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Aliases for ZNF596 Gene

Aliases for ZNF596 Gene

  • Zinc Finger Protein 596 2 3 5

External Ids for ZNF596 Gene

Previous GeneCards Identifiers for ZNF596 Gene

  • GC08P000173
  • GC08P000174
  • GC08P000026

Summaries for ZNF596 Gene

GeneCards Summary for ZNF596 Gene

ZNF596 (Zinc Finger Protein 596) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF705D.

UniProtKB/Swiss-Prot for ZNF596 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF596 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF596 Gene

Genomics for ZNF596 Gene

Regulatory Elements for ZNF596 Gene

Enhancers for ZNF596 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H000627 1.7 Ensembl ENCODE dbSUPER 140 +397.7 397663 4 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF766 ZNF302 ENSG00000273402 ENSG00000272240 ENSG00000272812 ZNF596 ENSG00000272293 RPL23AP53 ERICH1 TDRP LOC105377773 ENSG00000254207
GH08H000723 1 FANTOM5 Ensembl ENCODE 15.3 +492.2 492164 1 ZNF585B SP2 ENSG00000254207 ERICH1 ENSG00000273402 ZNF596 ENSG00000272240 TDRP PIR50649
GH08H000231 1 ENCODE 13.4 +0.5 543 1 PKNOX1 ATF1 ARID4B SIN3A DMAP1 GLIS2 ELK1 ZNF143 ZNF207 KLF7 ENSG00000272240 ZNF596 RPL23AP53 ENSG00000272812
GH08H000542 0.9 ENCODE 10.7 +312.8 312797 4 TBP FOXA2 SIN3A ZEB1 ZNF121 GLIS2 EGR2 THAP11 ZNF202 SP3 TDRP ENSG00000272812 ENSG00000272240 ENSG00000273402 ZNF596 ENSG00000254207 PIR54972
GH08H001205 0.5 ENCODE 15.2 +972.9 972939 0 ATF1 POLR2A ZNF140 ENSG00000273402 ENSG00000272240 ENSG00000272812 ZNF596 GC08M001176 PIR43464
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF596 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF596 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000220370 163 2601 PKNOX1 ATF1 FOXA2 ARID4B SIN3A ZNF143 ZNF207 KLF7 RUNX3 SP3

Transcription factor binding sites by QIAGEN in the ZNF596 gene promoter:

Genomic Location for ZNF596 Gene

Chromosome:
8
Start:
232,137 bp from pter
End:
264,703 bp from pter
Size:
32,567 bases
Orientation:
Plus strand

Genomic View for ZNF596 Gene

Genes around ZNF596 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF596 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF596 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF596 Gene

Proteins for ZNF596 Gene

  • Protein details for ZNF596 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC21-ZN596_HUMAN
    Recommended name:
    Zinc finger protein 596
    Protein Accession:
    Q8TC21
    Secondary Accessions:
    • B2R8P4
    • O95015
    • Q8N9X0

    Protein attributes for ZNF596 Gene

    Size:
    504 amino acids
    Molecular mass:
    58513 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD05197.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAG36241.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF596 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF596 Gene

Post-translational modifications for ZNF596 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for ZNF596

No data available for DME Specific Peptides for ZNF596 Gene

Domains & Families for ZNF596 Gene

Gene Families for ZNF596 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF596 Gene

Suggested Antigen Peptide Sequences for ZNF596 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TC21

UniProtKB/Swiss-Prot:

ZN596_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF596: view

Function for ZNF596 Gene

Molecular function for ZNF596 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF596 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF596: view
genes like me logo Genes that share phenotypes with ZNF596: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF596 Gene

Localization for ZNF596 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF596 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF596 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF596 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF596: view

Pathways & Interactions for ZNF596 Gene

SuperPathways for ZNF596 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF596: view

Pathways by source for ZNF596 Gene

2 Reactome pathways for ZNF596 Gene

Gene Ontology (GO) - Biological Process for ZNF596 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF596: view

