ZNF593 Gene
protein-coding GIFtS: 46
GCID: GC01P026496
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zinc finger protein 593
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Aliases
for ZNF593 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 5931 2 | | ZT861 2 | | Zinc Finger Protein T862 3 |
Export aliases for ZNF593 gene to outside databasesPrevious GC identifers: GC01P026093 GC01P026180 GC01P026361 GC01P024750 |
Summaries
for ZNF593 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN593_HUMAN, O00488Function: Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity.Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of otheroctamer-binding proteins
Gene Wiki entry for ZNF593
|
Genomic Views
for ZNF593 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF593 gene promoter:
c-Fos Elk-1 p53 AML1a AP-1 ATF-2 HEN1 FAC1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF593
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF593 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.11 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p35.3ZNF593 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P026496: view genomic region
(about GC identifiers)
Start:
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26,496,362 bp from pter |
End:
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26,498,551 bp from pter |
Size:
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2,190 bases |
Orientation:
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plus strand |
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Proteins
for ZNF593 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN593_HUMAN, O00488 (See
protein sequence)Recommended Name: Zinc finger protein 593 Size: 134 amino acids; 15199 Da
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=AAH02580.1; Type=Erroneous initiation; Sequence=AAH19267.1; Type=Erroneous initiation;Sequence=BAA20369.1; Type=Erroneous initiation; Sequence=BAG34867.1; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for ZNF593:1ZR9 (3D)
Secondary accessions: B2R4S0 Q5T2H7Explore the universe of human proteins at neXtProt for ZNF593: NX_O00488
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00488
ZNF593 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056955.2
ENSEMBL proteins: ENSP00000363384 ENSP00000270812
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF593 for ontologies About GeneDecksing
ZNF593 Antibody Products:
Assay Products for ZNF593: |
Protein
Domains /
Families
for ZNF593 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF593 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O00488ProtoNet protein and cluster: O00488 UniProtKB/Swiss-Prot: ZN593_HUMAN, O00488Domain: The protein is largely disordered, with the exception of the zinc finger domainSimilarity: Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein familySimilarity: Contains 1 C2H2-type zinc finger |
Function
for ZNF593 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN593_HUMAN, O00488Function: Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity.Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of otheroctamer-binding proteins
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF593 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF593 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF593 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ZNF593:
|
Pathways & Interactions
for ZNF593 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF593
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/45 Interacting proteins for ZNF593 (O004882, 3 ENSP000003633844) via UniProtKB, MINT, STRING, and/or I2D (see all 45)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
TAS | 9115366 | | GO:0006351 | transcription, DNA-dependent |
IEA | -- |
ZNF593 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF593 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF593
Search CenterWatch for drugs/clinical trials and news about ZNF593 / ZN593
|
Transcripts
for ZNF593 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF593 gene: NM_015871.4 Unigene Cluster for ZNF593: Zinc finger protein 593 Hs.477273 [show with all ESTs]Unigene Representative Sequence: BM5447552 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374266(uc001bll.4) ENST00000270812
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF593 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF593 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF593 (NM_015871) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF593 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF593 |
Additional cDNA sequence: AK311926.1 BC002580.2 BC019267.1 D45213.1 U38444.1 3 DOTS entries: DT.414472 DT.100021321 DT.92425432 24/150 AceView cDNA sequences (see all 150): AW005040 BQ222030 AA994217 BQ228403 BX280909 BU902082 BQ219689 BQ708788 AI083892 AI937417 AJ573919 BQ012777 BQ219353 BQ010582 AI809528 BC002580 AA243637 AI565673 BM544755 AI079457 AI343675 AI084082 AA256512 BM794397
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF593 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b |
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| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF593
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Expression
for ZNF593 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF593 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACAGTGACG
About this image
See ZNF593 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF593
SOURCE GeneReport for Unigene cluster: Hs.477273
UniProtKB/Swiss-Prot: ZN593_HUMAN, O00488Tissue specificity: Ubiquitous. Detected in spleen, prostate, testis, small intestine, colon and to a minor level inthymus and peripheral blood leukocytes
SABiosciences Custom PCR Arrays for ZNF593
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF593
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF593 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF593 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF593 |
Orthologs
for ZNF593 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZNF593 gene from 8/25 species (see all 25) About this table
ENSEMBL Gene Tree for ZNF593 (if available)
TreeFam Gene Tree for ZNF593 (if available) |
Paralogs
for ZNF593 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ZNF593 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF593 (26496362 - 26498551 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF593: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF593 |
|
Disorders
/ Diseases
for ZNF593 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF593 for disorders About GeneDecksing
2  diseases for ZNF593: About MalaCardsmalaria prostatitis
Export disorders for ZNF593 gene to outside databases
|
Publications
for ZNF593 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF593 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with ZNF593) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel genetic system to isolate a dominant negative effector on DNA-binding activity of Oct-2. (PubMed id 9115366)1, 2, 3 Terunuma A.... Noda T. (1997)
- The solution structure of ZNF593 from Homo sapiens reveals a zinc finger in a predominantly unstructured protein. (PubMed id 18287285)1, 2 Hayes P.L.... Peterson F.C. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- The conserved Bud20 zinc finger protein is a new compo nent of the ribosomal 60S subunit export machinery. (PubMed id 23045392)1 Bassler J....Bergler H. (2012)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
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External Searches for ZNF593 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF593 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF593 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF593 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF593 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ZNF593 gene:
Search GeneIP for patents involving ZNF593
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF593 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF593 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF593 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF593 | | | OriGene Protein Over-expression Lysate for ZNF593 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF593 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF593 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF593 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ZNF593 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF593 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF593 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF593 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF593 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF593 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF593 |
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 | | | ZNF593 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for ZNF593 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF593 |
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