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Aliases for ZNF600 Gene

Aliases for ZNF600 Gene

  • Zinc Finger Protein 600 2 3 5
  • Zinc Finger Protein KR-ZNF1 3
  • KR-ZNF1 3

External Ids for ZNF600 Gene

Previous GeneCards Identifiers for ZNF600 Gene

  • GC19M057959
  • GC19M057948
  • GC19M053267
  • GC19M049596

Summaries for ZNF600 Gene

GeneCards Summary for ZNF600 Gene

ZNF600 (Zinc Finger Protein 600) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF611.

UniProtKB/Swiss-Prot for ZNF600 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF600 Gene

Genomics for ZNF600 Gene

Regulatory Elements for ZNF600 Gene

Enhancers for ZNF600 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G052137 1.4 FANTOM5 ENCODE 25.1 +694.0 693997 3.3 PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF808 ZNF137P ENSG00000268970 ZNF816 ZNF350 ZNF836 ZNF600 ZNF468 ZNF616 ZNF841
GH19G053553 1.2 ENCODE dbSUPER 13.4 -720.9 -720920 2.6 HDGF PKNOX1 ZNF133 SIN3A ZNF2 ETS1 ZNF302 ZNF143 FOS ZNF548 ZNF845 PRPF31 ZNF347 ZNF600 LENG8-AS1 ZNF701 ZNF137P ENSG00000235681 ZNF665 ENSG00000269825
GH19G053364 1.1 ENCODE 14.4 -532.1 -532063 1.6 HDGF HNRNPUL1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B ZNF207 KLF13 ZNF525 ZNF808 ZNF845 ENSG00000268970 ZNF137P ZNF765 ZNF816 ENSG00000269825 ENSG00000269001 ZNF813
GH19G053389 1 Ensembl ENCODE 14.4 -556.3 -556301 1.8 KLF1 CREB3L1 SUZ12 ZSCAN4 ZNF76 DEAF1 FOSL1 ZNF766 DIDO1 ZNF366 ZNF525 ZNF808 ENSG00000268970 ZNF845 ZNF137P ZNF765 ZNF816 ENSG00000269825 ENSG00000269001 ZNF813
GH19G052785 1 ENCODE 13.7 +47.0 47019 2.0 HDGF ARID4B SIN3A DMAP1 ZNF48 SLC30A9 KDM4B SP3 SP5 MXD4 ZNF600 ZNF28 GC19M052801 LOC105372451
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF600 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF600 Gene

52,764,195 bp from pter
52,833,628 bp from pter
69,434 bases
Minus strand

Genomic View for ZNF600 Gene

Genes around ZNF600 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF600 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF600 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF600 Gene

Proteins for ZNF600 Gene

  • Protein details for ZNF600 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 600
    Protein Accession:
    Secondary Accessions:
    • Q6MZR0

    Protein attributes for ZNF600 Gene

    722 amino acids
    Molecular mass:
    83124 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF600 Gene

Post-translational modifications for ZNF600 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF600 Gene

No data available for DME Specific Peptides for ZNF600 Gene

Domains & Families for ZNF600 Gene

Gene Families for ZNF600 Gene

Protein Domains for ZNF600 Gene

Suggested Antigen Peptide Sequences for ZNF600 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF600: view

Function for ZNF600 Gene

Molecular function for ZNF600 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF600 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF600: view
genes like me logo Genes that share phenotypes with ZNF600: view

Animal Model Products

CRISPR Products

miRNA for ZNF600 Gene

miRTarBase miRNAs that target ZNF600

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF600 Gene

Localization for ZNF600 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF600 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF600 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF600 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF600: view

Pathways & Interactions for ZNF600 Gene

SuperPathways for ZNF600 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF600: view

Pathways by source for ZNF600 Gene

2 Reactome pathways for ZNF600 Gene

Gene Ontology (GO) - Biological Process for ZNF600 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF600: view

No data available for SIGNOR curated interactions for ZNF600 Gene

Drugs & Compounds for ZNF600 Gene

No Compound Related Data Available

Transcripts for ZNF600 Gene

Unigene Clusters for ZNF600 Gene

Zinc finger protein 600:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF600 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
SP1: - - - -
SP2: -
SP3: - -

Relevant External Links for ZNF600 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF600 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF600 Gene

Protein differential expression in normal tissues from HIPED for ZNF600 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF600 Gene

Protein tissue co-expression partners for ZNF600 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF600 Gene:


SOURCE GeneReport for Unigene cluster for ZNF600 Gene:


Evidence on tissue expression from TISSUES for ZNF600 Gene

  • Nervous system(4.1)
  • Intestine(3.3)
  • Pancreas(3.1)
  • Skin(3.1)
genes like me logo Genes that share expression patterns with ZNF600: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF600 Gene

Orthologs for ZNF600 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF600 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF600 34 35
  • 96.08 (n)
(Bos Taurus)
Mammalia -- 35
  • 43 (a)
(Canis familiaris)
Mammalia -- 35
  • 43 (a)
Species where no ortholog for ZNF600 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF600 Gene

Gene Tree for ZNF600 (if available)
Gene Tree for ZNF600 (if available)

Paralogs for ZNF600 Gene

(621) SIMAP similar genes for ZNF600 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF600: view

Variants for ZNF600 Gene

Sequence variations from dbSNP and Humsavar for ZNF600 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000188220 -- 52,774,441(+) AAAAA(A/C)AAAAC intron-variant
rs1000239116 -- 52,768,404(+) CTCTG(C/T)ACTCC intron-variant
rs1000322919 -- 52,764,699(+) TTTTT(A/G)GTAGA downstream-variant-500B, upstream-variant-2KB
rs1000495693 -- 52,769,558(+) ATCCA(A/G)TAAAT intron-variant
rs1000551525 -- 52,783,179(+) ACACT(G/T)AGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF600 Gene

Variant ID Type Subtype PubMed ID
dgv3629n100 CNV loss 25217958
dgv6527n54 CNV gain 21841781
esv2664794 CNV deletion 23128226
esv2671531 CNV deletion 23128226
esv2718786 CNV deletion 23290073
esv2718787 CNV deletion 23290073
esv2718796 CNV deletion 23290073
esv2718798 CNV deletion 23290073
esv3644719 CNV gain 21293372
esv3644720 CNV loss 21293372
esv3644721 CNV loss 21293372
esv3893231 CNV loss 25118596
esv3893234 CNV gain 25118596
nsv1055617 CNV loss 25217958
nsv1057118 CNV gain 25217958
nsv1062976 CNV gain 25217958
nsv1066762 CNV gain 25217958
nsv1067557 CNV gain 25217958
nsv1078889 OTHER inversion 25765185
nsv1140479 CNV deletion 24896259
nsv1146332 OTHER inversion 26484159
nsv458745 CNV gain 19166990
nsv458746 CNV gain 19166990
nsv509752 CNV insertion 20534489
nsv527597 CNV loss 19592680
nsv580030 CNV gain 21841781
nsv580031 CNV gain 21841781
nsv833875 CNV loss 17160897
nsv961240 CNV duplication 23825009

Variation tolerance for ZNF600 Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.60; 65.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF600 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF600 Gene

Disorders for ZNF600 Gene

Relevant External Links for ZNF600

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF600 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF600 Gene

Publications for ZNF600 Gene

  1. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A. … Schmitz G. (PLoS Genet. 2012) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs. (PMID: 12576331) Yang X.O. … Willerford D.M. (Blood 2003) 2 3 64
  4. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3 64
  5. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V. … Han D.K. (Sci. Signal. 2009) 4 64

Products for ZNF600 Gene

Sources for ZNF600 Gene

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