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Set Analyses:

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ZNF610 Gene

protein-coding GIFtS: 47
GCID: GC19P052839

Zinc Finger Protein 610

Search for ZNF610
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Zinc Finger Protein 610¹ ²
Zink Finger Protein²

External Ids:	HGNC: 26687¹	Entrez Gene: 162963²	Ensembl: ENSG00000167554⁷	UniProtKB: Q8N9Z0³

Export aliases for ZNF610 gene to outside databases

Previous GC identifers: GC19P057540 GC19P049169

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF610 Gene:

ZNF610 (zinc finger protein 610) is a protein-coding gene. An important paralog of this gene is ZNF534.

UniProtKB/Swiss-Prot: ZN610_HUMAN, Q8N9Z0

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000019.10 NC_018930.2 NT_011109.17

Regulatory elements:

Regulatory transcription factor binding sites in the ZNF610 gene promoter:
HTF ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF610 promoter sequence

Search Chromatin IP Primers for ZNF610

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF610

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.41

ZNF610 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF610 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P052839: view genomic region (about GC identifiers)

Start:	52,839,498 bp from pter	End:	52,871,031 bp from pter
Size:	31,534 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN610_HUMAN, Q8N9Z0 (See protein sequence)

Recommended Name: Zinc finger protein 610

Size: 462 amino acids; 53489 Da

Secondary accessions: A8K4C3 Q86YH8 Q8NDS9

Alternative splicing: 2 isoforms: Q8N9Z0-1 Q8N9Z0-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF610: NX_Q8N9Z0

Explore proteomics data for ZNF610 at MOPED

Post-translational modifications:

Ubiquitination² at Lys412

Modification sites at PhosphoSitePlus

See ZNF610 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts):

NP_001154897.1 NP_001154898.1 NP_001154899.1 NP_775801.2

ENSEMBL proteins:

ENSP00000324441 ENSP00000383922 ENSP00000471021 ENSP00000469935 ENSP00000327597

Reactome Protein details: Q8N9Z0

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

ZNF: Zinc fingers, C2H2-type

4 InterPro protein domains:

IPR001909 Krueppel-associated_box

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q8N9Z0

ProtoNet protein and cluster: Q8N9Z0

2 Blocks protein domains:

IPB001909 KRAB box

IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN610_HUMAN, Q8N9Z0

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 9 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

ZNF610 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: ZN610_HUMAN, Q8N9Z0

Function: May be involved in transcriptional regulation

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0046872	metal ion binding	IEA	--

ZNF610 for ontologies About GeneDecksing

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

ZN610_HUMAN, Q8N9Z0: Nucleus (Probable)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	4
cytosol	1
endoplasmic reticulum	1
mitochondrion	1
peroxisome	1

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZNF610 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ZNF610 About

See pathways by source

SuperPath

Contained pathways About

Gene Expression

Generic Transcription Pathway

0.40

Gene Expression

0.40

Pathways by source See SuperPaths
Show all pathways

1 Reactome Pathway for ZNF610

Generic Transcription Pathway

ZNF610 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for ZNF610
Interactions:

Search GeneGlobe Interaction Network for ZNF610

Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-templated	IEA	--
GO:0006355	regulation of transcription, DNA-templated	IEA	--

ZNF610 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

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Browse compounds at ApexBio

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ZNF610 gene (4 alternative transcripts):

NM_001161425.1 NM_001161426.1 NM_001161427.1 NM_173530.2

Unigene Cluster for ZNF610:

Zinc finger protein 610

Hs.147025 [show with all ESTs]

Unigene Representative Sequence: BC039903

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000321287(uc002pyz.4) ENST00000599508 ENST00000403906(uc002pyx.4 uc002pyy.4)

ENST00000601151 ENST00000594919 ENST00000593698 ENST00000327920(uc002pza.3)

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Additional mRNA sequence:

AK093359.1 AK290888.1 AL831871.1 BC039903.2 BC105967.1

6 DOTS entries:

DT.100754443 DT.206155 DT.121450832 DT.91872979 DT.100795739 DT.121450828

Selected AceView cDNA sequences (see all 32):

CA397023 AI031846 BQ437257 BQ437307 AI160765 BQ787421 BX509697 BV188958

CD642256 AA774749 AX748076 AA758974 BC039903 BU070401 H84134 NM_173530

AK093359 AI334229 BQ217234 BX111252 AL831871 AA973137 AA584209 AW386242

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF610 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5a	·	5b
SP1:			-
SP2:									-		-
SP3:

ECgene alternative splicing isoforms for ZNF610

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF610 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTTTAAGTAA

About this image

ZNF610 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ZNF610 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.147025

Custom PCR Arrays for ZNF610

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF610

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of mammals.

