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Aliases for ZNF598 Gene

Aliases for ZNF598 Gene

  • Zinc Finger Protein 598 2 3 5

External Ids for ZNF598 Gene

Previous GeneCards Identifiers for ZNF598 Gene

  • GC16M001989
  • GC16M001990
  • GC16M002047
  • GC16M001971
  • GC16M001998

Summaries for ZNF598 Gene

Entrez Gene Summary for ZNF598 Gene

  • Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex. The complex is thought to function as a translation repressor in embryonic development. [provided by RefSeq, Oct 2012]

GeneCards Summary for ZNF598 Gene

ZNF598 (Zinc Finger Protein 598) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF598 Gene

Genomics for ZNF598 Gene

Regulatory Elements for ZNF598 Gene

Enhancers for ZNF598 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF598 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF598 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF598 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF598 Gene

1,997,652 bp from pter
2,009,823 bp from pter
12,172 bases
Minus strand

Genomic View for ZNF598 Gene

Genes around ZNF598 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF598 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF598 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF598 Gene

Proteins for ZNF598 Gene

  • Protein details for ZNF598 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 598
    Protein Accession:
    Secondary Accessions:
    • Q8IW49
    • Q8N3D9
    • Q96FG3
    • Q9H7J3

    Protein attributes for ZNF598 Gene

    904 amino acids
    Molecular mass:
    98637 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15777.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF598 Gene


neXtProt entry for ZNF598 Gene

Proteomics data for ZNF598 Gene at MOPED

Post-translational modifications for ZNF598 Gene

  • Ubiquitination at Lys 263
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF598 Gene

No data available for DME Specific Peptides for ZNF598 Gene

Domains & Families for ZNF598 Gene

Gene Families for ZNF598 Gene

Protein Domains for ZNF598 Gene

Suggested Antigen Peptide Sequences for ZNF598 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2H2-type zinc finger.
  • Contains 1 C2H2-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with ZNF598: view

Function for ZNF598 Gene

Gene Ontology (GO) - Molecular Function for ZNF598 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ZNF598: view
genes like me logo Genes that share phenotypes with ZNF598: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF598 Gene

Localization for ZNF598 Gene

Subcellular locations from

Jensen Localization Image for ZNF598 Gene COMPARTMENTS Subcellular localization image for ZNF598 gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZNF598 Gene

Pathways & Interactions for ZNF598 Gene

SuperPathways for ZNF598 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF598 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZNF598 Gene

Drugs & Compounds for ZNF598 Gene

No Compound Related Data Available

Transcripts for ZNF598 Gene

mRNA/cDNA for ZNF598 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF598 Gene

Zinc finger protein 598:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF598 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ·
SP1: - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: -
SP8: - -

ExUns: 12d

Relevant External Links for ZNF598 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF598 Gene

mRNA expression in normal human tissues for ZNF598 Gene

Protein differential expression in normal tissues from HIPED for ZNF598 Gene

This gene is overexpressed in Serum (61.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF598 Gene

SOURCE GeneReport for Unigene cluster for ZNF598 Gene Hs.343828

genes like me logo Genes that share expression patterns with ZNF598: view

Protein tissue co-expression partners for ZNF598 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF598 Gene

Orthologs for ZNF598 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF598 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF598 35
  • 83.65 (n)
  • 83.05 (a)
ZNF598 36
  • 82 (a)
(Canis familiaris)
Mammalia ZNF598 35
  • 83.45 (n)
  • 82.61 (a)
ZNF598 36
  • 81 (a)
(Mus musculus)
Mammalia Zfp598 35
  • 80.81 (n)
  • 81.07 (a)
Zfp598 16
Zfp598 36
  • 81 (a)
(Pan troglodytes)
Mammalia ZNF598 35
  • 98.89 (n)
  • 98.62 (a)
ZNF598 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Zfp598 35
  • 80.53 (n)
  • 81.57 (a)
(Monodelphis domestica)
Mammalia ZNF598 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF598 36
  • 72 (a)
(Gallus gallus)
Aves ZNF598 35
  • 63.53 (n)
  • 63.89 (a)
ZNF598 36
  • 61 (a)
(Anolis carolinensis)
Reptilia ZNF598 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10897 35
znf598 35
  • 59.17 (n)
  • 56.89 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20891 35
(Danio rerio)
Actinopterygii znf598 35
  • 58.39 (n)
  • 55.73 (a)
znf598 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11414 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea C52E12.1 36
  • 19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
Species with no ortholog for ZNF598:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF598 Gene

Gene Tree for ZNF598 (if available)
Gene Tree for ZNF598 (if available)

Paralogs for ZNF598 Gene Pseudogenes for ZNF598 Gene

genes like me logo Genes that share paralogs with ZNF598: view

No data available for Paralogs for ZNF598 Gene

Variants for ZNF598 Gene

Sequence variations from dbSNP and Humsavar for ZNF598 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11556528 - 2,000,191(-) CACTT(A/C)CTCCT reference, missense
rs2286468 - 1,999,002(+) GACAC(A/T)GGCCG reference, missense
rs2286469 - 1,999,639(+) CCTCC(A/C/G)TGTGT reference, missense
rs11248905 - 1,999,727(-) CGCCC(A/G)CTACC reference, missense
rs3889 -- 1,997,862(+) GCACC(A/G)GTGGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF598 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2540n71 CNV Loss 21882294
dgv2544n71 CNV Loss 21882294
dgv2545n71 CNV Loss 21882294
nsv905048 CNV Loss 21882294
dgv2546n71 CNV Loss 21882294
dgv2547n71 CNV Loss 21882294
dgv2548n71 CNV Gain 21882294
dgv2549n71 CNV Loss 21882294
dgv2550n71 CNV Loss 21882294
nsv905061 CNV Loss 21882294
dgv2551n71 CNV Loss 21882294
nsv471070 CNV Gain 18288195
nsv905070 CNV Gain+Loss 21882294
dgv2552n71 CNV Gain+Loss 21882294
dgv336n27 CNV Loss 19166990
dgv2553n71 CNV Loss 21882294
nsv521569 CNV Loss 19592680
nsv523037 CNV Loss 19592680
nsv471072 CNV Loss 18288195
dgv2554n71 CNV Loss 21882294
nsv905091 CNV Loss 21882294
dgv2555n71 CNV Gain+Loss 21882294
dgv455n67 CNV Gain 20364138
nsv905094 CNV Gain 21882294
nsv905095 CNV Gain 21882294
nsv457348 CNV Loss 19166990
nsv905101 CNV Loss 21882294
nsv905102 CNV Loss 21882294
dgv2556n71 CNV Loss 21882294
nsv905105 CNV Loss 21882294

Variation tolerance for ZNF598 Gene

Gene Damage Index Score: 7.79; 83.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF598 Gene

Disorders for ZNF598 Gene

Relevant External Links for ZNF598

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF598 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF598 Gene

Publications for ZNF598 Gene

  1. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for ZNF598 Gene

Sources for ZNF598 Gene