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Aliases for ZNF613 Gene

Aliases for ZNF613 Gene

  • Zinc Finger Protein 613 2 3 5

External Ids for ZNF613 Gene

Previous GeneCards Identifiers for ZNF613 Gene

  • GC19P057123
  • GC19P057125
  • GC19P052430
  • GC19P048761
  • GC19P051879

Summaries for ZNF613 Gene

GeneCards Summary for ZNF613 Gene

ZNF613 (Zinc Finger Protein 613) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF614.

UniProtKB/Swiss-Prot for ZNF613 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF613 Gene

Genomics for ZNF613 Gene

Regulatory Elements for ZNF613 Gene

Enhancers for ZNF613 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F051926 1.1 ENCODE 11 +0.2 185 1.8 PKNOX1 CREB3L1 WRNIP1 SIN3A ARID4B FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF350-AS1 ENSG00000269483 ZNF480 ZNF613 ZNF615 ZNF808 ZNF577 ZNF841 PIR55859
GH19F051960 0.9 ENCODE 11.4 +33.7 33726 1.7 HDAC1 ARID4B DMAP1 RAD21 CREM ZNF654 ZEB2 REST PPARG KAT8 ZNF350-AS1 ZNF613 ZNF350 ZNF432 ZNF615 ZNF841
GH19F051887 0.8 ENCODE 10.9 -39.0 -38969 1.7 ZNF76 ZEB1 ETS1 YY1 GLIS2 ZNF280D SP3 HCFC1 YY2 ZEB2 ZNF577 ZNF613 FPR3 ZNF615 ZNF350 ZNF649-AS1
GH19F052687 1 ENCODE 5.2 +762.7 762745 4.3 HDGF PKNOX1 ATF1 ARNT SIN3A ARID4B ZNF48 GLIS2 ZNF263 SP3 ZNF766 ZNF808 ZNF28 ZNF83 ENSG00000269825 ZNF613
GH19F051460 1.5 FANTOM5 Ensembl ENCODE 2.9 -465.5 -465547 2.4 ELF3 HDAC1 CBX3 TBL1XR1 CREB3L1 ZBTB40 ETS1 ZNF143 KDM4B CREM ZNF480 SIGLEC5 RPL7P51 SIGLEC14 SIGLEC6 SIGLEC8 SIGLEC7 ZNF175 ZNF613 CD33
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF613 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF613 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001419991 254 2400 PKNOX1 CREB3L1 WRNIP1 SIN3A ARID4B FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for ZNF613 Gene

Chromosome:
19
Start:
51,927,147 bp from pter
End:
51,948,759 bp from pter
Size:
21,613 bases
Orientation:
Plus strand

Genomic View for ZNF613 Gene

Genes around ZNF613 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF613 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF613 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF613 Gene

Proteins for ZNF613 Gene

  • Protein details for ZNF613 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PF04-ZN613_HUMAN
    Recommended name:
    Zinc finger protein 613
    Protein Accession:
    Q6PF04
    Secondary Accessions:
    • Q96SS9

    Protein attributes for ZNF613 Gene

    Size:
    617 amino acids
    Molecular mass:
    70143 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF613 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF613 Gene

Post-translational modifications for ZNF613 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF613 Gene

Domains & Families for ZNF613 Gene

Gene Families for ZNF613 Gene

Suggested Antigen Peptide Sequences for ZNF613 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PF04

UniProtKB/Swiss-Prot:

ZN613_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF613: view

Function for ZNF613 Gene

Molecular function for ZNF613 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF613 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0044212 transcription regulatory region DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF613: view
genes like me logo Genes that share phenotypes with ZNF613: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF613 Gene

Localization for ZNF613 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF613 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF613 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF613 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF613: view

Pathways & Interactions for ZNF613 Gene

SuperPathways for ZNF613 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF613: view

Pathways by source for ZNF613 Gene

2 Reactome pathways for ZNF613 Gene

Interacting Proteins for ZNF613 Gene

Gene Ontology (GO) - Biological Process for ZNF613 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ZNF613: view

No data available for SIGNOR curated interactions for ZNF613 Gene

Transcripts for ZNF613 Gene

Unigene Clusters for ZNF613 Gene

Zinc finger protein 613:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF613 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - - -
SP2: - -
SP3: - - - -
SP4: - - - - -
SP5: - - - -
SP6: - -
SP7: - - - -
SP8:
SP9: - - - - - -

Relevant External Links for ZNF613 Gene

GeneLoc Exon Structure for
ZNF613
ECgene alternative splicing isoforms for
ZNF613

Expression for ZNF613 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF613 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ZNF613 Gene:

ZNF613

SOURCE GeneReport for Unigene cluster for ZNF613 Gene:

Hs.183390
genes like me logo Genes that share expression patterns with ZNF613: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF613 Gene

Orthologs for ZNF613 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF613 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF613 34 35
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia ZNF613 34 35
  • 84.36 (n)
cow
(Bos Taurus)
Mammalia ZNF613 34 35
  • 82.36 (n)
mouse
(Mus musculus)
Mammalia Zfp157 34 16
  • 59.86 (n)
rat
(Rattus norvegicus)
Mammalia Zfp157 34
  • 59.48 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 46 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 39 (a)
OneToMany
Species where no ortholog for ZNF613 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF613 Gene

ENSEMBL:
Gene Tree for ZNF613 (if available)
TreeFam:
Gene Tree for ZNF613 (if available)

Paralogs for ZNF613 Gene

(513) SIMAP similar genes for ZNF613 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF613: view

Variants for ZNF613 Gene

Sequence variations from dbSNP and Humsavar for ZNF613 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10409737 -- 51,940,124(+) TTGGT(A/G)AAAAT intron-variant
rs10411422 -- 51,940,061(+) TTGCC(G/T)CTATG intron-variant
rs10411484 -- 51,940,152(+) TCACA(C/T)TTCTT intron-variant
rs10420129 -- 51,929,176(+) ATGAA(C/T)GTTCT intron-variant
rs10525528 -- 51,938,751(+) ATATA(-/TG)TGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF613 Gene

Variant ID Type Subtype PubMed ID
dgv1067e212 CNV gain 25503493
dgv143e55 CNV gain 17911159
dgv3626n100 CNV gain 25217958
dgv425n27 CNV gain 19166990
dgv6523n54 CNV gain 21841781
esv2758767 CNV gain+loss 17122850
esv3644680 CNV gain 21293372
nsv1140251 OTHER inversion 24896259
nsv580001 CNV gain 21841781
nsv580005 CNV loss 21841781
nsv833872 CNV loss 17160897

Variation tolerance for ZNF613 Gene

Residual Variation Intolerance Score: 49.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 42.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF613 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF613

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF613 Gene

Disorders for ZNF613 Gene

Relevant External Links for ZNF613

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF613

No disorders were found for ZNF613 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF613 Gene

Publications for ZNF613 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for ZNF613 Gene

Sources for ZNF613 Gene

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