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Aliases for ZNF589 Gene

Aliases for ZNF589 Gene

  • Zinc Finger Protein 589 2 3 5
  • Stem Cell Zinc Finger Protein 1 3 4
  • SZF1 3 4
  • KRAB-Zinc Finger Protein SZF1-1 3
  • EC 2.1.1.43 63

External Ids for ZNF589 Gene

Previous GeneCards Identifiers for ZNF589 Gene

  • GC03P048244
  • GC03P048257
  • GC03P048282

Summaries for ZNF589 Gene

GeneCards Summary for ZNF589 Gene

ZNF589 (Zinc Finger Protein 589) is a Protein Coding gene. Diseases associated with ZNF589 include kleefstra syndrome. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF169.

UniProtKB/Swiss-Prot for ZNF589 Gene

  • May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA binding-dependent transcriptional repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF589 Gene

Genomics for ZNF589 Gene

Regulatory Elements for ZNF589 Gene

Promoters for ZNF589 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF589 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF589 Gene

Chromosome:
3
Start:
48,241,100 bp from pter
End:
48,299,253 bp from pter
Size:
58,154 bases
Orientation:
Plus strand

Genomic View for ZNF589 Gene

Genes around ZNF589 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF589 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF589 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF589 Gene

Proteins for ZNF589 Gene

  • Protein details for ZNF589 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UQ0-ZN589_HUMAN
    Recommended name:
    Zinc finger protein 589
    Protein Accession:
    Q86UQ0
    Secondary Accessions:
    • Q86UC9
    • Q9BRI6
    • Q9BRY3
    • Q9Y611
    • Q9Y612

    Protein attributes for ZNF589 Gene

    Size:
    364 amino acids
    Molecular mass:
    41189 Da
    Quaternary structure:
    • Interacts with TRIM28.
    SequenceCaution:
    • Sequence=AAH05859.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH06247.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH48798.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF589 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF589 Gene

Proteomics data for ZNF589 Gene at MOPED

Selected DME Specific Peptides for ZNF589 Gene

Post-translational modifications for ZNF589 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF589 Gene

Domains & Families for ZNF589 Gene

Gene Families for ZNF589 Gene

Protein Domains for ZNF589 Gene

Graphical View of Domain Structure for InterPro Entry

Q86UQ0

UniProtKB/Swiss-Prot:

ZN589_HUMAN :
  • The KRAB domain mediates interaction with TRIM28.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 4 C2H2-type zinc fingers.
Domain:
  • The KRAB domain mediates interaction with TRIM28.
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF589: view

Function for ZNF589 Gene

Molecular function for ZNF589 Gene

UniProtKB/Swiss-Prot Function:
May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA binding-dependent transcriptional repressor.

Enzyme Numbers (IUBMB) for ZNF589 Gene

genes like me logo Genes that share phenotypes with ZNF589: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF589 Gene

Localization for ZNF589 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF589 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF589 Gene COMPARTMENTS Subcellular localization image for ZNF589 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF589 Gene

Pathways & Interactions for ZNF589 Gene

SuperPathways for ZNF589 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF589: view

Pathways by source for ZNF589 Gene

2 Reactome pathways for ZNF589 Gene

Interacting Proteins for ZNF589 Gene

Gene Ontology (GO) - Biological Process for ZNF589 Gene

None

No data available for SIGNOR curated interactions for ZNF589 Gene

Drugs & Compounds for ZNF589 Gene

No Compound Related Data Available

Transcripts for ZNF589 Gene

Unigene Clusters for ZNF589 Gene

Zinc finger protein 589:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF589 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1:
SP2: - - - - - - -
SP3: - -
SP4: - -
SP5: - - - - - -
SP6:

Relevant External Links for ZNF589 Gene

GeneLoc Exon Structure for
ZNF589
ECgene alternative splicing isoforms for
ZNF589

Expression for ZNF589 Gene

mRNA expression in normal human tissues for ZNF589 Gene

Protein differential expression in normal tissues from HIPED for ZNF589 Gene

This gene is overexpressed in Fetal gut (32.5) and Testis (26.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF589 Gene



SOURCE GeneReport for Unigene cluster for ZNF589 Gene Hs.172602

mRNA Expression by UniProt/SwissProt for ZNF589 Gene

Q86UQ0-ZN589_HUMAN
Tissue specificity: Isoform 2 is widely expressed. Isoform 3 is only expressed in CD34(+) cells.
genes like me logo Genes that share expression patterns with ZNF589: view

Protein tissue co-expression partners for ZNF589 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF589 Gene

Orthologs for ZNF589 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF589 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF589 35
  • 98.81 (n)
  • 98.63 (a)
ZNF589 36
  • 98 (a)
OneToOne
Species with no ortholog for ZNF589:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF589 Gene

ENSEMBL:
Gene Tree for ZNF589 (if available)
TreeFam:
Gene Tree for ZNF589 (if available)

Paralogs for ZNF589 Gene

Paralogs for ZNF589 Gene

(564) SIMAP similar genes for ZNF589 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ZNF589 Gene

genes like me logo Genes that share paralogs with ZNF589: view

Variants for ZNF589 Gene

Sequence variations from dbSNP and Humsavar for ZNF589 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs11718329 - 48,268,338(+) AGTCA(C/G/T)GTTTG reference, missense
rs9847953 - 48,241,205(+) GCTGG(A/G)CTGCG reference, missense
rs3937 -- 48,270,912(-) attcc(A/G)gacac utr-variant-3-prime
rs1045482 -- 48,270,739(+) AGGAA(A/C/G/T)AAGGA utr-variant-3-prime
rs936427 -- 48,259,584(-) CTCTT(C/T)TCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF589 Gene

Variant ID Type Subtype PubMed ID
nsv834682 CNV Gain 17160897
nsv834683 CNV Gain 17160897

Variation tolerance for ZNF589 Gene

Residual Variation Intolerance Score: 81.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.79; 73.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF589 Gene

HapMap Linkage Disequilibrium report
ZNF589
Human Gene Mutation Database (HGMD)
ZNF589

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF589 Gene

Disorders for ZNF589 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF589 Gene - From: DISEASES

Disorder Aliases PubMed IDs
kleefstra syndrome
  • 9q subtelomeric deletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF589

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF589
genes like me logo Genes that share disorders with ZNF589: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF589 Gene

Publications for ZNF589 Gene

  1. SZF1: a novel KRAB-zinc finger gene expressed in CD34+ stem/progenitor cells. (PMID: 10029171) Liu C. … Small D. (Exp. Hematol. 1999) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PMID: 23665872) Wang W. … Huang Z. (Cell. Mol. Life Sci. 2013) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF589 Gene

Sources for ZNF589 Gene

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