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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF589 Gene

protein-coding   GIFtS: 49
GCID: GC03P048282

Zinc Finger Protein 589

  Search for ZNF589
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 5891 2
Stem Cell Zinc Finger Protein 12 3
SZF12 3
KRAB-Zinc Finger Protein SZF1-12
EC 2.1.1.438

External Ids:    HGNC: 167471   Entrez Gene: 513852   Ensembl: ENSG000001640487   UniProtKB: Q86UQ03   

Export aliases for ZNF589 gene to outside databases

Previous GC identifers: GC03P048244 GC03P048257


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF589 Gene: 
ZNF589 (zinc finger protein 589) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF133.

UniProtKB/Swiss-Prot: ZN589_HUMAN, Q86UQ0
Function: May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA
binding-dependent transcriptional repressor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF589 gene promoter:
         E2F-3a   E2F-4   C/EBPbeta   E2F-5   Brachyury   E2F-2   Roaz   MZF-1   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF589 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF589

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF589


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

ZNF589 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF589 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P048282:  view genomic region     (about GC identifiers)

Start:
48,282,590 bp from pter      End:
48,340,743 bp from pter
Size:
58,154 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN589_HUMAN, Q86UQ0 (See protein sequence)
Recommended Name: Zinc finger protein 589  
Size: 364 amino acids; 41189 Da
Subunit: Interacts with TRIM28
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAH05859.2; Type=Erroneous initiation; Sequence=AAH06247.2; Type=Erroneous initiation;
Sequence=AAH48798.1; Type=Erroneous initiation;
Secondary accessions: Q86UC9 Q9BRI6 Q9BRY3 Q9Y611 Q9Y612
Alternative splicing: 3 isoforms:  Q86UQ0-1   Q86UQ0-2   Q86UQ0-3   (Probable target of nonsense-mediated mRNA decay. The proposed CDS is dubious. Isoform produced through aberrant splice sites)

Explore the universe of human proteins at neXtProt for ZNF589: NX_Q86UQ0

Explore proteomics data for ZNF589 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86UQ0

  • 2 DME Specific Peptides for ZNF589 (Q86UQ0)
     CRECGRGF  HQRTHTGEKPY 

    ZNF589 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF589 Protein Expression
    REFSEQ proteins: NP_057173.2  
    ENSEMBL proteins: 
     ENSP00000346729   ENSP00000392719   ENSP00000404398   ENSP00000408719   ENSP00000404592  
     ENSP00000401106  
    Reactome Protein details: Q86UQ0
    Human Recombinant Protein Products for ZNF589: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF589 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--

    ZNF589 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q86UQ0

    ProtoNet protein and cluster: Q86UQ0

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN589_HUMAN, Q86UQ0
    Domain: The KRAB domain mediates interaction with TRIM28
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 4 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF589 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN589_HUMAN, Q86UQ0
    Function: May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA
    binding-dependent transcriptional repressor

         Enzyme Number (IUBMB): EC 2.1.1.432

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF589 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF589:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF589 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZNF589

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF589 
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF589


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF589 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF589
        Generic Transcription Pathway
    Gene Expression



    ZNF589 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF589

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for ZNF589 (ENSP000003467294) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DMAP1ENSP000003126974STRING: ENSP00000312697
    ELAVL4ENSP000003495944STRING: ENSP00000349594
    KTI12ENSP000003606764STRING: ENSP00000360676
    NRD1ENSP000003468904STRING: ENSP00000346890
    RAB3BENSP000003607184STRING: ENSP00000360718
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF589 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF589 (ZN589)

    Search CenterWatch for drugs/clinical trials and news about ZNF589 / ZN589

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF589 gene: 
    NM_016089.2  

    Unigene Cluster for ZNF589:

    Zinc finger protein 589
    Hs.172602  [show with all ESTs]
    Unigene Representative Sequence: AB209387
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354698(uc003csl.4) ENST00000427617(uc003csm.3) ENST00000412564
    ENST00000440261 ENST00000448461(uc003csn.3 uc011bbg.2) ENST00000457782(uc010hjt.2)
    ENST00000454212
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF589:
    hsa-miR-629*
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    Inhib. RNA
    Products:
         
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                         Customized lentivirus expression plasmids for stable overexpression of ZNF589 
    Primer
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    OriGene qPCR primer pairs and template standards for ZNF589
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF589
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF589

    Additional mRNA sequence: 

