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Aliases for ZNF609 Gene

Aliases for ZNF609 Gene

  • Zinc Finger Protein 609 2 3 5
  • KIAA0295 4

External Ids for ZNF609 Gene

Previous GeneCards Identifiers for ZNF609 Gene

  • GC15P062507
  • GC15P062578
  • GC15P064752
  • GC15P041616
  • GC15P064792
  • GC15P064794
  • GC15P064743
  • GC15P065399

Summaries for ZNF609 Gene

GeneCards Summary for ZNF609 Gene

ZNF609 (Zinc Finger Protein 609) is a Protein Coding gene. An important paralog of this gene is ZNF608.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF609 Gene

Genomics for ZNF609 Gene

Regulatory Elements for ZNF609 Gene

Enhancers for ZNF609 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF609 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF609 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF609 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF609 Gene

64,460,742 bp from pter
64,686,068 bp from pter
225,327 bases
Plus strand

Genomic View for ZNF609 Gene

Genes around ZNF609 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF609 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF609 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF609 Gene

Proteins for ZNF609 Gene

  • Protein details for ZNF609 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 609
    Protein Accession:
    Secondary Accessions:
    • Q0D2I2

    Protein attributes for ZNF609 Gene

    1411 amino acids
    Molecular mass:
    151191 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF609 Gene

Proteomics data for ZNF609 Gene at MOPED

Post-translational modifications for ZNF609 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF609 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF609 Gene

Domains & Families for ZNF609 Gene

Gene Families for ZNF609 Gene

Protein Domains for ZNF609 Gene


Suggested Antigen Peptide Sequences for ZNF609 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2H2-type zinc finger.
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with ZNF609: view

Function for ZNF609 Gene

Phenotypes for ZNF609 Gene

GenomeRNAi human phenotypes for ZNF609:
genes like me logo Genes that share phenotypes with ZNF609: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF609 Gene

Localization for ZNF609 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF609 Gene

Subcellular locations from

Jensen Localization Image for ZNF609 Gene COMPARTMENTS Subcellular localization image for ZNF609 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF609 Gene

Pathways & Interactions for ZNF609 Gene

SuperPathways for ZNF609 Gene

No Data Available

Interacting Proteins for ZNF609 Gene

Gene Ontology (GO) - Biological Process for ZNF609 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZNF609 Gene

Drugs & Compounds for ZNF609 Gene

No Compound Related Data Available

Transcripts for ZNF609 Gene

Unigene Clusters for ZNF609 Gene

Zinc finger protein 609:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF609 Gene

No ASD Table

Relevant External Links for ZNF609 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF609 Gene

mRNA expression in normal human tissues for ZNF609 Gene

Protein differential expression in normal tissues from HIPED for ZNF609 Gene

This gene is overexpressed in Testis (18.3), CD8 Tcells (13.7), Cerebrospinal fluid (12.3), and Peripheral blood mononuclear cells (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF609 Gene

SOURCE GeneReport for Unigene cluster for ZNF609 Gene Hs.595451

genes like me logo Genes that share expression patterns with ZNF609: view

Protein tissue co-expression partners for ZNF609 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF609 Gene

Orthologs for ZNF609 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF609 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF609 35
  • 93.39 (n)
  • 97.31 (a)
ZNF609 36
  • 97 (a)
(Canis familiaris)
Mammalia ZNF609 35
  • 94.05 (n)
  • 97.45 (a)
ZNF609 36
  • 97 (a)
(Mus musculus)
Mammalia Zfp609 35
  • 91.18 (n)
  • 94.4 (a)
Zfp609 16
Zfp609 36
  • 94 (a)
(Pan troglodytes)
Mammalia ZNF609 35
  • 99.58 (n)
  • 99.83 (a)
ZNF609 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zfp609 35
  • 90.74 (n)
  • 94.19 (a)
(Monodelphis domestica)
Mammalia ZNF609 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF609 36
  • 88 (a)
(Gallus gallus)
Aves ZNF609 35
  • 77.71 (n)
  • 85.04 (a)
ZNF609 36
  • 84 (a)
(Anolis carolinensis)
Reptilia ZNF609 36
  • 82 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18738 35
(Danio rerio)
Actinopterygii wufc26a02 35
zgc:162740 35
  • 65.2 (n)
  • 64.58 (a)
znf609 36
  • 60 (a)
ZNF609 (2 of 2) 36
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta sbb 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
Species with no ortholog for ZNF609:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF609 Gene

Gene Tree for ZNF609 (if available)
Gene Tree for ZNF609 (if available)

Paralogs for ZNF609 Gene

Paralogs for ZNF609 Gene

(1) SIMAP similar genes for ZNF609 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF609: view

Variants for ZNF609 Gene

Sequence variations from dbSNP and Humsavar for ZNF609 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs5813305 -- 64,495,104(+) ACTAG(-/A)AAAAA intron-variant
rs5813306 -- 64,503,058(+) AAAAA(-/A/AA/AAA)GAAAG intron-variant
rs5813307 -- 64,506,723(+) AAAAA(-/A)GTTTG intron-variant
rs5813318 -- 64,667,712(+) AAAAA(-/A)GAAAA intron-variant
rs477966 -- 64,491,526(-) GCCAG(C/T)TGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF609 Gene

Variant ID Type Subtype PubMed ID
nsv827361 CNV Loss 20364138
nsv526185 CNV Loss 19592680
nsv833038 CNV Loss 17160897
dgv453e199 CNV Deletion 23128226
esv2749786 CNV Deletion 23290073
esv1105706 CNV Insertion 17803354
esv1482397 CNV Deletion 17803354
nsv827362 CNV Gain 20364138
esv2671821 CNV Deletion 23128226
esv2665503 CNV Deletion 23128226
nsv94275 CNV Loss 16902084

Variation tolerance for ZNF609 Gene

Residual Variation Intolerance Score: 1.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.73; 46.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF609 Gene

Disorders for ZNF609 Gene

Relevant External Links for ZNF609

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF609 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF609 Gene

Publications for ZNF609 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. An AUTS2-Polycomb complex activates gene expression in the CNS. (PMID: 25519132) Gao Z. … Reinberg D. (Nature 2014) 3
  5. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PMID: 23667531) Cox J.L. … Rizzino A. (PLoS ONE 2013) 3

Products for ZNF609 Gene

Sources for ZNF609 Gene