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ZNF585B Gene

protein-coding   GIFtS: 48
GCID: GC19M037677

Zinc Finger Protein 585B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 585B1 2
Zinc Finger Protein 41-Like Protein2 3
SZFP412

External Ids:    HGNC: 309481   Entrez Gene: 922852   Ensembl: ENSG000002456807   UniProtKB: Q52M933   

Export aliases for ZNF585B gene to outside databases

Previous GC identifers: GC19M042335 GC19M042367 GC19M037675 GC19M034141


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF585B Gene:
ZNF585B (zinc finger protein 585B) is a protein-coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF616.

UniProtKB/Swiss-Prot: Z585B_HUMAN, Q52M93
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF585B gene promoter:
         c-Fos   Pax-3   AP-1   HOXA5   ATF-2   c-Jun   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF585B promoter sequence
   Search Chromatin IP Primers for ZNF585B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF585B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.13

ZNF585B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF585B gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M037677:  view genomic region     (about GC identifiers)

Start:
37,672,481 bp from pter      End:
37,709,055 bp from pter
Size:
36,575 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: Z585B_HUMAN, Q52M93 (See protein sequence)
Recommended Name: Zinc finger protein 585B  
Size: 769 amino acids; 88066 Da
Sequence caution: Sequence=BAB55400.1; Type=Erroneous initiation;
Secondary accessions: Q8IZD3 Q96JW6

Explore the universe of human proteins at neXtProt for ZNF585B: NX_Q52M93

Explore proteomics data for ZNF585B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF585B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689492.3  
    ENSEMBL proteins: 
     ENSP00000433773   ENSP00000436774   ENSP00000435268   ENSP00000465871   ENSP00000467380  
     ENSP00000432760   ENSP00000467283   ENSP00000434541   ENSP00000442139  
    Reactome Protein details: Q52M93

    ZNF585B Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF585B

     
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    antibodies-online proteins for ZNF585B (2 products) 

     
    antibodies-online peptides for ZNF585B

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    antibodies-online antibodies for ZNF585B (4 products) 

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    Cloud-Clone Corp. CLIAs for ZNF585B
    Search eBioscience for ELISAs for ZNF585B 
    antibodies-online kits for ZNF585B (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q52M93

    ProtoNet protein and cluster: Q52M93

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: Z585B_HUMAN, Q52M93
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 21 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF585B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: Z585B_HUMAN, Q52M93
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF585B           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF585B

    miRNA
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    Block miRNA regulation of human, mouse, rat ZNF585B using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate ZNF585B:
    hsa-miR-641 hsa-miR-1255a hsa-miR-15b* hsa-miR-3617 hsa-miR-1255b
    SwitchGear 3'UTR luciferase reporter plasmidZNF585B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF585B

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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF585B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    Z585B_HUMAN, Q52M93: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF585B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF585B About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF585B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF585B
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF585B
    Interactions:

        Search GeneGlobe Interaction Network for ZNF585B

    1 Interacting protein for ZNF585B (Q52M932, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RIC8AQ9NPQ82, 3MINT-65222 I2D: score=4 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    Find genes that share ontologies with ZNF585B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF585B (Z585B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF585B gene: 
    NM_152279.3  

    Unigene Cluster for ZNF585B:

    Zinc finger protein 585B
    Hs.390568  [show with all ESTs]
    Unigene Representative Sequence: NM_152279
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000532828(uc002ofq.3 uc002ofr.1) ENST00000531805 ENST00000527838
    ENST00000591492 ENST00000586320 ENST00000392156 ENST00000591273 ENST00000526705
    ENST00000534363 ENST00000312908
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZNF585B using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate ZNF585B:
    hsa-miR-641 hsa-miR-1255a hsa-miR-15b* hsa-miR-3617 hsa-miR-1255b
    SwitchGear 3'UTR luciferase reporter plasmidZNF585B 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF585B
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    GenScript: all cDNA clones in your preferred vector: ZNF585B (NM_152279)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF585B
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF585B
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF585B
      QuantiFast Probe-based Assays in human, mouse, rat ZNF585B

