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Aliases for ZNF587B Gene

Aliases for ZNF587B Gene

  • Zinc Finger Protein 587B 2 3 5

External Ids for ZNF587B Gene

Previous GeneCards Identifiers for ZNF587B Gene

  • GC19P058334

Summaries for ZNF587B Gene

GeneCards Summary for ZNF587B Gene

ZNF587B (Zinc Finger Protein 587B) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF418.

UniProtKB/Swiss-Prot for ZNF587B Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF587B Gene

Genomics for ZNF587B Gene

Regulatory Elements for ZNF587B Gene

Enhancers for ZNF587B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G058580 1.2 Ensembl ENCODE 16.3 +761.5 761524 1.5 PKNOX1 ATF1 CREB3L1 GTF3C2 ZNF766 ZNF143 KDM4B REST ZNF592 MEF2D TRIM28 ZNF587B ZNF324B ZNF134 ZNF587 CENPBD1P1 ZBTB45 UBE2M CHMP2A ZNF417
GH19G057809 1.7 FANTOM5 ENCODE dbSUPER 11.2 -6.5 -6524 7.2 CREB3L1 MLX ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF134 ZNF264 TRIM28 ZNF17 ZNF417 ZNF256 ZNF543 ZNF805 ZNF606 ZNF773
GH19G057099 0.9 ENCODE 16.3 -720.4 -720414 0.2 ELF3 CBX3 PTBP1 TBL1XR1 ARID4B ZNF48 ZSCAN9 RAD21 GTF3C2 ZNF143 ZNF805 ZNF264 ZNF587B ZNF134 ZNF587 ZNF548 ZNF417 ZNF543 ZIM3 ZNF550
GH19G058325 1.2 ENCODE 10.8 +507.1 507130 3.6 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ZNF134 ZNF256 ZNF549 ZNF17 ZNF548 ZNF606 ZNF773 TRIM28 ZNF417 ZNF551
GH19G058001 1.1 ENCODE 11.5 +182.8 182822 2.2 HDGF HNRNPUL1 CREB3L1 MLX AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 LOC100128398 TRIM28 ZNF417 ZNF606 ZNF548 ZNF264 ZNF134 ZNF773 ZNF17 ZNF256
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF587B on UCSC Golden Path with GeneCards custom track

Promoters for ZNF587B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111829 159 1801 PKNOX1 FOXA2 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for ZNF587B Gene

Chromosome:
19
Start:
57,819,741 bp from pter
End:
57,846,238 bp from pter
Size:
26,498 bases
Orientation:
Plus strand

Genomic View for ZNF587B Gene

Genes around ZNF587B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF587B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF587B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF587B Gene

Proteins for ZNF587B Gene

  • Protein details for ZNF587B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E7ETH6-Z587B_HUMAN
    Recommended name:
    Zinc finger protein 587B
    Protein Accession:
    E7ETH6
    Secondary Accessions:
    • B4DR41

    Protein attributes for ZNF587B Gene

    Size:
    402 amino acids
    Molecular mass:
    45541 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF587B Gene

Post-translational modifications for ZNF587B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF587B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF587B Gene

Domains & Families for ZNF587B Gene

Gene Families for ZNF587B Gene

Protein Domains for ZNF587B Gene

Graphical View of Domain Structure for InterPro Entry

E7ETH6

UniProtKB/Swiss-Prot:

Z587B_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF587B: view

No data available for Suggested Antigen Peptide Sequences for ZNF587B Gene

Function for ZNF587B Gene

Molecular function for ZNF587B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF587B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF587B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF587B Gene

Localization for ZNF587B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF587B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF587B gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF587B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF587B: view

Pathways & Interactions for ZNF587B Gene

SuperPathways for ZNF587B Gene

No Data Available

Interacting Proteins for ZNF587B Gene

Gene Ontology (GO) - Biological Process for ZNF587B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF587B: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF587B Gene

Drugs & Compounds for ZNF587B Gene

No Compound Related Data Available

Transcripts for ZNF587B Gene

mRNA/cDNA for ZNF587B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF587B Gene

Zinc finger protein 587B:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF587B Gene

No ASD Table

Relevant External Links for ZNF587B Gene

GeneLoc Exon Structure for
ZNF587B
ECgene alternative splicing isoforms for
ZNF587B

Expression for ZNF587B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF587B Gene

Protein differential expression in normal tissues from HIPED for ZNF587B Gene

This gene is overexpressed in Esophagus (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF587B Gene



Protein tissue co-expression partners for ZNF587B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF587B Gene:

ZNF587B

SOURCE GeneReport for Unigene cluster for ZNF587B Gene:

Hs.658251
genes like me logo Genes that share expression patterns with ZNF587B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF587B Gene

Orthologs for ZNF587B Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF587B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF587B 35
  • 48 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 38 (a)
OneToMany
Species where no ortholog for ZNF587B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF587B Gene

ENSEMBL:
Gene Tree for ZNF587B (if available)
TreeFam:
Gene Tree for ZNF587B (if available)

Paralogs for ZNF587B Gene

(527) SIMAP similar genes for ZNF587B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF587B: view

Variants for ZNF587B Gene

Sequence variations from dbSNP and Humsavar for ZNF587B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000292881 -- 57,830,984(+) TGGTT(A/G)CAGGA intron-variant
rs1000293255 -- 57,841,976(+) ACTAC(A/G)GAAAG intron-variant
rs1000457341 -- 57,837,138(+) ACTCT(A/C)TTCAT intron-variant
rs1000574512 -- 57,838,293(+) AAAAA(-/T)TAAAA intron-variant
rs1000636782 -- 57,831,747(+) TCACC(C/T)AGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF587B Gene

Variant ID Type Subtype PubMed ID
dgv3686n100 CNV gain 25217958
esv2763213 CNV gain 21179565
esv3644912 CNV loss 21293372
esv3893258 CNV gain 25118596
nsv1055845 CNV gain 25217958
nsv1066059 CNV gain 25217958
nsv1134816 CNV deletion 24896259
nsv7311 OTHER inversion 18451855
nsv961251 CNV duplication 23825009

Variation tolerance for ZNF587B Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF587B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF587B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF587B Gene

Disorders for ZNF587B Gene

Relevant External Links for ZNF587B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF587B

No disorders were found for ZNF587B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF587B Gene

Publications for ZNF587B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 4 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64

Products for ZNF587B Gene

Sources for ZNF587B Gene

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