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Aliases for ZNF608 Gene

Aliases for ZNF608 Gene

  • Zinc Finger Protein 608 2 3 5
  • Renal Carcinoma Antigen NY-REN-36 3 4
  • NY-REN-36 3
  • KIAA1281 4

External Ids for ZNF608 Gene

Previous GeneCards Identifiers for ZNF608 Gene

  • GC05M124049
  • GC05M124000
  • GC05M123966
  • GC05M119162

Summaries for ZNF608 Gene

GeneCards Summary for ZNF608 Gene

ZNF608 (Zinc Finger Protein 608) is a Protein Coding gene. An important paralog of this gene is ZNF609.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF608 Gene

Genomics for ZNF608 Gene

Regulatory Elements for ZNF608 Gene

Enhancers for ZNF608 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G124734 3 FANTOM5 Ensembl ENCODE dbSUPER 7.8 +5.7 5694 18.1 PKNOX1 FOXA2 ARNT WRNIP1 SIN3A FEZF1 ZNF2 YY1 CBX5 FOS ZNF608 GC05P124742
GH05G124773 1.6 ENCODE 11.6 -25.0 -25046 1.0 ARID1B PRDM6 PBX2 TAL1 ZSCAN5C REST SP7 ZNF608 ENSG00000251456 LOC105379156
GH05G124658 1.9 FANTOM5 Ensembl ENCODE dbSUPER 8.8 +87.3 87333 7.0 HNRNPUL1 PKNOX1 FOXA2 MLX ARNT SIN3A FEZF1 ZNF2 YY1 SLC30A9 ENSG00000251456 ZNF608 GC05P124616 ENSG00000249112
GH05G124627 1.6 Ensembl ENCODE dbSUPER 10.2 +119.1 119077 3.9 PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF302 ZNF416 FOS ZNF263 ZNF608 GC05P124616 ENSG00000249112
GH05G124789 1.2 Ensembl ENCODE 11.7 -42.7 -42710 3.5 PKNOX1 ARNT SIN3A FEZF1 ZNF2 TSHZ1 REST ZNF518A MAFF ZNF610 ZNF608 ENSG00000251456 LOC105379156
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF608 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF608 Gene

124,636,913 bp from pter
124,748,824 bp from pter
111,912 bases
Minus strand

Genomic View for ZNF608 Gene

Genes around ZNF608 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF608 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF608 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF608 Gene

Proteins for ZNF608 Gene

  • Protein details for ZNF608 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 608
    Protein Accession:
    Secondary Accessions:
    • A7E2W9
    • Q3SYM6
    • Q68D12
    • Q8IY05
    • Q9Y5A1

    Protein attributes for ZNF608 Gene

    1512 amino acids
    Molecular mass:
    162208 Da
    Quaternary structure:
    No Data Available
    • Antigen recognized by autologous antibody in patients with renal-cell carcinoma.
    • Sequence=BAA86595.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF608 Gene


neXtProt entry for ZNF608 Gene

Post-translational modifications for ZNF608 Gene

  • Ubiquitination at isoforms=21250
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF608 Gene

Domains & Families for ZNF608 Gene

Gene Families for ZNF608 Gene

Protein Domains for ZNF608 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF608: view

No data available for UniProtKB/Swiss-Prot for ZNF608 Gene

Function for ZNF608 Gene

Gene Ontology (GO) - Molecular Function for ZNF608 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF608: view
genes like me logo Genes that share phenotypes with ZNF608: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF608 Gene

Localization for ZNF608 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF608 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZNF608 Gene

Pathways & Interactions for ZNF608 Gene

SuperPathways for ZNF608 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF608 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZNF608 Gene

Drugs & Compounds for ZNF608 Gene

No Compound Related Data Available

Transcripts for ZNF608 Gene

Unigene Clusters for ZNF608 Gene

Zinc finger protein 608:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF608 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP3: - -
SP4: - - - - - - -

Relevant External Links for ZNF608 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF608 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF608 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF608 Gene

This gene is overexpressed in Breast (24.0), Blymphocyte (18.8), Monocytes (8.1), and Tlymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF608 Gene

Protein tissue co-expression partners for ZNF608 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF608 Gene:


SOURCE GeneReport for Unigene cluster for ZNF608 Gene:


Evidence on tissue expression from TISSUES for ZNF608 Gene

  • Liver(4.2)
  • Skin(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF608: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF608 Gene

Orthologs for ZNF608 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF608 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF608 34 35
  • 99.65 (n)
(Bos Taurus)
Mammalia ZNF608 34 35
  • 92.18 (n)
(Canis familiaris)
Mammalia ZNF608 34 35
  • 90.12 (n)
(Mus musculus)
Mammalia Zfp608 34 16 35
  • 89.85 (n)
(Rattus norvegicus)
Mammalia Zfp608 34
  • 89.44 (n)
(Ornithorhynchus anatinus)
Mammalia ZNF608 35
  • 87 (a)
(Monodelphis domestica)
Mammalia ZNF608 35
  • 86 (a)
(Gallus gallus)
Aves ZNF608 34 35
  • 82.97 (n)
(Anolis carolinensis)
Reptilia ZNF608 35
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf608 34
  • 72.51 (n)
Str.10279 34
(Danio rerio)
Actinopterygii LOC100329407 34
  • 54.2 (n)
ZNF608 35
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta sbb 35
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
Species where no ortholog for ZNF608 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF608 Gene

Gene Tree for ZNF608 (if available)
Gene Tree for ZNF608 (if available)

Paralogs for ZNF608 Gene

Paralogs for ZNF608 Gene

(2) SIMAP similar genes for ZNF608 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF608: view

Variants for ZNF608 Gene

Sequence variations from dbSNP and Humsavar for ZNF608 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000000396 -- 124,745,341(+) AAACC(C/T)GAAAA intron-variant, upstream-variant-2KB
rs1000014558 -- 124,689,275(+) GACCC(G/T)GTCTC intron-variant
rs1000019869 -- 124,700,260(+) ATATG(A/C)AACAC intron-variant
rs1000031178 -- 124,715,402(+) AAGCA(C/T)CCCAC intron-variant
rs1000073354 -- 124,699,991(+) TCTTG(C/T)TACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF608 Gene

Variant ID Type Subtype PubMed ID
esv3309844 CNV mobile element insertion 20981092
esv3417666 CNV insertion 20981092
esv3436875 CNV insertion 20981092
esv3606634 CNV gain 21293372
esv3606635 CNV loss 21293372
nsv830473 CNV gain 17160897

Variation tolerance for ZNF608 Gene

Residual Variation Intolerance Score: 2.59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF608 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF608 Gene

Disorders for ZNF608 Gene

Relevant External Links for ZNF608

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF608 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF608 Gene

Publications for ZNF608 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PMID: 10508479) Scanlan M.J. … Old L.J. (Int. J. Cancer 1999) 2 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4 64
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64

Products for ZNF608 Gene

Sources for ZNF608 Gene

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