    Additional mRNA sequence: 

    AK027834.1 AK090574.1 AK091586.1 AK094989.1 AY147015.1 BC029737.1 BC051277.1 BC067088.1 
    BC080550.1 BC093625.1 

    12 DOTS entries:

    DT.92000716  DT.101984114  DT.95314324  DT.421870  DT.121446781  DT.91828139  DT.121446977  DT.121446799 
    DT.97767451  DT.121446958  DT.40130505  DT.121446755 

    Selected AceView cDNA sequences (see all 173):

    AA885386 AK123296 AW051065 AA258427 AA926909 AA970119 CK903687 BC063820 
    AI126900 BX492658 BU166940 BM681180 CA412120 AA332171 AW512384 NM_152655 
    BM974650 AI478543 BC029737 BU506929 BM128621 AI362284 CA413916 BM128386 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF585B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTATTTAT
    ZNF585B Expression
    About this image

    ZNF585B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF585B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.390568
        Custom PCR Arrays for ZNF585B
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF585B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    ENSEMBL Gene Tree for ZNF585B (if available)
    TreeFam Gene Tree for ZNF585B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF585B gene
    ZNF6162  ZNF4732  ZNF1602  ZNF4932  ZNF5462  ZNF992  ZNF8362  ZNF7212  
    ZNF5942  ZFP622  ZNF8412  ZNF432  ZNF780B2  ZNF1972  ZNF1072  ZNF585A2  
    ZNF8082  ZNF3472  ZNF8452  ZNF6582  ZNF6292  ZNF6242  ZNF2682  ZNF8142  
    Selected SIMAP similar genes for ZNF585B using alignment to 9 protein entries:     Z585B_HUMAN (see all proteins) (see all similar genes):
    ZNF585A    AURA2    LINC00596    LYRM4    NSRP1    FAM3A
    APOD    C18orf8    kr-znf3    DCTN5    MPP4    ZNF78L1
    POM121C    C4orf19    CTSS    NF2    ZFS-5    ZNF212

    Find genes that share paralogs with ZNF585B           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ZNF585B
    PGOHUM00000247838 PGOHUM00000260954


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF585B (see all 729)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1124438811,2
    C,F--37672130(+) AAGTCC/AGACTC 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1406552831,2
    --37672138(+) CTCAAA/GAAGAG 1 -- ds50010--------
    rs1131322791,2
    C,F--37672146(+) GAGAGG/ATACAT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1851176801,2
    --37672302(+) GGAAAC/TGTAGG 1 -- ds50010--------
    rs1467066291,2
    --37672357(+) ATGATC/GTAATT 1 -- ds50010--------
    rs1166494931,2
    C,F--37672382(+) AATTCC/TACACT 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs736248031,2
    C,F--37672386(+) CCACAC/TTAAAA 1 -- ds50012Minor allele frequency- T:0.08WA 120
    rs1904755311,2
    C--37672438(+) CGACCC/TTAAAA 1 -- ds50010--------
    rs1136541581,2
    C,F--37672471(+) AAACCC/TGCACA 1 -- ds50011Minor allele frequency- T:0.00CSA 1
    rs353159781,2
    C--37672599(+) AAAAA-/AGAGCT 1 -- ut311Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for ZNF585B (37672481 - 37709055 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZNF585B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911655CNV Loss21882294
    dgv3856n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ZNF585B
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF585B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF585B           About GenesLikeMe

    Genetic Association Database (GAD): ZNF585B

    Export disorders for ZNF585B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF585B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF585B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    6. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S.... Obuse C. (Nat. Cell Biol. 2010)
    7. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    8. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 92285 HGNC: 30948 AceView: ZNF585BandZNF585A Ensembl:ENSG00000245680 euGenes: HUgn92285
    ECgene: ZNF585B H-InvDB: ZNF585B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF585B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF585B gene:
    Search GeneIP for patents involving ZNF585B

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