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ZNF593 Gene

protein-coding   GIFtS: 50
GCID: GC01P026496

Zinc Finger Protein 593

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 5931 2
Zinc Finger Protein T862 3
ZT862

External Ids:    HGNC: 309431   Entrez Gene: 510422   Ensembl: ENSG000001426847   UniProtKB: O004883   

Export aliases for ZNF593 gene to outside databases

Previous GC identifers: GC01P026093 GC01P026180 GC01P026361 GC01P024750


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF593 Gene:
ZNF593 (zinc finger protein 593) is a protein-coding gene. Diseases associated with ZNF593 include malaria, and prostatitis. GO annotations related to this gene include transcription corepressor activity.

UniProtKB/Swiss-Prot: ZN593_HUMAN, O00488
Function: Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory
activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of
other octamer-binding proteins

Gene Wiki entry for ZNF593 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF593 gene promoter:
         c-Fos   Elk-1   p53   AML1a   AP-1   ATF-2   HEN1   FAC1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF593 promoter sequence
   Search Chromatin IP Primers for ZNF593

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF593


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p35.3

ZNF593 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF593 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P026496:  view genomic region     (about GC identifiers)

Start:
26,496,362 bp from pter      End:
26,498,551 bp from pter
Size:
2,190 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN593_HUMAN, O00488 (See protein sequence)
Recommended Name: Zinc finger protein 593  
Size: 134 amino acids; 15199 Da
Sequence caution: Sequence=AAH02580.1; Type=Erroneous initiation; Sequence=AAH19267.1; Type=Erroneous initiation;
Sequence=BAA20369.1; Type=Erroneous initiation; Sequence=BAG34867.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ZNF593:
1ZR9 (3D)    
Secondary accessions: B2R4S0 Q5T2H7

Explore the universe of human proteins at neXtProt for ZNF593: NX_O00488

Explore proteomics data for ZNF593 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF593 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056955.2  
    ENSEMBL proteins: 
     ENSP00000363384   ENSP00000270812  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2
     IPR022755 Znf_C2H2_jaz

    Graphical View of Domain Structure for InterPro Entry O00488

    ProtoNet protein and cluster: O00488

    UniProtKB/Swiss-Prot: ZN593_HUMAN, O00488
    Domain: The protein is largely disordered, with the exception of the zinc finger domain
    Similarity: Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family
    Similarity: Contains 1 C2H2-type zinc finger


    ZNF593 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN593_HUMAN, O00488
    Function: Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory
    activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of
    other octamer-binding proteins

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003714transcription corepressor activity TAS9115366
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF593 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZNF593:
     Increased G2M DNA content  S arrest 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF593
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    miRTarBase miRNAs that target ZNF593:
    hsa-mir-877-3p (MIRT037146)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN593_HUMAN, O00488: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--

    ZNF593 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF593
    Interactions:

        Search GeneGlobe Interaction Network for ZNF593

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZNF593 (O004882, 3 ENSP000003633844) via UniProtKB, MINT, STRING, and/or I2D (see all 115)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB1AP628202, 3MINT-63965 I2D: score=4 
    MAP3K7O433182, 3MINT-8259954 I2D: score=2 
    MAPK8IP2Q133872, 3MINT-8262707 I2D: score=2 
    ZAKQ9NYL22, 3MINT-8277408 I2D: score=2 
    ENSG00000206502Q9P1U03, ENSP000003835034I2D: score=1 STRING: ENSP00000383503
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS9115366
    GO:0006351transcription, DNA-templated IEA--

    ZNF593 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF593 (ZN593)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF593 gene: 
    NM_015871.4  

    Unigene Cluster for ZNF593:

    Zinc finger protein 593
    Hs.477273  [show with all ESTs]
    Unigene Representative Sequence: BM544755
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374266(uc001bll.4) ENST00000270812
    miRNA
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    Additional mRNA sequence: 

    AK311926.1 BC002580.2 BC019267.1 D45213.1 U38444.1 

    3 DOTS entries:

    DT.414472  DT.100021321  DT.92425432 

    Selected AceView cDNA sequences (see all 150):

    BQ219689 BX280909 AA994217 AI083892 BQ228403 BQ708788 AJ573919 AI937417 
    BQ222030 AW005040 BU902082 CF529794 CB114104 AW262018 AV661314 AW628430 
    BM986834 AI589657 BQ012777 BE396586 AA258482 BQ219353 BC002580 N81106 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF593    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for ZNF593

