ZNF596 Gene
protein-coding GIFtS: 48
GCID: GC08P000174
|
|
zinc finger protein 596
| |
Aliases
for ZNF596 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 5961 2 |
Export aliases for ZNF596 gene to outside databasesPrevious GC identifers: GC08P000173 GC08P000026 |
Summaries
for ZNF596 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN596_HUMAN, Q8TC21Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF596 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_023736.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF596 gene promoter:
TBP TFIID LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF596
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF596 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p23.3 Ensembl cytogenetic band: 8p23.3 HGNC cytogenetic band: 8p23.3ZNF596 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P000174: view genomic region
(about GC identifiers)
Start:
|
182,137 bp from pter |
End:
|
197,342 bp from pter |
Size:
|
15,206 bases |
Orientation:
|
plus strand |
|
Proteins
for ZNF596 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN596_HUMAN, Q8TC21 (See
protein sequence)Recommended Name: Zinc finger protein 596 Size: 504 amino acids; 58513 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAD05197.1; Type=Erroneous gene model prediction; Sequence=BAG36241.1; Type=Erroneousinitiation;
Secondary accessions: B2R8P4 O95015 Q8N9X0Alternative splicing: 3 isoforms: Q8TC21-1 Q8TC21-2 Q8TC21-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF596: NX_Q8TC21
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TC21
ZNF596 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001035880.1 NP_001035881.1 NP_775810.2
ENSEMBL proteins: ENSP00000429671 ENSP00000430346 ENSP00000310033 ENSP00000430650 ENSP00000428179 ENSP00000430552 ENSP00000429386 ENSP00000318719 ENSP00000381613 Reactome Protein details: Q8TC21
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF596 for ontologies About GeneDecksing
ZNF596 Antibody Products:
Assay Products for ZNF596: |
Protein
Domains /
Families
for ZNF596 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF596 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TC21ProtoNet protein and cluster: Q8TC21 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN596_HUMAN, Q8TC21Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 11 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF596 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN596_HUMAN, Q8TC21Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF596 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF596 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): ZNF596 (NM_001042415) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF596 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF596 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF596 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF596 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZNF596:
|
Pathways & Interactions
for ZNF596 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF596
ZNF596 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF596
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZNF596 (ENSP000003100334) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF596 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF596 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF596
Search CenterWatch for drugs/clinical trials and news about ZNF596 / ZN596
|
Transcripts
for ZNF596 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF596 gene (3 alternative transcripts): NM_001042415.1 NM_001042416.1 NM_173539.2 Unigene Cluster for ZNF596: Zinc finger protein 596 Hs.591388 [show with all ESTs]Unigene Representative Sequence: NM_00104241613 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000521145 ENST00000523418 ENST00000308811(uc003wot.3 uc003wou.3)
ENST00000523162 ENST00000522866 ENST00000518414 ENST00000521270 ENST00000518320
ENST00000521238 ENST00000523333 ENST00000521350 ENST00000320552 ENST00000398612(uc003wov.3 uc003wow.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF596 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF596 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): ZNF596 (NM_001042415) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF596 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF596 |
Additional cDNA sequence: AK313454.1 BC026190.1 7 DOTS entries: DT.97834857 DT.121474871 DT.121474854 DT.99984575 DT.121474821 DT.121474836 DT.97789655 21 AceView cDNA sequences: BQ270809 BU101564 BM478564 NM_173539 BU101562 BC026190 BG771504 BX490598 BG986526 BG986427 AI539590 BU101563 BF979971 BF845120 BF575242 AX748129 AK093442 BU941827 BG945279 Z21473 N89399
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF596 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c |
|---|
|
| SP1: | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF596
|
Expression
for ZNF596 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF596 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGTAGAACT
About this image
See ZNF596 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF596
SOURCE GeneReport for Unigene cluster: Hs.591388
SABiosciences Custom PCR Arrays for ZNF596
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF596
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF596 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF596 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF596 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF596 |
Orthologs
for ZNF596 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF596 gene from 1/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
26(a) |
1 → many |
GL343915.1(63411-81262) |
ENSEMBL Gene Tree for ZNF596 (if available)
TreeFam Gene Tree for ZNF596 (if available) |
Paralogs
for ZNF596 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF596 gene
- ZNF705A2 ZNF705G2 ZNF705D2 LOC7284292 ZNF705B2
18/494 SIMAP similar genes for ZNF596 using alignment to 7 protein entries: ZN596_HUMAN (see all proteins)
(see all similar genes):ZNF230 ZNF625 ZNF124 ZNF10 ZNF439 ZNF559
ZNF224 ZNF81 ZNF317 ZNF529 ZNF627 ZNF78L1
ZFP90 ZNF763 ZNF556 ZNF235 ZNF155 ZNF561
ZNF596 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF596 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF596 (182137 - 197342 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for ZNF596
5 CNVs: 2723 4575 31413 3716 8587 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF596 |
|
Disorders
/ Diseases
for ZNF596 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZNF596 for disorders About MalaCards
ZNF596 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: ZNF596 (1 document)
Export disorders for ZNF596 gene to outside databases
|
Publications
for ZNF596 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF596 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF596) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for ZNF596 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF596 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF596 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF596 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF596 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF596 gene:
Search GeneIP for patents involving ZNF596
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF596 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF596 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF596 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF596 | | | OriGene Protein Over-expression Lysate for ZNF596 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for ZNF596 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF596 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF596 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF596 | | OriGene Custom Protein Services for ZNF596 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF596 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF596 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF596 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF596 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF596 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF596 |
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 | | | ZNF596 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF596 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF596 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF596 |
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