Set Analyses:
GeneALaCart
GeneDecks
VarElect
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 


ZNF589 Gene

protein-coding   GIFtS: 50
GCID: GC03P048282

Zinc Finger Protein 589
  Search for ZNF589
at
MalaCards
 

Aliases
for ZNF589 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus
Aliases
Zinc Finger Protein 5891 2
Stem Cell Zinc Finger Protein 12 3
SZF12 3
KRAB-Zinc Finger Protein SZF1-12
EC 2.1.1.438

External Ids:    HGNC: 167471   Entrez Gene: 513852   Ensembl: ENSG000001640487   UniProtKB: Q86UQ03   

Export aliases for ZNF589 gene to outside databases

Previous GC identifers: GC03P048244 GC03P048257


Summaries
for ZNF589 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus
GeneCards Summary for ZNF589 Gene:
ZNF589 (zinc finger protein 589) is a protein-coding gene. An important paralog of this gene is ZNF432.

UniProtKB/Swiss-Prot: ZN589_HUMAN, Q86UQ0
Function: May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA
binding-dependent transcriptional repressor




Genomic Views
for ZNF589 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF589 gene promoter:
         E2F-3a   E2F-4   C/EBPbeta   E2F-5   Brachyury   E2F-2   Roaz   MZF-1   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF589 promoter sequence
   Search Chromatin IP Primers for ZNF589

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF589


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

ZNF589 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF589 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P048282:  view genomic region     (about GC identifiers)

Start:
 48,282,590 bp from pter      End:
 48,340,743 bp from pter
Size:
 58,154 bases      Orientation:
 plus strand

Proteins
for ZNF589 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus
UniProtKB/Swiss-Prot: ZN589_HUMAN, Q86UQ0 (See protein sequence)
Recommended Name: Zinc finger protein 589  
Size: 364 amino acids; 41189 Da
Subunit: Interacts with TRIM28
Sequence caution: Sequence=AAH05859.2; Type=Erroneous initiation; Sequence=AAH06247.2; Type=Erroneous initiation;
Sequence=AAH48798.1; Type=Erroneous initiation;
Secondary accessions: Q86UC9 Q9BRI6 Q9BRY3 Q9Y611 Q9Y612
Alternative splicing: 3 isoforms:  Q86UQ0-1   Q86UQ0-2   Q86UQ0-3   (Probable target of nonsense-mediated mRNA decay. The proposed CDS is dubious. Isoform produced through aberrant splice sites)

Explore the universe of human proteins at neXtProt for ZNF589: NX_Q86UQ0

Explore proteomics data for ZNF589 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
    • 2 DME Specific Peptides for ZNF589 (Q86UQ0)
     CRECGRGF  HQRTHTGEKPY 


    See ZNF589 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057173.2  
    ENSEMBL proteins: 
     ENSP00000346729   ENSP00000392719   ENSP00000404398   ENSP00000408719   ENSP00000404592  
     ENSP00000401106  
    Reactome Protein details: Q86UQ0

    ZNF589 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ZNF589
    GenScript Custom Purified and Recombinant Proteins Services for ZNF589
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF589

    ZNF589 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ZNF589
    Novus Biologicals ZNF589 Antibodies
    Abcam antibodies for ZNF589
    Cloud-Clone Corp. Antibodies for ZNF589
    Search ThermoFisher Antibodies for ZNF589
    LSBio Antibodies in human, mouse, rat for ZNF589

    ZNF589 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZNF589
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZNF589
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZNF589
    Cloud-Clone Corp. CLIAs for ZNF589

    Domains /
    Families
    for ZNF589 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q86UQ0

    ProtoNet protein and cluster: Q86UQ0

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN589_HUMAN, Q86UQ0
    Domain: The KRAB domain mediates interaction with TRIM28
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 4 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF589 for domains           About GeneDecksing


    Function
    for ZNF589 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN589_HUMAN, Q86UQ0
    Function: May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA
    binding-dependent transcriptional repressor

         Enzyme Number (IUBMB): EC 2.1.1.432

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF589 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF589:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF589
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZNF589

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF589
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF589

    miRNA
    Products:            		miRTarBase miRNAs that target ZNF589:
    hsa-mir-30b-5p (MIRT046155)

    Block miRNA regulation of human, mouse, rat ZNF589 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ZNF589:
    hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmid: ZNF589 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for ZNF589
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF589

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ZNF589

    Clone
    Products:             		 OriGene clones in human, mouse for ZNF589 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZNF589 (NM_016089)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF589
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF589

