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ZNF614 Gene

protein-coding   GIFtS: 47
GCID: GC19M052516

Zinc Finger Protein 614

  Search for ZNF614
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 6141 2

External Ids:    HGNC: 247221   Entrez Gene: 801102   Ensembl: ENSG000001425567   UniProtKB: Q8N8833   

Export aliases for ZNF614 gene to outside databases

Previous GC identifers: GC19M057208 GC19M057209 GC19M057210 GC19M057211 GC19M057212 GC19M057213 GC19M057214 GC19M057215 GC19M048847


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF614 Gene:
ZNF614 (zinc finger protein 614) is a protein-coding gene. An important paralog of this gene is ZNF175.

UniProtKB/Swiss-Prot: ZN614_HUMAN, Q8N883
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF614
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF614 promoter sequence
   Search Chromatin IP Primers for ZNF614

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF614


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

ZNF614 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF614 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M052516:  view genomic region     (about GC identifiers)

Start:
52,516,018 bp from pter      End:
52,533,493 bp from pter
Size:
17,476 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN614_HUMAN, Q8N883 (See protein sequence)
Recommended Name: Zinc finger protein 614  
Size: 585 amino acids; 67215 Da
Secondary accessions: Q494T8 Q8TCF4

Explore the universe of human proteins at neXtProt for ZNF614: NX_Q8N883

Explore proteomics data for ZNF614 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys509
  • Modification sites at PhosphoSitePlus

  • See ZNF614 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079316.2  
    ENSEMBL proteins: 
     ENSP00000348674   ENSP00000270649   ENSP00000471869   ENSP00000469809  
    Reactome Protein details: Q8N883

    ZNF614 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N883

    ProtoNet protein and cluster: Q8N883

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN614_HUMAN, Q8N883
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF614 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN614_HUMAN, Q8N883
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF614 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF614:
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF614
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    miRNA
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    miRTarBase miRNAs that target ZNF614:
    hsa-let-7c-5p (MIRT051733), hsa-mir-128-3p (MIRT021968), hsa-mir-375 (MIRT019816)

    Block miRNA regulation of human, mouse, rat ZNF614 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate ZNF614:
    hsa-miR-199a-5p hsa-miR-124 hsa-miR-544b hsa-miR-199b-5p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidZNF614 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN614_HUMAN, Q8N883: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF614 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF614 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF614
        Generic Transcription Pathway



    ZNF614 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF614
    Interactions:

        Search GeneGlobe Interaction Network for ZNF614

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0008150biological_process ND--

    ZNF614 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF614 (ZN614)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF614 gene: 
    NM_025040.3  

    Unigene Cluster for ZNF614:

    Zinc finger protein 614
    Hs.292336  [show with all ESTs]
    Unigene Representative Sequence: NM_025040
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356322(uc002pyi.4) ENST00000270649(uc002pyj.3 uc010epj.3)
    ENST00000595189 ENST00000597952
    miRNA
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    Block miRNA regulation of human, mouse, rat ZNF614 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate ZNF614:
    hsa-miR-199a-5p hsa-miR-124 hsa-miR-544b hsa-miR-199b-5p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidZNF614 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF614
      QuantiFast Probe-based Assays in human, mouse, rat ZNF614

    Additional mRNA sequence: 

    AK023547.1 AK025594.1 AK097156.1 AK309346.1 BC004930.1 BC022246.1 BC101392.1 BC101393.2 
    BC101394.1 BC101395.1 

    4 DOTS entries:

    DT.310183  DT.100754958  DT.91896065  DT.95089491 

    Selected AceView cDNA sequences (see all 66):

    NM_025040 BX505692 BU154861 BX643157 CK819577 BM129319 AK097156 AI274461 
    CK819576 D60700 AW189300 AI698680 BQ025846 AA682908 BX472844 BC004930 
    BG104347 BM799836 D60971 AI087872 BE390527 AA659823 BM129588 BG436055 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF614    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7
    SP1:                                            -     -                 -     -         
    SP2:                                            -     -                                 
    SP3:                          -     -     -     -                                       
    SP4:                                                                                    


    ECgene alternative splicing isoforms for ZNF614

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF614 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF614 Expression
    About this image

    ZNF614 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF614 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.292336
        Custom PCR Arrays for ZNF614
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF614

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF614 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF6146
    zinc finger protein 614
    77(a)
    1 ↔ 1
    1(105156383-105173451)


    ENSEMBL Gene Tree for ZNF614 (if available)
    TreeFam Gene Tree for ZNF614 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF614 gene
    ZNF1752  ZNF6742  ZNF4872  ZNF5102  ZIM32  ZNF1572  ZNF262  ZNF6132  
    ZNF812  ZNF6492  ENSG000002673602  ZNF7822  ZNF7932  ZNF252  ZNF5682  ENSG000002365752  
    ENSG000002296312  ZNF5672  ZNF1822  ZNF37A2  ZNF2482  ZNF3002  ZNF3822  RBAK-RBAKDN2  
    Selected SIMAP similar genes for ZNF614 using alignment to 4 protein entries:     ZN614_HUMAN (see all proteins) (see all similar genes):
    ZNF350    ZNF721    ZNF420    ZNF615    ZNF669    FIK
    ZNF649    ZNF432    ZNF415    ZNF81    ZNF613    MGC12518
    ZNF208    ZNF738    ZFP90    ZNF177    ZNF91    ZNF675

    ZNF614 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF614
    PGOHUM00000242437


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF614 (see all 409)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs118795301,2
    C,F,H--52516112(+) agagaT/Cagtga 1 -- ds5001 ese34Minor allele frequency- C:0.30NA 10
    rs118821321,2
    C,F,A,H--52516124(+) aaggcG/Aggtgg 1 -- ds5001 ese32Minor allele frequency- A:0.50NA 6
    rs1425200951,2
    --52516254(+) GGCAGC/TGGAAG 1 -- ds50010--------
    rs116717021,2
    C,F,H--52516360(+) GCCTTC/TGGCTC 1 -- ds5001 ese310Minor allele frequency- T:0.25NS NA WA CSA EA 624
    rs1888470191,2
    --52516750(+) TATTCA/TTCAAC 1 -- ut310--------
    rs1450577701,2
    --52516853(+) TAAAAG/TTTATA 1 -- ut310--------
    rs775873581,2
    C,F--52517055(+) TTCTTA/TGAGTA 1 -- ut311Minor allele frequency- T:0.30WA 118
    rs351581771,2
    C--52517115(+) ATTAG-/TTTACTT 1 -- ut310--------
    rs1916506711,2
    --52517165(+) TTATGA/GTTATA 1 -- ut310--------
    rs765214501,2
    C,F--52517166(+) TATGGT/CTATAT 1 -- ut311Minor allele frequency- C:0.03NA 120

    HapMap Linkage Disequilibrium report for ZNF614 (52516018 - 52533493 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZNF614:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833872CNV Loss17160897
    dgv143e55CNV Gain17911159
    dgv425n27CNV Gain19166990
    esv638CNV CNV17122850
    dgv1113e1CNV Complex17122850
    dgv1112e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF614 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF614)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80110 HGNC: 24722 AceView: ZNF614 Ensembl:ENSG00000142556 euGenes: HUgn80110
    ECgene: ZNF614 H-InvDB: ZNF614

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF614 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF614 gene:
    Search GeneIP for patents involving ZNF614

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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