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Aliases for ZNF609 Gene

Aliases for ZNF609 Gene

  • Zinc Finger Protein 609 2 3 5
  • KIAA0295 4

External Ids for ZNF609 Gene

Previous GeneCards Identifiers for ZNF609 Gene

  • GC15P062507
  • GC15P062578
  • GC15P064752
  • GC15P041616
  • GC15P064792
  • GC15P064794
  • GC15P064743
  • GC15P065399
  • GC15P065441
  • GC15P066329

Summaries for ZNF609 Gene

GeneCards Summary for ZNF609 Gene

ZNF609 (Zinc Finger Protein 609) is a Protein Coding gene. Diseases associated with ZNF609 include Hirschsprung Disease 1. An important paralog of this gene is ZNF608.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF609 Gene

Genomics for ZNF609 Gene

Regulatory Elements for ZNF609 Gene

Enhancers for ZNF609 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F065318 1.2 Ensembl ENCODE 68.3 +858.3 858303 0.6 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF416 ZNF548 ZNF609 TRIP4 ENSG00000264937 ENSG00000259635 MTFMT SLC24A1 CILP RNU5B-1 ENSG00000259346 RNU5A-1
GH15F065295 1.1 FANTOM5 ENCODE 49.2 +836.6 836625 4.1 PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF609 MTFMT TRIP4 ENSG00000264937 PARP16 ENSG00000259635 SLC24A1 HACD3 SPG21 CILP
GH15F064246 1.4 FANTOM5 Ensembl ENCODE 39.5 -212.2 -212242 4.6 HDGF PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A FEZF1 ZNF2 FOS ZNF609 TRIP4 CSNK1G1 PPIB ENSG00000252774 ENSG00000265967 RNU6-549P SNX22 HERC1 RBPMS2
GH15F063495 1.4 FANTOM5 ENCODE 32 -959.5 -959493 12.4 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D LACTB ZNF609 USP3-AS1 USP3 TRIP4 HERC1 ENSG00000259498 RAB8B FBXL22 LOC102723344
GH15F064092 1 ENCODE 29.4 -365.3 -365316 6.5 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TRIP4 ZNF609 RPS27L SNX22 ENSG00000252774 ENSG00000239465 MTFMT SPG21 DAPK2 HERC1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF609 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF609 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZNF609 Gene

64,460,742 bp from pter
64,686,068 bp from pter
225,327 bases
Plus strand

Genomic View for ZNF609 Gene

Genes around ZNF609 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF609 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF609 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF609 Gene

Proteins for ZNF609 Gene

  • Protein details for ZNF609 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 609
    Protein Accession:
    Secondary Accessions:
    • Q0D2I2

    Protein attributes for ZNF609 Gene

    1411 amino acids
    Molecular mass:
    151191 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF609 Gene

Post-translational modifications for ZNF609 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF609 Gene

No data available for DME Specific Peptides for ZNF609 Gene

Domains & Families for ZNF609 Gene

Gene Families for ZNF609 Gene

Protein Domains for ZNF609 Gene


Suggested Antigen Peptide Sequences for ZNF609 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2H2-type zinc finger.
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with ZNF609: view

Function for ZNF609 Gene

Gene Ontology (GO) - Molecular Function for ZNF609 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF609: view

Phenotypes for ZNF609 Gene

MGI mutant phenotypes for ZNF609:
inferred from 1 alleles
GenomeRNAi human phenotypes for ZNF609:
genes like me logo Genes that share phenotypes with ZNF609: view

Animal Models for ZNF609 Gene

MGI Knock Outs for ZNF609:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF609 Gene

Localization for ZNF609 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF609 Gene

Subcellular locations from

Jensen Localization Image for ZNF609 Gene COMPARTMENTS Subcellular localization image for ZNF609 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF609 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF609: view

Pathways & Interactions for ZNF609 Gene

SuperPathways for ZNF609 Gene

No Data Available

Interacting Proteins for ZNF609 Gene

Gene Ontology (GO) - Biological Process for ZNF609 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZNF609 Gene

Transcripts for ZNF609 Gene

Unigene Clusters for ZNF609 Gene

Zinc finger protein 609:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF609 Gene

