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Aliases for ZNF587 Gene

Aliases for ZNF587 Gene

  • Zinc Finger Protein 587 2 3 5
  • Zinc Finger Protein Zfp6 3
  • ZF6 3

External Ids for ZNF587 Gene

Previous GeneCards Identifiers for ZNF587 Gene

  • GC19P063054
  • GC19P063055
  • GC19P058361
  • GC19P054672
  • GC19P058333

Summaries for ZNF587 Gene

GeneCards Summary for ZNF587 Gene

ZNF587 (Zinc Finger Protein 587) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF17.

UniProtKB/Swiss-Prot for ZNF587 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF587 Gene

Genomics for ZNF587 Gene

Regulatory Elements for ZNF587 Gene

Enhancers for ZNF587 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF587 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF587 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF587 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF587 gene promoter:

Genomic Location for ZNF587 Gene

Chromosome:
19
Start:
57,849,813 bp from pter
End:
57,865,123 bp from pter
Size:
15,311 bases
Orientation:
Plus strand

Genomic View for ZNF587 Gene

Genes around ZNF587 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF587 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF587 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF587 Gene

Proteins for ZNF587 Gene

  • Protein details for ZNF587 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SQ5-ZN587_HUMAN
    Recommended name:
    Zinc finger protein 587
    Protein Accession:
    Q96SQ5
    Secondary Accessions:
    • A0AV72
    • G3V0H5
    • Q6ZMK8

    Protein attributes for ZNF587 Gene

    Size:
    575 amino acids
    Molecular mass:
    65622 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF587 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF587 Gene

Proteomics data for ZNF587 Gene at MOPED

Post-translational modifications for ZNF587 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF587 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF587 Gene

Domains & Families for ZNF587 Gene

Gene Families for ZNF587 Gene

Protein Domains for ZNF587 Gene

Suggested Antigen Peptide Sequences for ZNF587 Gene

Graphical View of Domain Structure for InterPro Entry

Q96SQ5

UniProtKB/Swiss-Prot:

ZN587_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF587: view

Function for ZNF587 Gene

Molecular function for ZNF587 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF587: view

Animal Model Products

CRISPR Products

miRNA for ZNF587 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF587 Gene

Localization for ZNF587 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF587 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF587 Gene COMPARTMENTS Subcellular localization image for ZNF587 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF587 Gene

Pathways & Interactions for ZNF587 Gene

SuperPathways for ZNF587 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF587: view

Pathways by source for ZNF587 Gene

2 Reactome pathways for ZNF587 Gene

Gene Ontology (GO) - Biological Process for ZNF587 Gene

None

No data available for SIGNOR curated interactions for ZNF587 Gene

Drugs & Compounds for ZNF587 Gene

No Compound Related Data Available

Transcripts for ZNF587 Gene

Unigene Clusters for ZNF587 Gene

Zinc finger protein 587:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF587 Gene

No ASD Table

Relevant External Links for ZNF587 Gene

GeneLoc Exon Structure for
ZNF587
ECgene alternative splicing isoforms for
ZNF587

Expression for ZNF587 Gene

mRNA expression in normal human tissues for ZNF587 Gene

SOURCE GeneReport for Unigene cluster for ZNF587 Gene Hs.642598

genes like me logo Genes that share expression patterns with ZNF587: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF587 Gene

Orthologs for ZNF587 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF587 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 36
  • 52 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
ManyToMany
-- 36
  • 96 (a)
ManyToMany
Species with no ortholog for ZNF587:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF587 Gene

ENSEMBL:
Gene Tree for ZNF587 (if available)
TreeFam:
Gene Tree for ZNF587 (if available)

Paralogs for ZNF587 Gene

(518) SIMAP similar genes for ZNF587 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNF587 Gene

genes like me logo Genes that share paralogs with ZNF587: view

Variants for ZNF587 Gene

Sequence variations from dbSNP and Humsavar for ZNF587 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs13344164 -- 57,853,735(+) AGTTG(C/G)TGCCA intron-variant
rs66515265 -- 57,863,854(+) CCTGG(A/C)CAATA utr-variant-3-prime
rs28369370 -- 57,850,082(+) TGTGG(C/T)GCCTT intron-variant
rs1061990 -- 57,864,896(-) AGGCT(A/G)GAGTG utr-variant-3-prime
rs1061996 -- 57,865,116(-) AATCT(G/T)TTGTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF587 Gene

Variant ID Type Subtype PubMed ID
nsv912528 CNV Gain 21882294
nsv912529 CNV Loss 21882294
dgv4029n71 CNV Gain 21882294
nsv7311 OTHER Inversion 18451855
esv2656978 CNV Deletion 23128226

Variation tolerance for ZNF587 Gene

Residual Variation Intolerance Score: 88.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.74; 73.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF587 Gene

Disorders for ZNF587 Gene

Relevant External Links for ZNF587

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF587

No disorders were found for ZNF587 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF587 Gene

Publications for ZNF587 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Computer sequence analysis of human highly conserved zinc finger modules. (PMID: 10520746) Petroni D. … Comi P. (DNA Seq. 1998) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PMID: 18854154) KAPnig R. … Chanda S.K. (Cell 2008) 3
  5. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PMID: 17474147) Wu C. … Li S.S. (Proteomics 2007) 3

Products for ZNF587 Gene

Sources for ZNF587 Gene

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