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ZNF605 Gene

protein-coding   GIFtS: 41
GCID: GC12M133499

Zinc Finger Protein 605

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 6051 2
EC 2.1.1.438
EC 2.5.1.188

External Ids:    HGNC: 280681   Entrez Gene: 1002896352   Ensembl: ENSG000001964587   UniProtKB: Q86T293   

Export aliases for ZNF605 gene to outside databases

Previous GC identifers: GC12M131737 GC12M132108 GC12M132008 GC00U928747 GC12M130274


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF605 Gene:
ZNF605 (zinc finger protein 605) is a protein-coding gene. An important paralog of this gene is ZNF334.

UniProtKB/Swiss-Prot: ZN605_HUMAN, Q86T29
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_024477.15  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF605
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF605 promoter sequence
   Search Chromatin IP Primers for ZNF605

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF605


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.33   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.33

ZNF605 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF605 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M133499:  view genomic region     (about GC identifiers)

Start:
133,498,019 bp from pter      End:
133,532,892 bp from pter
Size:
34,874 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN605_HUMAN, Q86T29 (See protein sequence)
Recommended Name: Zinc finger protein 605  
Size: 641 amino acids; 74376 Da
Secondary accessions: B3KVG4 D3DXJ0 Q86T91
Alternative splicing: 2 isoforms:  Q86T29-1   Q86T29-2   

Explore the universe of human proteins at neXtProt for ZNF605: NX_Q86T29

Explore proteomics data for ZNF605 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for ZNF605 (Q86T29)
     ELNKKLL  HQRTHTGEKPY 


    See ZNF605 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001158187.1  NP_899061.1  

    ENSEMBL proteins: 
     ENSP00000353314   ENSP00000376135  
    Reactome Protein details: Q86T29

    ZNF605 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q86T29

    ProtoNet protein and cluster: Q86T29

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN605_HUMAN, Q86T29
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 17 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF605           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN605_HUMAN, Q86T29
    Function: May be involved in transcriptional regulation

         Enzyme Numbers (IUBMB): EC 2.1.1.432 EC 2.5.1.182

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF605           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF605
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    miRNA
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    miRTarBase miRNAs that target ZNF605:
    hsa-mir-335-5p (MIRT018953)

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    Selected qRT-PCR Assays for microRNAs that regulate ZNF605 (see all 11):
    hsa-miR-124* hsa-miR-30c-2* hsa-miR-548am hsa-miR-578 hsa-miR-4314 hsa-miR-370 hsa-miR-548x hsa-miR-30c-1*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF605


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN605_HUMAN, Q86T29: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF605           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Find genes that share SuperPaths with ZNF605           About GenesLikeMe

    Pathways by sourceSee SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF605
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF605
    Interactions:

        Search GeneGlobe Interaction Network for ZNF605

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF605 (ENSP000003761354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK8ENSP000003534834STRING: ENSP00000353483
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    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    Find genes that share ontologies with ZNF605           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF605 (ZN605)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF605 gene (2 alternative transcripts): 
    NM_001164715.1  NM_183238.3  

    Unigene Cluster for ZNF605:

    Zinc finger protein 605
    Hs.29698  [show with all ESTs]
    Unigene Representative Sequence: AL832191
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360187(uc001ulh.3 uc001ulj.3) ENST00000392321(uc001uli.3)
    ENST00000331711 ENST00000412621(uc001ulk.1) ENST00000381215 ENST00000539809

    miRNA
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    Block miRNA regulation of human, mouse, rat ZNF605 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF605 (see all 11):
    hsa-miR-124* hsa-miR-30c-2* hsa-miR-548am hsa-miR-578 hsa-miR-4314 hsa-miR-370 hsa-miR-548x hsa-miR-30c-1*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF605
    Clone
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    GenScript Custom all cDNA clones Services for ZNF605
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZNF605
    Primer
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    Browse OriGene qPCR
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF605
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF605
      QuantiFast Probe-based Assays in human, mouse, rat ZNF605

    Additional mRNA sequence: 

