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Aliases for ZNF606 Gene

Aliases for ZNF606 Gene

  • Zinc Finger Protein 606 2 3 5
  • Zinc Finger Protein 328 3 4
  • ZNF328 3 4
  • KIAA1852 4

External Ids for ZNF606 Gene

Previous HGNC Symbols for ZNF606 Gene

  • ZNF328

Previous GeneCards Identifiers for ZNF606 Gene

  • GC19M063076
  • GC19M063181
  • GC19M058488
  • GC19M054799

Summaries for ZNF606 Gene

Entrez Gene Summary for ZNF606 Gene

  • This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) domain at its N-terminus, followed by contiguous C2H2 zinc finger motifs. The encoded protein is a nuclear protein that can act as a transcriptional repressor of growth factor-mediated signaling pathways in a reporter gene assay. This protein has been shown to interact with the SRY-box 9 gene product, and suppresses its transcriptional activity by inhibiting its DNA binding activity. Reduced expression of this gene promotes chondrocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

GeneCards Summary for ZNF606 Gene

ZNF606 (Zinc Finger Protein 606) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF180.

UniProtKB/Swiss-Prot for ZNF606 Gene

  • May act as a transcriptional repressor.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF606 Gene

Genomics for ZNF606 Gene

Regulatory Elements for ZNF606 Gene

Enhancers for ZNF606 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G057599 1.1 ENCODE 81.1 +403.3 403312 1.5 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 SP3 ZHX2 ZNF606 ZNF549 ZNF417 ZNF418 LOC100128398 ZNF17 ZNF773 LOC105372482 ZNF211 ENSG00000268201
GH19G057809 1.7 FANTOM5 ENCODE dbSUPER 38.1 +190.1 190132 7.2 CREB3L1 MLX ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF134 ZNF264 TRIM28 ZNF17 ZNF417 ZNF256 ZNF543 ZNF805 ZNF606 ZNF773
GH19G058181 1.1 ENCODE 53 -179.9 -179888 2.5 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF134 ZNF549 ZNF606 ZNF773 ZNF17 ZNF418 ZNF550 ZNF417 ZNF256 ZNF543
GH19G058517 2.1 FANTOM5 Ensembl ENCODE dbSUPER 22.2 -516.4 -516360 4.9 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF324B ZNF549 CENPBD1P1 MZF1 ZNF134 ZNF606 LOC100128398 ZNF324 ZBTB45 ZNF418
GH19G058553 1.4 ENCODE dbSUPER 24.8 -553.8 -553764 7.2 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 ZNF606 ZNF417 TRIM28 MZF1-AS1 ZNF550 ZNF134 ZNF584 CENPBD1P1 ZNF776 ZNF551
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF606 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF606 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZNF606 Gene

57,977,053 bp from pter
58,003,349 bp from pter
26,297 bases
Minus strand

Genomic View for ZNF606 Gene

Genes around ZNF606 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF606 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF606 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF606 Gene

Proteins for ZNF606 Gene

  • Protein details for ZNF606 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 606
    Protein Accession:
    Secondary Accessions:
    • A8KAN2
    • Q8NE04
    • Q96JH5

    Protein attributes for ZNF606 Gene

    792 amino acids
    Molecular mass:
    91812 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB47481.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ZNF606 Gene

Post-translational modifications for ZNF606 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF606 Gene

Domains & Families for ZNF606 Gene

Gene Families for ZNF606 Gene

Protein Domains for ZNF606 Gene

Suggested Antigen Peptide Sequences for ZNF606 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF606: view

Function for ZNF606 Gene

Molecular function for ZNF606 Gene

UniProtKB/Swiss-Prot Function:
May act as a transcriptional repressor.

Gene Ontology (GO) - Molecular Function for ZNF606 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF606: view
genes like me logo Genes that share phenotypes with ZNF606: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF606 Gene

Localization for ZNF606 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF606 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF606 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF606 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with ZNF606: view

Pathways & Interactions for ZNF606 Gene

SuperPathways for ZNF606 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF606: view

Pathways by source for ZNF606 Gene

2 Reactome pathways for ZNF606 Gene

Gene Ontology (GO) - Biological Process for ZNF606 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
genes like me logo Genes that share ontologies with ZNF606: view

No data available for SIGNOR curated interactions for ZNF606 Gene

Drugs & Compounds for ZNF606 Gene

No Compound Related Data Available

Transcripts for ZNF606 Gene

Unigene Clusters for ZNF606 Gene

Zinc finger protein 606:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF606 Gene

No ASD Table

Relevant External Links for ZNF606 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF606 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF606 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF606 Gene:


SOURCE GeneReport for Unigene cluster for ZNF606 Gene:


mRNA Expression by UniProt/SwissProt for ZNF606 Gene:

Tissue specificity: Widely expressed in adult and fetal tissues.

Evidence on tissue expression from TISSUES for ZNF606 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ZNF606: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF606 Gene

Orthologs for ZNF606 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF606 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF606 34 35
  • 99.62 (n)
(Canis familiaris)
Mammalia ZNF606 34 35
  • 92.24 (n)
(Bos Taurus)
Mammalia ZNF606 35
  • 91 (a)
(Mus musculus)
Mammalia Zfp606 34 16 35
  • 89.04 (n)
(Rattus norvegicus)
Mammalia Zfp606 34
  • 88.61 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 57 (a)
Species where no ortholog for ZNF606 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF606 Gene

Gene Tree for ZNF606 (if available)
Gene Tree for ZNF606 (if available)

Paralogs for ZNF606 Gene

Paralogs for ZNF606 Gene

(538) SIMAP similar genes for ZNF606 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ZNF606: view

Variants for ZNF606 Gene

Sequence variations from dbSNP and Humsavar for ZNF606 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs386352385 Uncertain significance 57,978,581(-) CCGGA(C/G)AACTC reference, missense
rs1000007153 -- 57,996,329(+) AAACC(-/CT)GTCTC intron-variant
rs1000313862 -- 58,003,253(+) CTCGA(C/T)GGCTG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000491496 -- 57,988,389(+) TGTGA(C/G)TTCTC intron-variant
rs1000492626 -- 57,990,531(+) CAAAA(C/T)CCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF606 Gene

Variant ID Type Subtype PubMed ID
esv3644917 CNV loss 21293372
esv3644918 CNV gain 21293372
esv3644919 CNV loss 21293372
esv3893258 CNV gain 25118596
nsv1066059 CNV gain 25217958
nsv1123282 CNV deletion 24896259
nsv516650 CNV loss 19592680
nsv833885 CNV loss 17160897

Variation tolerance for ZNF606 Gene

Residual Variation Intolerance Score: 19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.89; 74.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF606 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF606 Gene

Disorders for ZNF606 Gene

Relevant External Links for ZNF606

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF606 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF606 Gene

Publications for ZNF606 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. ZNF328, a novel human zinc-finger protein, suppresses transcriptional activities of SRE and AP-1. (PMID: 15964554) Ou Y. … Liu M. (Biochem. Biophys. Res. Commun. 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. ZNF606 interacts with Sox9 to regulate chondrocyte differentiation. (PMID: 27634221) Zhou Z. … Zhang H. (Biochem. Biophys. Res. Commun. 2016) 3 64

Products for ZNF606 Gene

Sources for ZNF606 Gene

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