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Aliases for ZNF589 Gene

Aliases for ZNF589 Gene

  • Zinc Finger Protein 589 2 3
  • Stem Cell Zinc Finger Protein 1 3 4
  • SZF1 3 4
  • KRAB-Zinc Finger Protein SZF1-1 3
  • EC 63

External Ids for ZNF589 Gene

Previous GeneCards Identifiers for ZNF589 Gene

  • GC03P048244
  • GC03P048257

Summaries for ZNF589 Gene

GeneCards Summary for ZNF589 Gene

ZNF589 (Zinc Finger Protein 589) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF169.

UniProtKB/Swiss-Prot for ZNF589 Gene

  • May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA binding-dependent transcriptional repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF589 Gene

Genomics for ZNF589 Gene

Regulatory Elements for ZNF589 Gene

Genomic Location for ZNF589 Gene

48,241,100 bp from pter
48,299,253 bp from pter
58,154 bases
Plus strand

Genomic View for ZNF589 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF589 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF589 Gene

Proteins for ZNF589 Gene

  • Protein details for ZNF589 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 589
    Protein Accession:
    Secondary Accessions:
    • Q86UC9
    • Q9BRI6
    • Q9BRY3
    • Q9Y611
    • Q9Y612

    Protein attributes for ZNF589 Gene

    364 amino acids
    Molecular mass:
    41189 Da
    Quaternary structure:
    • Interacts with TRIM28.
    • Sequence=AAH05859.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH06247.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH48798.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF589 Gene


neXtProt entry for ZNF589 Gene

Proteomics data for ZNF589 Gene at MOPED

Selected DME Specific Peptides for ZNF589 Gene

Post-translational modifications for ZNF589 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF589 Gene

Domains for ZNF589 Gene

Gene Families for ZNF589 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF589 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q86UQ0
  • The KRAB domain mediates interaction with TRIM28
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF589: view

Function for ZNF589 Gene

Molecular function for ZNF589 Gene

UniProtKB/Swiss-Prot Function: May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA binding-dependent transcriptional repressor.

Enzyme Numbers (IUBMB) for ZNF589 Gene

Gene Ontology (GO) - Molecular Function for ZNF589 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF589: view

Phenotypes for ZNF589 Gene

GenomeRNAi human phenotypes for ZNF589:
genes like me logo Genes that share phenotypes with ZNF589: view

miRNA for ZNF589 Gene

miRTarBase miRNAs that target ZNF589

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF589 Gene

Localization for ZNF589 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF589 Gene

Subcellular locations from

Jensen Localization Image for ZNF589 Gene COMPARTMENTS Subcellular localization image for ZNF589 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF589 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 23665872
genes like me logo Genes that share ontologies with ZNF589: view

Pathways for ZNF589 Gene

SuperPathways for ZNF589 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF589: view

Pathways by source for ZNF589 Gene

2 Reactome pathways for ZNF589 Gene

Interacting Proteins for ZNF589 Gene

Gene Ontology (GO) - Biological Process for ZNF589 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF589: view

Transcripts for ZNF589 Gene

Unigene Clusters for ZNF589 Gene

Zinc finger protein 589:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF589 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP2: - - - - - - -
SP3: - -
SP4: - -
SP5: - - - - - -

Relevant External Links for ZNF589 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF589 Gene

mRNA expression in normal human tissues for ZNF589 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF589 Gene

SOURCE GeneReport for Unigene cluster for ZNF589 Gene Hs.172602

mRNA Expression by UniProt/SwissProt for ZNF589 Gene

Tissue specificity: Isoform 2 is widely expressed. Isoform 3 is only expressed in CD34(+) cells.
genes like me logo Genes that share expressions with ZNF589: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF589 Gene

Orthologs for ZNF589 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF589 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF589 35
  • 98.81 (n)
  • 98.63 (a)
ZNF589 36
  • 98 (a)
Species with no ortholog for ZNF589:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF589 Gene

Gene Tree for ZNF589 (if available)
Gene Tree for ZNF589 (if available)

Paralogs for ZNF589 Gene

Paralogs for ZNF589 Gene

Selected SIMAP similar genes for ZNF589 Gene using alignment to 6 proteins: Pseudogenes for ZNF589 Gene

genes like me logo Genes that share paralogs with ZNF589: view

Variants for ZNF589 Gene

Sequence variations from dbSNP and Humsavar for ZNF589 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs3937 -- 48,270,912(-) attcc(A/G)gacac utr-variant-3-prime
rs936427 -- 48,259,584(-) CTCTT(C/T)TCTGA intron-variant
rs1045482 -- 48,270,739(+) AGGAA(A/C/G/T)AAGGA utr-variant-3-prime
rs5848849 -- 48,243,807(+) AAAAA(-/A)GGCAG intron-variant
rs6442110 -- 48,265,345(+) caatg(A/G)tggga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF589 Gene

Variant ID Type Subtype PubMed ID
nsv834682 CNV Gain 17160897
nsv834683 CNV Gain 17160897

Relevant External Links for ZNF589 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF589 Gene

Disorders for ZNF589 Gene

No disorders were found for ZNF589 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF589 Gene

Publications for ZNF589 Gene

  1. SZF1: a novel KRAB-zinc finger gene expressed in CD34+ stem/progenitor cells. (PMID: 10029171) Liu C. … Small D. (Exp. Hematol. 1999) 2 3 4 23
  2. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PMID: 23665872) Wang W. … Huang Z. (Cell. Mol. Life Sci. 2013) 3 4
  3. A common DNA-binding site for SZF1 and the BRCA1-associated zinc finger protein, ZBRK1. (PMID: 12097288) Peng H. … Rauscher F.J. III (Cancer Res. 2002) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for ZNF589 Gene

Sources for ZNF589 Gene

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