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Aliases for ZNF585A Gene

Aliases for ZNF585A Gene

  • Zinc Finger Protein 585A 2 3 5

External Ids for ZNF585A Gene

Previous GeneCards Identifiers for ZNF585A Gene

  • GC19M042334
  • GC19M042337
  • GC19M042289
  • GC19M037597
  • GC19M034110
  • GC19M037109
  • GC19M037114
  • GC19M037325
  • GC19M037386
  • GC19M037423

Summaries for ZNF585A Gene

GeneCards Summary for ZNF585A Gene

ZNF585A (Zinc Finger Protein 585A) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF585B.

UniProtKB/Swiss-Prot for ZNF585A Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF585A Gene

Genomics for ZNF585A Gene

Regulatory Elements for ZNF585A Gene

Enhancers for ZNF585A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G037973 1.9 FANTOM5 Ensembl ENCODE dbSUPER 72.9 -805.8 -805826 10.0 HDGF PKNOX1 WRNIP1 DMAP1 YBX1 ZNF2 YY1 CBX5 ZNF143 ZNF207 ZNF585B ZNF793 ZNF585A ZNF607 ZNF420 ZNF781 ENSG00000267152 ZNF573 ZNF383 WDR87
GH19G038002 2 FANTOM5 Ensembl ENCODE dbSUPER 38.4 -832.1 -832071 4.8 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZNF302 ZNF548 FOS ZNF263 SP3 ZNF585B ZNF793 ZNF585A ZNF607 ZNF420 ZNF571 ZNF383 ZNF781 ENSG00000267152 ENSG00000267672
GH19G037593 1.1 ENCODE 64.2 -422.0 -421959 2.0 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF302 ZNF383 ZNF567 ZNF345 ZNF585B ZNF850 ZNF571 ZNF793 ZNF607 ZNF790-AS1 LINC01535
GH19G037653 1.2 ENCODE 55.6 -482.5 -482541 2.9 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 ZNF383 ZNF567 ZNF345 ZNF585B ZNF850 ZNF571 LINC01535 ZNF585A ZNF607 ZNF790-AS1
GH19G038157 1.1 dbSUPER 58 -985.4 -985351 1.8 FOXA2 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF302 ZNF263 ZNF585B ZNF793 ZNF585A ZNF781 ZNF607 ENSG00000267152 ZNF383 ZNF571 ZNF573 SIPA1L3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF585A on UCSC Golden Path with GeneCards custom track

Promoters for ZNF585A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109157 140 1599 PKNOX1 FOXA2 WRNIP1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF766 CBX5
ENSR00000109157 140 1599 PKNOX1 FOXA2 WRNIP1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF766 CBX5

Transcription factor binding sites by QIAGEN in the ZNF585A gene promoter:

Genomic Location for ZNF585A Gene

Chromosome:
19
Start:
37,106,734 bp from pter
End:
37,172,741 bp from pter
Size:
66,008 bases
Orientation:
Minus strand

Genomic View for ZNF585A Gene

Genes around ZNF585A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF585A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF585A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF585A Gene

Proteins for ZNF585A Gene

  • Protein details for ZNF585A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P3V2-Z585A_HUMAN
    Recommended name:
    Zinc finger protein 585A
    Protein Accession:
    Q6P3V2
    Secondary Accessions:
    • Q8TE95
    • Q96MV3

    Protein attributes for ZNF585A Gene

    Size:
    769 amino acids
    Molecular mass:
    87974 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85057.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF585A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF585A Gene

Post-translational modifications for ZNF585A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF585A Gene

No data available for DME Specific Peptides for ZNF585A Gene

Domains & Families for ZNF585A Gene

Gene Families for ZNF585A Gene

Protein Domains for ZNF585A Gene

Suggested Antigen Peptide Sequences for ZNF585A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P3V2

UniProtKB/Swiss-Prot:

Z585A_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF585A: view

Function for ZNF585A Gene

Molecular function for ZNF585A Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF585A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF585A: view
genes like me logo Genes that share phenotypes with ZNF585A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF585A Gene

Localization for ZNF585A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF585A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF585A gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF585A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF585A: view

Pathways & Interactions for ZNF585A Gene

SuperPathways for ZNF585A Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF585A: view

Pathways by source for ZNF585A Gene

2 Reactome pathways for ZNF585A Gene

Interacting Proteins for ZNF585A Gene

Gene Ontology (GO) - Biological Process for ZNF585A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
genes like me logo Genes that share ontologies with ZNF585A: view

No data available for SIGNOR curated interactions for ZNF585A Gene

Transcripts for ZNF585A Gene

Unigene Clusters for ZNF585A Gene

Zinc finger protein 585A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF585A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
SP1: - - - -
SP2: - -
SP3: - - - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - -
SP8: - -

Relevant External Links for ZNF585A Gene

GeneLoc Exon Structure for
ZNF585A
ECgene alternative splicing isoforms for
ZNF585A

Expression for ZNF585A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF585A Gene

Protein differential expression in normal tissues from HIPED for ZNF585A Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF585A Gene



Protein tissue co-expression partners for ZNF585A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF585A Gene:

ZNF585A

SOURCE GeneReport for Unigene cluster for ZNF585A Gene:

Hs.659236

Evidence on tissue expression from TISSUES for ZNF585A Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with ZNF585A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF585A Gene

Orthologs for ZNF585A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF585A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF585A 34 35
  • 99.09 (n)
cow
(Bos Taurus)
Mammalia ZNF585A 34
  • 89.03 (n)
ZNF484 35
  • 46 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp27 34 16 35
  • 81.1 (n)
rat
(Rattus norvegicus)
Mammalia Zfp27 34
  • 79.52 (n)
dog
(Canis familiaris)
Mammalia ZNF585A 34
  • 77.06 (n)
-- 35
  • 45 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 45 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733764 34
  • 55.78 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
CSA.1668 35
  • 32 (a)
ManyToMany
Species where no ortholog for ZNF585A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF585A Gene

ENSEMBL:
Gene Tree for ZNF585A (if available)
TreeFam:
Gene Tree for ZNF585A (if available)

Paralogs for ZNF585A Gene

(538) SIMAP similar genes for ZNF585A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF585A: view

Variants for ZNF585A Gene

Sequence variations from dbSNP and Humsavar for ZNF585A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000091038 -- 37,167,995(+) TCTAT(C/T)CTTTG intron-variant
rs1000223814 -- 37,155,470(+) ACATG(A/G)TGAAA intron-variant
rs1000274262 -- 37,151,329(+) TGAGA(A/C)GGCTT utr-variant-3-prime
rs1000512090 -- 37,150,397(+) TTGCA(-/G)GGGGC utr-variant-3-prime
rs1000583601 -- 37,151,551(+) AATCA(G/T)ACCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF585A Gene

Variant ID Type Subtype PubMed ID
esv3893201 CNV gain 25118596
nsv1064851 CNV loss 25217958
nsv2477 CNV deletion 18451855
nsv579461 CNV gain 21841781
nsv828545 CNV loss 20364138

Variation tolerance for ZNF585A Gene

Residual Variation Intolerance Score: 51.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.86; 67.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF585A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF585A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF585A Gene

Disorders for ZNF585A Gene

Relevant External Links for ZNF585A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF585A

No disorders were found for ZNF585A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF585A Gene

Publications for ZNF585A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa R.S. … Obuse C. (Nat. Cell Biol. 2010) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for ZNF585A Gene

Sources for ZNF585A Gene

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