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Aliases for ZNF595 Gene

Aliases for ZNF595 Gene

  • Zinc Finger Protein 595 2 3

External Ids for ZNF595 Gene

Previous GeneCards Identifiers for ZNF595 Gene

  • GC04P000045

Summaries for ZNF595 Gene

Entrez Gene Summary for ZNF595 Gene

  • This gene encodes a protein belonging to the Cys2His2 zinc finger protein family, whose members function as transcription factors that can regulate a broad variety of developmental and cellular processes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013]

GeneCards Summary for ZNF595 Gene

ZNF595 (Zinc Finger Protein 595) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression.

UniProtKB/Swiss-Prot for ZNF595 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF595 Gene

Genomics for ZNF595 Gene

Regulatory Elements for ZNF595 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF595 Gene

Start:
53,285 bp from pter
End:
88,211 bp from pter
Size:
34,927 bases
Orientation:
Plus strand

Genomic View for ZNF595 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF595 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF595 Gene

Proteins for ZNF595 Gene

  • Protein details for ZNF595 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYB9-ZN595_HUMAN
    Recommended name:
    Zinc finger protein 595
    Protein Accession:
    Q8IYB9
    Secondary Accessions:

    Protein attributes for ZNF595 Gene

    Size:
    648 amino acids
    Molecular mass:
    74290 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF595 Gene

Proteomics data for ZNF595 Gene at MOPED

Post-translational modifications for ZNF595 Gene

  • Ubiquitination at Lys627
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF595 Gene

No data available for DME Specific Peptides for ZNF595 Gene

Domains for ZNF595 Gene

Gene Families for ZNF595 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF595 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYB9

UniProtKB/Swiss-Prot:

ZN595_HUMAN :
  • Q8IYB9
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 18 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF595: view

Function for ZNF595 Gene

Molecular function for ZNF595 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF595 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF595: view

Phenotypes for ZNF595 Gene

GenomeRNAi human phenotypes for ZNF595:
genes like me logo Genes that share phenotypes with ZNF595: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF595 Gene

Localization for ZNF595 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF595 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF595 Gene COMPARTMENTS Subcellular localization image for ZNF595 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for ZNF595 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF595: view

Pathways for ZNF595 Gene

SuperPathways for ZNF595 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF595: view

Pathways by source for ZNF595 Gene

2 Reactome pathways for ZNF595 Gene

Interacting Proteins for ZNF595 Gene

Gene Ontology (GO) - Biological Process for ZNF595 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF595: view

Transcripts for ZNF595 Gene

Unigene Clusters for ZNF595 Gene

Zinc finger protein 595:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF595

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF595 Gene

No ASD Table

Relevant External Links for ZNF595 Gene

GeneLoc Exon Structure for
ZNF595
ECgene alternative splicing isoforms for
ZNF595

Expression for ZNF595 Gene

mRNA expression in normal human tissues for ZNF595 Gene

SOURCE GeneReport for Unigene cluster for ZNF595 Gene Hs.709469

genes like me logo Genes that share expressions with ZNF595: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for ZNF595 Gene

Orthologs for ZNF595 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for ZNF595 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF595 35
  • 99.25 (n)
  • 99.36 (a)
mouse
(Mus musculus)
Mammalia Zfp595 35
  • 67.05 (n)
  • 56.53 (a)
Species with no ortholog for ZNF595:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF595 Gene

ENSEMBL:
Gene Tree for ZNF595 (if available)
TreeFam:
Gene Tree for ZNF595 (if available)

Paralogs for ZNF595 Gene

Selected SIMAP similar genes for ZNF595 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF595: view

No data available for Paralogs for ZNF595 Gene

Variants for ZNF595 Gene

Sequence variations from dbSNP and Humsavar for ZNF595 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs981863 -- 55,634(+) ggctg(A/C)cttca intron-variant
rs2006748 -- 87,223(+) GCCTA(C/T)AACTT synonymous-codon, reference
rs2006764 - 87,387(+) CAAAG(C/G)TTTTA reference, missense
rs2187874 -- 82,429(+) cccaa(G/T)ctgga intron-variant
rs2353625 -- 86,848(-) TTTTG(C/T)CCAGA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for ZNF595 Gene

Variant ID Type Subtype PubMed ID
nsv10409 CNV Loss 18304495
nsv821633 CNV Gain 15273396
dgv1563e1 CNV Complex 17122850
esv2752043 CNV Gain 17911159
esv33512 CNV Gain 17666407
essv5613 CNV CNV 17122850
nsv878233 CNV Gain 21882294
esv2420576 CNV Deletion 18987734
nsv878234 CNV Gain 21882294
dgv5384n71 CNV Loss 21882294
nsv878236 CNV Loss 21882294
esv2460685 CNV Deletion 19546169
esv2671718 CNV Deletion 23128226
esv7180 CNV Loss 19470904
esv5403 CNV Complex 18987735
nsv818206 CNV Loss 17921354
nsv461141 CNV Gain 19166990
nsv516451 CNV Gain+Loss 19592680
dgv5385n71 CNV Gain 21882294

Relevant External Links for ZNF595 Gene

HapMap Linkage Disequilibrium report
ZNF595

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF595 Gene

Disorders for ZNF595 Gene

No disorders were found for ZNF595 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF595 Gene

Publications for ZNF595 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Zinc finger domains: hypotheses and current knowledge. (PMID: 2114117) Berg J.M. (Annu Rev Biophys Biophys Chem 1990) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ZNF595 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF595
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF595
    • Block miRNA regulation of ZNF595 using miScript Target Protectors

    Sources for ZNF595 Gene

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