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Aliases for ZNF614 Gene

Aliases for ZNF614 Gene

  • Zinc Finger Protein 614 2 3 5

External Ids for ZNF614 Gene

Previous GeneCards Identifiers for ZNF614 Gene

  • GC19M057208
  • GC19M057209
  • GC19M057210
  • GC19M057211
  • GC19M057212
  • GC19M057213
  • GC19M057214
  • GC19M057215
  • GC19M052516
  • GC19M048847

Summaries for ZNF614 Gene

GeneCards Summary for ZNF614 Gene

ZNF614 (Zinc Finger Protein 614) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF615.

UniProtKB/Swiss-Prot for ZNF614 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF614 Gene

Genomics for ZNF614 Gene

Regulatory Elements for ZNF614 Gene

Enhancers for ZNF614 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF614 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF614 Gene

52,012,765 bp from pter
52,030,240 bp from pter
17,476 bases
Minus strand

Genomic View for ZNF614 Gene

Genes around ZNF614 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF614 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF614 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF614 Gene

Proteins for ZNF614 Gene

  • Protein details for ZNF614 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 614
    Protein Accession:
    Secondary Accessions:
    • Q494T8
    • Q8TCF4
    • Q9BSN8

    Protein attributes for ZNF614 Gene

    585 amino acids
    Molecular mass:
    67215 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF614 Gene


neXtProt entry for ZNF614 Gene

Proteomics data for ZNF614 Gene at MOPED

Post-translational modifications for ZNF614 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF614 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF614

No data available for DME Specific Peptides for ZNF614 Gene

Domains & Families for ZNF614 Gene

Gene Families for ZNF614 Gene

Protein Domains for ZNF614 Gene

Suggested Antigen Peptide Sequences for ZNF614 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF614: view

Function for ZNF614 Gene

Molecular function for ZNF614 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF614 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZNF614: view
genes like me logo Genes that share phenotypes with ZNF614: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF614 Gene

Localization for ZNF614 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF614 Gene

Subcellular locations from

Jensen Localization Image for ZNF614 Gene COMPARTMENTS Subcellular localization image for ZNF614 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ZNF614 Gene

Pathways & Interactions for ZNF614 Gene

SuperPathways for ZNF614 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF614: view

Pathways by source for ZNF614 Gene

2 Reactome pathways for ZNF614 Gene

Gene Ontology (GO) - Biological Process for ZNF614 Gene


No data available for SIGNOR curated interactions for ZNF614 Gene

Drugs & Compounds for ZNF614 Gene

No Compound Related Data Available

Transcripts for ZNF614 Gene

Unigene Clusters for ZNF614 Gene

Zinc finger protein 614:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF614 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7
SP1: - - - -
SP2: - -
SP3: - - - -

Relevant External Links for ZNF614 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF614 Gene

mRNA expression in normal human tissues for ZNF614 Gene

SOURCE GeneReport for Unigene cluster for ZNF614 Gene Hs.292336

genes like me logo Genes that share expression patterns with ZNF614: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF614 Gene

Orthologs for ZNF614 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF614 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF614 35
  • 82.02 (n)
  • 74.61 (a)
ZNF614 36
  • 74 (a)
(Pan troglodytes)
Mammalia ZNF614 35
  • 99.66 (n)
  • 99.49 (a)
ZNF614 36
  • 99 (a)
(Canis familiaris)
Mammalia ZNF614 36
  • 77 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
-- 36
  • 45 (a)
-- 36
  • 37 (a)
-- 36
  • 38 (a)
-- 36
  • 36 (a)
-- 36
  • 39 (a)
-- 36
  • 39 (a)
-- 36
  • 35 (a)
-- 36
  • 38 (a)
-- 36
  • 38 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
Species with no ortholog for ZNF614:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF614 Gene

Gene Tree for ZNF614 (if available)
Gene Tree for ZNF614 (if available)

Paralogs for ZNF614 Gene

Paralogs for ZNF614 Gene

(496) SIMAP similar genes for ZNF614 Gene using alignment to 4 proteins: Pseudogenes for ZNF614 Gene

genes like me logo Genes that share paralogs with ZNF614: view

Variants for ZNF614 Gene

Sequence variations from dbSNP and Humsavar for ZNF614 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs9636139 - 52,018,043(+) CTGTT(A/G)TCCAT reference, missense
rs35098634 - 52,016,930(+) TCTCA(C/T)GGTAA reference, missense
rs8104890 - 52,016,355(+) TATAA(C/T)GAGAG reference, missense
rs45596739 - 52,017,119(+) CACCT(C/T)CAATA reference, missense
rs7260171 -- 52,027,242(+) aacca(C/G/T)gtgtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF614 Gene

Variant ID Type Subtype PubMed ID
esv638 CNV CNV 17122850
dgv143e55 CNV Gain 17911159
dgv1112e1 CNV Complex 17122850
dgv425n27 CNV Gain 19166990
dgv1113e1 CNV Complex 17122850
nsv833872 CNV Loss 17160897

Variation tolerance for ZNF614 Gene

Residual Variation Intolerance Score: 19.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.69; 66.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF614 Gene

Disorders for ZNF614 Gene

Relevant External Links for ZNF614

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF614 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF614 Gene

Publications for ZNF614 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics. (PMID: 24280104) Wu A.C. … Tantisira K. (J. Allergy Clin. Immunol. 2014) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for ZNF614 Gene

Sources for ZNF614 Gene