
    NM_198480 AA678644 BX647556 Z44582 AA809513 BU952608 AK096691 AK128361 
    AK091029 BQ224764 BX648594 AI082819 AI332527 AL555338 BQ230210 BQ003208 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF615 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d
    SP1:                    -     -     -                                                                           
    SP2:                    -     -     -                                         -     -                           
    SP3:                    -     -     -                                         -     -     -                     
    SP4:                    -     -     -     -                                                                     
    SP5:                          -     -                                                                           


    ECgene alternative splicing isoforms for ZNF615

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF615 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCCTTTTG
    ZNF615 Expression
    About this image


    See ZNF615 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF615

    SOURCE GeneReport for Unigene cluster: Hs.368355
        SABiosciences Custom PCR Arrays for ZNF615
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF615 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    47(a)
    1 → many
    GL343667.1(293566-303659)
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii BX081777.12   -- 77.04(n)    BX081777.1 
            Species with no ortholog for ZNF615

    ENSEMBL Gene Tree for ZNF615 (if available)
    TreeFam Gene Tree for ZNF615 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF615 gene
    ZNF4202  ZNF780A2  ZNF6652  ZNF724P2  ZNF72  ZNF232  ZNF4322  ZNF33A2  
    ZNF2342  ZNF302  ZNF5732  ZNF4292  ZNF5402  ZNF2512  ZNF6052  ZNF842  
    ZNF1892  ZNF5712  ZNF6302  ZNF932  ZNF162  ZNF2832  ZNF3472  ZNF4842  
    ZNF1352  ZNF1842  ZNF585B2  ZNF412  ZNF5692  ZNF4702  
    18/553 SIMAP similar genes for ZNF615 using alignment to 6 protein entries:     ZN615_HUMAN (see all proteins) (see all similar genes):
    ZNF649    ZNF350    ZNF300P1    ZNF283    ZNF432    AVGR5
    ZNF614    ZNF844    ZNF613    ZNF559    ZFP90    ZNF84
    ZNF721    ZNF415    ZNF625    FIK    ZNF788    ZNF780A

    ZNF615 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/473 SNPs in ZNF615 are shown (see all 473)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1454418261,2
    --52494140(+) GGAGGC/TTGAGG 2 -- int10--------
    rs1887016931,2
    --52494236(+) AGGCGC/TAGTGG 2 -- int10--------
    rs1123151771,2
    C,F--52494247(+) CAGGCG/ACCTGT 2 -- int11Minor allele frequency- A:0.50NA 2
    rs1435168381,2
    C--52494393(+) AAAAC-/AAAAAA 2 -- int10--------
    rs730520171,2
    C,F--52494537(+) ATACTC/TTGCAG 2 -- int15Minor allele frequency- T:0.15NA CSA WA EA 362
    rs1177978811,2
    C,F--52494691(+) TCGTAT/CCATAG 2 -- ut311Minor allele frequency- C:0.03NA 120
    rs558961431,2
    C--52494778(+) TGAAAC/TAGCCA 2 -- ut310--------
    rs1931800291,2
    --52494994(+) GATTTC/TTTAAA 2 -- ut310--------
    rs1845130661,2
    --52495085(+) TAACAA/GTTTCA 2 -- ut310--------
    rs18359991,2
    C,F--52495109(+) ggtaaT/Cgaact 2 -- ut31 ese312Minor allele frequency- C:0.39NA EA WA CSA 560

    HapMap Linkage Disequilibrium report for ZNF615 (52494585 - 52511483 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZNF615:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833872CNV Loss17160897
    dgv143e55CNV Gain17911159
    dgv425n27CNV Gain19166990
    esv638CNV CNV17122850
    dgv1113e1CNV Complex17122850
    dgv1112e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF615 for disorders           About MalaCards

    ZNF615 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF615

    Export disorders for ZNF615 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF615 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF615)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 284370 HGNC: 24740 AceView: ZNF615 Ensembl:ENSG00000197619 euGenes: HUgn284370
    ECgene: ZNF615 H-InvDB: ZNF615

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF615 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF615 gene:
    Search GeneIP for patents involving ZNF615

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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