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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF589 Gene

protein-coding GIFtS: 49
GCID: GC03P048282

zinc finger protein 589

Search for ZNF589
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 589¹ ²
SZF1¹ ² ³
Stem Cell Zinc Finger Protein 1² ³
KRAB-Zinc Finger Protein SZF1-1²
EC 2.1.1.43⁸

External Ids:	HGNC: 16747¹	Entrez Gene: 51385²	Ensembl: ENSG00000164048⁷	UniProtKB: Q86UQ0³

Export aliases for ZNF589 gene to outside databases

Previous GC identifers: GC03P048244 GC03P048257

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN589_HUMAN, Q86UQ0

Function: May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA

binding-dependent transcriptional repressor

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF589 gene promoter:
E2F-3a E2F-4 C/EBPbeta E2F-5 Brachyury E2F-2 Roaz MZF-1 E2F-1 E2F
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF589 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF589

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF589

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21

ZNF589 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF589 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P048282: view genomic region (about GC identifiers)

Start:	48,282,590 bp from pter	End:	48,340,743 bp from pter
Size:	58,154 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN589_HUMAN, Q86UQ0 (See protein sequence)

Recommended Name: Zinc finger protein 589

Size: 364 amino acids; 41189 Da

Subunit: Interacts with TRIM28

Subcellular location: Nucleus (Potential)

Sequence caution: Sequence=AAH05859.2; Type=Erroneous initiation; Sequence=AAH06247.2; Type=Erroneous initiation;

Sequence=AAH48798.1; Type=Erroneous initiation;

Secondary accessions: Q86UC9 Q9BRI6 Q9BRY3 Q9Y611 Q9Y612

Alternative splicing: 3 isoforms: Q86UQ0-1 Q86UQ0-2 Q86UQ0-3 (Probable target of nonsense-mediated mRNA decay. The proposed CDS is dubious. Isoform produced through aberrant splice sites)

Explore the universe of human proteins at neXtProt for ZNF589: NX_Q86UQ0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86UQ0

2 DME Specific Peptides for ZNF589 (Q86UQ0)

CRECGRGF

HQRTHTGEKPY

ZNF589 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_057173.2

ENSEMBL proteins:

ENSP00000346729 ENSP00000392719 ENSP00000404398 ENSP00000408719 ENSP00000404592

ENSP00000401106

Reactome Protein details: Q86UQ0
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	Uscn Proteins for ZNF589

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZNF589 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF589 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q86UQ0

ProtoNet protein and cluster: Q86UQ0

1 Blocks protein family: IPB001909 KRAB box

UniProtKB/Swiss-Prot: ZN589_HUMAN, Q86UQ0

Domain: The KRAB domain mediates interaction with TRIM28

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 4 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN589_HUMAN, Q86UQ0

Function: May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA

binding-dependent transcriptional repressor

Enzyme Number (IUBMB): EC 2.1.1.43²

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		1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF589:
		hsa-miR-629*
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In Situ Assay
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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF589 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ZNF589:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZNF589

	Generic Transcription Pathway
	Gene Expression

ZNF589 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF589

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/7 Interacting proteins for ZNF589 (ENSP00000346729⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DMAP1	ENSP00000312697⁴	STRING: ENSP00000312697
ELAVL4	ENSP00000349594⁴	STRING: ENSP00000349594
KTI12	ENSP00000360676⁴	STRING: ENSP00000360676
NRD1	ENSP00000346890⁴	STRING: ENSP00000346890
RAB3B	ENSP00000360718⁴	STRING: ENSP00000360718

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF589 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF589
Search CenterWatch for drugs/clinical trials and news about ZNF589 / ZN589

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF589 gene:

NM_016089.2

Unigene Cluster for ZNF589:

Zinc finger protein 589

Hs.172602 [show with all ESTs]

Unigene Representative Sequence: AB209387

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000354698(uc003csl.4) ENST00000427617(uc003csm.3) ENST00000412564

ENST00000440261 ENST00000448461(uc003csn.3 uc011bbg.2) ENST00000457782(uc010hjt.2)

ENST00000454212

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		1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF589:
		hsa-miR-629*
		SwitchGear 3'UTR luciferase reporter plasmid: ZNF589 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AB209387.1 AK128351.1 AK298782.1 AL832831.1 AY258146.1 BC005859.2 BC006247.2 BC008213.1

BC028160.1 BC062690.1

10 DOTS entries:

DT.310418 DT.91890677 DT.95312694 DT.404912 DT.95268807 DT.101972120 DT.102834036 DT.120844072

DT.91811284 DT.120844134

24/79 AceView cDNA sequences (see all 79):

