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Aliases for ZNF594 Gene

Aliases for ZNF594 Gene

  • Zinc Finger Protein 594 2 3 5
  • Zinc Finger Protein HZF18 4
  • KIAA1871 4

External Ids for ZNF594 Gene

Previous GeneCards Identifiers for ZNF594 Gene

  • GC17M005284
  • GC17M005023
  • GC17M005082

Summaries for ZNF594 Gene

GeneCards Summary for ZNF594 Gene

ZNF594 (Zinc Finger Protein 594) is a Protein Coding gene. An important paralog of this gene is ZNF729.

UniProtKB/Swiss-Prot for ZNF594 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF594 Gene

Genomics for ZNF594 Gene

Regulatory Elements for ZNF594 Gene

Enhancers for ZNF594 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF594 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF594 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF594 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF594 Gene

5,179,535 bp from pter
5,191,883 bp from pter
12,349 bases
Minus strand

Genomic View for ZNF594 Gene

Genes around ZNF594 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF594 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF594 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF594 Gene

Proteins for ZNF594 Gene

  • Protein details for ZNF594 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 594
    Protein Accession:
    Secondary Accessions:
    • Q6RFS0

    Protein attributes for ZNF594 Gene

    807 amino acids
    Molecular mass:
    93907 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB47500.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF594 Gene

Proteomics data for ZNF594 Gene at MOPED

Post-translational modifications for ZNF594 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF594 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF594 Gene

Domains & Families for ZNF594 Gene

Gene Families for ZNF594 Gene

Protein Domains for ZNF594 Gene

Suggested Antigen Peptide Sequences for ZNF594 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 24 C2H2-type zinc fingers.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 24 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF594: view

Function for ZNF594 Gene

Molecular function for ZNF594 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF594 Gene

GenomeRNAi human phenotypes for ZNF594:
genes like me logo Genes that share phenotypes with ZNF594: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF594 Gene

Localization for ZNF594 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF594 Gene

Subcellular locations from

Jensen Localization Image for ZNF594 Gene COMPARTMENTS Subcellular localization image for ZNF594 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF594 Gene

Pathways & Interactions for ZNF594 Gene

SuperPathways for ZNF594 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF594 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF594: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF594 Gene

Drugs & Compounds for ZNF594 Gene

No Compound Related Data Available

Transcripts for ZNF594 Gene

Unigene Clusters for ZNF594 Gene

Zinc finger protein 594:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF594 Gene

No ASD Table

Relevant External Links for ZNF594 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF594 Gene

mRNA expression in normal human tissues for ZNF594 Gene

Protein differential expression in normal tissues from HIPED for ZNF594 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF594 Gene

SOURCE GeneReport for Unigene cluster for ZNF594 Gene Hs.658402

genes like me logo Genes that share expression patterns with ZNF594: view

Protein tissue co-expression partners for ZNF594 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF594 Gene

Orthologs for ZNF594 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF594 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF594 35
  • 99.3 (n)
  • 98.51 (a)
-- 36
  • 45 (a)
(Bos Taurus)
Mammalia ZNF192 36
  • 36 (a)
ZNF397 36
  • 50 (a)
(Canis familiaris)
Mammalia ZNF252 36
  • 38 (a)
(Monodelphis domestica)
Mammalia ZNF594 36
  • 55 (a)
(Mus musculus)
Mammalia 4930522L14Rik 36
  • 44 (a)
Gm5141 36
  • 43 (a)
Zfp26 36
  • 33 (a)
Zfp442 36
  • 45 (a)
Zfp788 36
  • 36 (a)
Zfp808 36
  • 42 (a)
Zfp873 36
  • 44 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
Species with no ortholog for ZNF594:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF594 Gene

Gene Tree for ZNF594 (if available)
Gene Tree for ZNF594 (if available)

Paralogs for ZNF594 Gene

(509) SIMAP similar genes for ZNF594 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF594: view

Variants for ZNF594 Gene

Sequence variations from dbSNP and Humsavar for ZNF594 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs9908414 - 5,183,745(+) GTATA(A/G)TAAGA reference, missense
rs3853648 - 5,183,661(+) GTCTC(A/C)CCAGA reference, missense
rs59197486 - 5,183,759(+) GAACT(G/T)TGATT reference, missense
rs1689965 -- 5,181,468(+) CTCAC(A/G)TTCTT utr-variant-3-prime
rs1730488 -- 5,182,562(-) GAAGC(A/G)AAAGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZNF594 Gene

Variant ID Type Subtype PubMed ID
dgv526e199 CNV Deletion 23128226

Variation tolerance for ZNF594 Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.28; 76.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF594 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF594 Gene

Disorders for ZNF594 Gene

Relevant External Links for ZNF594

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF594 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF594 Gene

Publications for ZNF594 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 67
  2. HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP. (PMID: 25925205) Bhattacharya S. … Ghosh M.K. (Cell Oncol (Dordr) 2015) 3
  3. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PMID: 18854154) KAPnig R. … Chanda S.K. (Cell 2008) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for ZNF594 Gene

Sources for ZNF594 Gene