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ZNF589
    Browse ESI BIO Cell Lines and PureStem Progenitors for ZNF589 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF589


    Localization
    for ZNF589 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus
    Subcellular locations from UniProtKB/Swiss-Prot
    ZN589_HUMAN, Q86UQ0: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--

    ZNF589 for ontologies           About GeneDecksing


    Pathways & Interactions
    for ZNF589 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ZNF589 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    		Generic Transcription Pathway0.40
    		Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF589
        Generic Transcription Pathway



    ZNF589 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF589
    Interactions:

        Search GeneGlobe Interaction Network for ZNF589

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for ZNF589 (ENSP000003467294) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DMAP1ENSP000003126974STRING: ENSP00000312697
    ELAVL4ENSP000003495944STRING: ENSP00000349594
    KTI12ENSP000003606764STRING: ENSP00000360676
    NRD1ENSP000003468904STRING: ENSP00000346890
    RAB3BENSP000003607184STRING: ENSP00000360718
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF589 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZNF589 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF589 (ZN589)



    Transcripts
    for ZNF589 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus
    REFSEQ mRNAs for ZNF589 gene: 
    NM_016089.2  

    Unigene Cluster for ZNF589:

    Zinc finger protein 589
    Hs.172602  [show with all ESTs]
    Unigene Representative Sequence: AB209387
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354698(uc003csl.4) ENST00000427617(uc003csm.3) ENST00000412564
    ENST00000440261 ENST00000448461(uc003csn.3 uc011bbg.2) ENST00000457782(uc010hjt.2)
    ENST00000454212
    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat ZNF589 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ZNF589:
    hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmid: ZNF589 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for ZNF589
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF589
    Clone
    Products:             		 OriGene clones in human, mouse for ZNF589 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZNF589 (NM_016089)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF589
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF589
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for ZNF589
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF589
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF589
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF589
      QuantiFast Probe-based Assays in human, mouse, rat ZNF589

    Additional mRNA sequence: 

    AB209387.1 AK128351.1 AK298782.1 AL832831.1 AY258146.1 BC005859.2 BC006247.2 BC008213.1 
    BC028160.1 BC062690.1 

    10 DOTS entries:

    DT.310418  DT.91890677  DT.95312694  DT.404912  DT.95268807  DT.101972120  DT.102834036  DT.120844072 
    DT.91811284  DT.120844134 

    Selected AceView cDNA sequences (see all 79):

    BX089629 N54653 AI590649 AY258146 BM799573 AU099267 BC005859 BM911496 
    BC028160 AV649347 BC008213 BI439025 AI540604 BG681219 BQ949842 CD627502 
    BG678453 CB145931 BM471526 AW004037 BM424003 BE255709 BC006247 BX461368 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF589 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
    SP1:                                                                              
    SP2:                          -     -           -     -     -     -     -         
    SP3:                          -     -                                             
    SP4:                          -     -                                             
    SP5:                          -     -           -     -     -     -               


    ECgene alternative splicing isoforms for ZNF589

    Expression
    for ZNF589 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ZNF589 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGGCCTAC
    ZNF589 Expression
    About this image

    ZNF589 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    ZNF589 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.172602

    UniProtKB/Swiss-Prot: ZN589_HUMAN, Q86UQ0
    Tissue specificity: Isoform 2 is widely expressed. Isoform 3 is only expressed in CD34(+) cells

        Custom PCR Arrays for ZNF589
    Primer
    Products:    		OriGene qPCR primer pairs and template standards for ZNF589
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF589
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF589
    QuantiTect SYBR Green Assays in human, mouse, rat ZNF589
    QuantiFast Probe-based Assays in human, mouse, rat ZNF589
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF589

    Orthologs
    for ZNF589 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus
    This gene was present in the common ancestor of human and chimp.

    Orthologs for ZNF589 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chimpanzee
    (Pan troglodytes)    		 Mammalia ZNF5891 zinc finger protein 589 98.81(n)
    98.63(a)    		   460342  XM_516434.4  XP_516434.4 


    ENSEMBL Gene Tree for ZNF589 (if available)
    TreeFam Gene Tree for ZNF589 (if available)

    Paralogs
    for ZNF589 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ZNF589 gene
    ZNF4322  PRDM92  ZNF1332  ENSG000002565662  ZNF3432  ZNF1692  HKR12  
    Selected SIMAP similar genes for ZNF589 using alignment to 6 protein entries:     ZN589_HUMAN (see all proteins) (see all similar genes):
    ZNF225    ZNF790    ZNF224    ZNF24    ZNF415    ZNF721
    ZNF738    ZNF233    PRMD9    ZNF544    ZNF71    ZNF573
    ZNF234    ZNF257    ZNF789    ZNF83    ZNF141    ZNF154

