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Aliases for ZNF585B Gene

Aliases for ZNF585B Gene

  • Zinc Finger Protein 585B 2 3 5
  • Zinc Finger Protein 41-Like Protein 3 4
  • SZFP41 3

External Ids for ZNF585B Gene

Previous GeneCards Identifiers for ZNF585B Gene

  • GC19M042335
  • GC19M042367
  • GC19M037675
  • GC19M034141
  • GC19M037677
  • GC19M037197
  • GC19M037232
  • GC19M037403
  • GC19M037430

Summaries for ZNF585B Gene

GeneCards Summary for ZNF585B Gene

ZNF585B (Zinc Finger Protein 585B) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF585A.

UniProtKB/Swiss-Prot for ZNF585B Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF585B Gene

Genomics for ZNF585B Gene

Regulatory Elements for ZNF585B Gene

Enhancers for ZNF585B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G037973 1.9 FANTOM5 Ensembl ENCODE dbSUPER 99.3 -760.4 -760414 10.0 HDGF PKNOX1 WRNIP1 DMAP1 YBX1 ZNF2 YY1 CBX5 ZNF143 ZNF207 ZNF585B ZNF793 ZNF585A ZNF607 ZNF420 ZNF781 ENSG00000267152 ZNF383 ZNF573 WDR87
GH19G038191 1.2 dbSUPER 89.5 -976.7 -976680 6.2 DMAP1 FEZF1 YY1 SLC30A9 ZNF263 SP3 GLIS1 RCOR2 NR2C1 KDM1A ZNF585B ZNF793 ZNF383 ZNF571 ZNF607 ZNF781 ENSG00000267152 ZNF573 SIPA1L3 LINC01535
GH19G037593 1.1 ENCODE 96 -376.5 -376547 2.0 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF302 ZNF383 ZNF567 ZNF345 ZNF585B ZNF850 ZNF571 ZNF793 ZNF607 ZNF790-AS1 LINC01535
GH19G037370 1.1 ENCODE 91.3 -152.8 -152831 1.8 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CBX5 ZNF383 ZNF567 ZNF585B ZNF793 ZNF345 ZNF850 ZNF571 ZNF790-AS1 ZNF529 ZNF461
GH19G037653 1.2 ENCODE 82.8 -437.1 -437129 2.9 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 ZNF383 ZNF567 ZNF345 ZNF585B ZNF850 ZNF571 LINC01535 ZNF585A ZNF607 ZNF790-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF585B on UCSC Golden Path with GeneCards custom track

Promoters for ZNF585B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109159 53 1801 HDGF FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1
ENSR00000109158 148 1600 PKNOX1 FOXA2 ARNT ARID4B DMAP1 ZNF2 YY1 CBX5 ZNF416 ZNF143

Genomic Location for ZNF585B Gene

Chromosome:
19
Start:
37,181,579 bp from pter
End:
37,218,153 bp from pter
Size:
36,575 bases
Orientation:
Minus strand

Genomic View for ZNF585B Gene

Genes around ZNF585B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF585B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF585B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF585B Gene

Proteins for ZNF585B Gene

  • Protein details for ZNF585B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q52M93-Z585B_HUMAN
    Recommended name:
    Zinc finger protein 585B
    Protein Accession:
    Q52M93
    Secondary Accessions:
    • Q8IZD3
    • Q96JW6

    Protein attributes for ZNF585B Gene

    Size:
    769 amino acids
    Molecular mass:
    88066 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55400.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF585B Gene

Post-translational modifications for ZNF585B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF585B Gene

Domains & Families for ZNF585B Gene

Gene Families for ZNF585B Gene

Protein Domains for ZNF585B Gene

Suggested Antigen Peptide Sequences for ZNF585B Gene

Graphical View of Domain Structure for InterPro Entry

Q52M93

UniProtKB/Swiss-Prot:

Z585B_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF585B: view

Function for ZNF585B Gene

Molecular function for ZNF585B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF585B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF585B: view

Animal Model Products

CRISPR Products

miRNA for ZNF585B Gene

miRTarBase miRNAs that target ZNF585B

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF585B Gene

Localization for ZNF585B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF585B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF585B gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF585B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF585B: view

Pathways & Interactions for ZNF585B Gene

SuperPathways for ZNF585B Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF585B: view

Pathways by source for ZNF585B Gene

2 Reactome pathways for ZNF585B Gene

Gene Ontology (GO) - Biological Process for ZNF585B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
genes like me logo Genes that share ontologies with ZNF585B: view

No data available for SIGNOR curated interactions for ZNF585B Gene

Drugs & Compounds for ZNF585B Gene

No Compound Related Data Available

Transcripts for ZNF585B Gene

Unigene Clusters for ZNF585B Gene

Zinc finger protein 585B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF585B Gene

No ASD Table

Relevant External Links for ZNF585B Gene

GeneLoc Exon Structure for
ZNF585B
ECgene alternative splicing isoforms for
ZNF585B

Expression for ZNF585B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF585B Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF585B Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF585B Gene:

ZNF585B

SOURCE GeneReport for Unigene cluster for ZNF585B Gene:

Hs.390568

Evidence on tissue expression from TISSUES for ZNF585B Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF585B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF585B Gene

Orthologs for ZNF585B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF585B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF585B 34 35
  • 98.4 (n)
mouse
(Mus musculus)
Mammalia Zfp27 35
  • 70 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 47 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 35 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
CSA.1668 35
  • 31 (a)
ManyToMany
Species where no ortholog for ZNF585B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF585B Gene

ENSEMBL:
Gene Tree for ZNF585B (if available)
TreeFam:
Gene Tree for ZNF585B (if available)

Paralogs for ZNF585B Gene

(620) SIMAP similar genes for ZNF585B Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for ZNF585B Gene

genes like me logo Genes that share paralogs with ZNF585B: view

Variants for ZNF585B Gene

Sequence variations from dbSNP and Humsavar for ZNF585B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000047061 -- 37,195,425(+) ACAAT(C/T)CAGTT intron-variant
rs1000340447 -- 37,183,438(+) TAGTG(A/G)TGAAC utr-variant-3-prime
rs1000450952 -- 37,190,488(+) ACCTT(C/G)TGATC intron-variant
rs1000470024 -- 37,190,785(+) GGTCT(C/T)TATCT intron-variant
rs1000501323 -- 37,190,571(+) TTTTG(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF585B Gene

Variant ID Type Subtype PubMed ID
esv3644280 CNV loss 21293372
esv3644282 CNV loss 21293372
esv3644283 CNV loss 21293372
nsv1064851 CNV loss 25217958
nsv579461 CNV gain 21841781

Variation tolerance for ZNF585B Gene

Residual Variation Intolerance Score: 19.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.10; 84.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF585B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF585B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF585B Gene

Disorders for ZNF585B Gene

Relevant External Links for ZNF585B

Genetic Association Database (GAD)
ZNF585B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF585B

No disorders were found for ZNF585B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF585B Gene

Publications for ZNF585B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64

Products for ZNF585B Gene

Sources for ZNF585B Gene

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