ZNF589 Gene

Aliases
for ZNF589 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC03P048244 GC03P048257

Summaries
for ZNF589 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for ZNF589 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000003.11  NC_018914.2  NT_022517.19  

SwitchGear Promoter luciferase reporter plasmid: ZNF589 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF589

ZNF589 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P048282:  view genomic region     (about GC identifiers)

Proteins
for ZNF589 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for ZNF589: NX_Q86UQ0

Explore proteomics data for ZNF589 at MOPED

Post-translational modifications: 

ZNF589 Human Recombinant Protein Products:

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Domains /
Families
for ZNF589 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q86UQ0

Find genes that share domains with ZNF589           About GenesLikeMe

Function
for ZNF589 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Enzyme Number (IUBMB): EC 2.1.1.43²

     Gene Ontology (GO): 3 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for ZNF589

miRNA Products:		miRTarBase miRNAs that target ZNF589: hsa-mir-30b-5p (MIRT046155)
		Block miRNA regulation of human, mouse, rat ZNF589 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate ZNF589:
		hsa-miR-629*
		SwitchGear 3'UTR luciferase reporter plasmid: ZNF589 3' UTR sequence

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		Predesigned siRNA for gene silencing in human, mouse, rat ZNF589

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ZNF589

Clone Products:		OriGene clones in human, mouse for ZNF589 (see all 6) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF589

Localization
for ZNF589 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	3
cytosol	2

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for ZNF589 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for ZNF589 About     See pathways by source

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	SuperPath	Contained pathways About
1	Gene Expression	Generic Transcription Pathway 0.40 Gene Expression 0.40

1 Reactome Pathway for ZNF589

Generic Transcription Pathway

Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for ZNF589 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for ZNF589 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for ZNF589 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF589 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CCTGGCCTAC

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for ZNF589 OriGene qSTAR qPCR primer pairs in human, mouse for ZNF589
		Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF589
		QuantiTect SYBR Green Assays in human, mouse, rat ZNF589
		QuantiFast Probe-based Assays in human, mouse, rat ZNF589

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF589

Orthologs
for ZNF589 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for ZNF589 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for ZNF589 gene

ZNF432²  PRDM9²  ZNF133²  ENSG00000256566²  ZNF343²  ZNF169²  HKR1²  

Selected SIMAP similar genes for ZNF589 using alignment to 6 protein entries:     ZN589_HUMAN (see all proteins) (see all similar genes):

ZNF225    ZNF790    ZNF224    ZNF24    ZNF415    ZNF721

ZNF738    ZNF233    PRMD9    ZNF544    ZNF71    ZNF573

ZNF234    ZNF257    ZNF789    ZNF83    ZNF141    ZNF154

Find genes that share paralogs with ZNF589           About GenesLikeMe


1 Pseudogenes.org Pseudogene for ZNF589
PGOHUM00000238029

Genomic Variants
for ZNF589 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF589 (see all 598)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs779650211,2	C	--	48280884(+)	CAGTCC/TGCAGT	1	--	us2k1		0	--	--	--	--
rs713233881,2	C,F	--	48280916(+)	GACTCC/TGTCTC	1	--	us2k1		2		NA	4
rs1127498171,2	C,F	--	48281215(+)	CTCTGC/GAATAA	1	--	us2k1		1		CSA	1
rs1894267651,2		--	48281320(+)	AGGGCC/TATTAT	1	--	us2k1		0	--	--	--	--
rs1821816471,2		--	48281386(+)	GACAAA/GGACAG	1	--	us2k1		0	--	--	--	--
rs1117044791,2	C,F	--	48281783(+)	CAAATA/GTAGGG	1	--	us2k1		1		CSA	1
rs2006077511,2	C	--	48281896(+)	GCGTC-/CAGTTTC	1	--	us2k1		0	--	--	--	--
rs2016650681,2	C	--	48281978(+)	AAACC-/TTTCTG	1	--	us2k1		0	--	--	--	--
rs1137149451,2	C,F	--	48282014(+)	TTCCCC/AAGGAC	1	--	us2k1		2		CSA	2
rs67963431,2	C,F	--	48282021(+)	ggaccC/Actttc	1	--	us2k1 trp3		6		NA WA EA	364

HapMap Linkage Disequilibrium report for ZNF589 (48282590 - 48340743 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for ZNF589:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv834683	CNV	Gain	17160897
nsv834682	CNV	Gain	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ZNF589

DNA2.0 Custom Variant and Variant Library Synthesis for ZNF589

Disorders / Diseases
for ZNF589 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for ZNF589 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. SZF1: a novel KRAB-zinc finger gene expressed in CD34+ stem/progenitor cells. (PubMed id 10029171)^{1, 2, 3, 9} Liu C.... Small D. (Exp. Hematol. 1999)
2. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PubMed id 23665872)² Wang W....Huang Z. (Cell. Mol. Life Sci. 2013)
3. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)² Daub H.... Mann M. (Mol. Cell 2008)
4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (amp 2008)
5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (BMC Genomics 2007)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S.... Malek J. (Genome Res. 2004)
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
8. A common DNA-binding site for SZF1 and the BRCA1-associated zinc finger protein, ZBRK1. (PubMed id 12097288)² Peng H.... Rauscher F.J. III (Cancer Res. 2002)

External Searches for ZNF589 gene

Genome Databases showing ZNF589 gene

Other Databases showing ZNF589 gene

Specialized Databases showing ZNF589 gene

Products
for ZNF589 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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