    AK027873.1 AK122878.1 AL832191.1 AL832623.2 BC020877.1 BC062737.1 

    10 DOTS entries:

    DT.454273  DT.92045508  DT.92037934  DT.100742317  DT.113539  DT.121213931  DT.121214152  DT.97768207 
    DT.100734563  DT.92020409 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF605    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
    SP1:                    -                     
    SP2:                                          
    SP3:                    -                     


    ECgene alternative splicing isoforms for ZNF605

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF605 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF605 Expression
    About this image

    ZNF605 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF605 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.29698
        Custom PCR Arrays for ZNF605
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF605

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF605 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp6051 , 5 zinc finger protein 6051, 5 76.05(n)1
    63.1(a)1
      5 (53.30 cM)5
    6758121  NM_001163996.11  NP_001157468.11 
     1101100925 


    ENSEMBL Gene Tree for ZNF605 (if available)
    TreeFam Gene Tree for ZNF605 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF605 gene
    ZNF3342  ZNF4202  ZNF780A2  ZNF6652  ZNF72  ZNF232  ZNF33A2  RBAK2  
    ZNF7172  ZNF302  ZNF5732  ZNF33B2  ZNF5402  ZNF2512  ZNF842  ZNF1892  
    ZNF5712  ZNF6302  ZNF3372  ZNF2832  ZNF4042  ZNF1352  ZNF4842  ZNF122  
    ZNF3452  ZNF1842  ZNF6992  ZNF412  ZNF6152  ZNF4702  ZNF5692  
    Selected SIMAP similar genes for ZNF605 using alignment to 2 protein entries:     ZN605_HUMAN (see all proteins) (see all similar genes):
    ZNF323    HZF36    ZNF146    ZNF232    ZNF391    ZNF502
    DKFZp547L155    ZNF16    ZNF662    ZNF774    DKFZp666M039    ZNF260
    ZNF271    ZNF572    ZNF665    ZNF696    ZNF852    HZF30

    Find genes that share paralogs with ZNF605           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF605
    PGOHUM00000239441


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF605 (see all 586)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1833088261,2
    --133497545(+) GTAGCC/TCGGAT 2 -- int10--------
    rs1457947091,2
    --133497573(+) ATGCCC/TGGCTA 2 -- int10--------
    rs1886051371,2
    --133497586(+) TTTTTC/TGTATT 2 -- int10--------
    rs1485653651,2
    --133497631(+) TGGTCA/GCGAAC 2 -- int10--------
    rs1444828341,2
    --133497658(+) TCCACC/TCACCT 2 -- int10--------
    rs1922228601,2
    --133497661(+) ACCCAC/TCTCGG 2 -- int10--------
    rs1173174621,2
    F--133497700(+) GCGTCA/GCTGCA 2 -- int11Minor allele frequency- G:0.01NA 120
    rs352774891,2
    C--133497730(+) TTAAA-/TTTTTT 2 -- int10--------
    rs1491030901,2
    --133497769(+) TCCAG-/CTGGTC
    TCAAACGC
    CTGGG
    2 -- int10--------
    rs111471641,2
    C,F,H--133497874(+) TGGATA/GTAACT 2 -- int120Minor allele frequency- G:0.24NS EA NA WA 2334

    HapMap Linkage Disequilibrium report for ZNF605 (133498019 - 133532892 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF605 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv331e199CNV Deletion23128226
    dgv330e199CNV Deletion23128226
    nsv509495CNV Insertion20534489
    nsv945CNV Insertion18451855
    esv1007810CNV Insertion20482838
    nsv470335CNV Loss18288195
    esv22416CNV Loss19812545
    nsv528637CNV Loss19592680
    nsv9046CNV Gain18304495
    nsv899834CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF605
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF605           About GenesLikeMe

    Genetic Association Database (GAD): ZNF605

    Export disorders for ZNF605 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF605 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF605)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)1, 2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100289635 HGNC: 28068 Ensembl:ENSG00000196458 euGenes: HUgn100289635 ECgene: ZNF605
    H-InvDB: ZNF605

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF605 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF605 gene:
    Search GeneIP for patents involving ZNF605

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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