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Aliases for ZNF585B Gene

Aliases for ZNF585B Gene

  • Zinc Finger Protein 585B 2 3 5
  • Zinc Finger Protein 41-Like Protein 3 4
  • SZFP41 3

External Ids for ZNF585B Gene

Previous GeneCards Identifiers for ZNF585B Gene

  • GC19M042335
  • GC19M042367
  • GC19M037675
  • GC19M034141
  • GC19M037677
  • GC19M037197

Summaries for ZNF585B Gene

GeneCards Summary for ZNF585B Gene

ZNF585B (Zinc Finger Protein 585B) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF729.

UniProtKB/Swiss-Prot for ZNF585B Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF585B Gene

Genomics for ZNF585B Gene

Regulatory Elements for ZNF585B Gene

Promoters for ZNF585B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF585B on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF585B Gene

Chromosome:
19
Start:
37,181,579 bp from pter
End:
37,218,153 bp from pter
Size:
36,575 bases
Orientation:
Minus strand

Genomic View for ZNF585B Gene

Genes around ZNF585B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF585B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF585B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF585B Gene

Proteins for ZNF585B Gene

  • Protein details for ZNF585B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q52M93-Z585B_HUMAN
    Recommended name:
    Zinc finger protein 585B
    Protein Accession:
    Q52M93
    Secondary Accessions:
    • Q8IZD3
    • Q96JW6

    Protein attributes for ZNF585B Gene

    Size:
    769 amino acids
    Molecular mass:
    88066 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55400.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF585B Gene

Proteomics data for ZNF585B Gene at MOPED

Post-translational modifications for ZNF585B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ZNF585B Gene

Domains & Families for ZNF585B Gene

Gene Families for ZNF585B Gene

Protein Domains for ZNF585B Gene

Suggested Antigen Peptide Sequences for ZNF585B Gene

Graphical View of Domain Structure for InterPro Entry

Q52M93

UniProtKB/Swiss-Prot:

Z585B_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 21 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 21 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF585B: view

Function for ZNF585B Gene

Molecular function for ZNF585B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF585B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZNF585B: view

Animal Model Products

CRISPR Products

miRNA for ZNF585B Gene

miRTarBase miRNAs that target ZNF585B

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF585B Gene

Localization for ZNF585B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF585B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF585B Gene COMPARTMENTS Subcellular localization image for ZNF585B gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF585B Gene

Pathways & Interactions for ZNF585B Gene

SuperPathways for ZNF585B Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF585B: view

Pathways by source for ZNF585B Gene

2 Reactome pathways for ZNF585B Gene

Interacting Proteins for ZNF585B Gene

Gene Ontology (GO) - Biological Process for ZNF585B Gene

None

No data available for SIGNOR curated interactions for ZNF585B Gene

Drugs & Compounds for ZNF585B Gene

No Compound Related Data Available

Transcripts for ZNF585B Gene

Unigene Clusters for ZNF585B Gene

Zinc finger protein 585B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF585B Gene

No ASD Table

Relevant External Links for ZNF585B Gene

GeneLoc Exon Structure for
ZNF585B
ECgene alternative splicing isoforms for
ZNF585B

Expression for ZNF585B Gene

mRNA expression in normal human tissues for ZNF585B Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF585B Gene



SOURCE GeneReport for Unigene cluster for ZNF585B Gene Hs.390568

genes like me logo Genes that share expression patterns with ZNF585B: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF585B Gene

Orthologs for ZNF585B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF585B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF585B 35
  • 98.4 (n)
  • 98.18 (a)
ZNF585B 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 35 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp27 36
  • 70 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
CSA.1668 36
  • 31 (a)
ManyToMany
Species with no ortholog for ZNF585B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF585B Gene

ENSEMBL:
Gene Tree for ZNF585B (if available)
TreeFam:
Gene Tree for ZNF585B (if available)

Paralogs for ZNF585B Gene

(620) SIMAP similar genes for ZNF585B Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for ZNF585B Gene

genes like me logo Genes that share paralogs with ZNF585B: view

Variants for ZNF585B Gene

Sequence variations from dbSNP and Humsavar for ZNF585B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1657509 - 37,186,138(+) GCATA(C/T)ATAGG reference, missense
rs320887 -- 37,202,536(+) CAACA(C/T)TTTAA intron-variant
rs320888 -- 37,202,737(+) acctg(A/G)gttca intron-variant
rs320889 -- 37,204,700(+) ctccc(A/G)agcag intron-variant
rs167673 -- 37,212,533(+) Ttttt(G/T)attgc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF585B Gene

Variant ID Type Subtype PubMed ID
dgv3856n71 CNV Gain 21882294
nsv911655 CNV Loss 21882294

Variation tolerance for ZNF585B Gene

Residual Variation Intolerance Score: 19.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.10; 84.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF585B Gene

HapMap Linkage Disequilibrium report
ZNF585B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF585B Gene

Disorders for ZNF585B Gene

Relevant External Links for ZNF585B

Genetic Association Database (GAD)
ZNF585B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF585B

No disorders were found for ZNF585B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF585B Gene

Publications for ZNF585B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa R.S. … Obuse C. (Nat. Cell Biol. 2010) 3

Products for ZNF585B Gene

Sources for ZNF585B Gene

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