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Aliases for ZNF598 Gene

Aliases for ZNF598 Gene

  • Zinc Finger Protein 598 2 3

External Ids for ZNF598 Gene

Summaries for ZNF598 Gene

Entrez Gene Summary for ZNF598 Gene

  • Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex. The complex is thought to function as a translation repressor in embryonic development. [provided by RefSeq, Oct 2012]

GeneCards Summary for ZNF598 Gene

ZNF598 (Zinc Finger Protein 598) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF598 Gene

Genomics for ZNF598 Gene

Genomic Location for ZNF598 Gene

Start:
1,997,652 bp from pter
End:
2,009,823 bp from pter
Size:
12,172 bases
Orientation:
Minus strand

Genomic View for ZNF598 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF598 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF598 Gene

Regulatory Elements for ZNF598 Gene

Proteins for ZNF598 Gene

  • Protein details for ZNF598 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UK7-ZN598_HUMAN
    Recommended name:
    Zinc finger protein 598
    Protein Accession:
    Q86UK7
    Secondary Accessions:
    • Q8IW49
    • Q8N3D9
    • Q96FG3
    • Q9H7J3

    Protein attributes for ZNF598 Gene

    Size:
    904 amino acids
    Molecular mass:
    98637 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15777.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF598 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF598 Gene

Proteomics data for ZNF598 Gene at MOPED

Post-translational modifications for ZNF598 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys263

Other Protein References for ZNF598 Gene

No data available for DME Specific Peptides for ZNF598 Gene

Domains for ZNF598 Gene

Gene Families for ZNF598 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF598 Gene

UniProtKB/Swiss-Prot:

ZN598_HUMAN
Similarity:
  • Contains 1 C2H2-type zinc finger.:
    • Q86UK7
  • Contains 1 RING-type zinc finger.:
    • Q86UK7
genes like me logo Genes that share domains with ZNF598: view

Function for ZNF598 Gene

Gene Ontology (GO) - Molecular Function for ZNF598 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZNF598: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF598 Gene

Localization for ZNF598 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF598 Gene COMPARTMENTS Subcellular localization image for ZNF598 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ZNF598 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
genes like me logo Genes that share ontologies with ZNF598: view

Pathways for ZNF598 Gene

SuperPathways for ZNF598 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF598 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with ZNF598: view

No data available for Pathways by source for ZNF598 Gene

Transcripts for ZNF598 Gene

mRNA/cDNA for ZNF598 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF598 Gene

Zinc finger protein 598:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF598 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ·
SP1: - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: -
SP6:
SP7:
SP8: - -

ExUns: 12d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ZNF598 Gene

GeneLoc Exon Structure for
ZNF598
ECgene alternative splicing isoforms for
ZNF598

Expression for ZNF598 Gene

mRNA expression in normal human tissues for ZNF598 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF598 Gene

SOURCE GeneReport for Unigene cluster for ZNF598 Gene Hs.343828

genes like me logo Genes that share expressions with ZNF598: view

Orthologs for ZNF598 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF598 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF598 36
  • 98.89 (n)
  • 98.62 (a)
ZNF598 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF598 36
  • 83.65 (n)
  • 83.05 (a)
ZNF598 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF598 36
  • 83.45 (n)
  • 82.61 (a)
ZNF598 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp598 36
  • 80.81 (n)
  • 81.07 (a)
Zfp598 16
Zfp598 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF598 37
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF598 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp598 36
  • 80.53 (n)
  • 81.57 (a)
chicken
(Gallus gallus)
Aves ZNF598 36
  • 63.53 (n)
  • 63.89 (a)
ZNF598 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF598 37
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.20891 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10897 36
znf598 36
  • 59.17 (n)
  • 56.89 (a)
zebrafish
(Danio rerio)
Actinopterygii znf598 36
  • 58.39 (n)
  • 55.73 (a)
znf598 37
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11414 37
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C52E12.1 37
  • 19 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 16 (a)
OneToOne
Species with no ortholog for ZNF598:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF598 Gene

ENSEMBL:
Gene Tree for ZNF598 (if available)
TreeFam:
Gene Tree for ZNF598 (if available)

Paralogs for ZNF598 Gene

Pseudogenes.org Pseudogenes for ZNF598 Gene

genes like me logo Genes that share paralogs with ZNF598: view

No data available for Paralogs for ZNF598 Gene

Variants for ZNF598 Gene

Sequence variations from dbSNP and Humsavar for ZNF598 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs3889 -- 1,997,862(+) GCACC(A/G)GTGGC utr-variant-3-prime
rs3890 -- 1,997,915(+) AGCTT(C/T)GGGAG utr-variant-3-prime
rs9081 -- 1,997,890(-) GTGGG(G/T)CCTCA utr-variant-3-prime
rs740582 -- 2,008,039(+) CGGGG(A/T)AGGCC intron-variant
rs757601 -- 2,008,517(+) CTATA(A/T)GCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF598 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2540n71 CNV Loss 21882294
dgv2544n71 CNV Loss 21882294
dgv2545n71 CNV Loss 21882294
nsv905048 CNV Loss 21882294
dgv2546n71 CNV Loss 21882294
dgv2547n71 CNV Loss 21882294
dgv2548n71 CNV Gain 21882294
dgv2549n71 CNV Loss 21882294
dgv2550n71 CNV Loss 21882294
nsv905061 CNV Loss 21882294
dgv2551n71 CNV Loss 21882294
nsv471070 CNV Gain 18288195
nsv905070 CNV Gain+Loss 21882294
dgv2552n71 CNV Gain+Loss 21882294
dgv336n27 CNV Loss 19166990
dgv2553n71 CNV Loss 21882294
nsv521569 CNV Loss 19592680
nsv523037 CNV Loss 19592680
nsv471072 CNV Loss 18288195
dgv2554n71 CNV Loss 21882294
nsv905091 CNV Loss 21882294
dgv2555n71 CNV Gain+Loss 21882294
dgv455n67 CNV Gain 20364138
nsv905094 CNV Gain 21882294
nsv905095 CNV Gain 21882294
nsv457348 CNV Loss 19166990
nsv905101 CNV Loss 21882294
nsv905102 CNV Loss 21882294
dgv2556n71 CNV Loss 21882294
nsv905105 CNV Loss 21882294

Relevant External Links for ZNF598 Gene

HapMap Linkage Disequilibrium report
ZNF598

Disorders for ZNF598 Gene

No disorders were found for ZNF598 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF598 Gene

Publications for ZNF598 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4
  4. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PMID: 16094384) Tao W.A. … Aebersold R. (Nat. Methods 2005) 3
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for ZNF598 Gene

Sources for ZNF598 Gene

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