ZNF599 Gene
protein-coding GIFtS: 46
GCID: GC19M035248
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zinc finger protein 599
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Aliases
for ZNF599 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 5991 2 | | FLJ306631 |
Export aliases for ZNF599 gene to outside databasesPrevious GC identifers: GC19M039940 GC19M031755 |
Summaries
for ZNF599 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN599_HUMAN, Q96NL3Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF599 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF599 gene promoter:
c-Rel POU2F1 POU2F1a NF-kappaB2 STAT3 NF-kappaB1 NF-kappaB
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF599
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF599 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.11 Ensembl cytogenetic band: 19q13.11 HGNC cytogenetic band: 19q13.13ZNF599 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M035248: view genomic region
(about GC identifiers)
Start:
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35,248,979 bp from pter |
End:
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35,264,134 bp from pter |
Size:
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15,156 bases |
Orientation:
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minus strand |
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Proteins
for ZNF599 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN599_HUMAN, Q96NL3 (See
protein sequence)Recommended Name: Zinc finger protein 599 Size: 588 amino acids; 67492 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH44615.1; Type=Erroneous initiation;
Secondary accessions: Q569K0 Q5PRG1Alternative splicing: 2 isoforms: Q96NL3-1 Q96NL3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF599: NX_Q96NL3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96NL3
ZNF599 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001007249.1
ENSEMBL proteins: ENSP00000333802 ENSP00000468446 ENSP00000465262 Reactome Protein details: Q96NL3
Human Recombinant Protein Products for ZNF599:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF599 for ontologies About GeneDecksing
ZNF599 Antibody Products:
Assay Products for ZNF599: |
Protein
Domains /
Families
for ZNF599 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF599 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96NL3ProtoNet protein and cluster: Q96NL3 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN599_HUMAN, Q96NL3Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 14 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF599 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZN599_HUMAN, Q96NL3Function: May be involved in transcriptional regulation Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF599 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF599 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF599
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF599 (NM_001007248) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF599 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF599 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF599 |
|
Pathways & Interactions
for ZNF599 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF599
ZNF599 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF599
1 Interacting protein for ZNF599 (Q96NL33) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF599 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF599 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF599
Search CenterWatch for drugs/clinical trials and news about ZNF599 / ZN599
|
Transcripts
for ZNF599 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF599 gene (2 alternative transcripts): NM_001007247.1 NM_001007248.2 Unigene Cluster for ZNF599: Zinc finger protein 599 Hs.590961 [show with all ESTs]Unigene Representative Sequence: BC0924284 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000329285(uc010edm.2 uc010edn.1 uc010xsd.2 uc010edo.2)
ENST00000587354 ENST00000588760 ENST00000588788
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF599 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF599
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF599 (NM_001007248) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF599 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF599 |
Additional cDNA sequence: AK055225.1 AK302548.1 AK307339.1 BC033354.1 BC044615.1 BC092428.1 6 DOTS entries: DT.210885 DT.75146047 DT.99986961 DT.40275419 DT.99973861 DT.100738896 24/75 AceView cDNA sequences (see all 75): BM314406 AI657182 AI768487 AK055225 AI341982 AA083044 BX107924 AL705963 CR624140 BE387657 BC033354 CD244184 AI871019 AA813536 BQ018905 AA628184 AI497798 AW173372 BM728512 BI838567 BG722045 AI199544 BX366918 BX283708
GeneLoc Exon Structure
|
Expression
for ZNF599 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF599 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF599 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF599
SOURCE GeneReport for Unigene cluster: Hs.590961
SABiosciences Custom PCR Arrays for ZNF599
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF599
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF599 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF599 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF599 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF599 |
Orthologs
for ZNF599 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF599 (if available)
TreeFam Gene Tree for ZNF599 (if available) |
Paralogs
for ZNF599 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF599 gene
- ENSG000002513692 ZNF802 ZNF4602 ZNF5432 ZNF8052 ZNF2642
18/453 SIMAP similar genes for ZNF599 using alignment to 2 protein entries: ZN599_HUMAN (see all proteins)
(see all similar genes):DKFZp666C237 ZNF501 DKFZp686H10254 HZF36 ZNF146 ZSCAN21
DKFZp547L155 DKFZp686D2168 ZNF16 ZNF232 ZNF345 ZSCAN16
ZNF805 ZNF391 ZNF80 ZNF814 ZNF124 HZF41
ZNF599 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF599 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF599 (35248979 - 35264134 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF599
1 CNV: 4077 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF599 |
|
Disorders
/ Diseases
for ZNF599 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF599 for disorders About GeneDecksing
1  disease for ZNF599: About MalaCardshypospadias
1 disease from the University of Copenhagen DISEASES database for ZNF599:Hypospadias Export disorders for ZNF599 gene to outside databases
|
Publications
for ZNF599 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF599 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF599) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A de novo paradigm for mental retardation. (PubMed id 21076407)2 Vissers L.E.... Veltman J.A. (2010)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF599 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF599 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF599 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF599 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF599 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF599 gene:
Search GeneIP for patents involving ZNF599
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF599 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF599 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF599 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF599 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF599 | | OriGene 3'-UTR Clone for ZNF599 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF599 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF599 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF599 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF599 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF599 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF599 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF599 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF599 |
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 | | | ZNF599 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF599 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for ZNF599 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF599 |
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