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Aliases for ZNF606 Gene

Aliases for ZNF606 Gene

  • Zinc Finger Protein 606 2 3 5
  • Zinc Finger Protein 328 3 4
  • ZNF328 3 4
  • KIAA1852 4

External Ids for ZNF606 Gene

Previous HGNC Symbols for ZNF606 Gene

  • ZNF328

Previous GeneCards Identifiers for ZNF606 Gene

  • GC19M063076
  • GC19M063181
  • GC19M058488
  • GC19M054799

Summaries for ZNF606 Gene

GeneCards Summary for ZNF606 Gene

ZNF606 (Zinc Finger Protein 606) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF10.

UniProtKB/Swiss-Prot for ZNF606 Gene

  • May act as a transcriptional repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF606 Gene

Genomics for ZNF606 Gene

Regulatory Elements for ZNF606 Gene

Enhancers for ZNF606 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF606 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF606 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF606 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF606 Gene

Chromosome:
19
Start:
57,977,053 bp from pter
End:
58,003,349 bp from pter
Size:
26,297 bases
Orientation:
Minus strand

Genomic View for ZNF606 Gene

Genes around ZNF606 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF606 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF606 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF606 Gene

Proteins for ZNF606 Gene

  • Protein details for ZNF606 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXB4-ZN606_HUMAN
    Recommended name:
    Zinc finger protein 606
    Protein Accession:
    Q8WXB4
    Secondary Accessions:
    • A8KAN2
    • Q8NE04
    • Q96JH5

    Protein attributes for ZNF606 Gene

    Size:
    792 amino acids
    Molecular mass:
    91812 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47481.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ZNF606 Gene

Proteomics data for ZNF606 Gene at MOPED

Post-translational modifications for ZNF606 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF606 Gene

No data available for DME Specific Peptides for ZNF606 Gene

Domains & Families for ZNF606 Gene

Gene Families for ZNF606 Gene

Protein Domains for ZNF606 Gene

Suggested Antigen Peptide Sequences for ZNF606 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXB4

UniProtKB/Swiss-Prot:

ZN606_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 16 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 16 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF606: view

Function for ZNF606 Gene

Molecular function for ZNF606 Gene

UniProtKB/Swiss-Prot Function:
May act as a transcriptional repressor.
genes like me logo Genes that share phenotypes with ZNF606: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF606 Gene

Localization for ZNF606 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF606 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF606 Gene COMPARTMENTS Subcellular localization image for ZNF606 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ZNF606 Gene

Pathways & Interactions for ZNF606 Gene

SuperPathways for ZNF606 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF606: view

Pathways by source for ZNF606 Gene

2 Reactome pathways for ZNF606 Gene

Interacting Proteins for ZNF606 Gene

Gene Ontology (GO) - Biological Process for ZNF606 Gene

None

No data available for SIGNOR curated interactions for ZNF606 Gene

Drugs & Compounds for ZNF606 Gene

No Compound Related Data Available

Transcripts for ZNF606 Gene

Unigene Clusters for ZNF606 Gene

Zinc finger protein 606:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF606 Gene

No ASD Table

Relevant External Links for ZNF606 Gene

GeneLoc Exon Structure for
ZNF606
ECgene alternative splicing isoforms for
ZNF606

Expression for ZNF606 Gene

mRNA expression in normal human tissues for ZNF606 Gene

SOURCE GeneReport for Unigene cluster for ZNF606 Gene Hs.654967

mRNA Expression by UniProt/SwissProt for ZNF606 Gene

Q8WXB4-ZN606_HUMAN
Tissue specificity: Widely expressed in adult and fetal tissues.
genes like me logo Genes that share expression patterns with ZNF606: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ZNF606 Gene

Orthologs for ZNF606 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF606 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ZNF606 35
  • 92.24 (n)
  • 93.92 (a)
ZNF606 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp606 35
  • 89.04 (n)
  • 89.63 (a)
Zfp606 16
Zfp606 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF606 35
  • 99.62 (n)
  • 99.37 (a)
ZNF606 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp606 35
  • 88.61 (n)
  • 88.52 (a)
cow
(Bos Taurus)
Mammalia ZNF606 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
OneToMany
Species with no ortholog for ZNF606:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF606 Gene

ENSEMBL:
Gene Tree for ZNF606 (if available)
TreeFam:
Gene Tree for ZNF606 (if available)

Paralogs for ZNF606 Gene

Paralogs for ZNF606 Gene

(538) SIMAP similar genes for ZNF606 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ZNF606: view

Variants for ZNF606 Gene

Sequence variations from dbSNP and Humsavar for ZNF606 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11673029 - 57,980,259(+) TTTGC(C/T)TTCAA reference, missense
rs8105738 -- 57,984,292(+) GACAG(C/G)TGAGA intron-variant
rs13346776 -- 57,981,761(+) CCCCT(A/G)AAGTT intron-variant
rs13346861 -- 57,982,346(+) ataaa(A/G)ggacc intron-variant
rs16988328 -- 57,980,365(+) TATTA(C/T)CAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF606 Gene

Variant ID Type Subtype PubMed ID
nsv833885 CNV Loss 17160897
nsv516650 CNV Loss 19592680
nsv912533 CNV Loss 21882294

Variation tolerance for ZNF606 Gene

Residual Variation Intolerance Score: 19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.89; 74.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF606 Gene

HapMap Linkage Disequilibrium report
ZNF606

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF606 Gene

Disorders for ZNF606 Gene

Relevant External Links for ZNF606

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF606

No disorders were found for ZNF606 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF606 Gene

Publications for ZNF606 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 67
  2. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. ZNF328, a novel human zinc-finger protein, suppresses transcriptional activities of SRE and AP-1. (PMID: 15964554) Ou Y. … Liu M. (Biochem. Biophys. Res. Commun. 2005) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF606 Gene

Sources for ZNF606 Gene

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