    ZNF589 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF589
    PGOHUM00000238029


    Genomic Variants
    for ZNF589 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Selected SNPs for ZNF589 (see all 598)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs779650211,2
    		C--48280884(+) CAGTCC/TGCAGT 1 -- us2k10--------
    rs713233881,2
    		C,F--48280916(+) GACTCC/TGTCTC 1 -- us2k12Minor allele frequency- T:0.50NA 4
    rs1127498171,2
    		C,F--48281215(+) CTCTGC/GAATAA 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs1894267651,2
    		--48281320(+) AGGGCC/TATTAT 1 -- us2k10--------
    rs1821816471,2
    		--48281386(+) GACAAA/GGACAG 1 -- us2k10--------
    rs1117044791,2
    		C,F--48281783(+) CAAATA/GTAGGG 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs2006077511,2
    		C--48281896(+) GCGTC-/CAGTTTC 1 -- us2k10--------
    rs2016650681,2
    		C--48281978(+) AAACC-/TTTCTG 1 -- us2k10--------
    rs1137149451,2
    		C,F--48282014(+) TTCCCC/AAGGAC 1 -- us2k12Minor allele frequency- A:0.00CSA 2
    rs67963431,2
    		C,F--48282021(+) ggaccC/Actttc 1 -- us2k1 trp36Minor allele frequency- A:0.16NA WA EA 364

    HapMap Linkage Disequilibrium report for ZNF589 (48282590 - 48340743 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF589:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834683CNV Gain17160897
    nsv834682CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF589
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF589

    Disorders / Diseases
    for ZNF589 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		   --

    Publications
    for ZNF589 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus
    PubMed articles for ZNF589 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF589)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. SZF1: a novel KRAB-zinc finger gene expressed in CD34+ stem/progenitor cells. (PubMed id 10029171)1, 2, 3, 9 Liu C.... Small D. (Exp. Hematol. 1999)
    2. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PubMed id 23665872)2 Wang W....Huang Z. (Cell. Mol. Life Sci. 2013)
    3. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (Mol. Cell 2008)
    4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. A common DNA-binding site for SZF1 and the BRCA1-associated zinc finger protein, ZBRK1. (PubMed id 12097288)2 Peng H.... Rauscher F.J. III (Cancer Res. 2002)

    External Searches for ZNF589 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZNF589 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 51385 HGNC: 16747 AceView: ZNF589 Ensembl:ENSG00000164048 euGenes: HUgn51385
    ECgene: ZNF589 H-InvDB: ZNF589

    Other Databases showing ZNF589 gene

    (According to HUGE)
    About This Section

    TryGeneCards Plus    		   --

    Specialized Databases showing ZNF589 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ZNF589 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZNF589 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for ZNF589 gene:
    Search GeneIP for patents involving ZNF589

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ZNF589 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ZNF589  
     OriGene qPCR primer pairs and template standards for ZNF589   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ZNF589  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZNF589   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZNF589   OriGene Custom Protein Services for ZNF589  

         		 
     Block miRNA regulation of human, mouse, rat ZNF589 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ZNF589
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF589 Predesigned siRNA for gene silencing in human, mouse, rat ZNF589
     QuantiFast Probe-based Assays in human, mouse, rat ZNF589 QuantiTect SYBR Green Assays in human, mouse, rat ZNF589
     Custom PCR Arrays for ZNF589 Search Chromatin IP Primers for ZNF589
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF589  Search GeneGlobe Interaction Network for ZNF589
     Regulatory tfbs in ZNF589 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ZNF589 GenScript cDNA clones with any tag delivered in your preferred vector for ZNF589
     GenScript Custom Assay Services for ZNF589 GenScript Custom overexpressing Cell Line Services for ZNF589
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ZNF589 (ZN589)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ZNF589 antibodies
     Antibodies for ZNF589
     See all of Abcam's Antibodies, Kits and Proteins for ZNF589
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ZNF589
     Antibodies for ZNF589
     ELISAs for ZNF589
     CLIAs for ZNF589



     Browse ESI BIO Cell Lines and PureStem Progenitors for ZNF589
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF589
     SwitchGear 3'UTR luciferase reporter plasmids for ZNF589
     SwitchGear Promoter luciferase reporter plasmids for ZNF589
     Search ThermoFisher Antibodies for ZNF589
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF589
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF589
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZNF589
     LSBio Antibodies in human, mouse, rat for ZNF589
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ZNF589 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4