ZNF595 Gene
protein-coding GIFtS: 44
GCID: GC04P000046
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zinc finger protein 595
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Aliases
for ZNF595 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 5951 2 | | FLJ317401 |
Export aliases for ZNF595 gene to outside databasesPrevious GC identifer: GC04P000045 |
Summaries
for ZNF595 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN595_HUMAN, Q8IYB9Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF595 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_037622.5
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF595 gene promoter:
HOXA9B TBP ER-alpha Brachyury Ik-3 Meis-1b GATA-1 AREB6 FAC1 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF595
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF595 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16.3 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16.3ZNF595 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P000046: view genomic region
(about GC identifiers)
Start:
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53,179 bp from pter |
End:
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88,099 bp from pter |
Size:
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34,921 bases |
Orientation:
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plus strand |
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Proteins
for ZNF595 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN595_HUMAN, Q8IYB9 (See
protein sequence)Recommended Name: Zinc finger protein 595 Size: 648 amino acids; 74290 Da
Subcellular location: Nucleus (Probable)Explore the universe of human proteins at neXtProt for ZNF595: NX_Q8IYB9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IYB9
ZNF595 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_872330.1
ENSEMBL proteins: ENSP00000434858 ENSP00000437878 Reactome Protein details: Q8IYB9
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF595 for ontologies About GeneDecksing
ZNF595 Antibody Products:
Assay Products for ZNF595: |
Protein
Domains /
Families
for ZNF595 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF595 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IYB9ProtoNet protein and cluster: Q8IYB9 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN595_HUMAN, Q8IYB9Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 18 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF595 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN595_HUMAN, Q8IYB9Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF595
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF595
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for ZNF595 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF595 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF595 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZNF595:
|
Pathways & Interactions
for ZNF595 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF595
ZNF595 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF595
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF595 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF595 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF595
Search CenterWatch for drugs/clinical trials and news about ZNF595 / ZN595
|
Transcripts
for ZNF595 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF595 gene: NM_182524.2 Unigene Cluster for ZNF595: Zinc finger protein 595 Hs.709469 [show with all ESTs]Unigene Representative Sequence: BX5378876 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000339368(uc003fzv.1 uc011bus.1 uc011but.1) ENST00000507368
ENST00000512065 ENST00000509152(uc010iay.1) ENST00000502981 ENST00000526473(uc003fzu.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF595
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF595
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF595 (NM_182524) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF595 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF595 |
Additional cDNA sequence: AK056302.1 AK124097.1 AK300505.1 AK301848.1 AK309855.1 AK311343.1 BC009008.1 BC036110.1 BC043151.1 BX537887.1 12 DOTS entries: DT.101985182 DT.208789 DT.101970209 DT.95262182 DT.100682383 DT.92419137 DT.99983759 DT.97837833 DT.121227692 DT.210522 DT.95262184 DT.99963003 24/41 AceView cDNA sequences (see all 41): AI470295 BC043151 BX537887 CA405497 BQ435199 AA362547 BX956154 NM_182524 AL550746 AK056302 T70381 BX646431 AI718402 BU568415 BC009008 AL546296 BI560805 BC036110 CB994354 AL545089 BF056061 BP870457 R77914 AA380162
GeneLoc Exon Structure
|
Expression
for ZNF595 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF595 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
Genevestigator expression for ZNF595
SOURCE GeneReport for Unigene cluster: Hs.709469
SABiosciences Custom PCR Arrays for ZNF595
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF595
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF595 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF595 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF595 |
Orthologs
for ZNF595 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF595 gene from 1/3 species (see all 3) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1005357231 |
zinc finger protein 658-like |
62.77(n)
55.32(a) |
|
100535723 XM_003198398.1 XP_003198446.1 |
Species with no ortholog for ZNF595
ENSEMBL Gene Tree for ZNF595 (if available)
TreeFam Gene Tree for ZNF595 (if available) |
Paralogs
for ZNF595 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF595 gene
- ZNF7262 ZNF7202 ZNF7382
18/465 SIMAP similar genes for ZNF595 using alignment to 4 protein entries: ZN595_HUMAN (see all proteins)
(see all similar genes):MGC12518 ZNF519 ZNF721 ZNF283 ZNF66 ZNF718
ZNF141 ZNF273 ZNF429 ZNF708 ZNF761 ZNF506
ZNF93 ZNF527 HZF30 HZF36 ZFS-1 ZNF420
ZNF595 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for ZNF595
PGOHUM00000251093 PGOHUM00000258180
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Genomic Variants
for ZNF595 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 18 variations for ZNF595
15/17 CNVs (see all 17): 91868 80135 8441 32562 0273 51426 98598 91867 62153 7441 51427 10032 80138 91865 91869
1 Indel: 46654 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF595 |
|
Disorders
/ Diseases
for ZNF595 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF595 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF595 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF595) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
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External Searches for ZNF595 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ZNF595 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF595 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF595 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF595 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF595 gene:
Search GeneIP for patents involving ZNF595
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF595 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF595 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF595 | | | OriGene Protein Over-expression Lysate for ZNF595 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for ZNF595 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF595 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF595 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | ZNF595 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for ZNF595 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF595 |
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