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ZNF594 Gene

protein-coding   GIFtS: 43
GCID: GC17M005082

Zinc Finger Protein 594

  Search for ZNF594
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 5941 2
Zinc Finger Protein HZF182 3
KIAA18713

External Ids:    HGNC: 293921   Entrez Gene: 846222   Ensembl: ENSG000001806267   UniProtKB: Q96JF63   

Export aliases for ZNF594 gene to outside databases

Previous GC identifers: GC17M005284 GC17M005023


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF594 Gene:
ZNF594 (zinc finger protein 594) is a protein-coding gene. An important paralog of this gene is ZNF616.

UniProtKB/Swiss-Prot: ZN594_HUMAN, Q96JF6
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF594 gene promoter:
         TBP   HFH-3   FOXI1   p53   HFH-1   FOXL1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZNF594

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF594


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13

ZNF594 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF594 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M005082:  view genomic region     (about GC identifiers)

Start:
5,082,831 bp from pter      End:
5,095,178 bp from pter
Size:
12,348 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN594_HUMAN, Q96JF6 (See protein sequence)
Recommended Name: Zinc finger protein 594  
Size: 807 amino acids; 93907 Da
Sequence caution: Sequence=BAB47500.2; Type=Erroneous initiation;
Secondary accessions: Q6RFS0

Explore the universe of human proteins at neXtProt for ZNF594: NX_Q96JF6

Explore proteomics data for ZNF594 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF594 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115919.1  
    ENSEMBL proteins: 
     ENSP00000382513   ENSP00000461032   ENSP00000461696  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96JF6

    ProtoNet protein and cluster: Q96JF6

    UniProtKB/Swiss-Prot: ZN594_HUMAN, Q96JF6
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 24 C2H2-type zinc fingers


    ZNF594 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN594_HUMAN, Q96JF6
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF594 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF594:
     Decreased viability with cispl 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF594
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    hsa-mir-181a-5p (MIRT025185), hsa-mir-32-5p (MIRT028316)

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    Selected qRT-PCR Assays for microRNAs that regulate ZNF594 (see all 13):
    hsa-miR-3611 hsa-miR-181c hsa-miR-1260b hsa-miR-513c hsa-miR-181a hsa-miR-181d hsa-miR-1260 hsa-miR-188-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN594_HUMAN, Q96JF6: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF594 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF594
    Interactions:

        Search GeneGlobe Interaction Network for ZNF594

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF594 (Q96JF62, 3 ENSP000003825134) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOLGA2Q083792, 3, ENSP000004160974MINT-65218 I2D: score=5 STRING: ENSP00000416097
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF594 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF594 (ZN594)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF594 gene: 
    NM_032530.1  

    Unigene Cluster for ZNF594:

    Zinc finger protein 594
    Hs.658402  [show with all ESTs]
    Unigene Representative Sequence: NM_032530
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399604(uc021tol.1) ENST00000575779(uc010cla.1) ENST00000576772

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZNF594 (see all 13):
    hsa-miR-3611 hsa-miR-181c hsa-miR-1260b hsa-miR-513c hsa-miR-181a hsa-miR-181d hsa-miR-1260 hsa-miR-188-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF594
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF594
      QuantiFast Probe-based Assays in human, mouse, rat ZNF594

    Additional mRNA sequence: 

    AB058774.2 AK131271.1 AL833185.1 AY500358.1 BC136604.1 

    5 DOTS entries:

    DT.40237865  DT.100748865  DT.100707776  DT.437292  DT.97826495 

    Selected AceView cDNA sequences (see all 39):

    AA063598 AI334369 BF732329 AI340995 AB058774 BQ185321 BX472376 CA394774 
    AW978739 BX102213 AW977343 R95956 BG119353 AA487546 AL045639 AI308989 
    AK131271 AL833185 AY500358 BU954345 AA743406 BE763853 BX472377 AA491488 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF594 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGGGCACG
    ZNF594 Expression
    About this image

    ZNF594 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF594 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.658402
        Custom PCR Arrays for ZNF594
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF594

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for ZNF594 (if available)
    TreeFam Gene Tree for ZNF594 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF594 gene
    ZNF6162  ZNF4732  ZNF1602  ZNF4932  ZNF5462  ZNF992  ZNF8362  ZNF7212  
    ZFP622  ZNF8412  ZNF432  ZNF780B2  ZNF1972  ZNF1072  ZNF585A2  ZNF8082  
    ZNF3472  ZNF8452  ZNF585B2  ZNF6582  ZNF6292  ZNF6242  ZNF2682  ZNF8142  
    Selected SIMAP similar genes for ZNF594 using alignment to 3 protein entries:     ZN594_HUMAN (see all proteins) (see all similar genes):
    ZFS-4    ZNF78L1    kr-znf3    ZFS-5    ZNF808    DKFZp434J0650
    ZNF818P    ZNF    DKFZp666C237    ZNF24    ZNF436    ZSCAN23
    ZNF345    HZF16    ZNF702P    DKFZp686H10254    HZF40    ZFS-6

    ZNF594 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF594 (see all 325)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1150448081,2
    C,F--5082405(+) GGGCAG/AGCCTC 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1115304651,2
    F--5082411(+) GCCTCT/CGCCTT 1 -- ds50012Minor allele frequency- C:0.12CSA WA 120
    rs1864279991,2
    --5082432(+) CCTGGC/TGGGCT 1 -- ds50010--------
    rs1149451971,2
    F--5082447(+) GGGCCG/AGGAAG 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1388096141,2
    C--5082544(+) GGATGC/TGCTCA 1 -- ds50010--------
    rs733334041,2
    C,F--5082545(+) GATGCG/ACTCAC 1 -- ds50013Minor allele frequency- A:0.35WA CSA 121
    rs1911472951,2
    --5082798(+) AATTAC/TGGCCC 1 -- ds50010--------
    rs1815446681,2
    --5082836(+) AATTCC/G/TTAAAT 2 -- ut310--------
    rs1493499531,2
    --5082921(+) CCTTAC/GTTTGA 1 -- ut310--------
    rs178247081,2
    C,F,H--5083008(+) TAACAT/CAGACG 1 -- ut3126Minor allele frequency- C:0.11NA EA NS WA 2978

    HapMap Linkage Disequilibrium report for ZNF594 (5082831 - 5095178 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF594:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv526e199CNV Deletion23128226

    Human Gene Mutation Database (HGMD): ZNF594
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF594
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF594

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    ZNF594 for disorders           About GeneDecksing


    Export disorders for ZNF594 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF594 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF594)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2001)
    2. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PubMed id 7865130)1, 2 Abrink M.... Hellman L. (DNA Cell Biol. 1995)
    3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    4. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PubMed id 18854154)1 KAPnig R....Chanda S.K. (Cell 2008)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    6. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)2 Nakajima D.... Nagase T. (DNA Res. 2002)
    9. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84622 HGNC: 29392 AceView: ZNF594 Ensembl:ENSG00000180626 euGenes: HUgn84622
    ECgene: ZNF594 H-InvDB: ZNF594

    (According to HUGE)
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    HUGE: KIAA1871

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF594 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF594 gene:
    Search GeneIP for patents involving ZNF594

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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