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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF586 Gene

protein-coding   GIFtS: 47
GCID: GC19P058281

Zinc Finger Protein 586

  Search for ZNF586
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 5861 2

External Ids:    HGNC: 259491   Entrez Gene: 548072   Ensembl: ENSG000000838287   UniProtKB: Q9NXT03   

Export aliases for ZNF586 gene to outside databases

Previous GC identifers: GC19P062973 GC19P062974 GC19P054592


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF586 Gene: 
ZNF586 (zinc finger protein 586) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF549.

UniProtKB/Swiss-Prot: ZN586_HUMAN, Q9NXT0
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF586 gene promoter:
         HTF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF586 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF586

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF586


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF586 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF586 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P058281:  view genomic region     (about GC identifiers)

Start:
58,281,020 bp from pter      End:
58,331,307 bp from pter
Size:
50,288 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN586_HUMAN, Q9NXT0 (See protein sequence)
Recommended Name: Zinc finger protein 586  
Size: 402 amino acids; 46413 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAA90930.1; Type=Frameshift; Positions=145;
Secondary accessions: A0JLV8 A8MY63 B3KTS9 E7ERT1 G3XAH3
Alternative splicing: 3 isoforms:  Q9NXT0-1   Q9NXT0-2   Q9NXT0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF586: NX_Q9NXT0

Explore proteomics data for ZNF586 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NXT0

  • ZNF586 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF586 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001070894.1  NP_001191743.1  NP_060122.2  

    ENSEMBL proteins: 
     ENSP00000375583   ENSP00000470397   ENSP00000471663   ENSP00000379458   ENSP00000472972  
     ENSP00000379454  
    Reactome Protein details: Q9NXT0
    Human Recombinant Protein Products for ZNF586: 
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    Cloud-Clone Corp. Proteins for ZNF586 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF586 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9NXT0

    ProtoNet protein and cluster: Q9NXT0

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN586_HUMAN, Q9NXT0
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF586 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN586_HUMAN, Q9NXT0
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF586 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF586:
     Increased 8N DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF586 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZNF586

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF586 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF586
        Generic Transcription Pathway
    Gene Expression



    ZNF586 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF586

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF586 (Q9NXT03 ENSP000003794584) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF586 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF586 (ZN586)

    Search CenterWatch for drugs/clinical trials and news about ZNF586 / ZN586

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF586 gene (3 alternative transcripts): 
    NM_001077426.2  NM_001204814.1  NM_017652.3  

    Unigene Cluster for ZNF586:

    Zinc finger protein 586
    Hs.625133  [show with all ESTs]
    Unigene Representative Sequence: NM_001204814
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391702(uc010euh.3 uc002qqf.2) ENST00000598885 ENST00000598183
    ENST00000396154(uc002qqd.3 uc002qqe.3) ENST00000599802 ENST00000396150

    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF586
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF586
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    Sirion Biotech Customized lentivirus for stable overexpression of ZNF586 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF586 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF586

    Additional mRNA sequence: 

    AB074270.1 AK000077.1 AK095993.1 AK300419.1 AK302151.1 BC027922.1 BC041660.1 BC051325.1 
    BC124558.1 

    16 DOTS entries:

    DT.100703582  DT.102834404  DT.431171  DT.121503642  DT.100021376  DT.40284649  DT.95260361  DT.121503760 
    DT.306533  DT.95342260  DT.91671501  DT.86851471  DT.100683666  DT.100751796  DT.100751797  DT.91799066 

    20 AceView cDNA sequences:

    BF849477 BC011243 T41403 BM541859 AA488104 AI689080 AA548930 AI655109 
    BQ889777 AW849952 BQ069130 BP341661 BC051325 AA554212 AW372280 BC041660 
    NM_017652 BF345117 NM_032828 BQ673176 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF586    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
    SP1:                                                      
    SP2:                    -                                 
    SP3:                    -                                 
    SP4:                    -     -                           


    ECgene alternative splicing isoforms for ZNF586

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF586 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGCTCCAA
    ZNF586 Expression
    About this image


    See ZNF586 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF586

    SOURCE GeneReport for Unigene cluster: Hs.625133
        SABiosciences Custom PCR Arrays for ZNF586
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF586

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF586 gene from 1/3 species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    ZNF5846
    zinc finger protein 584
    32(a)
    31(a)
    possible ortholog
    possible ortholog
    1(100616658-100633190)
    1(99519870-99527897)


    ENSEMBL Gene Tree for ZNF586 (if available)
    TreeFam Gene Tree for ZNF586 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF586 gene
    ZNF5492  ENSG000002695332  ZNF4172  ENSG000002681332  ENSG000002681072  ZNF4162  ZNF172  ZNF5482  
    ZNF587B2  ZNF7732  ZIK12  ZNF1342  ZNF6712  ZNF7722  ZNF5302  ZNF4192  
    ZNF5872  ZNF2112  ZNF7922  ZNF7492  ZNF5512  ENSG000002687502  ZNF7762  ZNF5472  
    ZNF5842  ENSG000002690262  ZNF3042  ZNF1322  ZNF4182  ZNF2562  ZNF5522  ZNF1542  
    ZNF8142  
    18/525 SIMAP similar genes for ZNF586 using alignment to 5 protein entries:     ZN586_HUMAN (see all proteins) (see all similar genes):
    ZNF776    ZNF814    HZF36    ZNF577    ZNF208    ZNF78L1
    ZNF808    ZSCAN16    ZNF418    ZFP41    ZNF24    FLJ00301
    DKFZp666C237    ZNF345    ZNF98    ZSCAN22    kr-znf3    MGC12518

    ZNF586 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF586
    PGOHUM00000263019


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/287 SNPs in ZNF586 are shown (see all 287)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1118381041,2
    C,F--58279026(+) AGGATA/GGTCTC 3 -- us2k12Minor allele frequency- G:0.33WA CSA 3
    rs1931181141,2
    C--58279028(+) GATGGC/TCTCGA 3 -- us2k10--------
    rs1854992271,2
    --58279151(+) GGCGCG/TGTGGC 3 -- us2k10--------
    rs1510835751,2
    --58279182(+) GCTCGC/GGGGGC 3 -- us2k10--------
    rs1176512961,2
    F--58279183(+) CTCGGG/TGGGCT 3 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1140543611,2
    C--58279431(+) CTAATA/GCATTA 3 -- us2k10--------
    rs1497953971,2
    --58279486(+) CATCAC/GCATCT 3 -- us2k10--------
    rs1881908981,2
    --58279590(+) TCCTGC/TGACTA 3 -- us2k10--------
    rs1468302281,2
    C--58279594(+) GTGACC/TAAGAA 3 -- us2k10--------
    rs781025151,2
    C,F--58279620(+) TGCAGC/TCGAGT 3 -- us2k11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for ZNF586 (58281020 - 58331307 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ZNF586:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2670311CNV Deletion23128226
    esv2719091CNV Deletion23290073
    nsv520155CNV Loss19592680
    nsv912529CNV Loss21882294
    esv7167CNV Loss19470904
    nsv912530CNV Gain21882294
    dgv4029n71CNV Gain21882294
    nsv912528CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF586 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF586)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    6. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54807 HGNC: 25949 AceView: ZNF586andZNF587 Ensembl:ENSG00000083828 euGenes: HUgn54807
    ECgene: ZNF586 H-InvDB: ZNF586

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF586 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF586 gene:
    Search GeneIP for patents involving ZNF586

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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