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ZNF607 Gene

protein-coding   GIFtS: 51
GCID: GC19M038187

Zinc Finger Protein 607

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 6071 2

External Ids:    HGNC: 281921   Entrez Gene: 847752   Ensembl: ENSG000001981827   UniProtKB: Q96SK33   

Export aliases for ZNF607 gene to outside databases

Previous GC identifers: GC19M042880 GC19M042881 GC19M034637


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF607 Gene:
ZNF607 (zinc finger protein 607) is a protein-coding gene. Diseases associated with ZNF607 include pulmonary function, and hypertension.

UniProtKB/Swiss-Prot: ZN607_HUMAN, Q96SK3
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF607 gene promoter:
         Ik-2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF607 promoter sequence
   Search Chromatin IP Primers for ZNF607

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF607


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.1

ZNF607 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF607 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M038187:  view genomic region     (about GC identifiers)

Start:
38,187,264 bp from pter      End:
38,210,691 bp from pter
Size:
23,428 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN607_HUMAN, Q96SK3 (See protein sequence)
Recommended Name: Zinc finger protein 607  
Size: 696 amino acids; 80507 Da
Secondary accessions: F5H141 Q6ZMN2 Q6ZMN4 Q96C40
Alternative splicing: 3 isoforms:  Q96SK3-1   Q96SK3-2   Q96SK3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF607: NX_Q96SK3

Explore proteomics data for ZNF607 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF607 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001166148.1  NP_116078.4  

    ENSEMBL proteins: 
     ENSP00000347338   ENSP00000438015   ENSP00000466265   ENSP00000466785   ENSP00000468817  
    Reactome Protein details: Q96SK3

    ZNF607 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for ZNF607


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96SK3

    ProtoNet protein and cluster: Q96SK3

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZN607_HUMAN, Q96SK3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 20 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF607 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN607_HUMAN, Q96SK3
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    ZNF607 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF607
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF607
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    miRNA
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    miRTarBase miRNAs that target ZNF607:
    hsa-mir-331-3p (MIRT043273), hsa-mir-320a (MIRT044700)

    Block miRNA regulation of human, mouse, rat ZNF607 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate ZNF607:
    hsa-miR-516a-3p hsa-miR-4309 hsa-miR-516b*
    SwitchGear 3'UTR luciferase reporter plasmidZNF607 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF607

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF607

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF607


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN607_HUMAN, Q96SK3: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF607 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF607 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF607
        Generic Transcription Pathway



    ZNF607 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF607
    Interactions:

        Search GeneGlobe Interaction Network for ZNF607

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for ZNF607 (Q96SK33 ENSP000003473384) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDFIQ997503, ENSP000002303214I2D: score=3 STRING: ENSP00000230321
    CEP70Q8NHQ13I2D: score=1 
    MIF4GDA9UHW63I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    ZNF607 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF607 (ZN607)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF607 gene (2 alternative transcripts): 
    NM_001172677.1  NM_032689.4  

    Unigene Cluster for ZNF607:

    Zinc finger protein 607
    Hs.116622  [show with all ESTs]
    Unigene Representative Sequence: NM_032689
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355202(uc002ohc.2) ENST00000395835(uc002ohb.2) ENST00000586559
    ENST00000590670 ENST00000591664
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZNF607 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate ZNF607:
    hsa-miR-516a-3p hsa-miR-4309 hsa-miR-516b*
    SwitchGear 3'UTR luciferase reporter plasmidZNF607 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF607
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF607
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF607
    Primer
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    OriGene qPCR primer pairs and template standards for ZNF607
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF607
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF607
      QuantiFast Probe-based Assays in human, mouse, rat ZNF607

    Additional mRNA sequence: 

    AB209242.1 AK027708.1 AK127464.1 AK131557.1 AK131559.1 BC005085.1 BC014850.1 

    5 DOTS entries:

    DT.99986710  DT.408823  DT.102821167  DT.99973278  DT.121294986 

    Selected AceView cDNA sequences (see all 36):

    BM758133 AI335883 BU508376 BC005085 BM833114 AK027708 BF771882 AK131559 
    BE562558 NM_032689 BE549509 N54277 BU622679 H61231 BX442094 AW956332 
    BC014850 BX496992 BX096709 AK127464 AA296661 N58717 AK131557 CF121198 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF607 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e
    SP1:        -     -     -                                                   
    SP2:                    -                                                   
    SP3:                                                                        
    SP4:                    -                 -                                 
    SP5:                          -     -                                       


    ECgene alternative splicing isoforms for ZNF607

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF607 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATATACTG
    ZNF607 Expression
    About this image

    ZNF607 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF607 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.116622
        Custom PCR Arrays for ZNF607
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF607

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF607 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia ZNF6076
    zinc finger protein 607
    40(a)
    1 ↔ 1
    2(198098571-198116176)
            Species with no ortholog for ZNF607

    ENSEMBL Gene Tree for ZNF607 (if available)
    TreeFam Gene Tree for ZNF607 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF607 gene
    Selected SIMAP similar genes for ZNF607 using alignment to 5 protein entries:     ZN607_HUMAN (see all proteins) (see all similar genes):
    PHB    HEL-S-54e    FIK    ZFP90    ZNF780A    ZNF84
    ZNF573    ZNF232    ZNF721    ZFP14    ZNF350    ZNF649
    ZNF577    ZNF780B    ZFS-1    ZNF78L1    ZNF826P    ZNF470

    ZNF607 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ZNF607
    PGOHUM00000234300 PGOHUM00000234684 PGOHUM00000240085


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF607 (see all 568)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs355241841,2
    C--38186767(+) TTTTTT/-GAGAT 2 -- ds50011Minor allele frequency- -:0.50NA 2
    rs1859166701,2
    --38186834(+) CTCCGC/TGCACC 2 -- ds50010--------
    rs1137575991,2
    C,F--38186853(+) CACCTC/TCCGGG 2 -- ds50013Minor allele frequency- T:0.44NA 124
    rs1910803391,2
    --38186858(+) CCCGGA/GTTCAA 2 -- ds50010--------
    rs1508885581,2
    --38186938(+) TTGCAC/TTTTTA 2 -- ds50010--------
    rs736215701,2
    C,F--38187152(+) ATCTGT/ATTACC 2 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1832708061,2
    --38187350(+) TAACTC/TATGTA 2 -- ut310--------
    rs40067321,2
    C--38187360(-) AAAAA-/CAAA  
            
    NNNGA
    2 -- ut310--------
    rs1861848161,2
    --38187477(+) GGGGCC/TGTGGC 2 -- ut310--------
    rs1496407171,2
    --38187496(+) CTCACA/GGAGGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF607 (38187264 - 38210691 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF607:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833820CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF607
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF607

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for ZNF607:    
    About MalaCards
    pulmonary function    hypertension


    ZNF607 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF607
    Human Genome Epidemiology (HuGE) Navigator: ZNF607 (2 documents)

    Export disorders for ZNF607 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF607 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF607)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PubMed id 17903307)4 Wilk J.B....O'Connor G.T. (BMC Med. Genet. 2007)
    6. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84775 HGNC: 28192 AceView: ZNF607 Ensembl:ENSG00000198182 euGenes: HUgn84775
    ECgene: ZNF607 H-InvDB: ZNF607

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZNF607 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF607 gene:
    Search GeneIP for patents involving ZNF607

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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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