No ASD Table

Relevant External Links for ZNF609 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF609 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF609 Gene

Protein differential expression in normal tissues from HIPED for ZNF609 Gene

This gene is overexpressed in Testis (18.3), CD8 Tcells (13.7), Cerebrospinal fluid (12.3), and Peripheral blood mononuclear cells (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF609 Gene

Protein tissue co-expression partners for ZNF609 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF609 Gene:


SOURCE GeneReport for Unigene cluster for ZNF609 Gene:

genes like me logo Genes that share expression patterns with ZNF609: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF609 Gene

Orthologs for ZNF609 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF609 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF609 34 35
  • 99.58 (n)
(Canis familiaris)
Mammalia ZNF609 34 35
  • 94.05 (n)
(Bos Taurus)
Mammalia ZNF609 34 35
  • 93.39 (n)
(Mus musculus)
Mammalia Zfp609 34 16 35
  • 91.18 (n)
(Rattus norvegicus)
Mammalia Zfp609 34
  • 90.74 (n)
(Monodelphis domestica)
Mammalia ZNF609 35
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF609 35
  • 88 (a)
(Gallus gallus)
Aves ZNF609 34 35
  • 77.71 (n)
(Anolis carolinensis)
Reptilia ZNF609 35
  • 82 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18738 34
(Danio rerio)
Actinopterygii zgc:162740 34
  • 65.2 (n)
znf609 35
  • 60 (a)
ZNF609 (2 of 2) 35
  • 60 (a)
wufc26a02 34
fruit fly
(Drosophila melanogaster)
Insecta sbb 35
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
Species where no ortholog for ZNF609 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF609 Gene

Gene Tree for ZNF609 (if available)
Gene Tree for ZNF609 (if available)

Paralogs for ZNF609 Gene

Paralogs for ZNF609 Gene

(1) SIMAP similar genes for ZNF609 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF609: view

Variants for ZNF609 Gene

Sequence variations from dbSNP and Humsavar for ZNF609 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10152796 -- 64,514,944(+) TTTTT(A/T)AAAAT intron-variant
rs10400912 -- 64,515,572(+) GGGGA(A/G)GGGTA intron-variant
rs10400913 -- 64,515,575(+) GAGGG(G/T)TAGGA intron-variant
rs10519272 -- 64,634,852(+) GAAAC(A/G)TTAGG intron-variant, upstream-variant-2KB
rs10519273 -- 64,634,972(+) TATAC(C/T)TTTGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF609 Gene

Variant ID Type Subtype PubMed ID
dgv453e199 CNV deletion 23128226
esv1105706 CNV insertion 17803354
esv1482397 CNV deletion 17803354
esv2665503 CNV deletion 23128226
esv2671821 CNV deletion 23128226
esv2749786 CNV deletion 23290073
esv3552565 CNV deletion 23714750
esv3552570 CNV deletion 23714750
esv3581745 CNV loss 25503493
esv3636735 CNV loss 21293372
esv3636736 CNV loss 21293372
esv3636737 CNV loss 21293372
esv3636738 CNV loss 21293372
esv3636739 CNV loss 21293372
nsv1070278 CNV deletion 25765185
nsv1070703 CNV deletion 25765185
nsv1127441 CNV deletion 24896259
nsv1134460 CNV deletion 24896259
nsv476506 CNV novel sequence insertion 20440878
nsv526185 CNV loss 19592680
nsv827361 CNV loss 20364138
nsv827362 CNV gain 20364138
nsv833038 CNV loss 17160897
nsv94275 CNV deletion 16902084
nsv974587 CNV duplication 23825009
nsv976944 CNV duplication 23825009
nsv984084 CNV duplication 23825009

Variation tolerance for ZNF609 Gene

Residual Variation Intolerance Score: 1.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.73; 46.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF609 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF609 Gene

Disorders for ZNF609 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF609 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hirschsprung disease 1
  • hirschsprung's disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF609

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZNF609: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF609 Gene

Publications for ZNF609 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4 64
  2. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 3 4 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64

Products for ZNF609 Gene

Sources for ZNF609 Gene

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