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Aliases for ZNF597 Gene

Aliases for ZNF597 Gene

  • Zinc Finger Protein 597 2 3 5
  • HIT-4 3

External Ids for ZNF597 Gene

Previous GeneCards Identifiers for ZNF597 Gene

  • GC16M003487
  • GC16M003426
  • GC16M003488
  • GC16M003467
  • GC16M003472

Summaries for ZNF597 Gene

Entrez Gene Summary for ZNF597 Gene

  • This gene encodes a protein with multiple zinc finger domains. Loss of the related gene in rodents results in defects in neural development and embryonic lethality in mutant homozygotes. This gene is adjacent to a differentially methylated region (DMR) and is imprinted and maternally expressed. [provided by RefSeq, Nov 2015]

GeneCards Summary for ZNF597 Gene

ZNF597 (Zinc Finger Protein 597) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF200.

UniProtKB/Swiss-Prot for ZNF597 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF597 Gene

Genomics for ZNF597 Gene

Regulatory Elements for ZNF597 Gene

Enhancers for ZNF597 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF597 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF597 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF597 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF597 Gene

3,432,422 bp from pter
3,443,542 bp from pter
11,121 bases
Minus strand

Genomic View for ZNF597 Gene

Genes around ZNF597 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF597 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF597 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF597 Gene

Proteins for ZNF597 Gene

  • Protein details for ZNF597 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 597
    Protein Accession:

    Protein attributes for ZNF597 Gene

    424 amino acids
    Molecular mass:
    48076 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF597 Gene

Proteomics data for ZNF597 Gene at MOPED

Post-translational modifications for ZNF597 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF597 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF597 Gene

Domains & Families for ZNF597 Gene

Gene Families for ZNF597 Gene

Protein Domains for ZNF597 Gene

Suggested Antigen Peptide Sequences for ZNF597 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 7 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF597: view

Function for ZNF597 Gene

Molecular function for ZNF597 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
UniProtKB/Swiss-Prot Induction:
Imprinted. Promoter methylation of the paternal allele may restrict expression to the maternal allele in leukocytes.

Phenotypes for ZNF597 Gene

genes like me logo Genes that share phenotypes with ZNF597: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF597 Gene

Localization for ZNF597 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF597 Gene

Subcellular locations from

Jensen Localization Image for ZNF597 Gene COMPARTMENTS Subcellular localization image for ZNF597 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF597 Gene

Pathways & Interactions for ZNF597 Gene

SuperPathways for ZNF597 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF597: view

Pathways by source for ZNF597 Gene

2 Reactome pathways for ZNF597 Gene

Interacting Proteins for ZNF597 Gene

Gene Ontology (GO) - Biological Process for ZNF597 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF597: view

No data available for SIGNOR curated interactions for ZNF597 Gene

Drugs & Compounds for ZNF597 Gene

No Compound Related Data Available

Transcripts for ZNF597 Gene

mRNA/cDNA for ZNF597 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF597 Gene

Zinc finger protein 597:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF597 Gene

No ASD Table

Relevant External Links for ZNF597 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF597 Gene

mRNA expression in normal human tissues for ZNF597 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF597 Gene

SOURCE GeneReport for Unigene cluster for ZNF597 Gene Hs.88630

genes like me logo Genes that share expression patterns with ZNF597: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF597 Gene

Orthologs for ZNF597 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF597 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ZNF597 35
  • 80.87 (n)
  • 68.1 (a)
ZNF597 36
  • 68 (a)
(Mus musculus)
Mammalia Zfp597 35
  • 76 (n)
  • 63.64 (a)
Zfp597 16
Zfp597 36
  • 63 (a)
(Pan troglodytes)
Mammalia ZNF597 35
  • 98.82 (n)
  • 98.11 (a)
ZNF597 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Zfp597 35
  • 74.82 (n)
  • 62.35 (a)
(Bos Taurus)
Mammalia ZNF597 36
  • 57 (a)
(Monodelphis domestica)
Mammalia ZNF597 36
  • 32 (a)
(Danio rerio)
Actinopterygii CR352258.1 36
  • 30 (a)
Species with no ortholog for ZNF597:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF597 Gene

Gene Tree for ZNF597 (if available)
Gene Tree for ZNF597 (if available)

Paralogs for ZNF597 Gene

Paralogs for ZNF597 Gene

(231) SIMAP similar genes for ZNF597 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF597: view

Variants for ZNF597 Gene

Sequence variations from dbSNP and Humsavar for ZNF597 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs2270493 - 3,440,879(+) CAGAG(A/T)CACGC reference, missense
rs12737 -- 3,436,285(+) AATCA(A/C)GGTTG utr-variant-3-prime
rs37821 -- 3,434,590(+) CTCTC(C/T)CTGGG utr-variant-3-prime
rs37822 -- 3,435,034(+) TAGCA(A/G)TATCT utr-variant-3-prime
rs37823 -- 3,435,460(+) AGAGA(A/G)ACCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF597 Gene

Variant ID Type Subtype PubMed ID
nsv905212 CNV Gain 21882294
esv29492 CNV Gain 19812545

Variation tolerance for ZNF597 Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.46% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF597 Gene

Disorders for ZNF597 Gene

Relevant External Links for ZNF597

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF597 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF597 Gene

Publications for ZNF597 Gene

  1. Methylation screening of reciprocal genome-wide UPDs identifies novel human-specific imprinted genes. (PMID: 21593219) Nakabayashi K. … Monk D. (Hum. Mol. Genet. 2011) 3 4 67
  2. Molecular characterization and gene disruption of a novel zinc-finger protein, HIT-4, expressed in rodent brain. (PMID: 19968752) Tanabe Y. … Nawa H. (J. Neurochem. 2010) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  5. A novel approach identifies new differentially methylated regions (DMRs) associated with imprinted genes. (PMID: 21324877) Choufani S. … Weksberg R. (Genome Res. 2011) 3

Products for ZNF597 Gene

Sources for ZNF597 Gene