Aliases for ZNF589 Gene
Aliases for ZNF589 Gene
External Ids for ZNF589 Gene
- HGNC: 16747
- Entrez Gene: 51385
- Ensembl: ENSG00000164048
- OMIM: 616702
- UniProtKB: Q86UQ0
Previous GeneCards Identifiers for ZNF589 Gene
- GC03P048244
- GC03P048257
- GC03P048282
Summaries for ZNF589 Gene
GeneCards Summary for ZNF589 Gene
ZNF589 (Zinc Finger Protein 589) is a Protein Coding gene. Diseases associated with ZNF589 include Kleefstra Syndrome. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF343.
UniProtKB/Swiss-Prot for ZNF589 Gene
-
May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA binding-dependent transcriptional repressor.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF589 Gene
Genomics for ZNF589 Gene
Regulatory Elements for ZNF589 Gene
Enhancers for ZNF589 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ZNF589 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for ZNF589 Gene
- Chromosome:
- 3
- Start:
- 48,241,100 bp from pter
- End:
- 48,299,253 bp from pter
- Size:
- 58,154 bases
- Orientation:
- Plus strand
Genomic View for ZNF589 Gene
Genes around ZNF589 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p21.31 by Ensembl
- 3p21.31 by Entrez Gene
- 3p21.31 by HGNC
ZNF589 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF589 Gene
Proteins for ZNF589 Gene
-
Protein details for ZNF589 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86UQ0-ZN589_HUMAN
- Recommended name:
- Zinc finger protein 589
- Protein Accession:
- Q86UQ0
- Q86UC9
- Q9BRI6
- Q9BRY3
- Q9Y611
- Q9Y612
Protein attributes for ZNF589 Gene
- Size:
- 364 amino acids
- Molecular mass:
- 41189 Da
- Quaternary structure:
-
- Interacts with TRIM28.
- SequenceCaution:
-
- Sequence=AAH05859.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH06247.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH48798.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ZNF589 Gene
Selected DME Specific Peptides for ZNF589 Gene
- Q86UQ0:
-
- HQRTHTGEKPY
- CRECGRGF
Post-translational modifications for ZNF589 Gene
Other Protein References for ZNF589 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ZNF589
-
Abcam antibodies for ZNF589
- Invitrogen Antibodies for ZNF589
- antibodies-online Antibodies for ZNF589: See all 24
- Search GeneTex for Antibodies for ZNF589
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ZNF589
- Origene Custom Protein Services for ZNF589
- Novus Biologicals proteins for ZNF589
- Search GeneTex for Proteins for ZNF589
Domains & Families for ZNF589 Gene
Gene Families for ZNF589 Gene
Protein Domains for ZNF589 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF589 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86UQ0UniProtKB/Swiss-Prot:
ZN589_HUMAN :- The KRAB domain mediates interaction with TRIM28.
- Belongs to the krueppel C2H2-type zinc-finger protein family.
- Domain:
-
- The KRAB domain mediates interaction with TRIM28.
- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZNF589 Gene
Molecular function for ZNF589 Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA binding-dependent transcriptional repressor.
