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Aliases for ZNF586 Gene

Aliases for ZNF586 Gene

  • Zinc Finger Protein 586 2 3 5

External Ids for ZNF586 Gene

Previous GeneCards Identifiers for ZNF586 Gene

  • GC19P062973
  • GC19P062974
  • GC19P058281
  • GC19P054592

Summaries for ZNF586 Gene

GeneCards Summary for ZNF586 Gene

ZNF586 (Zinc Finger Protein 586) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF665.

UniProtKB/Swiss-Prot for ZNF586 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF586 Gene

Genomics for ZNF586 Gene

Regulatory Elements for ZNF586 Gene

Enhancers for ZNF586 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F057809 1.2 FANTOM5 ENCODE 14 +43.6 43566 7.2 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF134 ZNF805 ZNF264 TRIM28 ZNF256 ZNF543 ZNF417 ZNF773 ZNF17 ENSG00000269867
GH19F057800 0.8 Ensembl ENCODE 13.7 +31.3 31318 0.6 JUND ZKSCAN1 ZNF586 ZNF587 ZNF552 PIR55332
GH19F057773 0.2 ENCODE 13.1 +4.0 4036 0.2 ZNF586 ZNF671 PIR55332
GH19F057726 0.2 ENCODE 13.1 -42.1 -42122 1.4 PKNOX1 NFRKB ZBTB40 YY1 EGR1 CBX5 ELK1 ZNF143 REST KAT8 ZNF586 ZNF671 PIR59096
GH19F057769 0.9 ENCODE 12.2 +0.6 572 2.4 ATF1 PKNOX1 CREB3L1 WRNIP1 SIN3A ETS1 YY1 ELK1 ZNF143 FOS ZNF814 ZNF776 ZNF586 ZNF805 ZNF671 ZNF417 ZNF154 ZNF256 RPL19P19 ZSCAN4
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF586 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF586 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000349221 448 1801 ATF1 PKNOX1 CREB3L1 WRNIP1 SIN3A ETS1 YY1 ELK1 ZNF143 FOS

Transcription factor binding sites by QIAGEN in the ZNF586 gene promoter:

Genomic Location for ZNF586 Gene

Chromosome:
19
Start:
57,769,652 bp from pter
End:
57,819,939 bp from pter
Size:
50,288 bases
Orientation:
Plus strand

Genomic View for ZNF586 Gene

Genes around ZNF586 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF586 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF586 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF586 Gene

Proteins for ZNF586 Gene

  • Protein details for ZNF586 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXT0-ZN586_HUMAN
    Recommended name:
    Zinc finger protein 586
    Protein Accession:
    Q9NXT0
    Secondary Accessions:
    • A0JLV8
    • A8MY63
    • B3KTS9
    • E7ERT1
    • G3XAH3

    Protein attributes for ZNF586 Gene

    Size:
    402 amino acids
    Molecular mass:
    46413 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA90930.1; Type=Frameshift; Positions=145; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF586 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF586 Gene

Post-translational modifications for ZNF586 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF586 Gene

No data available for DME Specific Peptides for ZNF586 Gene

Domains & Families for ZNF586 Gene

Gene Families for ZNF586 Gene

Protein Domains for ZNF586 Gene

Suggested Antigen Peptide Sequences for ZNF586 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NXT0

UniProtKB/Swiss-Prot:

ZN586_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF586: view

Function for ZNF586 Gene

Molecular function for ZNF586 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF586 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF586: view
genes like me logo Genes that share phenotypes with ZNF586: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF586 Gene

Localization for ZNF586 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF586 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF586 Gene COMPARTMENTS Subcellular localization image for ZNF586 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF586 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF586: view

Pathways & Interactions for ZNF586 Gene

SuperPathways for ZNF586 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF586: view

Pathways by source for ZNF586 Gene

2 Reactome pathways for ZNF586 Gene

Interacting Proteins for ZNF586 Gene

Gene Ontology (GO) - Biological Process for ZNF586 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF586: view

No data available for SIGNOR curated interactions for ZNF586 Gene

Transcripts for ZNF586 Gene

Unigene Clusters for ZNF586 Gene

Zinc finger protein 586:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF586 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1:
SP2: -
SP3: -
SP4: - -

Relevant External Links for ZNF586 Gene

GeneLoc Exon Structure for
ZNF586
ECgene alternative splicing isoforms for
ZNF586

Expression for ZNF586 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF586 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF586 Gene

This gene is overexpressed in Whole Blood (x6.1).

Protein differential expression in normal tissues from HIPED for ZNF586 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF586 Gene



Protein tissue co-expression partners for ZNF586 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF586 Gene:

ZNF586

SOURCE GeneReport for Unigene cluster for ZNF586 Gene:

Hs.625133
genes like me logo Genes that share expression patterns with ZNF586: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ZNF586 Gene

Orthologs for ZNF586 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF586 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF586 34 35
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 42 (a)
OneToMany
Species where no ortholog for ZNF586 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF586 Gene

ENSEMBL:
Gene Tree for ZNF586 (if available)
TreeFam:
Gene Tree for ZNF586 (if available)

Paralogs for ZNF586 Gene

(527) SIMAP similar genes for ZNF586 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF586: view

Variants for ZNF586 Gene

Sequence variations from dbSNP and Humsavar for ZNF586 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401255 -- 57,780,194(+) CTTGC(C/T)AGACT utr-variant-3-prime
rs10408253 -- 57,768,487(+) attgg(C/G)cagct upstream-variant-2KB
rs10419004 -- 57,780,479(+) ACAGA(A/G)TTCTT utr-variant-3-prime
rs111230485 -- 57,769,871(+) GGCGC(C/T)TGCTC reference, missense, utr-variant-5-prime
rs111592293 -- 57,767,748(+) ACTTT(A/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF586 Gene

Variant ID Type Subtype PubMed ID
dgv3686n100 CNV gain 25217958
esv2670311 CNV deletion 23128226
esv2719091 CNV deletion 23290073
esv3644910 CNV loss 21293372
esv7167 CNV loss 19470904
nsv1066059 CNV gain 25217958
nsv520155 CNV loss 19592680

Variation tolerance for ZNF586 Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF586 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF586

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF586 Gene

Disorders for ZNF586 Gene

Relevant External Links for ZNF586

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF586

No disorders were found for ZNF586 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF586 Gene

Publications for ZNF586 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3 64

Products for ZNF586 Gene

Sources for ZNF586 Gene

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