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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF613 Gene

protein-coding GIFtS: 47
GCID: GC19P052430

zinc finger protein 613

Search for ZNF613
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 613¹ ²
FLJ13590¹

External Ids:	HGNC: 25827¹	Entrez Gene: 79898²	Ensembl: ENSG00000176024⁷	UniProtKB: Q6PF04³

Export aliases for ZNF613 gene to outside databases

Previous GC identifers: GC19P057123 GC19P057125 GC19P048761

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN613_HUMAN, Q6PF04

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF613 gene promoter:
c-Fos AP-1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF613 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF613

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF613

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.41

ZNF613 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF613 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P052430: view genomic region (about GC identifiers)

Start:	52,430,688 bp from pter	End:	52,449,011 bp from pter
Size:	18,324 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN613_HUMAN, Q6PF04 (See protein sequence)

Recommended Name: Zinc finger protein 613

Size: 617 amino acids; 70143 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: Q96SS9

Alternative splicing: 2 isoforms: Q6PF04-1 Q6PF04-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF613: NX_Q6PF04

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6PF04

ZNF613 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001026891.2 NP_079116.2

ENSEMBL proteins:

ENSP00000293471 ENSP00000375671

Reactome Protein details: Q6PF04
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	Uscn Proteins for ZNF613

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

ZNF613 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF613 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q6PF04

ProtoNet protein and cluster: Q6PF04

2 Blocks protein families:

IPB001909 KRAB box

IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN613_HUMAN, Q6PF04

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 12 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN613_HUMAN, Q6PF04

Function: May be involved in transcriptional regulation

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In Situ Assay
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF613 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ZNF613:

Decreased viability with pacli

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZNF613

	Generic Transcription Pathway
	Gene Expression

ZNF613 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF613

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF613 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF613
Search CenterWatch for drugs/clinical trials and news about ZNF613 / ZN613

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF613 gene (2 alternative transcripts):

NM_001031721.3 NM_024840.3

Unigene Cluster for ZNF613:

Zinc finger protein 613

Hs.183390 [show with all ESTs]

Unigene Representative Sequence: NM_001031721

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000293471(uc002pxz.2) ENST00000391794(uc002pya.2)

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Additional cDNA sequence:

AK023652.1 AK027565.1 BC057776.1

8 DOTS entries:

DT.309254 DT.97818173 DT.121458501 DT.121458505 DT.121458498 DT.121458507 DT.121458510 DT.121458497

24/34 AceView cDNA sequences (see all 34):

BQ232832 NM_024840 W19153 BX118268 BU627586 AA447439 BM661827 BM978342

BF434587 AI475432 AK027565 BC057776 CA427456 BG679145 AA779758 AU138838

AA309374 AK023652 AI888962 BF055471 BQ012400 CD685482 CB995038 AL709956

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF613 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	·	8d
SP1:															-		-		-										-
SP2:									-																				-
SP3:									-										-		-								-
SP4:									-						-		-		-										-
SP5:									-		-		-																-

ECgene alternative splicing isoforms for ZNF613

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF613 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGACTCTGC

About this image

ZNF613 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZNF613 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF613

SOURCE GeneReport for Unigene cluster: Hs.183390

SABiosciences Custom PCR Arrays for ZNF613

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZNF613 gene from 1/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	-- -- (see all 8)	--	37(a) 30(a) (see all 8)	many ↔ many many ↔ many (see all 8)	Un(41687425-41690654) Un(15138918-15143172)

ENSEMBL Gene Tree for ZNF613 (if available)
TreeFam Gene Tree for ZNF613 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF613 gene

ZNF175² ZNF674² LOC100287515² ZNF614² ZNF432² ZNF26² ZNF350² ZNF81²

ZNF649² ZNF605² ZNF577² ZNF84² ZNF630² ZFP37² ZNF484² ENSG00000229631²

ZNF182² ZNF41² ZNF268² LOC100996464² ZNF615² ZNF300²

18/492 SIMAP similar genes for ZNF613 using alignment to 3 protein entries: ZN613_HUMAN (see all proteins) (see all similar genes):

ZNF78L1 ZFS-4 DKFZp686D2168 HZF36 POM121C ZNF66

ZSCAN16 MGC12518 ZNF283 ZNF300P1 ZNF32 ZNF391

ZNF432 ZNF615 ZNF586 ZNF614 DKFZp666M039 ZFS-5

ZNF613 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs149462740^1,2		--	52428709(+)	`TATTTA/CCTGAG`	2	--	us2k¹		0	--	--	--	--
rs143852776^1,2		--	52428723(+)	`GGAGAA/TAACTG`	2	--	us2k¹		0	--	--	--	--
rs188995764^1,2		--	52428758(+)	`CTGGCA/GGCAAT`	2	--	us2k¹		0	--	--	--	--
rs148699345^1,2		--	52428820(+)	`CCTACA/GTGCAC`	2	--	us2k¹		0	--	--	--	--
rs113742009^1,2	C,	--	52428835(+)	`AGGCAC/TAGCAC`	2	--	us2k¹		0	--	--	--	--
rs111587586^1,2		--	52428847(+)	`TTTCCC/TTATTT`	2	--	us2k¹		1		CSA	1
rs12462746^1,2	C,F,H,	--	52428900(+)	`CTCCCC/TACCAT`	2	--	us2k¹ trp³		1		NA	6
rs139655668^1,2		--	52428936(+)	`CTCACC/TGAGAT`	2	--	us2k¹		0	--	--	--	--
rs186129914^1,2		--	52429004(+)	`TCCTTC/TGTATG`	2	--	us2k¹		0	--	--	--	--
rs189269215^1,2		--	52429204(+)	`TCAGTA/GGTATT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF613 (52430688 - 52449011 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for ZNF613
5 CNVs: 8875 4086 3195 34482 53103

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF613 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF613)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 79898	HGNC: 25827	AceView: ZNF613	Ensembl:ENSG00000176024	euGenes: HUgn79898
ECgene: ZNF613	H-InvDB: ZNF613

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF613	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF613 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF613 gene:
Search GeneIP for patents involving ZNF613

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF613 gene at Home site.

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ZNF613 Gene

zinc finger protein 613

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ZNF613 Gene

zinc finger protein 613

Aliasesfor ZNF613 gene

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