Enzyme Numbers (IUBMB) for ZNF589 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZNF589 Gene
- GenomeRNAi human phenotypes for ZNF589:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased hepcidin::fluc mRNA expression
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Decreased NF-kappaB reporter expression
- Decreased shRNA abundance
- Decreased viability with TRAIL
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ZNF589
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ZNF589 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF589 gene
- Search ViGene Biosciences for ZNF589
CRISPR Products
-
OriGene CRISPR knockouts for ZNF589
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF589
- GenScript: Design CRISPR guide RNA sequences for ZNF589
miRNA for ZNF589 Gene
- miRTarBase miRNAs that target ZNF589
-
- hsa-mir-30b-5p (MIRT046155)
- hsa-mir-1273e (MIRT453194)
- hsa-mir-139-3p (MIRT453195)
- hsa-mir-298 (MIRT453196)
- hsa-mir-1827 (MIRT453197)
- hsa-mir-219b-3p (MIRT453198)
- hsa-mir-4649-3p (MIRT453199)
- hsa-mir-6840-3p (MIRT453200)
- hsa-mir-4768-3p (MIRT453201)
- hsa-mir-665 (MIRT453202)
- hsa-mir-6511a-5p (MIRT453203)
- hsa-mir-1910-3p (MIRT453204)
- hsa-mir-302f (MIRT453205)
- hsa-mir-4724-3p (MIRT543655)
- hsa-mir-6849-3p (MIRT543656)
- hsa-mir-4999-3p (MIRT543657)
- hsa-mir-4461 (MIRT543658)
- hsa-mir-3680-5p (MIRT543659)
- hsa-mir-7849-3p (MIRT543660)
- hsa-mir-6750-3p (MIRT543661)
- hsa-mir-6771-5p (MIRT690782)
- hsa-mir-7977 (MIRT690783)
- hsa-mir-7160-5p (MIRT690784)
- hsa-mir-6884-5p (MIRT690785)
- hsa-mir-485-5p (MIRT690786)
- hsa-mir-6746-5p (MIRT690787)
- hsa-mir-5690 (MIRT690788)
- hsa-mir-4478 (MIRT690789)
- hsa-mir-4419b (MIRT690790)
- hsa-mir-3929 (MIRT690791)
miRNA Products
- Search ViGene Biosciences for ZNF589
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ZNF589
- Browse OriGene Inhibitory RNA Products For ZNF589
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF589 gene
Clone Products
-
OriGene ORF clones in human for ZNF589
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ZNF589
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ZNF589
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZNF589
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ZNF589
-
ViGene Biosciences adenoviral particle packaged cDNA for ZNF589 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ZNF589 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF589 gene
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF589 Gene
Localization for ZNF589 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF589 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IDA,IEA | 23665872 |
| GO:0005654 | nucleoplasm | IDA | -- |
Pathways & Interactions for ZNF589 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
Pathways by source for ZNF589 Gene
2 Reactome pathways for ZNF589 Gene
Interacting Proteins for ZNF589 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for SIGNOR curated interactions for ZNF589 Gene
Transcripts for ZNF589 Gene
mRNA/cDNA for ZNF589 Gene
- (6) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (79) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZNF589 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZNF589
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF589
- GenScript: Design CRISPR guide RNA sequences for ZNF589
miRNA Products
- Search ViGene Biosciences for ZNF589
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ZNF589
- Browse OriGene Inhibitory RNA Products For ZNF589
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF589 gene
Clone Products
-
OriGene ORF clones in human for ZNF589
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ZNF589
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ZNF589
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZNF589
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | ||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||
| SP6: |
Expression for ZNF589 Gene
This gene is overexpressed in Fetal gut (32.5) and Testis (26.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF589 Gene
NURSA nuclear receptor signaling pathways regulating expression of ZNF589 Gene:
ZNF589SOURCE GeneReport for Unigene cluster for ZNF589 Gene:
Hs.172602mRNA Expression by UniProt/SwissProt for ZNF589 Gene:
Q86UQ0-ZN589_HUMAN
Tissue specificity:
Isoform 2 is widely expressed. Isoform 3 is only expressed in CD34(+) cells.
