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Aliases for ZNF605 Gene

Aliases for ZNF605 Gene

  • Zinc Finger Protein 605 2 3 5
  • EC 2.5.1.18 61
  • EC 2.1.1.43 61

External Ids for ZNF605 Gene

Previous GeneCards Identifiers for ZNF605 Gene

  • GC12M131737
  • GC12M132108
  • GC12M132008
  • GC00U928747
  • GC12M133499
  • GC12M130274

Summaries for ZNF605 Gene

GeneCards Summary for ZNF605 Gene

ZNF605 (Zinc Finger Protein 605) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF615.

UniProtKB/Swiss-Prot for ZNF605 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF605 Gene

Genomics for ZNF605 Gene

Regulatory Elements for ZNF605 Gene

Enhancers for ZNF605 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F132487 1.8 FANTOM5 Ensembl ENCODE 20.4 +457.0 456957 23.9 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF26 EP400NL ZNF891 FBRSL1 EP400 ZNF10 GOLGA3 NOC4L ENSG00000256875 ZNF84
GH12F132597 1.3 Ensembl ENCODE 25.8 +358.0 357992 1.8 HDGF ARNT ZNF493 ZNF133 YBX1 GLI4 ZNF48 ZNF2 ZNF121 GLIS2 ZNF140 ZNF84 ENSG00000255933 EP400 ZNF26 ENSG00000250790 ZNF605 DDX51 GOLGA3 SFSWAP
GH12F133129 1.1 ENCODE 16 -174.1 -174090 2.3 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 ZNF891 ZNF10 ZNF84 ZNF605 ZNF140 ZNF268 ENSG00000250790 GOLGA3 DDX51 RPL23AP67
GH12F132593 0.8 ENCODE 16 +362.2 362246 0.7 HDGF ELF3 DRAP1 TBP ATF1 MXI1 CBX3 PKNOX1 SAP130 SIN3A ZNF84 ZNF605 ZNF140 EP400 ZNF10 FBRSL1 ENSG00000250790 GOLGA3 DDX51 P2RX2
GH12F132827 1.1 ENCODE 9.9 +127.8 127824 2.6 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ANKLE2 ZNF26 ZNF891 ZNF140 EP400 ZNF10 ENSG00000255919 PUS1 ZNF84 NOC4L
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF605 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF605 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001468571 305 2799 ATF1 ARID4B DMAP1 ZNF2 YY1 ETS1 GLIS2 CBX5 ZNF143 FOS

Genomic Location for ZNF605 Gene

Chromosome:
12
Start:
132,918,308 bp from pter
End:
132,956,306 bp from pter
Size:
37,999 bases
Orientation:
Minus strand

Genomic View for ZNF605 Gene

Genes around ZNF605 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF605 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF605 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF605 Gene

Proteins for ZNF605 Gene

  • Protein details for ZNF605 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86T29-ZN605_HUMAN
    Recommended name:
    Zinc finger protein 605
    Protein Accession:
    Q86T29
    Secondary Accessions:
    • B3KVG4
    • D3DXJ0
    • Q86T91

    Protein attributes for ZNF605 Gene

    Size:
    641 amino acids
    Molecular mass:
    74376 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF605 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF605 Gene

Selected DME Specific Peptides for ZNF605 Gene

Q86T29:
  • ELNKKLL
  • HQRTHTGEKPY

Post-translational modifications for ZNF605 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF605 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ZNF605 Gene

Gene Families for ZNF605 Gene

Graphical View of Domain Structure for InterPro Entry

Q86T29

UniProtKB/Swiss-Prot:

ZN605_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 17 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 17 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF605: view

Function for ZNF605 Gene

Molecular function for ZNF605 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Enzyme Numbers (IUBMB) for ZNF605 Gene

Gene Ontology (GO) - Molecular Function for ZNF605 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF605: view
genes like me logo Genes that share phenotypes with ZNF605: view

Animal Model Products

miRNA for ZNF605 Gene

miRTarBase miRNAs that target ZNF605

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF605 Gene

Localization for ZNF605 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF605 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF605 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF605 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF605: view

