ZNF587 Gene
protein-coding GIFtS: 43
GCID: GC19P058333
|
|
zinc finger protein 587
| |
Aliases
for ZNF587 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 5871 2 | | ZF61 2 | | FLJ147101 | | FLJ208131 | | UBF-Fl1 | | Zinc Finger Protein Zfp62 |
Export aliases for ZNF587 gene to outside databasesPrevious GC identifers: GC19P063054 GC19P063055 GC19P058361 GC19P054672 |
Summaries
for ZNF587 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN587_HUMAN, Q96SQ5Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF587 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF587 gene promoter:
HTF XBP-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF587
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF587 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43ZNF587 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P058333: view genomic region
(about GC identifiers)
Start:
|
58,331,099 bp from pter |
End:
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58,376,487 bp from pter |
Size:
|
45,389 bases |
Orientation:
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plus strand |
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Proteins
for ZNF587 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN587_HUMAN, Q96SQ5 (See
protein sequence)Recommended Name: Zinc finger protein 587 Size: 575 amino acids; 65622 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: A0AV72 Q6ZMK8Explore the universe of human proteins at neXtProt for ZNF587: NX_Q96SQ5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96SQ5
ZNF587 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001191746.1 NP_116217.1
ENSEMBL proteins: ENSP00000393865 ENSP00000345479 ENSP00000406999 ENSP00000350696 ENSP00000392410 Reactome Protein details: Q96SQ5
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF587 for ontologies About GeneDecksing
ZNF587 Antibody Products:
Assay Products for ZNF587: |
Protein
Domains /
Families
for ZNF587 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF587 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96SQ5ProtoNet protein and cluster: Q96SQ5 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN587_HUMAN, Q96SQ5Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 13 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF587 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN587_HUMAN, Q96SQ5Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF587
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF587
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF587 (NM_032828) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF587 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF587 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF587 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF587 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF587 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF587
ZNF587 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF587
2 Interacting proteins for ZNF587 (Q96SQ53) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF587 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF587 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF587
Search CenterWatch for drugs/clinical trials and news about ZNF587 / ZN587
|
Transcripts
for ZNF587 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF587 gene (2 alternative transcripts): NM_001204817.1 NM_032828.3 Unigene Clusters for ZNF587: Zinc finger protein 587 Hs.642598 [show with all ESTs], Hs.658251 [show with all ESTs]Unigene Representative Sequences: BF345117, NM_0328286 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000423137 ENST00000484707 ENST00000339656(uc002qql.3 uc010yhk.2)
ENST00000419854(uc002qqb.2 uc010yhh.2 uc021vco.1 uc002qqi.2 uc002qqj.1)
ENST00000316462 ENST00000442832(uc021vcn.1 uc021vcp.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF587
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF587
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF587 (NM_032828) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF587 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF587 |
Additional cDNA sequence: AK000820.1 AK026676.1 AK097992.1 AK160374.1 BC011810.2 BC017219.2 BC095898.1 BC126237.1 BC126239.1 BC144112.1 BC144113.1 24/32 DOTS entries (see all 32): DT.91653802 DT.86821299 DT.101978126 DT.106466 DT.97862743 DT.121503767 DT.100773927 DT.121503633 DT.100040721 DT.75117038 DT.86849824 DT.91749895 DT.100773930 DT.102845499 DT.121503841 DT.95193099 DT.100685851 DT.102834404 DT.102843466 DT.205752 DT.95311029 DT.99996068 DT.100683666 DT.100689001 20 AceView cDNA sequences: AA548930 BQ889777 BC041660 BC051325 BQ069130 AA554212 AW849952 AW372280 BF849477 T41403 AI655109 AI689080 BC011243 BM541859 AA488104 BP341661 BQ673176 NM_017652 BF345117 NM_032828
GeneLoc Exon Structure
|
Expression
for ZNF587 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF587 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAAATGTC
About this image
See ZNF587 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF587
SOURCE GeneReport for Unigene clusters: Hs.642598 Hs.658251
SABiosciences Custom PCR Arrays for ZNF587
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF587
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF587 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF587 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF587 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF587 |
Orthologs
for ZNF587 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF587 (if available)
TreeFam Gene Tree for ZNF587 (if available) |
Paralogs
for ZNF587 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF587 gene
- ZNF4171 2 ZNF5492 ZNF2112 ZNF7922 ZNF7492 ZNF5512 ZNF7762 ZNF5472
- ZNF172 ZNF4162 ZNF5482 ZNF3042 ZNF7732 ZNF1322 ZIK12 ZNF6712
- ZNF1342 ZNF4182 ZNF2562 ZNF1542 ZNF5522 ZNF7722 ZNF5302 ZNF4192
18/516 SIMAP similar genes for ZNF587 using alignment to 3 protein entries: ZN587_HUMAN (see all proteins)
(see all similar genes):ZNF417 ZNF78L1 ZNF818P HZF36 kr-znf3 DKFZp313M0722
FLJ00301 ZNF323 ZNF774 ZNF418 ZNF146 ZNF696
ZSCAN23 DKFZp686M04222 ZFP41 ZNF32 ZSCAN22 ZSCAN30
ZNF587 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF587
PGOHUM00000237978
|
Genomic Variants
for ZNF587 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF587 (58331099 - 58376487 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF587: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF587 |
|
Disorders
/ Diseases
for ZNF587 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF587 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF587 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF587) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Computer sequence analysis of human highly conserved zinc finger modules. (PubMed id 10520746)1, 3 Petroni D.... Comi P. (1998)
- Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF587 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF587 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF587 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF587 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF587 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF587 gene:
Search GeneIP for patents involving ZNF587
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF587 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF587 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF587 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF587 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF587 | | OriGene 3'-UTR Clone for ZNF587 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF587 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF587 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF587 | | OriGene Custom Protein Services for ZNF587 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF587 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF587 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF587 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF587 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF587 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF587 |
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 |  |  |  | |
| | | | Search Tocris compounds for ZNF587 |
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 | | | ZNF587 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF587 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF587 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF587 |
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