    AB209387.1 AK128351.1 AK298782.1 AL832831.1 AY258146.1 BC005859.2 BC006247.2 BC008213.1 
    BC028160.1 BC062690.1 

    10 DOTS entries:

    DT.310418  DT.91890677  DT.95312694  DT.404912  DT.95268807  DT.101972120  DT.102834036  DT.120844072 
    DT.91811284  DT.120844134 

    24/79 AceView cDNA sequences (see all 79):

    N54653 BI439025 AI540604 AI590649 AU099267 BM799573 BC028160 BC008213 
    AY258146 BC005859 BM911496 BX089629 AV649347 BX451604 BM712438 AW241395 
    AF114817 BC048798 BG678453 BQ949842 AW004037 BG681219 BG121574 AA932312 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF589 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
    SP1:                                                                              
    SP2:                          -     -           -     -     -     -     -         
    SP3:                          -     -                                             
    SP4:                          -     -                                             
    SP5:                          -     -           -     -     -     -               


    ECgene alternative splicing isoforms for ZNF589

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF589 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGGCCTAC
    ZNF589 Expression
    About this image


    See ZNF589 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF589

    SOURCE GeneReport for Unigene cluster: Hs.172602

    UniProtKB/Swiss-Prot: ZN589_HUMAN, Q86UQ0
    Tissue specificity: Isoform 2 is widely expressed. Isoform 3 is only expressed in CD34(+) cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for ZNF589 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia ZNF5891 zinc finger protein 589 98.81(n)
    98.63(a)
      460342  XM_516434.4  XP_516434.4 


    ENSEMBL Gene Tree for ZNF589 (if available)
    TreeFam Gene Tree for ZNF589 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF589 gene
    ZNF1332  ENSG000002565662  ZNF3432  ZNF1692  HKR12  
    18/564 SIMAP similar genes for ZNF589 using alignment to 6 protein entries:     ZN589_HUMAN (see all proteins) (see all similar genes):
    ZNF225    ZNF790    ZNF224    ZNF24    ZNF415    ZNF721
    ZNF233    PRMD9    ZNF71    ZNF738    ZNF573    ZNF83
    ZNF559    ZNF320    ZNF234    ZNF544    ZNF789    ZNF257

    ZNF589 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF589
    PGOHUM00000238029


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/598 SNPs in ZNF589 are shown (see all 598)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs779650211,2
    C--48280884(+) CAGTCC/TGCAGT 1 -- us2k10--------
    rs713233881,2
    C,F--48280916(+) GACTCC/TGTCTC 1 -- us2k12Minor allele frequency- T:0.50NA 4
    rs1127498171,2
    C,F--48281215(+) CTCTGC/GAATAA 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs1894267651,2
    --48281320(+) AGGGCC/TATTAT 1 -- us2k10--------
    rs1821816471,2
    --48281386(+) GACAAA/GGACAG 1 -- us2k10--------
    rs1117044791,2
    C,F--48281783(+) CAAATA/GTAGGG 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs2006077511,2
    C--48281896(+) GCGTC-/CAGTTTC 1 -- us2k10--------
    rs2016650681,2
    C--48281978(+) AAACC-/TTTCTG 1 -- us2k10--------
    rs1137149451,2
    C,F--48282014(+) TTCCCC/AAGGAC 1 -- us2k12Minor allele frequency- A:0.00CSA 2
    rs67963431,2
    C,F--48282021(+) ggaccC/Actttc 1 -- us2k1 trp36Minor allele frequency- A:0.16NA WA EA 364

    HapMap Linkage Disequilibrium report for ZNF589 (48282590 - 48340743 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF589:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834683CNV Gain17160897
    nsv834682CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF589 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF589)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SZF1: a novel KRAB-zinc finger gene expressed in CD34+ stem/progenitor cells. (PubMed id 10029171)1, 2, 3, 9 Liu C.... Small D. (1999)
    2. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
    3. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. A common DNA-binding site for SZF1 and the BRCA1-associated zinc finger protein, ZBRK1. (PubMed id 12097288)2 Peng H.... Rauscher F.J. III (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51385 HGNC: 16747 AceView: ZNF589 Ensembl:ENSG00000164048 euGenes: HUgn51385
    ECgene: ZNF589 H-InvDB: ZNF589

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF589 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF589 gene:
    Search GeneIP for patents involving ZNF589

    GeneCards and IP:
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