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Aliases for ZNF608 Gene

Aliases for ZNF608 Gene

  • Zinc Finger Protein 608 2 3 5
  • Renal Carcinoma Antigen NY-REN-36 3 4
  • NY-REN-36 3
  • KIAA1281 4

External Ids for ZNF608 Gene

Previous GeneCards Identifiers for ZNF608 Gene

  • GC05M124049
  • GC05M124000
  • GC05M123966
  • GC05M119162

Summaries for ZNF608 Gene

GeneCards Summary for ZNF608 Gene

ZNF608 (Zinc Finger Protein 608) is a Protein Coding gene. Diseases associated with ZNF608 include Renal Cell Carcinoma. An important paralog of this gene is ZNF609.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF608 Gene

Genomics for ZNF608 Gene

Regulatory Elements for ZNF608 Gene

Enhancers for ZNF608 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF608 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF608 Gene

124,636,913 bp from pter
124,748,824 bp from pter
111,912 bases
Minus strand

Genomic View for ZNF608 Gene

Genes around ZNF608 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF608 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF608 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF608 Gene

Proteins for ZNF608 Gene

  • Protein details for ZNF608 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 608
    Protein Accession:
    Secondary Accessions:
    • A7E2W9
    • Q3SYM6
    • Q68D12
    • Q8IY05
    • Q9Y5A1

    Protein attributes for ZNF608 Gene

    1512 amino acids
    Molecular mass:
    162208 Da
    Quaternary structure:
    No Data Available
    • Antigen recognized by autologous antibody in patients with renal-cell carcinoma.
    • Sequence=BAA86595.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF608 Gene


neXtProt entry for ZNF608 Gene

Proteomics data for ZNF608 Gene at MOPED

Post-translational modifications for ZNF608 Gene

  • Ubiquitination at Lys 1250
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF608 Gene

No data available for DME Specific Peptides for ZNF608 Gene

Domains & Families for ZNF608 Gene

Gene Families for ZNF608 Gene

Protein Domains for ZNF608 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2H2-type zinc finger.
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with ZNF608: view

Function for ZNF608 Gene

genes like me logo Genes that share phenotypes with ZNF608: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF608 Gene

Localization for ZNF608 Gene

Subcellular locations from

Jensen Localization Image for ZNF608 Gene COMPARTMENTS Subcellular localization image for ZNF608 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZNF608 Gene

Pathways & Interactions for ZNF608 Gene

SuperPathways for ZNF608 Gene

No Data Available

Interacting Proteins for ZNF608 Gene

Gene Ontology (GO) - Biological Process for ZNF608 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZNF608 Gene

Drugs & Compounds for ZNF608 Gene

No Compound Related Data Available

Transcripts for ZNF608 Gene

Unigene Clusters for ZNF608 Gene

Zinc finger protein 608:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF608 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP3: - -
SP4: - - - - - - -

Relevant External Links for ZNF608 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF608 Gene

mRNA expression in normal human tissues for ZNF608 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF608 Gene

This gene is overexpressed in Breast (24.0), Blymphocyte (18.8), Monocytes (8.1), and Tlymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF608 Gene

SOURCE GeneReport for Unigene cluster for ZNF608 Gene Hs.266616

genes like me logo Genes that share expression patterns with ZNF608: view

Protein tissue co-expression partners for ZNF608 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF608 Gene

Orthologs for ZNF608 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF608 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF608 35
  • 92.18 (n)
  • 94.96 (a)
ZNF608 36
  • 95 (a)
(Canis familiaris)
Mammalia ZNF608 35
  • 90.12 (n)
  • 93.58 (a)
ZNF608 36
  • 92 (a)
(Mus musculus)
Mammalia Zfp608 35
  • 89.85 (n)
  • 93.12 (a)
Zfp608 16
Zfp608 36
  • 93 (a)
(Pan troglodytes)
Mammalia ZNF608 35
  • 99.65 (n)
  • 99.6 (a)
ZNF608 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zfp608 35
  • 89.44 (n)
  • 91.99 (a)
(Monodelphis domestica)
Mammalia ZNF608 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF608 36
  • 87 (a)
(Gallus gallus)
Aves ZNF608 35
  • 82.97 (n)
  • 86.09 (a)
ZNF608 36
  • 85 (a)
(Anolis carolinensis)
Reptilia ZNF608 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10279 35
znf608 35
  • 72.51 (n)
  • 76.22 (a)
(Danio rerio)
Actinopterygii LOC100329407 35
  • 54.2 (n)
  • 47.72 (a)
ZNF608 36
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta sbb 36
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
Species with no ortholog for ZNF608:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF608 Gene

Gene Tree for ZNF608 (if available)
Gene Tree for ZNF608 (if available)

Paralogs for ZNF608 Gene

Paralogs for ZNF608 Gene

(2) SIMAP similar genes for ZNF608 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF608: view

Variants for ZNF608 Gene

Sequence variations from dbSNP and Humsavar for ZNF608 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs6862252 - 124,648,222(+) AGTTG(G/T)TAGCT nc-transcript-variant, reference, missense
rs1133492 -- 124,726,647(+) agtca(A/G)cagta intron-variant, upstream-variant-2KB
rs6595535 -- 124,646,167(+) ACCAT(C/T)TCGCT intron-variant
rs6595536 -- 124,666,649(+) GATTA(G/T)TAACT intron-variant
rs6595537 -- 124,678,205(+) CCACC(A/G)CCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF608 Gene

Variant ID Type Subtype PubMed ID
nsv882818 CNV Gain 21882294
nsv830473 CNV Gain 17160897
esv274116 CNV Insertion 20981092

Variation tolerance for ZNF608 Gene

Residual Variation Intolerance Score: 2.59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.12% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF608 Gene

Disorders for ZNF608 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF608 Gene - From: GeneCards

Disorder Aliases PubMed IDs
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF608

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZNF608: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF608 Gene

Publications for ZNF608 Gene

  1. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PMID: 10508479) Scanlan M.J. … Old L.J. (Int. J. Cancer 1999) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Genetic loci associated with circulating levels of very long-chain saturated fatty acids. (PMID: 25378659) Lemaitre R.N. … Friedlander Y. (J. Lipid Res. 2015) 3
  5. Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese. (PMID: 24465431) Ma R.C. … Chan J.C. (PLoS ONE 2014) 3

Products for ZNF608 Gene

Sources for ZNF608 Gene