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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF595 Gene

protein-coding   GIFtS: 43
GCID: GC04P000046

Zinc Finger Protein 595

  Search for ZNF595
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 5951 2

External Ids:    HGNC: 271961   Entrez Gene: 1526872   Ensembl: ENSG000001977017   UniProtKB: Q8IYB93   

Export aliases for ZNF595 gene to outside databases

Previous GC identifer: GC04P000045


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF595 Gene: 
ZNF595 (zinc finger protein 595) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF720.

UniProtKB/Swiss-Prot: ZN595_HUMAN, Q8IYB9
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_037622.5  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF595 gene promoter:
         HOXA9B   TBP   ER-alpha   Brachyury   Ik-3   Meis-1b   GATA-1   AREB6   FAC1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF595 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF595

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF595


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

ZNF595 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF595 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P000046:  view genomic region     (about GC identifiers)

Start:
53,179 bp from pter      End:
88,099 bp from pter
Size:
34,921 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN595_HUMAN, Q8IYB9 (See protein sequence)
Recommended Name: Zinc finger protein 595  
Size: 648 amino acids; 74290 Da
Subcellular location: Nucleus (Probable)

Explore the universe of human proteins at neXtProt for ZNF595: NX_Q8IYB9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IYB9

  • ZNF595 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_872330.1  
    ENSEMBL proteins: 
     ENSP00000434858   ENSP00000437878  
    Reactome Protein details: Q8IYB9
    Human Recombinant Protein Products for ZNF595: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF595 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8IYB9

    ProtoNet protein and cluster: Q8IYB9

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN595_HUMAN, Q8IYB9
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 18 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF595 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN595_HUMAN, Q8IYB9
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF595 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF595:
     Decreased Wnt reporter activit 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF595 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF595
        Generic Transcription Pathway
    Gene Expression



    ZNF595 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF595

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF595 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF595 (ZN595)

    Search CenterWatch for drugs/clinical trials and news about ZNF595 / ZN595

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF595 gene: 
    NM_182524.2  

    Unigene Cluster for ZNF595:

    Zinc finger protein 595
    Hs.709469  [show with all ESTs]
    Unigene Representative Sequence: BX537887
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339368(uc003fzv.1 uc011bus.1 uc011but.1) ENST00000507368
    ENST00000512065 ENST00000509152(uc010iay.1) ENST00000502981 ENST00000526473(uc003fzu.1)

    miRNA
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    Inhib. RNA
    Products:
         
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    Additional mRNA sequence: 

    AK056302.1 AK124097.1 AK300505.1 AK301848.1 AK309855.1 AK311343.1 BC009008.1 BC036110.1 
    BC043151.1 BX537887.1 

    12 DOTS entries:

    DT.101985182  DT.208789  DT.101970209  DT.95262182  DT.100682383  DT.92419137  DT.99983759  DT.97837833 
    DT.121227692  DT.210522  DT.95262184  DT.99963003 

    24/41 AceView cDNA sequences (see all 41):

    AI470295 BC009008 BQ435199 AL546296 AL550746 CA405497 AL545089 BX537887 
    BI560805 BC036110 AI718402 NM_182524 BX646431 CB994354 BC043151 AK056302 
    AA362547 T70381 BU568415 BX956154 BI561969 AA380162 BF056061 R77914 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF595 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF595 Expression
    About this image


    Genevestigator expression for ZNF595

    SOURCE GeneReport for Unigene cluster: Hs.709469
        SABiosciences Custom PCR Arrays for ZNF595
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF595

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF595 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005357231 zinc finger protein 658-like 62.77(n)
    55.32(a)
      100535723  XM_003198398.1  XP_003198446.1 
            Species with no ortholog for ZNF595

    ENSEMBL Gene Tree for ZNF595 (if available)
    TreeFam Gene Tree for ZNF595 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF595 gene
    ZNF7202  ZNF6072  ZNF7382  ENSG000002684612  ENSG000002692372  ENSG000002675522  
    18/474 SIMAP similar genes for ZNF595 using alignment to 4 protein entries:     ZN595_HUMAN (see all proteins) (see all similar genes):
    MGC12518    ZNF519    ZNF721    ZNF677    ZNF283    ZNF257
    ZNF718    ZNF141    ZNF273    ZNF724P    ZNF616    ZNF320
    ZNF708    ZNF761    ZNF429    ZNF506    ZNF845    ZNF93

    ZNF595 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZNF595
    PGOHUM00000251093 PGOHUM00000258180


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/936 SNPs in ZNF595 are shown (see all 936)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0619584
    ----see VAR_0619582 A G mis40--------
    rs27804111,2
    C,A,H--22643(-) ccttgG/Acaaca 1 -- us2k12Minor allele frequency- A:0.25NA 4
    rs28592121,2
    C,F,O,A,H--22790(+) AATTAA/GGTCCA 1 -- us2k16Minor allele frequency- G:0.38NA WA 16
    rs123311491,2
    F,H--22797(+) TCCAGA/TTTAGG 1 -- us2k14Minor allele frequency- T:0.01NS EA 408
    rs125036701,2
    C,H--22801(+) GATTAA/G/TGTCCA 1 -- us2k10--------
    rs784945541,2
    C--22833(+) AGATTA/GCCTTT 1 -- us2k10--------
    rs104468851,2
    H--22900(+) ACATGG/ATGTTC 1 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs76924941,2
    C,A,H--22919(+) TGTGGC/TCCCAA 1 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs49702881,2
    C,A,H--22998(+) ggttaG/Tgcaga 1 -- us2k13Minor allele frequency- T:0.01EA NS NA 158
    rs49702891,2
    C,A--23040(+) gtgtgC/Ggaccg 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF595 (53179 - 88099 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for ZNF595 (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2460685CNV Deletion19546169
    esv2420576CNV Deletion18987734
    esv2671718CNV Deletion23128226
    nsv818206CNV Loss17921354
    nsv878236CNV Loss21882294
    esv7180CNV Loss19470904
    dgv5384n71CNV Loss21882294
    nsv10409CNV Loss18304495
    nsv878233CNV Gain21882294
    nsv461141CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF595 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF595)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 152687 HGNC: 27196 AceView: ZNF595 Ensembl:ENSG00000197701 euGenes: HUgn152687
    ECgene: ZNF595 H-InvDB: ZNF595

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF595 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF595 gene:
    Search GeneIP for patents involving ZNF595

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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