ZNF585B Gene
protein-coding GIFtS: 44
GCID: GC19M037675
|
|
zinc finger protein 585B
| |
Aliases
for ZNF585B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 585B1 2 | | SZFP411 2 | | Zinc Finger Protein 41-Like Protein2 3 | | FLJ149281 |
Export aliases for ZNF585B gene to outside databasesPrevious GC identifers: GC19M042335 GC19M042367 GC19M034141 |
Summaries
for ZNF585B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: Z585B_HUMAN, Q52M93Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF585B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF585B gene promoter:
c-Fos Pax-3 AP-1 HOXA5 ATF-2 c-Jun MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF585B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF585B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.12 Ensembl cytogenetic band: 19q13.12 HGNC cytogenetic band: 19q13.13ZNF585B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M037675: view genomic region
(about GC identifiers)
Start:
|
37,672,481 bp from pter |
End:
|
37,709,055 bp from pter |
Size:
|
36,575 bases |
Orientation:
|
minus strand |
|
Proteins
for ZNF585B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: Z585B_HUMAN, Q52M93 (See
protein sequence)Recommended Name: Zinc finger protein 585B Size: 769 amino acids; 88066 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAB55400.1; Type=Erroneous initiation;
Secondary accessions: Q8IZD3 Q96JW6Explore the universe of human proteins at neXtProt for ZNF585B: NX_Q52M93
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q52M93
ZNF585B Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_689492.3
ENSEMBL proteins: ENSP00000433773 ENSP00000436774 ENSP00000435268 ENSP00000465871 ENSP00000467380 ENSP00000432760 ENSP00000467283 ENSP00000434541 ENSP00000442139 Reactome Protein details: Q52M93
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF585B for ontologies About GeneDecksing
ZNF585B Antibody Products:
Assay Products for ZNF585B: |
Protein
Domains /
Families
for ZNF585B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF585B for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q52M93ProtoNet protein and cluster: Q52M93 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: Z585B_HUMAN, Q52M93Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 21 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF585B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: Z585B_HUMAN, Q52M93Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF585B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF585B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF585B (NM_152279) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF585B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF585B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF585B |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
ZNF585B for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF585B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF585B
ZNF585B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF585B
1 Interacting protein for ZNF585B (Q52M932, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF585B for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF585B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF585B
Search CenterWatch for drugs/clinical trials and news about ZNF585B / Z585B
|
Transcripts
for ZNF585B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF585B gene: NM_152279.3 Unigene Cluster for ZNF585B: Zinc finger protein 585B Hs.390568 [show with all ESTs]Unigene Representative Sequence: NM_15227910 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000532828(uc002ofq.3 uc002ofr.1) ENST00000531805 ENST00000527838
ENST00000591492 ENST00000586320 ENST00000392156 ENST00000591273 ENST00000526705
ENST00000534363 ENST00000312908
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF585B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF585B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF585B (NM_152279) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF585B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF585B |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF585B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF585B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF585B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF585B |
Additional cDNA sequence: AK027834.1 AK090574.1 AK091586.1 AK094989.1 AY147015.1 BC029737.1 BC051277.1 BC067088.1 BC080550.1 BC093625.1 13 DOTS entries: DT.92000716 DT.101984114 DT.95314324 DT.421870 DT.121446781 DT.91828139 DT.121446977 DT.121446799 DT.97767451 DT.121446958 DT.40130505 DT.121446755 DT.212248 24/173 AceView cDNA sequences (see all 173): AI206034 AL710064 AK056389 AI362284 AA885386 AA926909 AW051065 BQ012714 AA258427 CA413916 AK123296 BM128621 AA970119 BC063820 CK903687 AI126900 BX492658 BU166940 BM681180 CA412120 AA332171 BM726521 AI798808 AI360282
GeneLoc Exon Structure
|
Expression
for ZNF585B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF585B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTATTTAT
About this image
Genevestigator expression for ZNF585B
SOURCE GeneReport for Unigene cluster: Hs.390568
SABiosciences Custom PCR Arrays for ZNF585B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF585B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF585B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF585B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF585B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF585B |
Orthologs
for ZNF585B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF585B gene from 1/4 species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
34(a) |
1 → many |
GL343557.1(371826-420180) |
ENSEMBL Gene Tree for ZNF585B (if available)
TreeFam Gene Tree for ZNF585B (if available) |
Paralogs
for ZNF585B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF585B gene
- ZNF6162 ZNF1602 ZNF8502 ZNF992 ZNF5462 ZNF6652 ZNF7212 ZNF8362
- ZNF8412 ZNF912 ZNF432 ZNF780B2 ZNF1972 ZNF585A2 ZNF8082 ZNF7292
- ZNF3472 ZNF8452 ZNF1842 ZNF6582 ZNF6242 ZNF2082
18/609 SIMAP similar genes for ZNF585B using alignment to 9 protein entries: Z585B_HUMAN (see all proteins)
(see all similar genes):ZNF585A AURA2 LINC00596 LYRM4 NSRP1 FAM3A
APOD C18orf8 kr-znf3 TCEB1 DCTN5 ZNF78L1
POM121C C4orf19 NF2 ZFS-5 ZNF212 DNMT1
ZNF585B for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for ZNF585B
PGOHUM00000247838 PGOHUM00000260954
|
Genomic Variants
for ZNF585B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF585B (37672481 - 37709055 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF585B: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ZNF585B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF585B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF585B gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF585B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S....Obuse C. (2010)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for ZNF585B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF585B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF585B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF585B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF585B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF585B gene:
Search GeneIP for patents involving ZNF585B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF585B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF585B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF585B | | | OriGene Protein Over-expression Lysate for ZNF585B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF585B | | OriGene 3'-UTR Clone for ZNF585B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF585B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF585B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF585B | | OriGene Custom Protein Services for ZNF585B | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF585B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF585B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF585B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF585B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF585B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF585B |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ZNF585B |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ZNF585B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF585B |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF585B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF585B |
|
|
|
|