Evidence on tissue expression from TISSUES for ZNF589 Gene
- Lung(4.2)
- Lymph node(4.2)
- Muscle(4.1)
- Eye(4)
Primer Products
-
OriGene qPCR primer pairs and template standards for ZNF589
-
OriGene qPCR primer pairs for ZNF589
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF589 Gene
Orthologs for ZNF589 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZNF589 34 35 |
|
- Species where no ortholog for ZNF589 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for ZNF589 Gene
(564) SIMAP similar genes for ZNF589 Gene using alignment to 6 proteins:
- ZNF790
- ZNF225
- ZNF224
- ZNF24
- ZNF415
- ZNF721
- ZNF738
- ZNF233
- PRMD9
- ZNF71
- ZNF544
- ZNF573
- ZNF257
- ZNF234
- ZNF789
- ZNF83
- ZNF78L1
- ZNF497
- ZNF391
- ZNF154
- ZNF141
- ZNF559
- ZNF155
- ZNF285
- PRDM9
- ZNF519
- ZNF320
- ZSCAN2
- ZNF792
- ZNF696
- ZFP3
- KRBOX4
- MGC12518
- ZNF528
- ZNF283
- ZSCAN30
- ZNF709
- ZNF510
- ZNF471
- ZNF436
- ZNF433
- ZNF394
- ZNF324
- ZNF28
- ZNF256
- ZNF239
- ZNF180
- ZNF157
- ZNF112
- FIK
- DKFZp686B16128
- ZNF223
- ZNF267
- ZNF230
- ZNF274
- ZNF177
- ZNF780B
- ZNF443
- ZNF264
- POM121C
- ZNF595
- ZNF682
- ZNF43
- ZNF226
- ZNF525
- ZNF675
- ZNF91
- ZNF70
- ZNF697
- ZNF658B
- ZNF658
- ZNF587
- ZNF582
- ZNF502
- ZNF41
- ZNF285A
- ZNF260
- MZF1
- DKFZp434G1621
- DKFZp313M0722
- LOC101928664
- ZNF677
- ZNF669
- ZNF596
- ZNF
- ZNF599
- ZSCAN31
- ZNF852
- HZF36
- ZNF208
- ZNF773
- ZNF527
- ZNF720
- ZSCAN9
- ZSCAN23
- ZSCAN21
- ZSCAN16
- ZSCAN12
- ZNF883
- ZNF853
- ZNF786
- ZNF761
- ZNF681
- ZNF665
- ZNF627
- ZNF493
- ZNF483
- ZNF45
- ZNF317
- ZNF286B
- ZNF266
- ZNF232
- ZNF213
- ZNF205
- ZKSCAN1
- ZFP41
- RhitH
- KIAA1829
- HZF11
- DKFZp761O1618
- DKFZp686H10254
- DKFZp666M039
- DKFZp666C237
- ZNF649
- ZFP90
- ZNF506
- ZNF583
- ZNF841
- ZNF514
- ZNF354B
- ZNF540
- ZNF667
- ZNF878
- ZNF846
- ZNF778
- ZNF146
- ZNF664
- ZNF500
- ZNF419
- ZNF84
- ZNF726
- ZNF195
- ZSCAN29
- ZSCAN10
- ZNF891
- ZNF85
- ZNF799
- ZNF718
- ZNF676
- ZNF670
- ZNF558
- ZNF37A
- ZNF358
- ZNF323
- ZFS-1
- ZFP14
- ZF6
- Nbla00121
- GLI4
- DKFZp686K03205
- DKFZp686D2168
- DKFZp434G1930
- ZNF420
- ZNF169
- ZNF432
- ZNF34
- ZNF350
- ZNF263
- ZNF221
- ZNF227
- ZNF430
- ZNF135
- ZNF577
- ZNF780A
- ZNF774
- ZNF695
- ZNF662
- ZNF585B
- ZNF345
- ZNF251
- ZNF615
- ZNF551
- ZNF607
- ZNF222
- ZNF845
- ZNF12
- ZFP30
- ZNF700
- ZNF426
- ZNF548
- zf30
- ZNF840
- ZNF823
- ZNF732
- ZNF672
- ZNF668
- ZNF605
- ZNF584
- ZNF492
- ZNF484
- ZNF468
- ZNF442
- ZNF425
- ZNF343
- ZNF136
- ZNF10
- ZKSCAN2
- DKFZp686G16228
- ZNF724P
- ZNF33A
- ZNF793
- ZNF616
- ZNF808
- ZNF791
- ZNF529
- ZNF300
- ZNF140
- ZNF93
- ZNF850
- ZNF35
- ZNF329
- ZNF304
- HKR1
- ZNF766
- ZNF90
- ZNF707
- ZNF569
- ZNF429
- ZNF550
- ZNF431
- ZNF701
- ZNF836
- ZNF782
- ZNF768
- ZNF729
- ZNF708
- ZNF691
- ZNF674
- ZNF566
- ZNF56
- ZNF556
- ZNF491
- ZNF480
- ZNF441
- ZNF396
- ZNF334
- ZNF287
- ZKSCAN8
- HZF40
- HZF30
- HZF14
- DKFZp686O111
- DKFZp686M04222
- DKFZp572F2170
- ZNF705A
- ZNF485
- ZNF273
- ZNF98
- ZNF23
- ZNF66
- ZNF844
- ZNF547
- ZNF101
- ZNF181
- ZNF888
- ZNF614
- ZNF613
- ZNF572
