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Aliases for ZNF600 Gene

Aliases for ZNF600 Gene

  • Zinc Finger Protein 600 2 3 5
  • Zinc Finger Protein KR-ZNF1 3
  • KR-ZNF1 3

External Ids for ZNF600 Gene

Previous GeneCards Identifiers for ZNF600 Gene

  • GC19M057959
  • GC19M057948
  • GC19M053267
  • GC19M049596

Summaries for ZNF600 Gene

GeneCards Summary for ZNF600 Gene

ZNF600 (Zinc Finger Protein 600) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF860.

UniProtKB/Swiss-Prot for ZNF600 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF600 Gene

Genomics for ZNF600 Gene

Regulatory Elements for ZNF600 Gene

Enhancers for ZNF600 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF600 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF600 Gene

Chromosome:
19
Start:
52,764,195 bp from pter
End:
52,833,628 bp from pter
Size:
69,434 bases
Orientation:
Minus strand

Genomic View for ZNF600 Gene

Genes around ZNF600 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF600 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF600 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF600 Gene

Proteins for ZNF600 Gene

  • Protein details for ZNF600 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNG1-ZN600_HUMAN
    Recommended name:
    Zinc finger protein 600
    Protein Accession:
    Q6ZNG1
    Secondary Accessions:
    • Q6MZR0

    Protein attributes for ZNF600 Gene

    Size:
    722 amino acids
    Molecular mass:
    83124 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF600 Gene

Proteomics data for ZNF600 Gene at MOPED

Post-translational modifications for ZNF600 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF600 Gene

No data available for DME Specific Peptides for ZNF600 Gene

Domains & Families for ZNF600 Gene

Gene Families for ZNF600 Gene

Protein Domains for ZNF600 Gene

Suggested Antigen Peptide Sequences for ZNF600 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZNG1

UniProtKB/Swiss-Prot:

ZN600_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 20 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 20 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF600: view

Function for ZNF600 Gene

Molecular function for ZNF600 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF600: view

Animal Model Products

CRISPR Products

miRNA for ZNF600 Gene

miRTarBase miRNAs that target ZNF600

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF600 Gene

Localization for ZNF600 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF600 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF600 Gene COMPARTMENTS Subcellular localization image for ZNF600 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF600 Gene

Pathways & Interactions for ZNF600 Gene

SuperPathways for ZNF600 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF600: view

Pathways by source for ZNF600 Gene

2 Reactome pathways for ZNF600 Gene

Gene Ontology (GO) - Biological Process for ZNF600 Gene

None

No data available for SIGNOR curated interactions for ZNF600 Gene

Drugs & Compounds for ZNF600 Gene

No Compound Related Data Available

Transcripts for ZNF600 Gene

Unigene Clusters for ZNF600 Gene

Zinc finger protein 600:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF600 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
SP1: - - - -
SP2: -
SP3: - -
SP4:

Relevant External Links for ZNF600 Gene

GeneLoc Exon Structure for
ZNF600
ECgene alternative splicing isoforms for
ZNF600

Expression for ZNF600 Gene

mRNA expression in normal human tissues for ZNF600 Gene

Protein differential expression in normal tissues from HIPED for ZNF600 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF600 Gene



SOURCE GeneReport for Unigene cluster for ZNF600 Gene Hs.696848

genes like me logo Genes that share expression patterns with ZNF600: view

Protein tissue co-expression partners for ZNF600 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF600 Gene

Orthologs for ZNF600 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF600 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF600 35
  • 96.08 (n)
  • 95.43 (a)
ZNF600 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 43 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 43 (a)
ManyToMany
Species with no ortholog for ZNF600:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF600 Gene

ENSEMBL:
Gene Tree for ZNF600 (if available)
TreeFam:
Gene Tree for ZNF600 (if available)

Paralogs for ZNF600 Gene

(621) SIMAP similar genes for ZNF600 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF600: view

Variants for ZNF600 Gene

Sequence variations from dbSNP and Humsavar for ZNF600 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7252818 - 52,767,752(+) CTTCA(C/T)CATGC reference, missense
rs7252128 - 52,767,718(+) CTTCT(C/G)TATTG reference, missense
rs1820128 - 52,767,131(+) TCTAC(A/C/G)ATGGC reference, missense
rs7256193 -- 52,783,156(+) ACGCC(A/G)TCATT intron-variant
rs7256445 -- 52,783,303(+) TCACC(A/G)CTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF600 Gene

Variant ID Type Subtype PubMed ID
esv2718786 CNV Deletion 23290073
esv2718787 CNV Deletion 23290073
dgv3980n71 CNV Gain 21882294
dgv3981n71 CNV Gain 21882294
nsv509752 CNV Insertion 20534489
esv2718796 CNV Deletion 23290073
dgv3984n71 CNV Gain 21882294
nsv458745 CNV Gain 19166990
nsv833875 CNV Loss 17160897
esv2671531 CNV Deletion 23128226
nsv527597 CNV Loss 19592680
esv2664794 CNV Deletion 23128226
esv2718798 CNV Deletion 23290073
nsv458746 CNV Gain 19166990

Variation tolerance for ZNF600 Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.60; 65.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF600 Gene

Human Gene Mutation Database (HGMD)
ZNF600

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF600 Gene

Disorders for ZNF600 Gene

Relevant External Links for ZNF600

Genetic Association Database (GAD)
ZNF600
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF600

No disorders were found for ZNF600 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF600 Gene

Publications for ZNF600 Gene

  1. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A. … Schmitz G. (PLoS Genet. 2012) 3 48 67
  2. Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs. (PMID: 12576331) Yang X.O. … Willerford D.M. (Blood 2003) 2 3
  3. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF600 Gene

Sources for ZNF600 Gene

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