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Aliases for ZNF586 Gene

Aliases for ZNF586 Gene

  • Zinc Finger Protein 586 2 3 5

External Ids for ZNF586 Gene

Previous GeneCards Identifiers for ZNF586 Gene

  • GC19P062973
  • GC19P062974
  • GC19P058281
  • GC19P054592

Summaries for ZNF586 Gene

GeneCards Summary for ZNF586 Gene

ZNF586 (Zinc Finger Protein 586) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF180.

UniProtKB/Swiss-Prot for ZNF586 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF586 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF586 Gene

Genomics for ZNF586 Gene

Regulatory Elements for ZNF586 Gene

Enhancers for ZNF586 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H057809 1.6 FANTOM5 ENCODE dbSUPER 14 +43.6 43566 7.2 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 TRIM28 ZNF264 ZNF805 ZNF543 ENSG00000269867 ZNF134 ZNF587 ZNF324B ZNF586 ZNF416
GH19H057801 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +34.3 34282 5.3 CTCF KLF1 SAP130 ZNF384 POLR2A SMC3 RUNX3 IKZF2 ZNF202 NR2F1 ENSG00000269867 ZNF587 TRIM28 ZNF324B ZNF814 ZNF264 ZNF417 ZNF550 ZNF543 ZNF548
GH19H058553 1.4 ENCODE dbSUPER 13.2 +787.5 787461 7.2 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A ZFP41 MEF2D TRIM28 ZNF606 MZF1 LOC100128398 ERVK3-1 ZNF134 ZNF417 ZNF329 ZNF324B ZNF418
GH19H058304 1.1 ENCODE 15 +535.9 535875 2.3 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF548 ZNF134 ZNF417 ZNF773 ZNF274 TRIM28 ZNF324B ZNF329 ZNF550 ZNF446
GH19H058325 1.2 ENCODE 13.1 +557.2 557219 3.6 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ZFP41 ZNF134 ZNF606 ZNF549 ZNF446 ZNF17 ZNF135 ZNF417 ZNF324B TRIM28 LOC100128398
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF586 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF586 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111825 248 1401 PKNOX1 ATF1 SIN3A YY1 ETS1 ZNF766 CBX5 ELK1 ZNF143 FOS

Transcription factor binding sites by QIAGEN in the ZNF586 gene promoter:

Genomic Locations for ZNF586 Gene

Genomic Locations for ZNF586 Gene
50,288 bases
Plus strand

Genomic View for ZNF586 Gene

Genes around ZNF586 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF586 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF586 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF586 Gene

Proteins for ZNF586 Gene

  • Protein details for ZNF586 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 586
    Protein Accession:
    Secondary Accessions:
    • A0JLV8
    • A8MY63
    • B3KTS9
    • E7ERT1
    • G3XAH3

    Protein attributes for ZNF586 Gene

    402 amino acids
    Molecular mass:
    46413 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA90930.1; Type=Frameshift; Positions=145; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF586 Gene


neXtProt entry for ZNF586 Gene

Post-translational modifications for ZNF586 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF586 Gene

No data available for DME Specific Peptides for ZNF586 Gene

Domains & Families for ZNF586 Gene

Gene Families for ZNF586 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF586 Gene


Suggested Antigen Peptide Sequences for ZNF586 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF586: view

Function for ZNF586 Gene

Molecular function for ZNF586 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF586 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF586: view
genes like me logo Genes that share phenotypes with ZNF586: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF586 Gene

Localization for ZNF586 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF586 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF586 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF586 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF586: view

Pathways & Interactions for ZNF586 Gene

SuperPathways for ZNF586 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF586: view

Pathways by source for ZNF586 Gene

2 Reactome pathways for ZNF586 Gene

Gene Ontology (GO) - Biological Process for ZNF586 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF586: view

No data available for SIGNOR curated interactions for ZNF586 Gene

Drugs & Compounds for ZNF586 Gene

No Compound Related Data Available

Transcripts for ZNF586 Gene

Unigene Clusters for ZNF586 Gene

Zinc finger protein 586:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF586 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP2: -
SP3: -
SP4: - -

Relevant External Links for ZNF586 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF586 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF586 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF586 Gene

This gene is overexpressed in Whole Blood (x6.1).

Protein differential expression in normal tissues from HIPED for ZNF586 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF586 Gene

Protein tissue co-expression partners for ZNF586 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF586 Gene:


SOURCE GeneReport for Unigene cluster for ZNF586 Gene:


Evidence on tissue expression from TISSUES for ZNF586 Gene

  • Intestine(4.3)
  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with ZNF586: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF586 Gene

Orthologs for ZNF586 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF586 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF586 33 34
  • 99.75 (n)
(Canis familiaris)
Mammalia -- 34
  • 42 (a)
Species where no ortholog for ZNF586 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF586 Gene

Gene Tree for ZNF586 (if available)
Gene Tree for ZNF586 (if available)

Paralogs for ZNF586 Gene

(527) SIMAP similar genes for ZNF586 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF586: view

Variants for ZNF586 Gene

Sequence variations from dbSNP and Humsavar for ZNF586 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000041046 -- 57,771,882(+) TGCAA(C/T)AGTGG intron-variant
rs1000052760 -- 57,778,010(+) CTCAA(C/T)TTCCC intron-variant
rs1000445531 -- 57,768,397(+) AAAGC(A/C)CCCTG upstream-variant-2KB
rs1000751240 -- 57,768,097(+) AGGAT(A/G)ACCAC upstream-variant-2KB
rs1000841670 -- 57,771,029(+) GGGCG(C/T)GGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF586 Gene

Variant ID Type Subtype PubMed ID
nsv520155 CNV loss 19592680
nsv1066059 CNV gain 25217958
esv7167 CNV loss 19470904
esv3644910 CNV loss 21293372
esv2719091 CNV deletion 23290073
esv2670311 CNV deletion 23128226
dgv3686n100 CNV gain 25217958

Variation tolerance for ZNF586 Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF586 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF586 Gene

Disorders for ZNF586 Gene

Relevant External Links for ZNF586

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF586 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF586 Gene

Publications for ZNF586 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 60
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60

Products for ZNF586 Gene

Sources for ZNF586 Gene

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