No data available for SIGNOR curated interactions for ZNF596 Gene

Drugs & Compounds for ZNF596 Gene

No Compound Related Data Available

Transcripts for ZNF596 Gene

Unigene Clusters for ZNF596 Gene

Zinc finger protein 596:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF596 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - - - - - - -
SP2: - - -
SP3: -
SP4:
SP5: - - - -
SP6: - -
SP7: - -

Relevant External Links for ZNF596 Gene

GeneLoc Exon Structure for
ZNF596
ECgene alternative splicing isoforms for
ZNF596

Expression for ZNF596 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF596 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF596 Gene:

ZNF596

SOURCE GeneReport for Unigene cluster for ZNF596 Gene:

Hs.591388

Evidence on tissue expression from TISSUES for ZNF596 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF596: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF596 Gene

Orthologs for ZNF596 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF596 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF596 33 34
  • 99.27 (n)
cow
(Bos Taurus)
Mammalia ZNF596 33
  • 81.79 (n)
-- 34
  • 43 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia ZNF596 33 34
  • 81.53 (n)
Species where no ortholog for ZNF596 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF596 Gene

ENSEMBL:
Gene Tree for ZNF596 (if available)
TreeFam:
Gene Tree for ZNF596 (if available)

Paralogs for ZNF596 Gene

Paralogs for ZNF596 Gene

(502) SIMAP similar genes for ZNF596 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF596: view

Variants for ZNF596 Gene

Sequence variations from dbSNP and Humsavar for ZNF596 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000156163 -- 240,290(+) GCTAC(A/G)TTTAT intron-variant, utr-variant-5-prime
rs1000199500 -- 237,526(+) ATACC(C/G)CTTTG intron-variant, upstream-variant-2KB
rs1000252952 -- 240,700(+) CAACC(C/G)AACCC intron-variant, utr-variant-5-prime
rs1000271515 -- 240,076(+) TGCCA(C/G)GAACT intron-variant, utr-variant-5-prime
rs1000331276 -- 232,152(+) GAAGC(A/G)GCGCG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF596 Gene

Variant ID Type Subtype PubMed ID
dgv1350e214 CNV gain 21293372
dgv240e55 CNV gain 17911159
dgv6788n100 CNV gain 25217958
dgv6789n100 CNV gain 25217958
dgv6790n100 CNV gain 25217958
dgv6791n100 CNV gain 25217958
esv2759581 CNV gain+loss 17122850
esv2761228 CNV gain+loss 21179565
esv3576500 CNV gain 25503493
esv3615771 CNV gain 21293372
nsv1023686 CNV gain 25217958
nsv1030422 CNV gain 25217958
nsv1030576 CNV gain 25217958
nsv1031378 CNV loss 25217958
nsv428193 CNV gain+loss 18775914
nsv465263 CNV gain 19166990
nsv465264 CNV loss 19166990
nsv470163 CNV loss 18288195
nsv470164 CNV gain 18288195
nsv520036 CNV gain 19592680
nsv524542 CNV gain 19592680
nsv527387 CNV gain 19592680
nsv6034 CNV insertion 18451855
nsv609448 CNV loss 21841781
nsv609449 CNV gain 21841781
nsv609450 CNV gain 21841781
nsv609451 CNV loss 21841781
nsv609452 CNV loss 21841781
nsv8254 CNV gain 18304495
nsv831205 CNV loss 17160897
nsv831206 CNV loss 17160897

Variation tolerance for ZNF596 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.18; 80.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF596 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF596

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF596 Gene

Disorders for ZNF596 Gene

Relevant External Links for ZNF596

Genetic Association Database (GAD)
ZNF596
Human Genome Epidemiology (HuGE) Navigator
ZNF596
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF596

No disorders were found for ZNF596 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF596 Gene

Publications for ZNF596 Gene

  1. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 60

Products for ZNF596 Gene

Sources for ZNF596 Gene

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