BC008213 BC028160 BM911496 AV649347 BX089629 N54653 AU099267 AI540604

BC005859 BM799573 BI439025 AI590649 AY258146 BX451604 AI925192 BM712438

CD515818 AA743749 BC048798 BG681219 AL832831 NM_016089 BM471526 BQ000352

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF589 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	·	6d	^	7	^	8
SP1:
SP2:									-		-				-		-		-		-		-
SP3:									-		-
SP4:									-		-
SP5:									-		-				-		-		-		-

ECgene alternative splicing isoforms for ZNF589

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF589 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGGCCTAC

About this image
See ZNF589 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF589

SOURCE GeneReport for Unigene cluster: Hs.172602

UniProtKB/Swiss-Prot: ZN589_HUMAN, Q86UQ0

Tissue specificity: Isoform 2 is widely expressed. Isoform 3 is only expressed in CD34(+) cells

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for ZNF589 (if available)
TreeFam Gene Tree for ZNF589 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF589 gene

ZNF169² ZNF343² ZNF133² ZNF337² HKR1²

18/568 SIMAP similar genes for ZNF589 using alignment to 6 protein entries: ZN589_HUMAN (see all proteins) (see all similar genes):

ZNF225 ZNF790 ZNF224 ZNF24 ZNF721 ZNF544

ZNF738 ZNF233 PRMD9 ZNF789 ZNF71 ZNF573

ZNF559 ZNF234 ZNF141 ZNF154 ZNF391 ZNF432

ZNF589 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ZNF589
PGOHUM00000238029

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77965021^1,2	C	--	48280884(+)	`CAGTCC/TGCAGT`	1	--	us2k¹		0	--	--	--	--
rs71323388^1,2	C,F,	--	48280916(+)	`GACTCC/TGTCTC`	1	--	us2k¹		2		NA	4
rs112749817^1,2		--	48281215(+)	`CTCTGC/GAATAA`	1	--	us2k¹		1		CSA	1
rs189426765^1,2		--	48281320(+)	`AGGGCC/TATTAT`	1	--	us2k¹		0	--	--	--	--
rs182181647^1,2		--	48281386(+)	`GACAAA/GGACAG`	1	--	us2k¹		0	--	--	--	--
rs111704479^1,2		--	48281783(+)	`CAAATA/GTAGGG`	1	--	us2k¹		1		CSA	1
rs200607751^1,2		--	48281896(+)	`GCGTC-/CAGTTTC`	1	--	us2k¹		0	--	--	--	--
rs113714945^1,2		--	48282014(+)	`TTCCCC/AAGGAC`	1	--	us2k¹		2		CSA	2
rs6796343^1,2	C,F,	--	48282021(+)	`GGACCC/ACTTTC`	1	--	us2k¹ trp³		6		NA WA EA	364
rs144385993^1,2		--	48282167(+)	`AACAAC/TAAGTT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZNF589 (48282590 - 48340743 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF589
1 CNV: 4334

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF589

DNA2.0 Custom Variant and Variant Library Synthesis for ZNF589

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF589 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF589)

Utopia: connect your pdf to the dynamic
world of online information

SZF1: a novel KRAB-zinc finger gene expressed in CD34+ stem/progenitor cells. (PubMed id 10029171)^{1, 2, 3, 9} Liu C.... Small D. (1999)
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)² Daub H.... Mann M. (2008)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
A common DNA-binding site for SZF1 and the BRCA1-associated zinc finger protein, ZBRK1. (PubMed id 12097288)² Peng H.... Rauscher F.J. III (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 51385	HGNC: 16747	AceView: ZNF589	Ensembl:ENSG00000164048	euGenes: HUgn51385
ECgene: ZNF589	H-InvDB: ZNF589

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF589	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF589 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF589 gene:
Search GeneIP for patents involving ZNF589

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF589 gene at Home site.

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ZNF589 Gene

zinc finger protein 589

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ZNF589 Gene

zinc finger protein 589

Aliasesfor ZNF589 gene

Summariesfor ZNF589 gene

Genomic Viewsfor ZNF589 gene

Proteinsfor ZNF589 gene

Protein Domains /Familiesfor ZNF589 gene

Functionfor ZNF589 gene

Pathways & Interactionsfor ZNF589 gene

Drugs & Compoundsfor ZNF589 gene

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Expression for ZNF589 gene

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for ZNF589 gene

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for ZNF589 gene

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for ZNF589 gene

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