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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF585A Gene

protein-coding   GIFtS: 45
GCID: GC19M037597

Zinc Finger Protein 585A

  Search for ZNF585A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 585A1 2

External Ids:    HGNC: 263051   Entrez Gene: 1997042   Ensembl: ENSG000001969677   UniProtKB: Q6P3V23   

Export aliases for ZNF585A gene to outside databases

Previous GC identifers: GC19M042334 GC19M042337 GC19M042289 GC19M034110


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF585A Gene: 
ZNF585A (zinc finger protein 585A) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include zinc ion binding and nucleic acid binding. An important paralog of this gene is ZNF616.

UniProtKB/Swiss-Prot: Z585A_HUMAN, Q6P3V2
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF585A gene promoter:
         POU6F1 (c2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF585A promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF585A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF585A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.13

ZNF585A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF585A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M037597:  view genomic region     (about GC identifiers)

Start:
37,597,636 bp from pter      End:
37,663,643 bp from pter
Size:
66,008 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: Z585A_HUMAN, Q6P3V2 (See protein sequence)
Recommended Name: Zinc finger protein 585A  
Size: 769 amino acids; 87974 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAB85057.1; Type=Erroneous initiation;
Secondary accessions: Q8TE95 Q96MV3
Alternative splicing: 2 isoforms:  Q6P3V2-1   Q6P3V2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF585A: NX_Q6P3V2

Explore proteomics data for ZNF585A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6P3V2

  • ZNF585A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF585A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_689868.1  NP_954577.1  

    ENSEMBL proteins: 
     ENSP00000466825   ENSP00000349440   ENSP00000375998   ENSP00000466185   ENSP00000292841  
     ENSP00000347724  
    Reactome Protein details: Q6P3V2
    Human Recombinant Protein Products for ZNF585A: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF585A 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF585A for ontologies           About GeneDecksing



    ZNF585A Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6P3V2

    ProtoNet protein and cluster: Q6P3V2

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: Z585A_HUMAN, Q6P3V2
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 22 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF585A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: Z585A_HUMAN, Q6P3V2
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF585A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZNF585A:
     Decreased viability with pacli  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF585A 
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF585A:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF585A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF585A
        Generic Transcription Pathway
    Gene Expression



    ZNF585A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF585A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF585A (ENSP000002928414) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBX5ENSP000002098754STRING: ENSP00000209875
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF585A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF585A (Z585A)

    Search CenterWatch for drugs/clinical trials and news about ZNF585A / Z585A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF585A gene (2 alternative transcripts): 
    NM_152655.2  NM_199126.1  

    Unigene Clusters for ZNF585A:

    Zinc finger protein 585A
    Hs.659236  [show with all ESTs], Hs.729172  [show with all ESTs]
    Unigene Representative Sequences: AK123296, NM_152655
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587817 ENST00000588723 ENST00000356958(uc002ofo.1) ENST00000392157(uc002ofm.1)
    ENST00000588354 ENST00000292841(uc002ofn.1) ENST00000355533
    miRNA
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    hsa-miR-513b hsa-miR-571 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidZNF585A 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF585A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF585A

    Additional mRNA sequence: 

    AF024705.1 AF086428.1 AK056389.1 AK074345.1 AK290660.1 BC039557.1 BC052956.1 BC063820.1 

    14 DOTS entries:

    DT.75107045  DT.409518  DT.121446965  DT.212248  DT.97835130  DT.91815874  DT.121446864  DT.121446968 
    DT.95370533  DT.121446990  DT.100778577  DT.405331  DT.97800348  DT.121446755 

    24/173 AceView cDNA sequences (see all 173):

    BX492658 AK123296 AI126900 AA885386 AI362284 AI862006 BQ012714 BM681180 
    CK903687 BC063820 CA413916 AA258427 NM_152655 BM974650 AI478543 BC029737 
    BU506929 BM128386 AA810805 AW662821 AA885235 AK074345 NM_199126 AI360282 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF585A (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
    SP1:                    -     -                 -                 -                                 
    SP2:                                            -                 -                                 
    SP3:                    -     -           -     -                 -     -     -     -     -         
    SP4:                    -     -           -     -                 -                                 
    SP5:                    -     -           -     -                 -                                 


    ECgene alternative splicing isoforms for ZNF585A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF585A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAATGAATA
    ZNF585A Expression
    About this image


    See ZNF585A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF585A

    SOURCE GeneReport for Unigene clusters: Hs.659236 Hs.729172
        SABiosciences Custom PCR Arrays for ZNF585A
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF585A gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp271 , 5 zinc finger protein 271, 5 81.17(n)1
    82.56(a)1
      7 (17.26 cM)5
    226891  NM_011754.21  NP_035884.21 
     298933335 
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii BX299042.22   -- 74.59(n)    BX299042.2 


    ENSEMBL Gene Tree for ZNF585A (if available)
    TreeFam Gene Tree for ZNF585A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF585A gene
    ZNF6162  ZNF4732  ZNF1602  ZNF5462  ZNF992  ZNF8362  ZNF7172  ZNF5942  
    ZNF6002  ZFP622  ZNF8412  ZNF780B2  ZNF1972  ZNF1072  ZNF8082  ZNF8452  
    ZNF6582  ZNF6242  ZNF2682  
    18/536 SIMAP similar genes for ZNF585A using alignment to 6 protein entries:     Z585A_HUMAN (see all proteins) (see all similar genes):
    ZNF585B    ZNF320    POM121C    ZNF845    ZNF420    ZNF780A
    ZNF283    ZNF78L1    ZNF3    ZNF616    ZNF56    ZNF761
    ZNF519    ZNF350    ZNF84    ZNF569    kr-znf3    ZNF677

    ZNF585A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/519 SNPs in ZNF585A are shown (see all 519)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs761202251,2
    F--37640505(+) TGAGAA/CAATTG 2 -- ds50011Minor allele frequency- C:0.07WA 118
    rs1874681951,2
    --37640516(+) AGGCCC/TAGAGG 2 -- ds50010--------
    rs1478140011,2
    C--37640518(+) GCCCA-/GAGGAGGT 2 -- ds50010--------
    rs1147575061,2
    F--37640747(+) TGGGAC/TCTCAT 2 -- ds50011Minor allele frequency- T:0.07WA 118
    rs1920767991,2
    --37640842(+) GGAACC/TGCATG 2 -- ds50010--------
    rs1848335371,2
    --37640880(+) AGACAC/TTGGGT 2 -- ds50010--------
    rs1154055591,2
    F--37640897(+) GACAAT/CGGGGA 2 -- ds50011Minor allele frequency- C:0.06WA 118
    rs1877833481,2
    --37640898(+) ACAATA/GGGGAG 2 -- ds50010--------
    rs736227201,2
    C,F--37640989(+) TTTTTG/TTTTTT 2 -- ds50012Minor allele frequency- T:0.50WA CSA 4
    rs1122546031,2
    C,F--37641245(+) CAAGAC/TATCCT 2 -- ut311Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for ZNF585A (37597636 - 37663643 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZNF585A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911655CNV Loss21882294
    nsv828545CNV Loss20364138
    nsv2477CNV Loss18451855
    dgv3856n71CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF585A gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF585A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S....Obuse C. (2010)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 199704 HGNC: 26305 AceView: ZNF585BandZNF585A Ensembl:ENSG00000196967 euGenes: HUgn199704
    ECgene: ZNF585A H-InvDB: ZNF585A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF585A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF585A gene:
    Search GeneIP for patents involving ZNF585A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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