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Aliases for ZNF599 Gene

Aliases for ZNF599 Gene

  • Zinc Finger Protein 599 2 3 5

External Ids for ZNF599 Gene

Previous GeneCards Identifiers for ZNF599 Gene

  • GC19M039940
  • GC19M035248
  • GC19M031755

Summaries for ZNF599 Gene

GeneCards Summary for ZNF599 Gene

ZNF599 (Zinc Finger Protein 599) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF805.

UniProtKB/Swiss-Prot for ZNF599 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF599 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF599 Gene

Genomics for ZNF599 Gene

Regulatory Elements for ZNF599 Gene

Enhancers for ZNF599 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H034994 2.1 FANTOM5 Ensembl ENCODE dbSUPER 127.6 -227.7 -227703 13 MLX YBX1 DMAP1 YY1 SLC30A9 ZNF416 ZNF548 SP3 ZC3H11A NFYC TMEM147-AS1 ZNF599 LSM14A HAUS5 KMT2B ZNF792 ZNF302 KIAA0355 PROSER3 RBM42
GH19H033819 1.9 FANTOM5 Ensembl ENCODE dbSUPER 118 +952.6 952587 2 ZFP64 ARID4B SIN3A FEZF1 ZNF302 ZNF416 SP3 ZC3H11A REST SMARCA4 GPATCH1 CEP89 ZNF599 LSM14A KIAA0355 ZNF181 ENSG00000267219 WTIP FAAP24 ENSG00000271049
GH19H035461 1.9 FANTOM5 Ensembl ENCODE dbSUPER 98.1 -689.7 -689723 1 HDGF PKNOX1 ZNF493 ZFP64 ZNF121 ATF7 KLF7 RUNX3 ZNF202 SP3 TMEM147-AS1 HAUS5 ZNF599 PROSER3 KMT2B RBM42 ZNF146 SDHAF1 ZNF792 ZFP82
GH19H035208 2 FANTOM5 Ensembl ENCODE dbSUPER 92.4 -439.2 -439196 7 PKNOX1 FOXA2 FEZF1 ZNF2 SP3 SP5 JUNB ZNF592 MEF2D SREBF1 ZNF599 TMEM147-AS1 KIAA0355 HAUS5 PROSER3 RBM42 MAG ZNF792 SDHAF1 USF2
GH19H035296 1 dbSUPER 176.3 -525.0 -524997 3 HDGF ZNF493 ZNF133 ZNF2 TCF12 ZNF121 ZNF302 ZNF416 ZNF207 ATF7 ZNF599 TMEM147-AS1 HAUS5 ZNF146 ZNF181 PROSER3 KMT2B RBM42 ENSG00000267219 ZNF792
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF599 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF599 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108917 329 1400 PKNOX1 ZNF133 ARID4B SIN3A DMAP1 ZNF2 YY1 ETS1 ELK1 ZNF207

Genomic Location for ZNF599 Gene

Chromosome:
19
Start:
34,758,074 bp from pter
End:
34,773,229 bp from pter
Size:
15,156 bases
Orientation:
Minus strand

Genomic View for ZNF599 Gene

Genes around ZNF599 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF599 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF599 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF599 Gene

Proteins for ZNF599 Gene

  • Protein details for ZNF599 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NL3-ZN599_HUMAN
    Recommended name:
    Zinc finger protein 599
    Protein Accession:
    Q96NL3
    Secondary Accessions:
    • Q569K0
    • Q5PRG1

    Protein attributes for ZNF599 Gene

    Size:
    588 amino acids
    Molecular mass:
    67492 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH44615.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF599 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF599 Gene

Post-translational modifications for ZNF599 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF599 Gene

No data available for DME Specific Peptides for ZNF599 Gene

Domains & Families for ZNF599 Gene

Gene Families for ZNF599 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF599 Gene

Suggested Antigen Peptide Sequences for ZNF599 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96NL3

UniProtKB/Swiss-Prot:

ZN599_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF599: view

Function for ZNF599 Gene

Molecular function for ZNF599 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF599 Gene

Gene Ontology (GO) - Molecular Function for ZNF599 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF599: view
genes like me logo Genes that share phenotypes with ZNF599: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF599
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF599 Gene

Localization for ZNF599 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF599 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF599 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF599 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF599: view

Pathways & Interactions for ZNF599 Gene

SuperPathways for ZNF599 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF599: view

Pathways by source for ZNF599 Gene

2 Reactome pathways for ZNF599 Gene

Gene Ontology (GO) - Biological Process for ZNF599 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF599: view

No data available for SIGNOR curated interactions for ZNF599 Gene

Drugs & Compounds for ZNF599 Gene

No Compound Related Data Available

Transcripts for ZNF599 Gene

Unigene Clusters for ZNF599 Gene

Zinc finger protein 599:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF599
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF599 Gene

No ASD Table

Relevant External Links for ZNF599 Gene

GeneLoc Exon Structure for
ZNF599
ECgene alternative splicing isoforms for
ZNF599

Expression for ZNF599 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF599 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF599 Gene



Protein tissue co-expression partners for ZNF599 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF599 Gene:

ZNF599

SOURCE GeneReport for Unigene cluster for ZNF599 Gene:

Hs.590961

Evidence on tissue expression from TISSUES for ZNF599 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF599: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF599 Gene

Orthologs for ZNF599 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF599 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF599 33 34
  • 98.79 (n)
dog
(Canis familiaris)
Mammalia ZNF599 33 34
  • 88.38 (n)
cow
(Bos Taurus)
Mammalia ZNF599 33 34
  • 86.96 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 38 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-7j22.3 34
  • 52 (a)
ManyToMany
CU138542.3 34
  • 43 (a)
ManyToMany
Species where no ortholog for ZNF599 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF599 Gene

ENSEMBL:
Gene Tree for ZNF599 (if available)
TreeFam:
Gene Tree for ZNF599 (if available)

Paralogs for ZNF599 Gene

Paralogs for ZNF599 Gene

(459) SIMAP similar genes for ZNF599 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF599: view

Variants for ZNF599 Gene

Sequence variations from dbSNP and Humsavar for ZNF599 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000355057 -- 34,774,404(+) GCCCA(C/T)CACCC nc-transcript-variant, upstream-variant-2KB
rs1000508215 -- 34,770,082(+) CCCAC(G/T)TCACC intron-variant
rs1000578688 -- 34,768,893(+) GTGCT(C/T)CCTTT intron-variant
rs1000613845 -- 34,761,729(+) CACAT(A/G)GAGAA intron-variant
rs1000648350 -- 34,762,166(+) TCACT(C/G)TACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF599 Gene

Variant ID Type Subtype PubMed ID
esv2758756 CNV gain 17122850

Variation tolerance for ZNF599 Gene

Residual Variation Intolerance Score: 87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.65; 56.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF599 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF599

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF599 Gene

Disorders for ZNF599 Gene

Relevant External Links for ZNF599

Genetic Association Database (GAD)
ZNF599
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF599

No disorders were found for ZNF599 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF599 Gene

Publications for ZNF599 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3 60
  5. A de novo paradigm for mental retardation. (PMID: 21076407) Vissers LE … Veltman JA (Nature genetics 2010) 4 60

Products for ZNF599 Gene

Sources for ZNF599 Gene

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