- ZNF354A
- ZNF229
- ZNF383
- ZNF324B
- ZNF714
- ZNF606
- ZNF33B
- ZNF763
- ZNF133
- ZNF567
- ZNF7
- ZNF248
- ZSCAN25
- ZNF835
- ZNF813
- ZNF73
- ZNF498
- ZNF473
- ZNF449
- ZNF382
- ZNF322
- ZNF254
- ZNF121
- ZFP37
- RBAK
- DKFZp686J1732
- ZNF816
- ZNF282
- ZNF571
- ZNF585A
- ZNF554
- ZNF32
- ZFP1
- ZNF501
- ZNF776
- ZNF20
- ZNF302
- ZNF546
- ZNF3
- ZNF728
- ZNF275
- ZNF737
- ZNF619
- ZNF235
- ZSCAN5B
- ZNF879
- ZNF814
- ZNF771
- ZNF713
- ZNF689
- ZNF586
- ZNF563
- ZNF470
- ZNF418
- ZNF204
- ZNF197
- ZNF174
- ZNF14
- ZNF117
- ZIM3
- ZFP62
- ZFP2
- ZBTB24
- E4F1
- DKFZp762K012
- ZNF565
- ZNF625
- ZNF561
- ZNF564
- ZNF16
- DKFZp547L155
- ZNF684
- ZNF570
- ZNF337
- ZNF189
- ZNF19
- ZIK1
- ZNF26
- ZNF100
- ZNF2
- ZNF331
- ZSCAN5C
- ZSCAN5A
- ZSCAN32
- ZNF812
- ZNF781
- ZNF75D
- ZNF75CP
- ZNF630
- ZNF560
- ZNF490
- ZNF439
- ZNF397
- ZNF268
- ZNF22
- ZNF200
- ZNF165
- ZKSCAN4
- HZF41
- DKFZp451F083
- ZNF461
- ZNF250
- ZNF124
- ZNF138
- ZNF416
- ZNF81
- ZNF880
- ZNF562
- ZNF8
- ZNF271
- ZNF182
- ZNF417
- ZNF805
- ZNF568
- ZNF460
- ZNF286A
- ZNF134
- ZSCAN26
- ZNF99
- ZNF92
- ZNF806
- ZNF79
- ZNF717
- ZNF716
- ZNF699
- ZNF671
- ZNF626
- ZNF623
- ZNF620
- ZNF610
- ZNF587B
- ZNF549
- ZNF355P
- ZNF25
- ZNF215
- ZNF114
- TIPUH1
- MST154
- FEZF2
- DKFZp686N14223
- DKFZp686H20223
- DKFZp571N1833
- DKFZp570I0164
- ZFP28
- ZNF479
- ZNF833P
- ZNF679
- ZNF17
- ZFP92
- ZNF160
- ZKSCAN7
- ZNF486
- ZSCAN4
- ZNF876P
- ZNF785
- ZNF749
- ZNF727
- ZNF628
- ZNF398
- ZNF319
- ZNF184
- ZNF175
- ZNF132
- HZF17
- HKR3
- GZF1
- ZNF440
- ZNF253
- ZNF578
- ZNF600
- ZNF543
- ZNF530
- ZNF214
- ZFP112
- ZNF678
- smap-7
- ZNF747
- ZNF726P1
- ZNF705G
- ZNF648
- ZNF487
- ZNF107
- ZKSCAN3
- ZBTB49
- ZBTB14
- OSR2
- FEZF1
- ZNF44
- ZNF629
- ZNF167
- ZBTB17
- ZNF333
- ZNF705F
- ZNF705E
- ZNF705D
- ZNF705B
- ZNF611
- ZNF557
- ZNF552
- ZNF445
- ZNF408
- ZNF354C
- ZNF347
- ZNF316
- ZNF311
- ZNF30
- ZNF18
- MYNN
- GD
- ZNF624
- ZNF74
- ZNF594
- ZNF772
- ZNF730
- ZNF69
- ZNF454
- ZNF77
- ZNF517
- ZNF211
- ZNF72
- ZSCAN22
- ZNF735
- ZNF702P
- ZNF641
- ZNF621
- ZNF444
- ZNF362
- ZNF202
- ZNF148
- ZFP82
- ZFP69
- WT1
- SNAI2
- REPIN1
- HZF28
- GFI1
- ZNF829
- ZNF765
- ZNF736
- ZNF534
- PRDM5
- DKFZp686C13142
- ZNF76
- ZNF860
- ZNF643
- ZNF574
- ZNF384
- ZNF143
- ZFP95
- ZFP69B
- ZBTB41
- SCRT2
- FP972
- DKFZp564M2178
- ZNF788
- ZNF660
- ZNF555
- ZKSCAN5
- DKFZp686L0787
- ZNF837
- ZNF777
- ZNF764
- ZNF680
- ZNF513
- ZNF410
- ZNF404
- ZBTB48
- PRDM6
- GFI1B
- AVGR8
- ZNF80
- ZNF652
- ZSCAN5D
- ZNF710
- ZNF57
- ZNF298
- ZBTB47
- SCRT1
- PRDM15
- PRDM1
- MECOM
- EVI1
- DKFZp666P0310
- ZNF75A
- PRDM10
- ZBTB16
- BCL6
- ZSCAN20
- LOC126295
- ZNF784
- ZNF526
- ZNF467
- ZNF366
- ZNF281
- ZNF137P
- PRDM16
Pseudogenes.org Pseudogenes for ZNF589 Gene
Variants for ZNF589 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000076173 | -- | 48,271,649(+) | GGTGC(A/G)TTTAC | utr-variant-3-prime | |
| rs1000096079 | -- | 48,263,703(+) | GCAGT(G/T)AGCTG | intron-variant | |
| rs1000116200 | -- | 48,258,818(+) | TGTGC(A/G)GTCTG | intron-variant | |
