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ZNF597 Gene

protein-coding   GIFtS: 50
GCID: GC16M003488

Zinc Finger Protein 597

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 5971 2

External Ids:    HGNC: 265731   Entrez Gene: 1464342   Ensembl: ENSG000001679817   OMIM: 6146855   UniProtKB: Q96LX83   

Export aliases for ZNF597 gene to outside databases

Previous GC identifers: GC16M003487 GC16M003426


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF597 Gene:
ZNF597 (zinc finger protein 597) is a protein-coding gene. An important paralog of this gene is ZNF200.

UniProtKB/Swiss-Prot: ZN597_HUMAN, Q96LX8
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF597 gene promoter:
         NF-1   Nkx2-2   HNF-4alpha2   LCR-F1   HNF-4alpha1   FAC1   Zic1   NF-Y   Ik-1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF597 promoter sequence
   Search Chromatin IP Primers for ZNF597

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF597


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

ZNF597 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF597 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M003488:  view genomic region     (about GC identifiers)

Start:
3,486,104 bp from pter      End:
3,493,542 bp from pter
Size:
7,439 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN597_HUMAN, Q96LX8 (See protein sequence)
Recommended Name: Zinc finger protein 597  
Size: 424 amino acids; 48076 Da

Explore the universe of human proteins at neXtProt for ZNF597: NX_Q96LX8

Explore proteomics data for ZNF597 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF597 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689670.1  
    ENSEMBL proteins: 
     ENSP00000301744  
    Reactome Protein details: Q96LX8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96LX8

    ProtoNet protein and cluster: Q96LX8

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN597_HUMAN, Q96LX8
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 7 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF597           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN597_HUMAN, Q96LX8
    Function: May be involved in transcriptional regulation
    Induction: Imprinted. Promoter methylation of the paternal allele may restrict expression to the maternal allele
    in leukocytes

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF597           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF597:
     Increased S DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF597

    miRNA
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    miRTarBase miRNAs that target ZNF597:
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    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-302e hsa-miR-520a-3p hsa-miR-372 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidZNF597 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN597_HUMAN, Q96LX8: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF597           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF597 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF597           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF597
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF597
    Interactions:

        Search GeneGlobe Interaction Network for ZNF597

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF597           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF597 (ZN597)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF597 gene: 
    NM_152457.1  

    Unigene Cluster for ZNF597:

    Zinc finger protein 597
    Hs.88630  [show with all ESTs]
    Unigene Representative Sequence: BC029899
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000301744(uc002cvd.3)
    miRNA
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    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-302e hsa-miR-520a-3p hsa-miR-372 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidZNF597 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF597
      QuantiFast Probe-based Assays in human, mouse, rat ZNF597

    Additional mRNA sequence: 

    AK057633.1 BC029899.1 

    2 DOTS entries:

    DT.309446  DT.40285097 

    Selected AceView cDNA sequences (see all 27):

    AW085970 AL701654 BX377346 BE463982 AK057633 AA279510 AI188008 AA279783 
    BG767847 BX371532 AL710181 BI820764 NM_152457 BC029899 AW241236 BX089862 
    AI696097 AA928231 BI547496 AA905199 AI825587 AI188000 AW613947 AA279700 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF597 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATACTTAA
    ZNF597 Expression
    About this image

    ZNF597 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF597 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.88630
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF597 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp5971 , 5 zinc finger protein 5971, 5 76(n)1
    63.64(a)1
      16 (2.27 cM)5
    710631  NM_001033159.21  NP_001028331.21 
     38583215 
    zebrafish
    (Danio rerio)
    Actinopterygii CR352258.16
    Uncharacterized protein
    30(a)
    1 → many
    3(60488590-60489672) ENSDARG00000079203


    ENSEMBL Gene Tree for ZNF597 (if available)
    TreeFam Gene Tree for ZNF597 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF597 gene
    ZNF2002  
    Selected SIMAP similar genes for ZNF597 using alignment to 1 protein entry:     ZN597_HUMAN(see all similar genes):
    ZFP2    ZNF175    ZNF182    ZNF658    ZNF658B    ZFP37
    ZNF135    ZNF211    ZNF300    ZNF323    ZNF416    ZNF510
    ZNF569    ZNF570    ZNF665    ZNF717    ZNF84    DKFZp686B16128

    Find genes that share paralogs with ZNF597           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF597 (see all 318)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1474086381,2
    C--3455302(+) CTGAGA/CAACAA 1 -- int10--------
    rs740058041,2
    C,F--3455311(+) AATTAC/TAATTA 1 -- int12Minor allele frequency- T:0.10WA 120
    rs1395291661,2
    C--3455344(+) GCTTCA/TGTAGC 1 -- int10--------
    rs801484691,2
    F--3455480(+) AGTATG/ATGCCC 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1863850681,2
    --3455486(+) TGCCCC/TTGGCA 1 -- int10--------
    rs1451320071,2
    C--3455515(+) ACTCCA/GGATAC 1 -- int10--------
    rs1908489281,2
    C--3455616(+) TAGAAC/TAGCAA 1 -- int10--------
    rs1808282641,2
    --3455627(+) TCTTAA/TACAAG 1 -- int10--------
    rs171364051,2
    C,F,H--3455639(+) ATTACA/CTTCAA 1 -- int121Minor allele frequency- C:0.04NA NS EA WA 2124
    rs727763891,2
    C,F--3455674(+) AAACAT/CATAAA 1 -- int11Minor allele frequency- C:0.03NA 120

    HapMap Linkage Disequilibrium report for ZNF597 (3486104 - 3493542 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF597:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv29492CNV Gain19812545
    nsv905212CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF597
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF597

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614685    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for ZNF597:
    Silver-Russell syndrome

    Find genes that share disorders with ZNF597           About GenesLikeMe


    Export disorders for ZNF597 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF597 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF597)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. Methylation screening of reciprocal genome-wide UPDs identifies novel human-specific imprinted genes. (PubMed id 21593219)2 Nakabayashi K.... Monk D. (Hum. Mol. Genet. 2011)
    6. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    8. Analysis of allelic differential expression in human white blood cells. (PubMed id 16467561)2 Pant P.V....Frazer K.A. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 146434 HGNC: 26573 AceView: ZNF597 Ensembl:ENSG00000167981 euGenes: HUgn146434
    ECgene: ZNF597 H-InvDB: ZNF597

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF597 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF597 gene:
    Search GeneIP for patents involving ZNF597

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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