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Aliases for ZNF614 Gene

Aliases for ZNF614 Gene

  • Zinc Finger Protein 614 2 3

External Ids for ZNF614 Gene

Previous GeneCards Identifiers for ZNF614 Gene

  • GC19M057208
  • GC19M057209
  • GC19M057210
  • GC19M057211
  • GC19M057212
  • GC19M057213
  • GC19M057214
  • GC19M057215
  • GC19M052516
  • GC19M048847

Summaries for ZNF614 Gene

GeneCards Summary for ZNF614 Gene

ZNF614 (Zinc Finger Protein 614) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF182.

UniProtKB/Swiss-Prot for ZNF614 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF614 Gene

Genomics for ZNF614 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF614 Gene

Chromosome:
19
Start:
52,012,765 bp from pter
End:
52,030,240 bp from pter
Size:
17,476 bases
Orientation:
Minus strand

Genomic View for ZNF614 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF614 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF614 Gene

No data available for Regulatory Elements for ZNF614 Gene

Proteins for ZNF614 Gene

  • Protein details for ZNF614 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N883-ZN614_HUMAN
    Recommended name:
    Zinc finger protein 614
    Protein Accession:
    Q8N883
    Secondary Accessions:
    • Q494T8
    • Q8TCF4
    • Q9BSN8

    Protein attributes for ZNF614 Gene

    Size:
    585 amino acids
    Molecular mass:
    67215 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF614 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF614 Gene

Proteomics data for ZNF614 Gene at MOPED

Post-translational modifications for ZNF614 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF614 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF614

No data available for DME Specific Peptides for ZNF614 Gene

Domains & Families for ZNF614 Gene

Gene Families for ZNF614 Gene

Protein Domains for ZNF614 Gene

Suggested Antigen Peptide Sequences for ZNF614 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N883

UniProtKB/Swiss-Prot:

ZN614_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF614: view

Function for ZNF614 Gene

Molecular function for ZNF614 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF614 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 22458338
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF614: view
genes like me logo Genes that share phenotypes with ZNF614: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF614

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF614 Gene

Localization for ZNF614 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF614 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF614 Gene COMPARTMENTS Subcellular localization image for ZNF614 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF614 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF614: view

Pathways & Interactions for ZNF614 Gene

SuperPathways for ZNF614 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF614: view

Pathways by source for ZNF614 Gene

2 Reactome pathways for ZNF614 Gene

Gene Ontology (GO) - Biological Process for ZNF614 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF614: view

No data available for SIGNOR curated interactions for ZNF614 Gene

Drugs & Compounds for ZNF614 Gene

No Compound Related Data Available

Transcripts for ZNF614 Gene

Unigene Clusters for ZNF614 Gene

Zinc finger protein 614:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF614

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF614 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7
SP1: - - - -
SP2: - -
SP3: - - - -
SP4:

Relevant External Links for ZNF614 Gene

GeneLoc Exon Structure for
ZNF614
ECgene alternative splicing isoforms for
ZNF614

Expression for ZNF614 Gene

mRNA expression in normal human tissues for ZNF614 Gene

SOURCE GeneReport for Unigene cluster for ZNF614 Gene Hs.292336

genes like me logo Genes that share expression patterns with ZNF614: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF614 Gene

Orthologs for ZNF614 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF614 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF614 35
  • 82.02 (n)
  • 74.61 (a)
ZNF614 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF614 35
  • 99.66 (n)
  • 99.49 (a)
ZNF614 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF614 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
OneToMany
Species with no ortholog for ZNF614:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF614 Gene

ENSEMBL:
Gene Tree for ZNF614 (if available)
TreeFam:
Gene Tree for ZNF614 (if available)

Paralogs for ZNF614 Gene

(496) SIMAP similar genes for ZNF614 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ZNF614 Gene

genes like me logo Genes that share paralogs with ZNF614: view

Variants for ZNF614 Gene

Sequence variations from dbSNP and Humsavar for ZNF614 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2288884 -- 52,029,018(-) AACAT(A/G)TAGAT upstream-variant-2KB
rs3217389 -- 52,029,707(-) TGAAC(-/TTA)TTATA upstream-variant-2KB
rs3840908 -- 52,028,350(-) TTACC(-/C)GCTCA utr-variant-5-prime
rs4802892 -- 52,024,891(+) ccagc(A/G)tgaca intron-variant
rs6509613 -- 52,025,821(+) AGTTT(C/T)TGAAG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF614 Gene

Variant ID Type Subtype PubMed ID
esv638 CNV CNV 17122850
dgv143e55 CNV Gain 17911159
dgv1112e1 CNV Complex 17122850
dgv425n27 CNV Gain 19166990
dgv1113e1 CNV Complex 17122850
nsv833872 CNV Loss 17160897

Variation tolerance for ZNF614 Gene

Residual Variation Intolerance Score: 19.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.69; 66.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF614 Gene

HapMap Linkage Disequilibrium report
ZNF614

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF614 Gene

Disorders for ZNF614 Gene

Relevant External Links for ZNF614

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF614
genes like me logo Genes that share disorders with ZNF614: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF614 Gene

Publications for ZNF614 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 67
  3. Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics. (PMID: 24280104) Wu A.C. … Tantisira K. (J. Allergy Clin. Immunol. 2014) 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses. (PMID: 22458338) Simonis N. … Twizere J.C. (Retrovirology 2012) 67

Products for ZNF614 Gene

Sources for ZNF614 Gene

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