| rs1000166995 | -- | 48,252,624(+) | TTTTT(-/C)TTTTT | intron-variant | |
| rs1000252678 | -- | 48,258,266(+) | AGGCA(C/T)CTCTT | intron-variant |
Residual Variation Intolerance Score:
81.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.79;
73.64% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ZNF589 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF589 Gene
Disorders for ZNF589 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| kleefstra syndrome |
|
|
Search ZNF589 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ZNF589
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ZNF589
No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF589 Gene
Publications for ZNF589 Gene
- SZF1: a novel KRAB-zinc finger gene expressed in CD34+ stem/progenitor cells. (PMID: 10029171) Liu C. … Small D. (Exp. Hematol. 1999) 2 3 4 22 64
- Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PMID: 23665872) Wang W. … Huang Z. (Cell. Mol. Life Sci. 2013) 3 4 64
- The stem cell zinc finger 1 (SZF1)/ZNF589 protein has a human-specific evolutionary nucleotide DNA change and acts as a regulator of cell viability in the hematopoietic system. (PMID: 26738774) Venturini L. … Ganser A. (Exp. Hematol. 2016) 3 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
Products for ZNF589 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ZNF589
- Origene Custom Protein Services for ZNF589
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ZNF589
- Browse OriGene Inhibitory RNA Products For ZNF589
- OriGene qPCR primer pairs and template standards for ZNF589
- OriGene qPCR primer pairs for ZNF589
- OriGene CRISPR knockouts for ZNF589
- OriGene ORF clones in human for ZNF589
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ZNF589
- GenScript: Next-day shipping cDNA ORF clone for ZNF589 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ZNF589
- GenScript Custom Assay Services for ZNF589
- GenScript Custom overexpressing Cell Line Services for ZNF589
- GenScript: Design CRISPR guide RNA sequences for ZNF589
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ZNF589
- Sino Biological Human cDNA Clone for ZNF589
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for ZNF589
- Novus Biologicals proteins for ZNF589
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for ZNF589
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Invitrogen Antibodies for ZNF589
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Search GeneTex for Antibodies for ZNF589
- Search GeneTex for Proteins for ZNF589
- ViGene Biosciences adenoviral particle packaged cDNA for ZNF589 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ZNF589 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ZNF589 gene
- Search ViGene Biosciences for ZNF589
- Horizon Cell Lines for ZNF589
- Cyagen custom Knockout/knockin (KOKI) mouse models for ZNF589
- VectorBuilder custom plasmid, inducible vectors for ZNF589
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZNF589
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ZNF589 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer