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Aliases for ZNF589 Gene

Aliases for ZNF589 Gene

  • Zinc Finger Protein 589 2 3 5
  • Stem Cell Zinc Finger Protein 1 3 4
  • SZF1 3 4
  • KRAB-Zinc Finger Protein SZF1-1 3
  • EC 2.1.1.43 61

External Ids for ZNF589 Gene

Previous GeneCards Identifiers for ZNF589 Gene

  • GC03P048244
  • GC03P048257
  • GC03P048282

Summaries for ZNF589 Gene

GeneCards Summary for ZNF589 Gene

ZNF589 (Zinc Finger Protein 589) is a Protein Coding gene. Diseases associated with ZNF589 include Kleefstra Syndrome. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF343.

UniProtKB/Swiss-Prot for ZNF589 Gene

  • May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA binding-dependent transcriptional repressor.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF589 Gene

Genomics for ZNF589 Gene

Regulatory Elements for ZNF589 Gene

Enhancers for ZNF589 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G048239 1.1 ENCODE 72.7 -0.2 -177 2.8 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF589 QRICH1 CCDC71 CDC25A PLXNB1 NME6 TMA7 CCDC51 ATRIP ENSG00000244380
GH03G048186 1.1 ENCODE 71.3 -53.2 -53186 2.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF589 QRICH1 CCDC71 PFKFB4 CDC25A NDUFB1P1
GH03G048299 1.1 ENCODE 62.8 +60.3 60348 3.4 HDGF HNRNPUL1 PKNOX1 MLX CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF589 NME6 FCF1P2
GH03G048267 0.9 Ensembl ENCODE 75.3 +27.6 27582 3.2 PAF1 MTA2 MNT PAX8 TBX21 ZFHX2 POLR2A GATA2 IKZF1 NBN ZNF589 WDR6 FBXW12 PLXNB1 CDC25A NME6 SPINK8 CAMP ATRIP ENSG00000244380
GH03G047778 1.4 Ensembl ENCODE 34 -460.3 -460300 5.2 MLX CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 SP3 TBX21 MEF2D ZNF589 CCDC12 NME6 BOLA2P2 MRPS18AP1 DHX30 MAP4 SCAP SMARCC1 TMEM89
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF589 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF589 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152086 400 1401 HDGF MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for ZNF589 Gene

Chromosome:
3
Start:
48,241,100 bp from pter
End:
48,299,253 bp from pter
Size:
58,154 bases
Orientation:
Plus strand

Genomic View for ZNF589 Gene

Genes around ZNF589 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF589 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF589 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF589 Gene

Proteins for ZNF589 Gene

  • Protein details for ZNF589 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UQ0-ZN589_HUMAN
    Recommended name:
    Zinc finger protein 589
    Protein Accession:
    Q86UQ0
    Secondary Accessions:
    • Q86UC9
    • Q9BRI6
    • Q9BRY3
    • Q9Y611
    • Q9Y612

    Protein attributes for ZNF589 Gene

    Size:
    364 amino acids
    Molecular mass:
    41189 Da
    Quaternary structure:
    • Interacts with TRIM28.
    SequenceCaution:
    • Sequence=AAH05859.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH06247.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH48798.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF589 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF589 Gene

Selected DME Specific Peptides for ZNF589 Gene

Q86UQ0:
  • HQRTHTGEKPY
  • CRECGRGF

Post-translational modifications for ZNF589 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ZNF589 Gene

Gene Families for ZNF589 Gene

Protein Domains for ZNF589 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q86UQ0

UniProtKB/Swiss-Prot:

ZN589_HUMAN :
  • The KRAB domain mediates interaction with TRIM28.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The KRAB domain mediates interaction with TRIM28.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF589: view

Function for ZNF589 Gene

Molecular function for ZNF589 Gene

UniProtKB/Swiss-Prot Function:
May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA binding-dependent transcriptional repressor.

Enzyme Numbers (IUBMB) for ZNF589 Gene

Gene Ontology (GO) - Molecular Function for ZNF589 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF589: view
genes like me logo Genes that share phenotypes with ZNF589: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF589 Gene

Localization for ZNF589 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF589 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF589 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF589 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA,IEA 23665872
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF589: view

Pathways & Interactions for ZNF589 Gene

SuperPathways for ZNF589 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF589: view

Pathways by source for ZNF589 Gene

2 Reactome pathways for ZNF589 Gene

Gene Ontology (GO) - Biological Process for ZNF589 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF589: view

No data available for SIGNOR curated interactions for ZNF589 Gene

Drugs & Compounds for ZNF589 Gene

No Compound Related Data Available

Transcripts for ZNF589 Gene

Unigene Clusters for ZNF589 Gene

Zinc finger protein 589:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF589 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1:
SP2: - - - - - - -
SP3: - -
SP4: - -
SP5: - - - - - -
SP6:

Relevant External Links for ZNF589 Gene

GeneLoc Exon Structure for
ZNF589
ECgene alternative splicing isoforms for
ZNF589

Expression for ZNF589 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF589 Gene

Protein differential expression in normal tissues from HIPED for ZNF589 Gene

This gene is overexpressed in Fetal gut (32.5) and Testis (26.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF589 Gene



Protein tissue co-expression partners for ZNF589 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF589 Gene:

ZNF589

SOURCE GeneReport for Unigene cluster for ZNF589 Gene:

Hs.172602

mRNA Expression by UniProt/SwissProt for ZNF589 Gene:

Q86UQ0-ZN589_HUMAN
Tissue specificity: Isoform 2 is widely expressed. Isoform 3 is only expressed in CD34(+) cells.

Evidence on tissue expression from TISSUES for ZNF589 Gene

  • Lung(4.2)
  • Lymph node(4.2)
  • Muscle(4.1)
  • Eye(4)
genes like me logo Genes that share expression patterns with ZNF589: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF589 Gene

Orthologs for ZNF589 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF589 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF589 34 35
  • 98.81 (n)
Species where no ortholog for ZNF589 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF589 Gene

ENSEMBL:
Gene Tree for ZNF589 (if available)
TreeFam:
Gene Tree for ZNF589 (if available)

Paralogs for ZNF589 Gene

Paralogs for ZNF589 Gene

(564) SIMAP similar genes for ZNF589 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ZNF589 Gene

genes like me logo Genes that share paralogs with ZNF589: view

Variants for ZNF589 Gene

Sequence variations from dbSNP and Humsavar for ZNF589 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000076173 -- 48,271,649(+) GGTGC(A/G)TTTAC utr-variant-3-prime
rs1000096079 -- 48,263,703(+) GCAGT(G/T)AGCTG intron-variant
rs1000116200 -- 48,258,818(+) TGTGC(A/G)GTCTG intron-variant
rs1000166995 -- 48,252,624(+) TTTTT(-/C)TTTTT intron-variant
rs1000252678 -- 48,258,266(+) AGGCA(C/T)CTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF589 Gene

Variant ID Type Subtype PubMed ID
esv3596103 CNV loss 21293372
nsv472083 CNV novel sequence insertion 20440878
nsv474252 CNV novel sequence insertion 20440878
nsv834682 CNV gain 17160897
nsv834683 CNV gain 17160897

Variation tolerance for ZNF589 Gene

Residual Variation Intolerance Score: 81.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.79; 73.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF589 Gene

Human Gene Mutation Database (HGMD)
ZNF589
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF589

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF589 Gene

Disorders for ZNF589 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF589 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
kleefstra syndrome
  • 9q subtelomeric deletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF589

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF589
genes like me logo Genes that share disorders with ZNF589: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF589 Gene

Publications for ZNF589 Gene

  1. SZF1: a novel KRAB-zinc finger gene expressed in CD34+ stem/progenitor cells. (PMID: 10029171) Liu C. … Small D. (Exp. Hematol. 1999) 2 3 4 22 64
  2. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PMID: 23665872) Wang W. … Huang Z. (Cell. Mol. Life Sci. 2013) 3 4 64
  3. The stem cell zinc finger 1 (SZF1)/ZNF589 protein has a human-specific evolutionary nucleotide DNA change and acts as a regulator of cell viability in the hematopoietic system. (PMID: 26738774) Venturini L. … Ganser A. (Exp. Hematol. 2016) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64

Products for ZNF589 Gene

Sources for ZNF589 Gene

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