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Aliases for ZNF586 Gene

Aliases for ZNF586 Gene

  • Zinc Finger Protein 586 2 3

External Ids for ZNF586 Gene

Summaries for ZNF586 Gene

GeneCards Summary for ZNF586 Gene

ZNF586 (Zinc Finger Protein 586) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF17.

UniProtKB/Swiss-Prot for ZNF586 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF586 Gene

Genomics for ZNF586 Gene

Genomic Location for ZNF586 Gene

Start:
57,769,652 bp from pter
End:
57,819,939 bp from pter
Size:
50,288 bases
Orientation:
Plus strand

Genomic View for ZNF586 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF586 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF586 Gene

Regulatory Elements for ZNF586 Gene

Transcription factor binding sites by QIAGEN in the ZNF586 gene promoter:

Proteins for ZNF586 Gene

  • Protein details for ZNF586 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXT0-ZN586_HUMAN
    Recommended name:
    Zinc finger protein 586
    Protein Accession:
    Q9NXT0
    Secondary Accessions:
    • A0JLV8
    • A8MY63
    • B3KTS9
    • E7ERT1
    • G3XAH3

    Protein attributes for ZNF586 Gene

    Size:
    402 amino acids
    Molecular mass:
    46413 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA90930.1; Type=Frameshift; Positions=145; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF586 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF586 Gene

Proteomics data for ZNF586 Gene at MOPED

Post-translational modifications for ZNF586 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF586 Gene

No data available for DME Specific Peptides for ZNF586 Gene

Domains for ZNF586 Gene

Gene Families for ZNF586 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF586 Gene

Suggested Antigen Peptide Sequences for ZNF586 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NXT0

UniProtKB/Swiss-Prot:

ZN586_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q9NXT0
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q9NXT0
Similarity:
  • Contains 11 C2H2-type zinc fingers.:
    • Q9NXT0
genes like me logo Genes that share domains with ZNF586: view

Function for ZNF586 Gene

Molecular function for ZNF586 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF586 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF586: view

Phenotypes for ZNF586 Gene

GenomeRNAi human phenotypes for ZNF586:
genes like me logo Genes that share phenotypes with ZNF586: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF586 Gene

Localization for ZNF586 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF586 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF586 Gene COMPARTMENTS Subcellular localization image for ZNF586 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF586 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF586: view

Pathways for ZNF586 Gene

SuperPathways for ZNF586 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF586: view

Pathways by source for ZNF586 Gene

2 Reactome pathways for ZNF586 Gene

Interacting Proteins for ZNF586 Gene

Gene Ontology (GO) - Biological Process for ZNF586 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF586: view

Transcripts for ZNF586 Gene

Unigene Clusters for ZNF586 Gene

Zinc finger protein 586:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF586 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1:
SP2: -
SP3: -
SP4: - -

Relevant External Links for ZNF586 Gene

GeneLoc Exon Structure for
ZNF586
ECgene alternative splicing isoforms for
ZNF586

Expression for ZNF586 Gene

mRNA expression in normal human tissues for ZNF586 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF586 Gene

This gene is overexpressed in Whole Blood (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF586 Gene

SOURCE GeneReport for Unigene cluster for ZNF586 Gene Hs.625133

genes like me logo Genes that share expressions with ZNF586: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF586 Gene

Orthologs for ZNF586 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF586 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF586 35
  • 99.75 (n)
  • 99.75 (a)
ZNF586 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 42 (a)
OneToMany
Species with no ortholog for ZNF586:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF586 Gene

ENSEMBL:
Gene Tree for ZNF586 (if available)
TreeFam:
Gene Tree for ZNF586 (if available)

Paralogs for ZNF586 Gene

Selected SIMAP similar genes for ZNF586 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZNF586 Gene

genes like me logo Genes that share paralogs with ZNF586: view

Variants for ZNF586 Gene

Sequence variations from dbSNP and Humsavar for ZNF586 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2158013 -- 57,779,860(+) ACACC(A/G)GATCA utr-variant-3-prime
rs2285614 -- 57,770,006(+) GGCGG(A/G)TGGGA intron-variant
rs2285615 -- 57,776,801(+) TTGGT(C/T)GGACT intron-variant
rs2360116 -- 57,775,154(-) ccggg(C/T)gtggt intron-variant
rs2360117 -- 57,772,845(-) ccaaa(A/G)gttaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF586 Gene

Variant ID Type Subtype PubMed ID
nsv912528 CNV Gain 21882294
nsv912529 CNV Loss 21882294
nsv520155 CNV Loss 19592680
nsv912530 CNV Gain 21882294
dgv4029n71 CNV Gain 21882294
esv7167 CNV Loss 19470904
esv2719091 CNV Deletion 23290073
esv2670311 CNV Deletion 23128226

Relevant External Links for ZNF586 Gene

HapMap Linkage Disequilibrium report
ZNF586

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF586 Gene

Disorders for ZNF586 Gene

No disorders were found for ZNF586 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF586 Gene

Publications for ZNF586 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for ZNF586 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF586
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF586
    • Block miRNA regulation of ZNF586 using miScript Target Protectors

    Sources for ZNF586 Gene

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