Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF599 Gene

Aliases for ZNF599 Gene

  • Zinc Finger Protein 599 2 3

External Ids for ZNF599 Gene

Previous GeneCards Identifiers for ZNF599 Gene

  • GC19M039940
  • GC19M035248
  • GC19M031755

Summaries for ZNF599 Gene

GeneCards Summary for ZNF599 Gene

ZNF599 (Zinc Finger Protein 599) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF460.

UniProtKB/Swiss-Prot for ZNF599 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF599 Gene

Genomics for ZNF599 Gene

Regulatory Elements for ZNF599 Gene

Genomic Location for ZNF599 Gene

34,758,074 bp from pter
34,773,229 bp from pter
15,156 bases
Minus strand

Genomic View for ZNF599 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF599 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF599 Gene

Proteins for ZNF599 Gene

  • Protein details for ZNF599 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 599
    Protein Accession:
    Secondary Accessions:
    • Q569K0
    • Q5PRG1

    Protein attributes for ZNF599 Gene

    588 amino acids
    Molecular mass:
    67492 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH44615.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF599 Gene


neXtProt entry for ZNF599 Gene

Proteomics data for ZNF599 Gene at MOPED

Post-translational modifications for ZNF599 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF599 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF599 Gene

Domains for ZNF599 Gene

Gene Families for ZNF599 Gene

  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF599 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96NL3
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 14 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF599: view

Function for ZNF599 Gene

Molecular function for ZNF599 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF599 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF599: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF599 Gene

Localization for ZNF599 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF599 Gene

Subcellular locations from

Jensen Localization Image for ZNF599 Gene COMPARTMENTS Subcellular localization image for ZNF599 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZNF599 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF599: view

Pathways for ZNF599 Gene

SuperPathways for ZNF599 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF599: view

Pathways by source for ZNF599 Gene

2 Reactome pathways for ZNF599 Gene

Gene Ontology (GO) - Biological Process for ZNF599 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF599: view

Transcripts for ZNF599 Gene

Unigene Clusters for ZNF599 Gene

Zinc finger protein 599:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF599 Gene

No ASD Table

Relevant External Links for ZNF599 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF599 Gene

mRNA expression in normal human tissues for ZNF599 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF599 Gene

SOURCE GeneReport for Unigene cluster for ZNF599 Gene Hs.590961

genes like me logo Genes that share expressions with ZNF599: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF599 Gene

Orthologs for ZNF599 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF599 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF599 35
  • 98.79 (n)
  • 98.91 (a)
ZNF599 36
  • 98 (a)
(Bos Taurus)
Mammalia ZNF599 35
  • 86.96 (n)
  • 84.69 (a)
ZNF599 36
  • 85 (a)
(Canis familiaris)
Mammalia ZNF599 35
  • 88.38 (n)
  • 87.18 (a)
ZNF599 36
  • 87 (a)
(Mus musculus)
Mammalia Zfp599 16
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
(Danio rerio)
Actinopterygii CU138542.3 36
  • 43 (a)
si:dkey-7j22.3 36
  • 52 (a)
Species with no ortholog for ZNF599:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF599 Gene

Gene Tree for ZNF599 (if available)
Gene Tree for ZNF599 (if available)

Paralogs for ZNF599 Gene

Paralogs for ZNF599 Gene

Selected SIMAP similar genes for ZNF599 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF599: view

Variants for ZNF599 Gene

Sequence variations from dbSNP and Humsavar for ZNF599 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs14480 -- 34,767,239(+) GCCCA(A/T)GGCAT intron-variant
rs716040 -- 34,760,796(+) GAGAC(C/T)GCTCC intron-variant
rs1056023 -- 34,774,381(+) CTTGT(C/T)TCATC upstream-variant-2KB
rs1134524 -- 34,758,171(-) TTCTT(C/T)TATGG utr-variant-3-prime
rs1982537 -- 34,772,474(+) GAGCA(C/G)TGAAA intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF599 Gene

Variant ID Type Subtype PubMed ID
dgv1074e1 CNV Complex 17122850

Relevant External Links for ZNF599 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF599 Gene

Disorders for ZNF599 Gene

(1) University of Copenhagen DISEASES for ZNF599 Gene

Relevant External Links for ZNF599

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with ZNF599: view

No data available for UniProtKB/Swiss-Prot for ZNF599 Gene

Publications for ZNF599 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PMID: 23000965) Povlsen L.K. … Choudhary C. (Nat. Cell Biol. 2012) 3

Products for ZNF599 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF599
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF599
  • Block miRNA regulation of ZNF599 using miScript Target Protectors

Sources for ZNF599 Gene

Back to Top