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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF597 Gene

protein-coding   GIFtS: 50
GCID: GC16M003488

Zinc Finger Protein 597

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 5971 2

External Ids:    HGNC: 265731   Entrez Gene: 1464342   Ensembl: ENSG000001679817   OMIM: 6146855   UniProtKB: Q96LX83   

Export aliases for ZNF597 gene to outside databases

Previous GC identifers: GC16M003487 GC16M003426


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF597 Gene: 
ZNF597 (zinc finger protein 597) is a protein-coding gene. Diseases associated with ZNF597 include silver-russell syndrome, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF200.

UniProtKB/Swiss-Prot: ZN597_HUMAN, Q96LX8
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF597 gene promoter:
         NF-1   Nkx2-2   HNF-4alpha2   LCR-F1   HNF-4alpha1   FAC1   Zic1   NF-Y   Ik-1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF597 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF597

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF597


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

ZNF597 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF597 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M003488:  view genomic region     (about GC identifiers)

Start:
3,486,104 bp from pter      End:
3,493,542 bp from pter
Size:
7,439 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN597_HUMAN, Q96LX8 (See protein sequence)
Recommended Name: Zinc finger protein 597  
Size: 424 amino acids; 48076 Da
Subcellular location: Nucleus (Potential)

Explore the universe of human proteins at neXtProt for ZNF597: NX_Q96LX8

Explore proteomics data for ZNF597 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96LX8

  • ZNF597 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF597 Protein Expression
    REFSEQ proteins: NP_689670.1  
    ENSEMBL proteins: 
     ENSP00000301744  
    Reactome Protein details: Q96LX8
    Human Recombinant Protein Products for ZNF597: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF597 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96LX8

    ProtoNet protein and cluster: Q96LX8

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN597_HUMAN, Q96LX8
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 7 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF597 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN597_HUMAN, Q96LX8
    Function: May be involved in transcriptional regulation
    Induction: Imprinted. Promoter methylation of the paternal allele may restrict expression to the maternal allele
    in leukocytes

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF597 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF597:
     Increased S DNA content 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidZNF597 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF597 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF597
        Generic Transcription Pathway
    Gene Expression



    ZNF597 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF597

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF597 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF597 (ZN597)

    Search CenterWatch for drugs/clinical trials and news about ZNF597 / ZN597

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF597 gene: 
    NM_152457.1  

    Unigene Cluster for ZNF597:

    Zinc finger protein 597
    Hs.88630  [show with all ESTs]
    Unigene Representative Sequence: BC029899
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000301744(uc002cvd.3)
    miRNA
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    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-302e hsa-miR-520a-3p hsa-miR-372 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidZNF597 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF597

    Additional mRNA sequence: 

    AK057633.1 BC029899.1 

    2 DOTS entries:

    DT.309446  DT.40285097 

    24/27 AceView cDNA sequences (see all 27):

    AL701654 AW085970 AL710181 AW241236 AA279510 BX371532 BG767847 BE463982 
    BC029899 AI696097 AA279783 BX377346 BI820764 AI188008 AK057633 NM_152457 
    BX089862 AI825587 AA928231 AW613947 AA905199 AI188000 BI547496 AA279700 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF597 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATACTTAA
    ZNF597 Expression
    About this image


    See ZNF597 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF597

    SOURCE GeneReport for Unigene cluster: Hs.88630
        SABiosciences Custom PCR Arrays for ZNF597
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF597

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF597 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp5971 , 5 zinc finger protein 5971, 5 75.92(n)1
    63.64(a)1
      16 (2.27 cM)5
    710631  NM_001033159.21  NP_001028331.21 
     38583215 


    ENSEMBL Gene Tree for ZNF597 (if available)
    TreeFam Gene Tree for ZNF597 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF597 gene
    ZNF2002  
    18/230 SIMAP similar genes for ZNF597 using alignment to 1 protein entry:     ZN597_HUMAN(see all similar genes):
    ZFP2    ZNF175    ZNF182    ZNF658    ZNF658B    ZFP37
    ZNF135    ZNF211    ZNF300    ZNF323    ZNF416    ZNF510
    ZNF569    ZNF570    ZNF665    ZNF717    ZNF84    DKFZp686B16128

    ZNF597 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/318 SNPs in ZNF597 are shown (see all 318)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1474086381,2
    C--3455302(+) CTGAGA/CAACAA 1 -- int10--------
    rs740058041,2
    C,F--3455311(+) AATTAC/TAATTA 1 -- int12Minor allele frequency- T:0.10WA 120
    rs1395291661,2
    C--3455344(+) GCTTCA/TGTAGC 1 -- int10--------
    rs801484691,2
    F--3455480(+) AGTATG/ATGCCC 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1863850681,2
    --3455486(+) TGCCCC/TTGGCA 1 -- int10--------
    rs1451320071,2
    C--3455515(+) ACTCCA/GGATAC 1 -- int10--------
    rs1908489281,2
    C--3455616(+) TAGAAC/TAGCAA 1 -- int10--------
    rs1808282641,2
    --3455627(+) TCTTAA/TACAAG 1 -- int10--------
    rs171364051,2
    C,F,H--3455639(+) ATTACA/CTTCAA 1 -- int121Minor allele frequency- C:0.04NA NS EA WA 2124
    rs727763891,2
    C,F--3455674(+) AAACAT/CATAAA 1 -- int11Minor allele frequency- C:0.03NA 120

    HapMap Linkage Disequilibrium report for ZNF597 (3486104 - 3493542 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF597:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv29492CNV Gain19812545
    nsv905212CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614685    OMIM disorders: --

    2 diseases for ZNF597:    About MalaCards
    silver-russell syndrome    

    1 disease from the University of Copenhagen DISEASES database for ZNF597:
    Silver-Russell syndrome

    ZNF597 for disorders           About GeneDecksing


    Export disorders for ZNF597 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF597 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF597)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. Methylation screening of reciprocal genome-wide UPDs identifies novel human-specific imprinted genes. (PubMed id 21593219)2 Nakabayashi K.... Monk D. (2011)
    6. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    8. Analysis of allelic differential expression in human white blood cells. (PubMed id 16467561)2 Pant P.V....Frazer K.A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 146434 HGNC: 26573 AceView: ZNF597 Ensembl:ENSG00000167981 euGenes: HUgn146434
    ECgene: ZNF597 H-InvDB: ZNF597

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF597 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF597 gene:
    Search GeneIP for patents involving ZNF597

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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