ZNF586 Gene
protein-coding GIFtS: 48
GCID: GC19P058281
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|
zinc finger protein 586
| |
Aliases
for ZNF586 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 5861 2 | | FLJ200701 |
Export aliases for ZNF586 gene to outside databasesPrevious GC identifers: GC19P062973 GC19P062974 GC19P054592 |
Summaries
for ZNF586 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN586_HUMAN, Q9NXT0Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF586 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF586 gene promoter:
HTF
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF586
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF586 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43ZNF586 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P058281: view genomic region
(about GC identifiers)
Start:
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58,280,997 bp from pter |
End:
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58,291,984 bp from pter |
Size:
|
10,988 bases |
Orientation:
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plus strand |
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Proteins
for ZNF586 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN586_HUMAN, Q9NXT0 (See
protein sequence)Recommended Name: Zinc finger protein 586 Size: 402 amino acids; 46413 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAA90930.1; Type=Frameshift; Positions=145;
Secondary accessions: A0JLV8 A8MY63 B3KTS9 E7ERT1 G3XAH3Alternative splicing: 3 isoforms: Q9NXT0-1 Q9NXT0-2 Q9NXT0-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF586: NX_Q9NXT0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NXT0
ZNF586 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001070894.1 NP_001191743.1 NP_060122.2
ENSEMBL proteins: ENSP00000410984 ENSP00000379458 ENSP00000379454 ENSP00000375583 Reactome Protein details: Q9NXT0
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF586 for ontologies About GeneDecksing
ZNF586 Antibody Products:
Assay Products for ZNF586: |
Protein
Domains /
Families
for ZNF586 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF586 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NXT0ProtoNet protein and cluster: Q9NXT0 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN586_HUMAN, Q9NXT0Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 11 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF586 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN586_HUMAN, Q9NXT0Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF586 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF586 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): ZNF586 (NM_017652) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF586 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF586 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF586 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF586 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZNF586:
|
Pathways & Interactions
for ZNF586 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF586
ZNF586 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF586
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZNF586 (Q9NXT03 ENSP000003794584) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF586 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF586 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF586
Search CenterWatch for drugs/clinical trials and news about ZNF586 / ZN586
|
Transcripts
for ZNF586 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF586 gene (3 alternative transcripts): NM_001077426.2 NM_001204814.1 NM_017652.3 Unigene Cluster for ZNF586: Zinc finger protein 586 Hs.625133 [show with all ESTs]Unigene Representative Sequence: NM_0012048144 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000449441 ENST00000396154(uc002qqd.3 uc002qqe.3) ENST00000396150
ENST00000391702(uc010euh.3 uc002qqf.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF586 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF586 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): ZNF586 (NM_017652) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF586 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF586 |
Additional cDNA sequence: AB074270.1 AK000077.1 AK095993.1 AK300419.1 AK302151.1 BC027922.1 BC041660.1 BC051325.1 BC124558.1 15 DOTS entries: DT.100703582 DT.102834404 DT.431171 DT.121503642 DT.100021376 DT.40284649 DT.95260361 DT.121503760 DT.95342260 DT.306533 DT.91671501 DT.86851471 DT.100751796 DT.100751797 DT.91799066 20 AceView cDNA sequences: BF849477 AI655109 BM541859 BP341661 AI689080 AA488104 BQ889777 AA548930 AA554212 AW372280 BC011243 BC051325 AW849952 BQ069130 BC041660 T41403 BF345117 BQ673176 NM_017652 NM_032828
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF586 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF586
|
Expression
for ZNF586 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF586 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGCTCCAA
About this image
See ZNF586 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF586
SOURCE GeneReport for Unigene cluster: Hs.625133
SABiosciences Custom PCR Arrays for ZNF586
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF586
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF586 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF586 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF586 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF586 |
Orthologs
for ZNF586 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF586 (if available)
TreeFam Gene Tree for ZNF586 (if available) |
Paralogs
for ZNF586 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF586 gene
- ZNF712 ZNF5012 ZNF162 ZNF6232 ZFP22 ZNF3452 ZNF232 ZNF8522
- ZFP32 ZNF5022 ZNF352 ZNF6602 ZKSCAN72
18/517 SIMAP similar genes for ZNF586 using alignment to 5 protein entries: ZN586_HUMAN (see all proteins)
(see all similar genes):FLJ00301 HZF36 ZNF577 ZNF78L1 ZSCAN16 ZNF776
ZNF808 ZNF569 ZFP41 ZNF24 ZNF195 DKFZp666C237
ZNF345 ZNF549 ZSCAN22 kr-znf3 ZFP3 ZNF146
ZNF586 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF586
PGOHUM00000263019
|
Genomic Variants
for ZNF586 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF586 (58280997 - 58291984 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ZNF586
2 CNVs: 50235 61731 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF586 |
|
Disorders
/ Diseases
for ZNF586 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF586 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF586 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF586) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for ZNF586 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF586 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF586 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF586 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF586 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF586 gene:
Search GeneIP for patents involving ZNF586
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF586 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF586 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF586 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF586 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF586 | | OriGene 3'-UTR Clone for ZNF586 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF586 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF586 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF586 | | OriGene Custom Protein Services for ZNF586 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF586 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF586 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF586 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF586 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF586 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF586 |
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 |  |  |  | |
| | | | Search Tocris compounds for ZNF586 |
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 | | | ZNF586 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF586 |
|  |  |  | | | | ThermoFisher Antibodies for ZNF586 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF586 |
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