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Aliases for ZNF598 Gene

Aliases for ZNF598 Gene

  • Zinc Finger Protein 598 2 3 5

External Ids for ZNF598 Gene

Previous GeneCards Identifiers for ZNF598 Gene

  • GC16M001989
  • GC16M001990
  • GC16M002047
  • GC16M001971
  • GC16M001998
  • GC16M002000
  • GC16M002009

Summaries for ZNF598 Gene

Entrez Gene Summary for ZNF598 Gene

  • Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex. The complex is thought to function as a translation repressor in embryonic development. [provided by RefSeq, Oct 2012]

GeneCards Summary for ZNF598 Gene

ZNF598 (Zinc Finger Protein 598) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF598 Gene

Genomics for ZNF598 Gene

Regulatory Elements for ZNF598 Gene


Enhancers around ZNF598 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF598 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000502393 323 1801 HDGF ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 ZNF207

Genomic Location for ZNF598 Gene

Chromosome:
16
Start:
1,997,652 bp from pter
End:
2,009,823 bp from pter
Size:
12,172 bases
Orientation:
Minus strand

Genomic View for ZNF598 Gene

Genes around ZNF598 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF598 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF598 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF598 Gene

Proteins for ZNF598 Gene

  • Protein details for ZNF598 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UK7-ZN598_HUMAN
    Recommended name:
    Zinc finger protein 598
    Protein Accession:
    Q86UK7
    Secondary Accessions:
    • Q8IW49
    • Q8N3D9
    • Q96FG3
    • Q9H7J3

    Protein attributes for ZNF598 Gene

    Size:
    904 amino acids
    Molecular mass:
    98637 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15777.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF598 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF598 Gene

Post-translational modifications for ZNF598 Gene

  • Ubiquitination at Lys 263
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF598 Gene

No data available for DME Specific Peptides for ZNF598 Gene

Domains & Families for ZNF598 Gene

Gene Families for ZNF598 Gene

Protein Domains for ZNF598 Gene

Suggested Antigen Peptide Sequences for ZNF598 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UK7

UniProtKB/Swiss-Prot:

ZN598_HUMAN :
  • Contains 1 C2H2-type zinc finger.
Similarity:
  • Contains 1 C2H2-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with ZNF598: view

Function for ZNF598 Gene

Gene Ontology (GO) - Molecular Function for ZNF598 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ZNF598: view
genes like me logo Genes that share phenotypes with ZNF598: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF598 Gene

Localization for ZNF598 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF598 gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZNF598 Gene

Pathways & Interactions for ZNF598 Gene

SuperPathways for ZNF598 Gene

No Data Available

Interacting Proteins for ZNF598 Gene

Gene Ontology (GO) - Biological Process for ZNF598 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF598 Gene

Transcripts for ZNF598 Gene

mRNA/cDNA for ZNF598 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF598 Gene

Zinc finger protein 598:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF598 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ·
SP1: - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: -
SP6:
SP7:
SP8: - -

ExUns: 12d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ZNF598 Gene

GeneLoc Exon Structure for
ZNF598
ECgene alternative splicing isoforms for
ZNF598

Expression for ZNF598 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF598 Gene

Protein differential expression in normal tissues from HIPED for ZNF598 Gene

This gene is overexpressed in Serum (61.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF598 Gene



Protein tissue co-expression partners for ZNF598 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF598 Gene:

ZNF598

SOURCE GeneReport for Unigene cluster for ZNF598 Gene:

Hs.343828
genes like me logo Genes that share expression patterns with ZNF598: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF598 Gene

Orthologs for ZNF598 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF598 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF598 34 35
  • 98.89 (n)
cow
(Bos Taurus)
Mammalia ZNF598 34 35
  • 83.65 (n)
dog
(Canis familiaris)
Mammalia ZNF598 34 35
  • 83.45 (n)
mouse
(Mus musculus)
Mammalia Zfp598 34 16 35
  • 80.81 (n)
rat
(Rattus norvegicus)
Mammalia Zfp598 34
  • 80.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF598 35
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF598 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF598 34 35
  • 63.53 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF598 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf598 34
  • 59.17 (n)
Str.10897 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.20891 34
zebrafish
(Danio rerio)
Actinopterygii znf598 34 35
  • 58.39 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11414 35
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C52E12.1 35
  • 19 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 16 (a)
OneToOne
Species where no ortholog for ZNF598 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF598 Gene

ENSEMBL:
Gene Tree for ZNF598 (if available)
TreeFam:
Gene Tree for ZNF598 (if available)

Paralogs for ZNF598 Gene

Pseudogenes.org Pseudogenes for ZNF598 Gene

genes like me logo Genes that share paralogs with ZNF598: view

No data available for Paralogs for ZNF598 Gene

Variants for ZNF598 Gene

Sequence variations from dbSNP and Humsavar for ZNF598 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1058474 -- 1,998,795(-) GAGAG(A/G)AACCT reference, synonymous-codon
rs1058502 -- 1,997,810(-) GTTTC(A/G)TGCTT utr-variant-3-prime
rs111253059 -- 1,998,145(+) GCCTC(A/T)CCAGG utr-variant-3-prime
rs111288389 -- 2,002,255(+) TCGAT(A/C/G/T)TGGCG reference, synonymous-codon, missense
rs111294778 -- 2,010,136(+) AGGCT(C/G)ATACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF598 Gene

Variant ID Type Subtype PubMed ID
nsv952901 CNV deletion 24416366
nsv571189 CNV loss 21841781
nsv523037 CNV loss 19592680
nsv521569 CNV loss 19592680
nsv471072 CNV loss 18288195
nsv471070 CNV gain 18288195
nsv457348 CNV loss 19166990
nsv1160329 CNV deletion 26073780
esv2422427 CNV duplication 17116639
dgv4859n54 CNV loss 21841781
dgv4858n54 CNV loss 21841781
dgv455n67 CNV gain 20364138
dgv336n27 CNV loss 19166990

Variation tolerance for ZNF598 Gene

Gene Damage Index Score: 7.79; 83.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF598 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF598

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF598 Gene

Disorders for ZNF598 Gene

Relevant External Links for ZNF598

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF598

No disorders were found for ZNF598 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF598 Gene

Publications for ZNF598 Gene

  1. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64

Products for ZNF598 Gene

Sources for ZNF598 Gene

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