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Aliases for ZNF584 Gene

Aliases for ZNF584 Gene

  • Zinc Finger Protein 584 2 3 5

External Ids for ZNF584 Gene

Previous GeneCards Identifiers for ZNF584 Gene

  • GC19P063612
  • GC19P063613
  • GC19P059046
  • GC19P059056
  • GC19P055229
  • GC19P059078
  • GC19P059096
  • GC19P059108
  • GC19P059150
  • GC19P059206
  • GC19P059248
  • GC19P059298

Summaries for ZNF584 Gene

GeneCards Summary for ZNF584 Gene

ZNF584 (Zinc Finger Protein 584) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF304.

UniProtKB/Swiss-Prot for ZNF584 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF584 Gene

Genomics for ZNF584 Gene

Regulatory Elements for ZNF584 Gene

Enhancers for ZNF584 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F058406 0.9 ENCODE 48.1 +7.0 6987 3.7 HDGF CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 FOS SP3 ZNF584 ZNF132 LOC100506634 TRIM28 RPS5 LOC105372483 GC19M058404
GH19F058439 1 ENCODE 46.6 +38.6 38611 2.1 HDGF PKNOX1 MXI1 TBL1XR1 SUZ12 WRNIP1 TEAD4 MAX BMI1 ZBTB40 ZNF584 ZNF132 LOC100506634 LOC105372483 ENSG00000268912 PIR40092
GH19F058400 1.4 FANTOM5 ENCODE 45.1 -0.1 -50 2.2 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YY1 SLC30A9 ZNF143 ZNF207 FOS ZNF584 ZNF132 TRIM28 ENSG00000268392 LOC100506634 A1BG ZNF324 ZNF329 ZNF497 MZF1
GH19F058474 0.2 ENCODE 34.9 +74.7 74654 3.8 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF207 ZNF143 ZNF584 ZNF132 LOC100506634 TRIM28 ENSG00000268392 ZNF134 ZNF324B RPS5 CENPBD1P1 ENSG00000269106
GH19F058450 0.2 ENCODE 33 +50.1 50145 1.3 ATF1 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 ZNF48 ETS1 YY1 GLIS2 ZNF584 RPS5 LOC100419848 ENSG00000269600 PIR34010
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF584 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF584 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000045668 96 1601 HDGF PKNOX1 ARID4B SIN3A YY1 SLC30A9 ZNF143 ZNF207 FOS SP3

Genomic Location for ZNF584 Gene

Chromosome:
19
Start:
58,401,504 bp from pter
End:
58,418,327 bp from pter
Size:
16,824 bases
Orientation:
Plus strand

Genomic View for ZNF584 Gene

Genes around ZNF584 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF584 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF584 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF584 Gene

Proteins for ZNF584 Gene

  • Protein details for ZNF584 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVC4-ZN584_HUMAN
    Recommended name:
    Zinc finger protein 584
    Protein Accession:
    Q8IVC4
    Secondary Accessions:
    • A8K203

    Protein attributes for ZNF584 Gene

    Size:
    421 amino acids
    Molecular mass:
    48272 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF584 Gene

Post-translational modifications for ZNF584 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF584 Gene

Domains & Families for ZNF584 Gene

Gene Families for ZNF584 Gene

Protein Domains for ZNF584 Gene

Suggested Antigen Peptide Sequences for ZNF584 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IVC4

UniProtKB/Swiss-Prot:

ZN584_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF584: view

Function for ZNF584 Gene

Molecular function for ZNF584 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF584 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF584: view
genes like me logo Genes that share phenotypes with ZNF584: view

Animal Model Products

miRNA for ZNF584 Gene

miRTarBase miRNAs that target ZNF584

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF584 Gene

Localization for ZNF584 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF584 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF584 Gene COMPARTMENTS Subcellular localization image for ZNF584 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF584 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF584: view

Pathways & Interactions for ZNF584 Gene

SuperPathways for ZNF584 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF584: view

Pathways by source for ZNF584 Gene

2 Reactome pathways for ZNF584 Gene

Gene Ontology (GO) - Biological Process for ZNF584 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF584: view

No data available for SIGNOR curated interactions for ZNF584 Gene

Transcripts for ZNF584 Gene

Unigene Clusters for ZNF584 Gene

Zinc finger protein 584:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF584 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ^ 12a ·
SP1: - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: - -
SP7: - - -
SP8: -
SP9: - -
SP10:
SP11: - - -

ExUns: 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ZNF584 Gene

GeneLoc Exon Structure for
ZNF584
ECgene alternative splicing isoforms for
ZNF584

Expression for ZNF584 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF584 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF584 Gene:

ZNF584

SOURCE GeneReport for Unigene cluster for ZNF584 Gene:

Hs.439551
genes like me logo Genes that share expression patterns with ZNF584: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF584 Gene

Orthologs for ZNF584 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF584 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF584 34 35
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia ZNF584 34 35
  • 83.33 (n)
cow
(Bos Taurus)
Mammalia ZNF584 34 35
  • 68.61 (n)
Species where no ortholog for ZNF584 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF584 Gene

ENSEMBL:
Gene Tree for ZNF584 (if available)
TreeFam:
Gene Tree for ZNF584 (if available)

Paralogs for ZNF584 Gene

(512) SIMAP similar genes for ZNF584 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for ZNF584 Gene

genes like me logo Genes that share paralogs with ZNF584: view

Variants for ZNF584 Gene

Sequence variations from dbSNP and Humsavar for ZNF584 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10404029 -- 58,409,311(+) GGCAG(C/T)GGGAG intron-variant, upstream-variant-2KB
rs10405898 -- 58,414,499(+) atgcc(C/T)gggta intron-variant
rs10406482 -- 58,406,319(+) ctcgg(C/T)atcag nc-transcript-variant, upstream-variant-2KB
rs10406593 -- 58,406,208(+) CAGGC(A/G)TGGCG nc-transcript-variant, upstream-variant-2KB
rs10407656 -- 58,415,243(+) agagt(A/C)caatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF584 Gene

Variant ID Type Subtype PubMed ID
esv1059195 CNV deletion 17803354
esv2546940 CNV deletion 19546169
nsv1057077 CNV gain 25217958
nsv515731 CNV gain+loss 19592680
nsv833887 CNV loss 17160897
nsv833888 CNV loss 17160897
nsv954672 CNV deletion 24416366

Variation tolerance for ZNF584 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.54; 88.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF584 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF584

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF584 Gene

Disorders for ZNF584 Gene

Relevant External Links for ZNF584

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF584

No disorders were found for ZNF584 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF584 Gene

Publications for ZNF584 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3 64
  4. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J. … Elledge S.J. (Cell 2009) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ZNF584 Gene

Sources for ZNF584 Gene

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