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Aliases for ZNF596 Gene

Aliases for ZNF596 Gene

  • Zinc Finger Protein 596 2 3 5

External Ids for ZNF596 Gene

Previous GeneCards Identifiers for ZNF596 Gene

  • GC08P000173
  • GC08P000174
  • GC08P000026

Summaries for ZNF596 Gene

GeneCards Summary for ZNF596 Gene

ZNF596 (Zinc Finger Protein 596) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF705G.

UniProtKB/Swiss-Prot for ZNF596 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF596 Gene

Genomics for ZNF596 Gene

Regulatory Elements for ZNF596 Gene

Enhancers for ZNF596 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF596 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF596 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF596 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF596 gene promoter:

Genomic Location for ZNF596 Gene

232,137 bp from pter
247,342 bp from pter
15,206 bases
Plus strand

Genomic View for ZNF596 Gene

Genes around ZNF596 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF596 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF596 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF596 Gene

Proteins for ZNF596 Gene

  • Protein details for ZNF596 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 596
    Protein Accession:
    Secondary Accessions:
    • B2R8P4
    • O95015
    • Q8N9X0

    Protein attributes for ZNF596 Gene

    504 amino acids
    Molecular mass:
    58513 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD05197.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAG36241.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF596 Gene


neXtProt entry for ZNF596 Gene

Proteomics data for ZNF596 Gene at MOPED

Post-translational modifications for ZNF596 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF596 Gene

Domains & Families for ZNF596 Gene

Gene Families for ZNF596 Gene

Protein Domains for ZNF596 Gene

Suggested Antigen Peptide Sequences for ZNF596 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF596: view

Function for ZNF596 Gene

Molecular function for ZNF596 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF596: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF596 Gene

Localization for ZNF596 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF596 Gene

Subcellular locations from

Jensen Localization Image for ZNF596 Gene COMPARTMENTS Subcellular localization image for ZNF596 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF596 Gene

Pathways & Interactions for ZNF596 Gene

SuperPathways for ZNF596 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF596: view

Pathways by source for ZNF596 Gene

2 Reactome pathways for ZNF596 Gene

Interacting Proteins for ZNF596 Gene

Gene Ontology (GO) - Biological Process for ZNF596 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF596: view

No data available for SIGNOR curated interactions for ZNF596 Gene

Drugs & Compounds for ZNF596 Gene

No Compound Related Data Available

Transcripts for ZNF596 Gene

Unigene Clusters for ZNF596 Gene

Zinc finger protein 596:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF596 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - - - - - - -
SP2: - - -
SP3: -
SP5: - - - -
SP6: - -
SP7: - -

Relevant External Links for ZNF596 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF596 Gene

mRNA expression in normal human tissues for ZNF596 Gene

SOURCE GeneReport for Unigene cluster for ZNF596 Gene Hs.591388

genes like me logo Genes that share expression patterns with ZNF596: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF596 Gene

Orthologs for ZNF596 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF596 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF596 35
  • 81.79 (n)
  • 73.79 (a)
-- 36
  • 43 (a)
(Canis familiaris)
Mammalia ZNF596 35
  • 81.53 (n)
  • 74.1 (a)
ZNF596 36
  • 70 (a)
(Pan troglodytes)
Mammalia ZNF596 35
  • 99.27 (n)
  • 99.01 (a)
ZNF596 36
  • 99 (a)
Species with no ortholog for ZNF596:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF596 Gene

Gene Tree for ZNF596 (if available)
Gene Tree for ZNF596 (if available)

Paralogs for ZNF596 Gene

Paralogs for ZNF596 Gene

(502) SIMAP similar genes for ZNF596 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF596: view

Variants for ZNF596 Gene

Sequence variations from dbSNP and Humsavar for ZNF596 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2074718 - 245,254(+) GAGAA(A/C/T)GAAAC reference, missense
rs2072174 - 246,274(+) ATATG(C/G/T)ATGTC reference, missense
rs2214750 -- 246,948(+) CAGCA(C/T)TTCTA utr-variant-3-prime
rs2240379 -- 243,585(+) TCAAT(A/G)TTGTC intron-variant
rs2240380 -- 244,109(+) GGTCT(C/T)GAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF596 Gene

Variant ID Type Subtype PubMed ID
nsv831205 CNV Loss 17160897
nsv428193 CNV Gain+Loss 18775914
dgv2168e1 CNV Complex 17122850
dgv2169e1 CNV Complex 17122850
nsv889662 CNV Loss 21882294
nsv889663 CNV Gain 21882294
nsv6034 CNV Insertion 18451855
nsv520036 CNV Gain 19592680
nsv527387 CNV Gain 19592680
nsv465263 CNV Gain 19166990
nsv524542 CNV Gain 19592680
nsv470163 CNV Loss 18288195
nsv465264 CNV Loss 19166990
nsv831206 CNV Loss 17160897
nsv889664 CNV Gain 21882294
dgv7582n71 CNV Gain 21882294
nsv8254 CNV Gain 18304495
dgv2170e1 CNV Complex 17122850
nsv470164 CNV Gain 18288195
dgv240e55 CNV Gain 17911159

Variation tolerance for ZNF596 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.18; 80.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF596 Gene

Disorders for ZNF596 Gene

Relevant External Links for ZNF596

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF596 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF596 Gene

Publications for ZNF596 Gene

  1. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF596 Gene

Sources for ZNF596 Gene