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Aliases for ZNF587B Gene

Aliases for ZNF587B Gene

  • Zinc Finger Protein 587B 2 3

External Ids for ZNF587B Gene

Previous GeneCards Identifiers for ZNF587B Gene

  • GC19P058334

Summaries for ZNF587B Gene

GeneCards Summary for ZNF587B Gene

ZNF587B (Zinc Finger Protein 587B) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF17.

UniProtKB/Swiss-Prot for ZNF587B Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF587B Gene

Genomics for ZNF587B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF587B Gene

Chromosome:
19
Start:
57,819,741 bp from pter
End:
57,846,238 bp from pter
Size:
26,498 bases
Orientation:
Plus strand

Genomic View for ZNF587B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF587B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF587B Gene

No data available for Regulatory Elements for ZNF587B Gene

Proteins for ZNF587B Gene

  • Protein details for ZNF587B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E7ETH6-Z587B_HUMAN
    Recommended name:
    Zinc finger protein 587B
    Protein Accession:
    E7ETH6
    Secondary Accessions:
    • B4DR41

    Protein attributes for ZNF587B Gene

    Size:
    402 amino acids
    Molecular mass:
    45541 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF587B Gene

Proteomics data for ZNF587B Gene at MOPED

Post-translational modifications for ZNF587B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF587B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF587B Gene

Domains & Families for ZNF587B Gene

Gene Families for ZNF587B Gene

Protein Domains for ZNF587B Gene

Graphical View of Domain Structure for InterPro Entry

E7ETH6

UniProtKB/Swiss-Prot:

Z587B_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 7 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 7 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF587B: view

No data available for Suggested Antigen Peptide Sequences for ZNF587B Gene

Function for ZNF587B Gene

Molecular function for ZNF587B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF587B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF587B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF587B Gene

Localization for ZNF587B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF587B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF587B Gene COMPARTMENTS Subcellular localization image for ZNF587B gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF587B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005654 nucleoplasm IBA --
genes like me logo Genes that share ontologies with ZNF587B: view

Pathways & Interactions for ZNF587B Gene

SuperPathways for ZNF587B Gene

No Data Available

Interacting Proteins for ZNF587B Gene

Gene Ontology (GO) - Biological Process for ZNF587B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0045892 negative regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF587B: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF587B Gene

Drugs & Compounds for ZNF587B Gene

No Compound Related Data Available

Transcripts for ZNF587B Gene

mRNA/cDNA for ZNF587B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF587B Gene

Zinc finger protein 587B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF587B Gene

No ASD Table

Relevant External Links for ZNF587B Gene

GeneLoc Exon Structure for
ZNF587B
ECgene alternative splicing isoforms for
ZNF587B

Expression for ZNF587B Gene

mRNA expression in normal human tissues for ZNF587B Gene

Protein differential expression in normal tissues from HIPED for ZNF587B Gene

This gene is overexpressed in Esophagus (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF587B Gene



SOURCE GeneReport for Unigene cluster for ZNF587B Gene Hs.658251

genes like me logo Genes that share expression patterns with ZNF587B: view

Protein tissue co-expression partners for ZNF587B Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF587B Gene

Orthologs for ZNF587B Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF587B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 36
  • 38 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ZNF587B 36
  • 48 (a)
OneToOne
Species with no ortholog for ZNF587B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF587B Gene

ENSEMBL:
Gene Tree for ZNF587B (if available)
TreeFam:
Gene Tree for ZNF587B (if available)

Paralogs for ZNF587B Gene

(527) SIMAP similar genes for ZNF587B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF587B: view

Variants for ZNF587B Gene

Sequence variations from dbSNP and Humsavar for ZNF587B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs12789 -- 57,845,926(-) CAGCG(C/T)TGCAA utr-variant-3-prime
rs384687 -- 57,834,083(+) cacag(C/G)acatg intron-variant
rs439490 -- 57,834,529(+) GTTGA(C/T)AGTGT intron-variant
rs1047128 -- 57,846,178(+) TATGA(C/T)GGAGT utr-variant-3-prime
rs1129340 -- 57,845,900(+) GAGGC(A/G)GAGGT utr-variant-3-prime

Variation tolerance for ZNF587B Gene

Residual Variation Intolerance Score: 93.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF587B Gene

HapMap Linkage Disequilibrium report
ZNF587B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF587B Gene

Disorders for ZNF587B Gene

Relevant External Links for ZNF587B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF587B
genes like me logo Genes that share disorders with ZNF587B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF587B Gene

Publications for ZNF587B Gene

  1. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  4. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 67
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 67

Products for ZNF587B Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF587B
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF587B
    • Block miRNA regulation of ZNF587B using miScript Target Protectors

    Sources for ZNF587B Gene

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