Pathways & Interactions for ZNF605 Gene

SuperPathways for ZNF605 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF605: view

Pathways by source for ZNF605 Gene

2 Reactome pathways for ZNF605 Gene

Gene Ontology (GO) - Biological Process for ZNF605 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF605: view

No data available for SIGNOR curated interactions for ZNF605 Gene

Transcripts for ZNF605 Gene

mRNA/cDNA for ZNF605 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF605 Gene

Zinc finger protein 605:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF605 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: -
SP2:
SP3: -

Relevant External Links for ZNF605 Gene

GeneLoc Exon Structure for
ZNF605
ECgene alternative splicing isoforms for
ZNF605

Expression for ZNF605 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF605 Gene

Protein differential expression in normal tissues from HIPED for ZNF605 Gene

This gene is overexpressed in Heart (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF605 Gene



Protein tissue co-expression partners for ZNF605 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF605 Gene:

ZNF605

SOURCE GeneReport for Unigene cluster for ZNF605 Gene:

Hs.29698
genes like me logo Genes that share expression patterns with ZNF605: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF605 Gene

Orthologs for ZNF605 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF605 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF605 34 35
  • 99.06 (n)
dog
(Canis familiaris)
Mammalia ZNF605 34 35
  • 86.92 (n)
cow
(Bos Taurus)
Mammalia ZNF605 34 35
  • 86.71 (n)
mouse
(Mus musculus)
Mammalia Zfp605 34 16 35
  • 76.05 (n)
rat
(Rattus norvegicus)
Mammalia LOC100365779 34
  • 72.48 (n)
Species where no ortholog for ZNF605 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF605 Gene

ENSEMBL:
Gene Tree for ZNF605 (if available)
TreeFam:
Gene Tree for ZNF605 (if available)

Paralogs for ZNF605 Gene

(445) SIMAP similar genes for ZNF605 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNF605 Gene

genes like me logo Genes that share paralogs with ZNF605: view

Variants for ZNF605 Gene

Sequence variations from dbSNP and Humsavar for ZNF605 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10357 -- 132,924,025(-) tttta(A/C)tggcc utr-variant-3-prime
rs1050225 -- 132,922,271(-) CTTCA(A/G)AAAGC utr-variant-3-prime
rs10870553 -- 132,957,163(+) TCTCC(C/T)GACCT upstream-variant-2KB
rs10870554 -- 132,957,167(+) CTGAC(C/T)TCGTG upstream-variant-2KB
rs111174074 -- 132,951,652(+) CACAC(A/G)TACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF605 Gene

Variant ID Type Subtype PubMed ID
nsv952514 CNV deletion 24416366
nsv945 CNV insertion 18451855
nsv9046 CNV gain 18304495
nsv561135 CNV loss 21841781
nsv528637 CNV loss 19592680
nsv513380 CNV insertion 21212237
nsv509495 CNV insertion 20534489
nsv470335 CNV loss 18288195
nsv1126337 CNV deletion 24896259
nsv1071081 CNV deletion 25765185
nsv1070156 CNV deletion 25765185
nsv1041440 CNV loss 25217958
esv3631325 CNV loss 21293372
esv3427404 CNV duplication 20981092
esv2759923 CNV loss 17122850
esv22416 CNV loss 19812545
esv1007810 CNV insertion 20482838
dgv949e59 CNV duplication 20981092
dgv917n106 CNV deletion 24896259
dgv331e199 CNV deletion 23128226
dgv330e199 CNV deletion 23128226
dgv1589n100 CNV gain 25217958

Variation tolerance for ZNF605 Gene

Gene Damage Index Score: 0.44; 9.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF605 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF605

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF605 Gene

Disorders for ZNF605 Gene

Relevant External Links for ZNF605

Genetic Association Database (GAD)
ZNF605
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF605

No disorders were found for ZNF605 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF605 Gene

Publications for ZNF605 Gene

  1. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3 64
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ZNF605 Gene

Sources for ZNF605 Gene

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