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF593 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAGTGACG
    ZNF593 Expression
    About this image

    ZNF593 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF593 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.477273

    UniProtKB/Swiss-Prot: ZN593_HUMAN, O00488
    Tissue specificity: Ubiquitous. Detected in spleen, prostate, testis, small intestine, colon and to a minor level
    in thymus and peripheral blood leukocytes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ZNF593 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp5931 , 5 zinc finger protein 5931, 5 86.07(n)1
    90.3(a)1
      4 (66.50 cM)5
    680401  NM_024215.21  NP_077177.21 
     1342432895 
    chicken
    (Gallus gallus)
    Aves ZNF5931 zinc finger protein 593 67.45(n)
    67.19(a)
      419549  NM_001006307.1  NP_001006307.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF5936
    zinc finger protein 593
    60(a)
    1 ↔ 1
    GL343480.1(369411-374084)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia znf5931 zinc finger protein 593 55.11(n)
    50(a)
      549304  NM_001016550.2  NP_001016550.1 
    zebrafish
    (Danio rerio)
    Actinopterygii znf5931 zinc finger protein 593 56.35(n)
    53.17(a)
      559352  NM_200817.2  NP_957111.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG32241 CG3224 52.94(n)
    47.06(a)
      31600  NM_132107.3  NP_572335.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y56A3A.181 Y56A3A.18 51.18(n)
    41.41(a)
      176624  NM_067151.6  NP_499552.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BUD20(YLR074C)4 Protein involved in bud-site selection; diploid mutants more   --   12(282456-281956) 850763  NP_013175.1 


    ENSEMBL Gene Tree for ZNF593 (if available)
    TreeFam Gene Tree for ZNF593 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF593 (see all 79)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1423402441,2
    C--26494472(+) ACAAAA/GCATGG 1 -- us2k10--------
    rs1466362391,2
    --26494477(+) GCATGA/GTCTAA 1 -- us2k10--------
    rs1114125041,2
    C,F--26494559(+) ATGGGG/ACTCAC 1 -- us2k12Minor allele frequency- A:0.05CSA WA 120
    rs1154093881,2
    F--26494607(+) GTCCAG/ACTAAG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1128996141,2
    F--26494622(+) CCCGTG/TTGCCT 1 -- us2k12Minor allele frequency- T:0.50CSA 4
    rs1137256121,2
    C,F--26494634(+) CTGCCC/TACTGG 1 -- us2k12Minor allele frequency- T:0.05CSA WA 120
    rs1391199331,2
    --26494648(+) TAGAAG/TAATCT 1 -- us2k10--------
    rs1135608601,2
    C,F--26494660(+) TTCCAT/CGTGGC 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    rs1432368761,2
    --26494816(+) CCCCAC/TCTCCA 1 -- us2k10--------
    rs37624591,2
    C,F,A,H--26494886(+) ACCCAG/CCATGC 1 -- us2k116Minor allele frequency- C:0.39EA NA NS CSA WA 2390

    HapMap Linkage Disequilibrium report for ZNF593 (26496362 - 26498551 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF593:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv871237CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for ZNF593:    
    About MalaCards
    malaria    prostatitis


    ZNF593 for disorders           About GeneDecksing


    Export disorders for ZNF593 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF593 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with ZNF593)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel genetic system to isolate a dominant negative effector on DNA-binding activity of Oct-2. (PubMed id 9115366)1, 2, 3 Terunuma A.... Noda T. (Nucleic Acids Res. 1997)
    2. The solution structure of ZNF593 from Homo sapiens reveals a zinc finger in a predominantly unstructured protein. (PubMed id 18287285)1, 2 Hayes P.L.... Peterson F.C. (Protein Sci. 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. The conserved Bud20 zinc finger protein is a new component of the ribosomal 60S subunit export machinery. (PubMed id 23045392)1 Bassler J....Bergler H. (Mol. Cell. Biol. 2012)
    7. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51042 HGNC: 30943 AceView: ZNF593 Ensembl:ENSG00000142684 euGenes: HUgn51042
    ECgene: ZNF593 H-InvDB: ZNF593

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF593 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF593 gene:
    Search GeneIP for patents involving ZNF593

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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