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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF613 Gene

protein-coding   GIFtS: 46
GCID: GC19P052430

Zinc Finger Protein 613

  Search for ZNF613
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 6131 2

External Ids:    HGNC: 258271   Entrez Gene: 798982   Ensembl: ENSG000001760247   UniProtKB: Q6PF043   

Export aliases for ZNF613 gene to outside databases

Previous GC identifers: GC19P057123 GC19P057125 GC19P048761


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF613 Gene: 
ZNF613 (zinc finger protein 613) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF334.

UniProtKB/Swiss-Prot: ZN613_HUMAN, Q6PF04
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF613 gene promoter:
         c-Fos   AP-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF613 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF613

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF613


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

ZNF613 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF613 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P052430:  view genomic region     (about GC identifiers)

Start:
52,430,400 bp from pter      End:
52,452,012 bp from pter
Size:
21,613 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN613_HUMAN, Q6PF04 (See protein sequence)
Recommended Name: Zinc finger protein 613  
Size: 617 amino acids; 70143 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q96SS9
Alternative splicing: 2 isoforms:  Q6PF04-1   Q6PF04-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF613: NX_Q6PF04

Explore proteomics data for ZNF613 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6PF04

  • ZNF613 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF613 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001026891.2  NP_079116.2  

    ENSEMBL proteins: 
     ENSP00000293471   ENSP00000375671   ENSP00000472455   ENSP00000468850  
    Reactome Protein details: Q6PF04
    Human Recombinant Protein Products for ZNF613: 
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    Novus Biologicals ZNF613 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF613 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF613 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for ZNF613 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6PF04

    ProtoNet protein and cluster: Q6PF04

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN613_HUMAN, Q6PF04
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF613 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN613_HUMAN, Q6PF04
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF613 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF613:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF613 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZNF613

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF613 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF613


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF613 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF613
        Generic Transcription Pathway
    Gene Expression



    ZNF613 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF613

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF613 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF613 (ZN613)

    Search CenterWatch for drugs/clinical trials and news about ZNF613 / ZN613

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF613 gene (2 alternative transcripts): 
    NM_001031721.3  NM_024840.3  

    Unigene Cluster for ZNF613:

    Zinc finger protein 613
    Hs.183390  [show with all ESTs]
    Unigene Representative Sequence: NM_001031721
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000593395 ENST00000293471(uc002pxz.2) ENST00000391794(uc002pya.2)
    ENST00000599683 ENST00000600853 ENST00000593379 ENST00000601794
    miRNA
    Products:
         
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ZNF613
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF613
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF613
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    OriGene clones in human, mouse for ZNF613 (see all 6)
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    GenScript: all cDNA clones in your preferred vector (see all 2): ZNF613 (NM_024840)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF613
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF613
    Sirion Biotech Customized lentivirus for stable overexpression of ZNF613 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF613 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF613
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF613
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF613

    Additional mRNA sequence: 

    AK023652.1 AK027565.1 BC057776.1 

    8 DOTS entries:

    DT.309254  DT.97818173  DT.121458501  DT.121458505  DT.121458498  DT.121458507  DT.121458510  DT.121458497 

    24/34 AceView cDNA sequences (see all 34):

    BX118268 BC057776 BU627586 W19153 NM_024840 AI475432 BM978342 AA447439 
    BM661827 BQ232832 BF434587 AK027565 BQ012400 AI888962 BG679145 CD685482 
    AA309374 AA779758 AU138838 AK023652 AL709956 BF055471 CB995038 CA427456 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF613 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d
    SP1:                                            -     -     -                             -                           
    SP2:                          -                                                           -                           
    SP3:                          -                             -     -                       -                           
    SP4:                          -                 -     -     -                             -                           
    SP5:                          -     -     -                                               -                           


    ECgene alternative splicing isoforms for ZNF613

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF613 expression in normal human tissues (normalized intensities)      ZNF613 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGACTCTGC
    ZNF613 Expression
    About this image


    ZNF613 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Prostate (Endocrine System)

    See ZNF613 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF613

    SOURCE GeneReport for Unigene cluster: Hs.183390
        SABiosciences Custom PCR Arrays for ZNF613
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF613

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF613 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    37(a)
    1 → many
    GL343667.1(293566-303659)
            Species with no ortholog for ZNF613

    ENSEMBL Gene Tree for ZNF613 (if available)
    TreeFam Gene Tree for ZNF613 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF613 gene
    ZNF3342  ZNF1752  ZNF6742  ZNF4872  ZNF5102  LOC1002875152  ZNF6142  RBAK2  
    ZNF262  ZNF812  ZNF6492  KRBOX42  ZNF33B2  ENSG000002673602  ZNF7822  ZNF122  
    ENSG000002296312  ZNF5672  ZNF1822  ZNF37A2  ZNF2482  ZNF3002  ZNF3822  
    18/511 SIMAP similar genes for ZNF613 using alignment to 3 protein entries:     ZN613_HUMAN (see all proteins) (see all similar genes):
    ZNF350    ZNF78L1    ZNF432    FIK    ZNF615    ZNF614
    ZNF283    MRPS17    ZNF649    ZNF84    ZNF420    ZNF814
    ZFP90    ZNF81    ZFS-4    ZNF124    ZNF250    ZNF569

    ZNF613 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/489 SNPs in ZNF613 are shown (see all 489)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1494627401,2
    --52428709(+) TATTTA/CCTGAG 2 -- us2k10--------
    rs1438527761,2
    --52428723(+) GGAGAA/TAACTG 2 -- us2k10--------
    rs1889957641,2
    --52428758(+) CTGGCA/GGCAAT 2 -- us2k10--------
    rs1486993451,2
    --52428820(+) CCTACA/GTGCAC 2 -- us2k10--------
    rs1137420091,2
    C--52428835(+) AGGCAC/TAGCAC 2 -- us2k10--------
    rs1115875861,2
    F--52428847(+) TTTCCC/TTATTT 2 -- us2k11Minor allele frequency- T:0.00CSA 1
    rs124627461,2
    C,F,H--52428900(+) ctcccC/Taccat 2 -- us2k1 trp31Minor allele frequency- T:0.33NA 6
    rs1396556681,2
    --52428936(+) CTCACC/TGAGAT 2 -- us2k10--------
    rs1861299141,2
    --52429004(+) TCCTTC/TGTATG 2 -- us2k10--------
    rs1892692151,2
    --52429204(+) TCAGTA/GGTATT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF613 (52430400 - 52452012 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZNF613:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833872CNV Loss17160897
    dgv143e55CNV Gain17911159
    dgv425n27CNV Gain19166990
    esv638CNV CNV17122850
    dgv1113e1CNV Complex17122850
    dgv1112e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF613
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF613

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF613 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF613)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79898 HGNC: 25827 AceView: ZNF613 Ensembl:ENSG00000176024 euGenes: HUgn79898
    ECgene: ZNF613 H-InvDB: ZNF613

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF613 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF613 gene:
    Search GeneIP for patents involving ZNF613

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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