Orthologs for ZNF610 gene from Selected species (see all 3) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
dog (Canis familiaris)	Mammalia	--	Uncharacterized protein	41(a)	many ↔ many	1(104870859-104886591)

ENSEMBL Gene Tree for ZNF610 (if available)
TreeFam Gene Tree for ZNF610 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ZNF610 gene

ZNF534² ZNF321P² ZNF468² ZNF578² ZNF880² ZNF766² ZNF320² ZNF525²

ZNF860² ZNF415² ZNF600² ZNF28² ZNF528² ZNF611² ZNF677² ZNF83²

ZNF816² ZNF701² ZNF765² ZNF480² ZNF813²

Selected SIMAP similar genes for ZNF610 using alignment to 2 protein entries: ZN610_HUMAN (see all proteins) (see all similar genes):

ZNF880 kr-znf3 ZNF766 ZNF528 ZNF721 ZNF83

ZNF78L1 ZNF616 ZNF534 ZNF677 ZNF480 ZNF320

HZF30 ZFS-6 ZNF836 ZNF611 DKFZp686M04222 DKFZp762K012

ZNF610 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for ZNF610
PGOHUM00000234752 PGOHUM00000238039

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189105945^1,2		--	52837549(+)	`GATCAA/CGAGGT`	3	--	us2k¹		0	--	--	--	--
rs71180442^1,2	C	--	52837637(-)	`AGGCA-/AAGTTTTGTATTTT/CGTGCCACCATGCCTGGC TAAGTTTTGTATTTT/TGGCTAAGTTTTGTATTTTCGTGC`	6	--	us2k¹ cds¹		1		NA	2
rs181489273^1,2	C	--	52837654(+)	`CCAGCC/TACTCG`	3	--	us2k¹		0	--	--	--	--
rs184261657^1,2		--	52837658(+)	`CTACTC/TGGGAG`	3	--	us2k¹		0	--	--	--	--
rs321924^1,2	C,F,H	--	52837682(-)	`ttcaaG/Ccaatt`	3	--	us2k¹		2		NA	4
rs321923^1,2	C,F,H	--	52837722(-)	`gtggcA/Gcaatc`	3	--	us2k¹		3		NA	6
rs321922^1,2	C,F,H	--	52837759(-)	`agacaG/Aagtct`	3	--	us2k¹		3		NA WA	6
rs145352931^1,2	C	--	52837767(+)	`TCTCA-/AAAAT AAAAT`	3	--	us2k¹		0	--	--	--	--
rs7256570^1,2	C,A,H	--	52837800(+)	`AAATTC/AAATGA`	3	--	us2k¹		8		NA WA CSA EA	367
rs181224224^1,2		--	52837813(+)	`ATTGAC/TTGGAA`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF610 (52839498 - 52871031 bp)

Structural Variations
Database of Genomic Variants (DGV) 9 variations for ZNF610: About this table

Variant ID	Type	Subtype	PubMed ID
esv2600634	CNV	Deletion	19546169
esv2671354	CNV	Deletion	23128226
esv2660483	CNV	Deletion	23128226
nsv458742	CNV	Loss	19166990
dgv3979n71	CNV	Loss	21882294
dgv3978n71	CNV	Loss	21882294
nsv2536	CNV	Loss	18451855
nsv833873	CNV	Gain	17160897
esv21813	CNV	Gain	19812545

Site Specific Mutation Identification with PCR Assays

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DNA2.0 Custom Variant and Variant Library Synthesis for ZNF610

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ZNF610 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF610)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)¹ Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (amp 2012)
A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (amp 2011)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (BMC Genomics 2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (Genome Res. 2006)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (Nature 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 162963	HGNC: 26687	AceView: ZNF610	Ensembl:ENSG00000167554	euGenes: HUgn162963
ECgene: ZNF610	H-InvDB: ZNF610

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ZNF610	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF610 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ZNF610 gene:
Search GeneIP for patents involving ZNF610

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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Hot genes Disease genes ZNF610 gene at Home site.

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ZNF610 Gene

Zinc Finger Protein 610

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ZNF610 Gene

Zinc Finger Protein 610

Aliasesfor ZNF610 gene

Summariesfor ZNF610 gene

Genomic Viewsfor ZNF610 gene

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ZNF610 Human Recombinant Protein Products:

ZNF610 Antibody Products:

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Localizationfor ZNF610 gene

Pathways & Interactionsfor ZNF610 gene

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Expression for ZNF610 gene

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for ZNF610 gene

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for ZNF610 gene

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for ZNF610 gene

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for ZNF610 gene

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