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Aliases for ZNF583 Gene

Aliases for ZNF583 Gene

  • Zinc Finger Protein 583 2 3 5
  • Zinc Finger Protein L3-5 4

External Ids for ZNF583 Gene

Previous GeneCards Identifiers for ZNF583 Gene

  • GC19P061611
  • GC19P061612
  • GC19P056930
  • GC19P053224
  • GC19P056932
  • GC19P056934
  • GC19P056936
  • GC19P056941
  • GC19P056946
  • GC19P056953
  • GC19P056962

Summaries for ZNF583 Gene

GeneCards Summary for ZNF583 Gene

ZNF583 (Zinc Finger Protein 583) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF570.

UniProtKB/Swiss-Prot for ZNF583 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF583 Gene

Genomics for ZNF583 Gene

Regulatory Elements for ZNF583 Gene

Enhancers for ZNF583 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F055671 1.1 ENCODE 19.2 -721.5 -721464 10.0 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF583 ZNF470 ZNF582-AS1 ENSG00000269696 ZNF542P ZNF667-AS1 ENSG00000267224 ZFP28 ZNF667 LOC729999
GH19F055519 1.6 FANTOM5 Ensembl ENCODE 11.5 -877.8 -877757 1.0 HDGF ATF1 ZNF493 ZNF133 GLI4 YBX1 ZNF416 ZNF548 FOS MCM3 FIZ1 ZNF580 NAT14 U2AF2 SHISA7 ZNF667 ZNF667-AS1 SSC5D SBK3 LOC100506374
GH19F055633 1.4 FANTOM5 ENCODE 11.5 -762.4 -762433 3.2 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF784 ZNF865 ZNF581 ZNF583 ZNF471 ZNF628 ZFP28 ZNF580 CCDC106
GH19F055640 1.1 ENCODE 11.5 -755.5 -755481 6.2 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF580 ZNF471 U2AF2 ZNF583 KMT5C ZFP28 FIZ1 CCDC106 PIR41897
GH19F055459 1.1 ENCODE 11.5 -936.8 -936827 3.1 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF583 ZNF628 U2AF2 ISOC2 SHISA7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF583 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF583 Gene

Chromosome:
19
Start:
56,397,966 bp from pter
End:
56,436,035 bp from pter
Size:
38,070 bases
Orientation:
Plus strand

Genomic View for ZNF583 Gene

Genes around ZNF583 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF583 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF583 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF583 Gene

Proteins for ZNF583 Gene

  • Protein details for ZNF583 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96ND8-ZN583_HUMAN
    Recommended name:
    Zinc finger protein 583
    Protein Accession:
    Q96ND8
    Secondary Accessions:
    • O14850
    • Q2NKK3

    Protein attributes for ZNF583 Gene

    Size:
    569 amino acids
    Molecular mass:
    66033 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF583 Gene

Post-translational modifications for ZNF583 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF583 Gene

Domains & Families for ZNF583 Gene

Gene Families for ZNF583 Gene

Protein Domains for ZNF583 Gene

Suggested Antigen Peptide Sequences for ZNF583 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96ND8

UniProtKB/Swiss-Prot:

ZN583_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF583: view

Function for ZNF583 Gene

Molecular function for ZNF583 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF583 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF583: view
genes like me logo Genes that share phenotypes with ZNF583: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF583 Gene

Localization for ZNF583 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF583 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF583 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF583 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF583: view

Pathways & Interactions for ZNF583 Gene

SuperPathways for ZNF583 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF583: view

Pathways by source for ZNF583 Gene

2 Reactome pathways for ZNF583 Gene

Interacting Proteins for ZNF583 Gene

Gene Ontology (GO) - Biological Process for ZNF583 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF583: view

No data available for SIGNOR curated interactions for ZNF583 Gene

Transcripts for ZNF583 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF583 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - - - - -
SP2: - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for ZNF583 Gene

GeneLoc Exon Structure for
ZNF583
ECgene alternative splicing isoforms for
ZNF583

Expression for ZNF583 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF583 Gene

Protein differential expression in normal tissues from HIPED for ZNF583 Gene

This gene is overexpressed in Retina (50.3) and Esophagus (18.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF583 Gene



Protein tissue co-expression partners for ZNF583 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF583 Gene:

ZNF583

SOURCE GeneReport for Unigene cluster for ZNF583 Gene:

Hs.146854
genes like me logo Genes that share expression patterns with ZNF583: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF583 Gene

Orthologs for ZNF583 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF583 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF583 34 35
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia ZNF583 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF583 34 35
  • 89.34 (n)
mouse
(Mus musculus)
Mammalia Zfp583 34 16 35
  • 85.27 (n)
rat
(Rattus norvegicus)
Mammalia Zfp583 34
  • 83.8 (n)
Species where no ortholog for ZNF583 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF583 Gene

ENSEMBL:
Gene Tree for ZNF583 (if available)
TreeFam:
Gene Tree for ZNF583 (if available)

Paralogs for ZNF583 Gene

(512) SIMAP similar genes for ZNF583 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF583: view

Variants for ZNF583 Gene

Sequence variations from dbSNP and Humsavar for ZNF583 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10418970 -- 56,403,131(+) ccttt(G/T)ttctg upstream-variant-2KB
rs10424112 -- 56,403,850(+) AAGAA(A/G)CAGAA upstream-variant-2KB
rs11084447 -- 56,406,773(+) TCGCC(A/C)GCCTC intron-variant
rs11084448 -- 56,406,892(+) AATGA(A/C)TTGCT intron-variant
rs111234998 -- 56,411,788(+) TGATG(C/G)GTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF583 Gene

Variant ID Type Subtype PubMed ID
nsv1055357 CNV gain 25217958
esv3389334 CNV duplication 20981092
dgv6591n54 CNV loss 21841781

Variation tolerance for ZNF583 Gene

Residual Variation Intolerance Score: 12.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF583 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF583

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF583 Gene

Disorders for ZNF583 Gene

Relevant External Links for ZNF583

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF583

No disorders were found for ZNF583 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF583 Gene

Publications for ZNF583 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ZNF583 Gene

Sources for ZNF583 Gene

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