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Aliases for ZNF583 Gene

Aliases for ZNF583 Gene

  • Zinc Finger Protein 583 2 3 5
  • Zinc Finger Protein L3-5 4

External Ids for ZNF583 Gene

Previous GeneCards Identifiers for ZNF583 Gene

  • GC19P061611
  • GC19P061612
  • GC19P056930
  • GC19P053224
  • GC19P056932
  • GC19P056934
  • GC19P056936
  • GC19P056941
  • GC19P056946
  • GC19P056953
  • GC19P056962

Summaries for ZNF583 Gene

GeneCards Summary for ZNF583 Gene

ZNF583 (Zinc Finger Protein 583) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF570.

UniProtKB/Swiss-Prot for ZNF583 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF583 Gene

Genomics for ZNF583 Gene

Regulatory Elements for ZNF583 Gene

Enhancers for ZNF583 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G055503 1.3 Ensembl ENCODE 40.8 -894.0 -893998 1.6 PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 CBX5 ZNF416 FIZ1 ZNF667 ZNF667-AS1 ZNF582-AS1 NAT14 ZNF542P ZNF583 U2AF2 LOC729999 ZNF580
GH19G055519 1.6 FANTOM5 Ensembl ENCODE 29.7 -877.8 -877757 1.0 HDGF ATF1 ZNF493 ZNF133 YBX1 GLI4 ZNF416 FOS ZNF548 SP3 FIZ1 ZNF471 NAT14 ZNF580 ZNF667 ZNF582-AS1 ZNF667-AS1 ZNF542P U2AF2 ZNF583
GH19G056594 1 ENCODE 40.8 +197.5 197475 1.4 HDGF PKNOX1 ZNF133 ARID4B SIN3A FEZF1 YBX1 GLI4 ZNF48 YY1 ZNF17 ENSG00000269696 ZNF549 ZNF773 ZNF543 U2AF2 ZFP28 ZNF667 ZNF470 FIZ1
GH19G055671 1.4 ENCODE dbSUPER 19.2 -721.5 -721464 10.0 HDGF PKNOX1 ARNT CREB3L1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF471 ZNF583 ZNF470 ZNF582-AS1 ENSG00000269696 ZNF542P ZNF667-AS1 ENSG00000267224 ZFP28 ZNF667
GH19G057388 1.1 ENCODE 22.6 +992.0 992034 2.2 PKNOX1 FOXA2 WRNIP1 SIN3A DMAP1 YY1 ZNF143 FOS SP3 CEBPZ ZSCAN18 ENSG00000269696 LOC100128398 ZNF470 ZNF582-AS1 ZNF583 ZNF304 ZNF264 ZNF667 ZNF667-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF583 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF583 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111755 -114 1401 HDGF CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF416 ZNF143 SP3

Genomic Location for ZNF583 Gene

56,397,966 bp from pter
56,436,035 bp from pter
38,070 bases
Plus strand

Genomic View for ZNF583 Gene

Genes around ZNF583 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF583 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF583 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF583 Gene

Proteins for ZNF583 Gene

  • Protein details for ZNF583 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 583
    Protein Accession:
    Secondary Accessions:
    • O14850
    • Q2NKK3

    Protein attributes for ZNF583 Gene

    569 amino acids
    Molecular mass:
    66033 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF583 Gene

Post-translational modifications for ZNF583 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF583 Gene

Domains & Families for ZNF583 Gene

Gene Families for ZNF583 Gene

Protein Domains for ZNF583 Gene

Suggested Antigen Peptide Sequences for ZNF583 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF583: view

Function for ZNF583 Gene

Molecular function for ZNF583 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF583 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF583: view
genes like me logo Genes that share phenotypes with ZNF583: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF583 Gene

Localization for ZNF583 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF583 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF583 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF583 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF583: view

Pathways & Interactions for ZNF583 Gene

SuperPathways for ZNF583 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF583: view

Pathways by source for ZNF583 Gene

2 Reactome pathways for ZNF583 Gene

Interacting Proteins for ZNF583 Gene

Gene Ontology (GO) - Biological Process for ZNF583 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF583: view

No data available for SIGNOR curated interactions for ZNF583 Gene

Drugs & Compounds for ZNF583 Gene

No Compound Related Data Available

Transcripts for ZNF583 Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF583 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - - - - -
SP2: - -
SP3: - - -
SP4: -

Relevant External Links for ZNF583 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF583 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF583 Gene

Protein differential expression in normal tissues from HIPED for ZNF583 Gene

This gene is overexpressed in Retina (50.3) and Esophagus (18.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF583 Gene

Protein tissue co-expression partners for ZNF583 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF583 Gene:


SOURCE GeneReport for Unigene cluster for ZNF583 Gene:


Evidence on tissue expression from TISSUES for ZNF583 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with ZNF583: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF583 Gene

Orthologs for ZNF583 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF583 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF583 34 35
  • 99.59 (n)
(Canis familiaris)
Mammalia ZNF583 35
  • 91 (a)
(Bos Taurus)
Mammalia ZNF583 34 35
  • 89.34 (n)
(Mus musculus)
Mammalia Zfp583 34 16 35
  • 85.27 (n)
(Rattus norvegicus)
Mammalia Zfp583 34
  • 83.8 (n)
Species where no ortholog for ZNF583 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF583 Gene

Gene Tree for ZNF583 (if available)
Gene Tree for ZNF583 (if available)

Paralogs for ZNF583 Gene

(512) SIMAP similar genes for ZNF583 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF583: view

Variants for ZNF583 Gene

Sequence variations from dbSNP and Humsavar for ZNF583 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000269750 -- 56,414,552(+) GACTC(-/A)AAGCC intron-variant
rs1000286757 -- 56,421,877(+) GAAAG(A/C)GAAAC intron-variant
rs1000356289 -- 56,402,454(+) GGGAG(A/G)CTGAG upstream-variant-2KB
rs1000360040 -- 56,422,161(+) GGTAG(A/G)AATTT intron-variant
rs1000528512 -- 56,403,651(+) ACGCA(C/T)TACTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF583 Gene

Variant ID Type Subtype PubMed ID
dgv6591n54 CNV loss 21841781
esv3389334 CNV duplication 20981092
nsv1055357 CNV gain 25217958

Variation tolerance for ZNF583 Gene

Residual Variation Intolerance Score: 12.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF583 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF583 Gene

Disorders for ZNF583 Gene

Relevant External Links for ZNF583

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF583 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF583 Gene

Publications for ZNF583 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ZNF583 Gene

Sources for ZNF583 Gene

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