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Aliases for ZNF596 Gene

Aliases for ZNF596 Gene

  • Zinc Finger Protein 596 2 3

External Ids for ZNF596 Gene

Summaries for ZNF596 Gene

GeneCards Summary for ZNF596 Gene

ZNF596 (Zinc Finger Protein 596) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF705G.

UniProtKB/Swiss-Prot for ZNF596 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF596 Gene

Genomics for ZNF596 Gene

Genomic Location for ZNF596 Gene

Start:
232,137 bp from pter
End:
247,342 bp from pter
Size:
15,206 bases
Orientation:
Plus strand

Genomic View for ZNF596 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF596 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF596 Gene

Regulatory Elements for ZNF596 Gene

Transcription factor binding sites by QIAGEN in the ZNF596 gene promoter:

Proteins for ZNF596 Gene

  • Protein details for ZNF596 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC21-ZN596_HUMAN
    Recommended name:
    Zinc finger protein 596
    Protein Accession:
    Q8TC21
    Secondary Accessions:
    • B2R8P4
    • O95015
    • Q8N9X0

    Protein attributes for ZNF596 Gene

    Size:
    504 amino acids
    Molecular mass:
    58513 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD05197.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAG36241.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF596 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF596 Gene

Proteomics data for ZNF596 Gene at MOPED

Post-translational modifications for ZNF596 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF596 Gene

Domains for ZNF596 Gene

Gene Families for ZNF596 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF596 Gene

UniProtKB/Swiss-Prot:

ZN596_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q8TC21
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q8TC21
Similarity:
  • Contains 11 C2H2-type zinc fingers.:
    • Q8TC21
genes like me logo Genes that share domains with ZNF596: view

Function for ZNF596 Gene

Molecular function for ZNF596 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF596 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF596: view

Phenotypes for ZNF596 Gene

GenomeRNAi human phenotypes for ZNF596:
genes like me logo Genes that share phenotypes with ZNF596: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF596 Gene

Localization for ZNF596 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF596 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF596 Gene COMPARTMENTS Subcellular localization image for ZNF596 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF596 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF596: view

Pathways for ZNF596 Gene

SuperPathways for ZNF596 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF596: view

Pathways by source for ZNF596 Gene

2 Reactome pathways for ZNF596 Gene

Interacting Proteins for ZNF596 Gene

Gene Ontology (GO) - Biological Process for ZNF596 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF596: view

Transcripts for ZNF596 Gene

Unigene Clusters for ZNF596 Gene

Zinc finger protein 596:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF596 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - - - - - - -
SP2: - - -
SP3: -
SP4:
SP5: - - - -
SP6: - -
SP7: - -

Relevant External Links for ZNF596 Gene

GeneLoc Exon Structure for
ZNF596
ECgene alternative splicing isoforms for
ZNF596

Expression for ZNF596 Gene

mRNA expression in normal human tissues for ZNF596 Gene

SOURCE GeneReport for Unigene cluster for ZNF596 Gene Hs.591388

genes like me logo Genes that share expressions with ZNF596: view

Orthologs for ZNF596 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF596 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF596 36
  • 99.27 (n)
  • 99.01 (a)
ZNF596 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 43 (a)
ManyToMany
ZNF596 36
  • 81.79 (n)
  • 73.79 (a)
dog
(Canis familiaris)
Mammalia ZNF596 36
  • 81.53 (n)
  • 74.1 (a)
ZNF596 37
  • 70 (a)
OneToOne
Species with no ortholog for ZNF596:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF596 Gene

ENSEMBL:
Gene Tree for ZNF596 (if available)
TreeFam:
Gene Tree for ZNF596 (if available)

Paralogs for ZNF596 Gene

Paralogs for ZNF596 Gene

Selected SIMAP similar genes for ZNF596 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF596: view

Variants for ZNF596 Gene

Sequence variations from dbSNP and Humsavar for ZNF596 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs763785 -- 246,936(+) TTCTT(A/T)ATACA utr-variant-3-prime
rs763786 -- 246,884(+) CCAGA(A/C)ATTCA utr-variant-3-prime
rs1053171 -- 235,432(+) ACCAC(A/G)TAAAG intron-variant
rs2072174 - 246,274(+) ATATG(G/T)ATGTC missense, reference
rs2074718 - 245,254(+) GAGAA(A/C)GAAAC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ZNF596 Gene

Variant ID Type Subtype PubMed ID
nsv831205 CNV Loss 17160897
nsv428193 CNV Gain+Loss 18775914
dgv2168e1 CNV Complex 17122850
dgv2169e1 CNV Complex 17122850
nsv889662 CNV Loss 21882294
nsv889663 CNV Gain 21882294
nsv6034 CNV Insertion 18451855
nsv520036 CNV Gain 19592680
nsv527387 CNV Gain 19592680
nsv465263 CNV Gain 19166990
nsv524542 CNV Gain 19592680
nsv470163 CNV Loss 18288195
nsv465264 CNV Loss 19166990
nsv831206 CNV Loss 17160897
nsv889664 CNV Gain 21882294
dgv7582n71 CNV Gain 21882294
nsv8254 CNV Gain 18304495
dgv2170e1 CNV Complex 17122850
nsv470164 CNV Gain 18288195
dgv240e55 CNV Gain 17911159

Relevant External Links for ZNF596 Gene

HapMap Linkage Disequilibrium report
ZNF596

Disorders for ZNF596 Gene

Relevant External Links for ZNF596

Genetic Association Database (GAD)
ZNF596
Human Genome Epidemiology (HuGE) Navigator
ZNF596
genes like me logo Genes that share disorders with ZNF596: view

No data available for UniProtKB/Swiss-Prot for ZNF596 Gene

Publications for ZNF596 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 3 4
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for ZNF596 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF596
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF596
    • Block miRNA regulation of ZNF596 using miScript Target Protectors

    Sources for ZNF596 Gene

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