ZNF606 Gene
protein-coding GIFtS: 47
GCID: GC19M058488
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zinc finger protein 606
(Previous symbol: ZNF328)
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Aliases
for ZNF606 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 6061 2 | | ZNF3281 2 3 | | KIAA18521 3 | | Zinc Finger Protein 3282 3 | | FLJ142601 |
Export aliases for ZNF606 gene to outside databasesPrevious GC identifers: GC19M063076 GC19M063181 GC19M054799 |
Summaries
for ZNF606 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN606_HUMAN, Q8WXB4Function: May act as a transcriptional repressor
|
Genomic Views
for ZNF606 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF606 gene promoter:
AP-1 GR-beta ATF-2 STAT3 AP-4 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF606
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF606 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.4 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43ZNF606 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M058488: view genomic region
(about GC identifiers)
Start:
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58,488,421 bp from pter |
End:
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58,514,717 bp from pter |
Size:
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26,297 bases |
Orientation:
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minus strand |
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Proteins
for ZNF606 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN606_HUMAN, Q8WXB4 (See
protein sequence)Recommended Name: Zinc finger protein 606 Size: 792 amino acids; 91812 Da
Subcellular location: Nucleus
Sequence caution: Sequence=BAB47481.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8KAN2 Q8NE04 Q96JH5Explore the universe of human proteins at neXtProt for ZNF606: NX_Q8WXB4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WXB4
ZNF606 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079303.2
ENSEMBL proteins: ENSP00000343617 ENSP00000446845 ENSP00000446972 ENSP00000446487 ENSP00000449865 ENSP00000447726 ENSP00000447075 ENSP00000445624 Reactome Protein details: Q8WXB4
Human Recombinant Protein Products for ZNF606:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
ZNF606 for ontologies About GeneDecksing
ZNF606 Antibody Products:
Assay Products for ZNF606: |
Protein
Domains /
Families
for ZNF606 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF606 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WXB4ProtoNet protein and cluster: Q8WXB4 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN606_HUMAN, Q8WXB4Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 16 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF606 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZN606_HUMAN, Q8WXB4Function: May act as a transcriptional repressor Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF606 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for ZNF606:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF606 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF606 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF606 (NM_025027) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF606 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF606 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF606 |
|
Pathways & Interactions
for ZNF606 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF606
ZNF606 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF606
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF606 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF606 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF606
Search CenterWatch for drugs/clinical trials and news about ZNF606 / ZN606
|
Transcripts
for ZNF606 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF606 gene: NM_025027.3 Unigene Cluster for ZNF606: Zinc finger protein 606 Hs.654967 [show with all ESTs]Unigene Representative Sequence: AF45535710 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000341164(uc002qqw.3 uc010yhp.2) ENST00000550599 ENST00000551380
ENST00000552579 ENST00000547828(uc002qqx.1) ENST00000547121 ENST00000546715
ENST00000552184 ENST00000550560 ENST00000536132
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF606 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF606 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF606 (NM_025027) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF606 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF606 |
Additional cDNA sequence: AB058755.1 AF455357.1 AK024322.1 AK056696.1 AK293097.1 AK294037.1 BC022533.1 BC036570.1 BC037209.1 8 DOTS entries: DT.443021 DT.95158670 DT.92416315 DT.121438339 DT.91665490 DT.100670171 DT.100775864 DT.40124482 24/113 AceView cDNA sequences (see all 113): BC037209 AI149734 CB162317 AI095614 BU616400 AI251879 BM713422 F07848 AB058755 BM678341 AI817719 BE677260 AI209120 Z40942 BU508814 AI122767 D25767 AI804981 AW082398 AK056696 BE348654 AI962373 AA825292 BP428966
GeneLoc Exon Structure
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Expression
for ZNF606 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF606 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAAGTTAA
About this image
See ZNF606 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF606
SOURCE GeneReport for Unigene cluster: Hs.654967
UniProtKB/Swiss-Prot: ZN606_HUMAN, Q8WXB4Tissue specificity: Widely expressed in adult and fetal tissues
SABiosciences Custom PCR Arrays for ZNF606
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF606
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF606 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF606 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF606 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF606 |
Orthologs
for ZNF606 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF606 gene from 2/11 species (see all 11) About this table
ENSEMBL Gene Tree for ZNF606 (if available)
TreeFam Gene Tree for ZNF606 (if available) |
Paralogs
for ZNF606 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF606 gene
- ZNF1802 ZNF3292 ZNF5442 ZNF102
18/531 SIMAP similar genes for ZNF606 using alignment to 8 protein entries: ZN606_HUMAN (see all proteins)
(see all similar genes):ZNF818P ZNF232 kr-znf3 ZNF78L1 HZF36 ZNF56
DKFZp666M039 ZFP41 ZFS-4 DKFZp666C237 ZNF24 ZNF331
ZNF738 PRDM9 ZFS-5 ZNF204 ZNF781 ZNF844
ZNF606 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF606 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF606 (58488421 - 58514717 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ZNF606
2 CNVs: 5118 50236 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF606 |
|
Disorders
/ Diseases
for ZNF606 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF606 for disorders About MalaCards
ZNF606 for disorders About GeneDecksing
OMIM gene information: 613905
OMIM disorders: --
Export disorders for ZNF606 gene to outside databases
|
Publications
for ZNF606 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF606 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF606) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2, 3 Nagase T.... Ohara O. (2001)
- ZNF328, a novel human zinc-finger protein, suppresses transcriptional activities of SRE and AP-1. (PubMed id 15964554)1, 2 Ou Y....Liu M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Generation and analysis of 280,000 human expressed sequence tags. (PubMed id 8889549)1 Hillier L.D....Marra M. (1996)
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External Searches for ZNF606 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF606 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF606 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZNF606 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF606 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ZNF606 gene:
Search GeneIP for patents involving ZNF606
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF606 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF606 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF606 | | | OriGene Protein Over-expression Lysate for ZNF606 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF606 | | OriGene 3'-UTR Clone for ZNF606 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF606 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF606 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ZNF606 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF606 | | OriGene Custom Protein Services for ZNF606 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF606 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF606 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF606 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF606 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF606 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF606 |
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| | | | Search Tocris compounds for ZNF606 |
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 | | | ZNF606 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF606 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for ZNF606 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF606 |
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