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ZNF613 Gene

protein-coding   GIFtS: 47
GCID: GC19P052430

Zinc Finger Protein 613

  Search for ZNF613
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 6131 2

External Ids:    HGNC: 258271   Entrez Gene: 798982   Ensembl: ENSG000001760247   UniProtKB: Q6PF043   

Export aliases for ZNF613 gene to outside databases

Previous GC identifers: GC19P057123 GC19P057125 GC19P048761


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF613 Gene:
ZNF613 (zinc finger protein 613) is a protein-coding gene. An important paralog of this gene is ZNF175.

UniProtKB/Swiss-Prot: ZN613_HUMAN, Q6PF04
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF613 gene promoter:
         c-Fos   AP-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF613 promoter sequence
   Search Chromatin IP Primers for ZNF613

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF613


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

ZNF613 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF613 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P052430:  view genomic region     (about GC identifiers)

Start:
52,430,400 bp from pter      End:
52,452,012 bp from pter
Size:
21,613 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN613_HUMAN, Q6PF04 (See protein sequence)
Recommended Name: Zinc finger protein 613  
Size: 617 amino acids; 70143 Da
Secondary accessions: Q96SS9
Alternative splicing: 2 isoforms:  Q6PF04-1   Q6PF04-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF613: NX_Q6PF04

Explore proteomics data for ZNF613 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF613 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001026891.2  NP_079116.2  

    ENSEMBL proteins: 
     ENSP00000293471   ENSP00000375671   ENSP00000472455   ENSP00000468850  
    Reactome Protein details: Q6PF04

    ZNF613 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6PF04

    ProtoNet protein and cluster: Q6PF04

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN613_HUMAN, Q6PF04
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF613           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN613_HUMAN, Q6PF04
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF613           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF613:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF613
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN613_HUMAN, Q6PF04: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF613           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF613 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF613           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF613
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF613
    Interactions:

        Search GeneGlobe Interaction Network for ZNF613

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF613           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF613 (ZN613)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF613 gene (2 alternative transcripts): 
    NM_001031721.3  NM_024840.3  

    Unigene Cluster for ZNF613:

    Zinc finger protein 613
    Hs.183390  [show with all ESTs]
    Unigene Representative Sequence: NM_001031721
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000593395 ENST00000293471(uc002pxz.2) ENST00000391794(uc002pya.2)
    ENST00000599683 ENST00000600853 ENST00000593379 ENST00000601794
    miRNA
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    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF613
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF613
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): ZNF613 (NM_024840)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF613
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF613
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF613
      QuantiFast Probe-based Assays in human, mouse, rat ZNF613

    Additional mRNA sequence: 

    AK023652.1 AK027565.1 BC057776.1 

    8 DOTS entries:

    DT.309254  DT.97818173  DT.121458501  DT.121458505  DT.121458498  DT.121458507  DT.121458510  DT.121458497 

    Selected AceView cDNA sequences (see all 34):

    BM978342 BF434587 AI475432 W19153 AA447439 BU627586 AK027565 BC057776 
    BM661827 BX118268 NM_024840 BQ232832 AK023652 AA779758 CB995038 CD685482 
    AA309374 CA427456 AU138838 BQ012400 AL709956 BF055471 BG679145 AI888962 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF613 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d
    SP1:                                            -     -     -                             -                           
    SP2:                          -                                                           -                           
    SP3:                          -                             -     -                       -                           
    SP4:                          -                 -     -     -                             -                           
    SP5:                          -     -     -                                               -                           


    ECgene alternative splicing isoforms for ZNF613

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF613 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGACTCTGC
    ZNF613 Expression
    About this image

    ZNF613 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF613 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.183390
        Custom PCR Arrays for ZNF613
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF613

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF613 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp1571 zinc finger protein 157 59.86(n)
    50.83(a)
      72154  NM_028130.3  NP_082406.2 


    ENSEMBL Gene Tree for ZNF613 (if available)
    TreeFam Gene Tree for ZNF613 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF613 gene
    ZNF1752  ZNF6742  ZNF4872  ZNF5102  ZIM32  ZNF6142  ZNF1572  ZNF262  
    ZNF812  ZNF6492  ENSG000002673602  ZNF7822  ZNF7932  ZNF252  ZNF5682  ENSG000002365752  
    ENSG000002296312  ZNF5672  ZNF1822  ZNF37A2  ZNF2482  ZNF3002  ZNF3822  RBAK-RBAKDN2  
    Selected SIMAP similar genes for ZNF613 using alignment to 3 protein entries:     ZN613_HUMAN (see all proteins) (see all similar genes):
    ZNF350    ZNF78L1    ZNF649    ZNF432    FIK    ZNF614
    ZNF625-ZNF20    ZNF615    MRPS17    ZNF84    ZNF283    ZNF814
    ZNF420    ZFP90    LOC101928664    ZFS-4    ZNF124    ZNF250

    Find genes that share paralogs with ZNF613           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF613 (see all 489)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1494627401,2
    --52428709(+) TATTTA/CCTGAG 2 -- us2k10--------
    rs1438527761,2
    --52428723(+) GGAGAA/TAACTG 2 -- us2k10--------
    rs1889957641,2
    --52428758(+) CTGGCA/GGCAAT 2 -- us2k10--------
    rs1486993451,2
    --52428820(+) CCTACA/GTGCAC 2 -- us2k10--------
    rs1137420091,2
    C--52428835(+) AGGCAC/TAGCAC 2 -- us2k10--------
    rs1115875861,2
    F--52428847(+) TTTCCC/TTATTT 2 -- us2k11Minor allele frequency- T:0.00CSA 1
    rs124627461,2
    C,F,H--52428900(+) ctcccC/Taccat 2 -- us2k1 trp31Minor allele frequency- T:0.33NA 6
    rs1396556681,2
    --52428936(+) CTCACC/TGAGAT 2 -- us2k10--------
    rs1861299141,2
    --52429004(+) TCCTTC/TGTATG 2 -- us2k10--------
    rs1892692151,2
    --52429204(+) TCAGTA/GGTATT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF613 (52430400 - 52452012 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZNF613:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833872CNV Loss17160897
    dgv143e55CNV Gain17911159
    dgv425n27CNV Gain19166990
    esv638CNV CNV17122850
    dgv1113e1CNV Complex17122850
    dgv1112e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF613 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF613)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79898 HGNC: 25827 AceView: ZNF613 Ensembl:ENSG00000176024 euGenes: HUgn79898
    ECgene: ZNF613 H-InvDB: ZNF613

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF613 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF613 gene:
    Search GeneIP for patents involving ZNF613

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ZNF613  
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     Block miRNA regulation of human, mouse, rat ZNF613 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ZNF613
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF613 Predesigned siRNA for gene silencing in human, mouse, rat ZNF613
     QuantiFast Probe-based Assays in human, mouse, rat ZNF613 QuantiTect SYBR Green Assays in human, mouse, rat ZNF613
     Custom PCR Arrays for ZNF613 Search Chromatin IP Primers for ZNF613
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     Search Addgene for plasmids for ZNF613
      Search eBioscience for proteins for ZNF613
      Search eBioscience for elisas for ZNF613
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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