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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF583 Gene

protein-coding   GIFtS: 45
GCID: GC19P056953

Zinc Finger Protein 583

  Search for ZNF583
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 5831 2
Zinc Finger Protein L3-52 3

External Ids:    HGNC: 264271   Entrez Gene: 1479492   Ensembl: ENSG000001984407   UniProtKB: Q96ND83   

Export aliases for ZNF583 gene to outside databases

Previous GC identifers: GC19P061611 GC19P061612 GC19P056930 GC19P053224 GC19P056932 GC19P056934 GC19P056936 GC19P056941 GC19P056946


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF583 Gene: 
ZNF583 (zinc finger protein 583) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF79.

UniProtKB/Swiss-Prot: ZN583_HUMAN, Q96ND8
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF583 gene promoter:
         USF1   STAT1   NCX/Ncx   CUTL1   Nkx2-5   YY1   POU2F1   POU2F1a   USF-1   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF583 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF583

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF583


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF583 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF583 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P056953:  view genomic region     (about GC identifiers)

Start:
56,909,335 bp from pter      End:
56,947,404 bp from pter
Size:
38,070 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN583_HUMAN, Q96ND8 (See protein sequence)
Recommended Name: Zinc finger protein 583  
Size: 569 amino acids; 66033 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: O14850 Q2NKK3

Explore the universe of human proteins at neXtProt for ZNF583: NX_Q96ND8

Explore proteomics data for ZNF583 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96ND8

  • ZNF583 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF583 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001153332.1  NP_001153333.1  NP_689691.2  

    ENSEMBL proteins: 
     ENSP00000444291   ENSP00000388502   ENSP00000375657   ENSP00000291598  
    Reactome Protein details: Q96ND8
    Human Recombinant Protein Products for ZNF583: 
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    Novus Biologicals ZNF583 Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF583 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF583 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96ND8

    ProtoNet protein and cluster: Q96ND8

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN583_HUMAN, Q96ND8
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF583 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN583_HUMAN, Q96ND8
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF583 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF583:
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF583 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF583 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF583
        Generic Transcription Pathway
    Gene Expression



    ZNF583 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF583

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF583 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF583 (ZN583)

    Search CenterWatch for drugs/clinical trials and news about ZNF583 / ZN583

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF583 gene (3 alternative transcripts): 
    NM_001159860.1  NM_001159861.1  NM_152478.2  

    Unigene Clusters for ZNF583:

    Zinc finger protein 583
    Hs.146854  [show with all ESTs], Hs.745489
    Unigene Representative Sequences: NM_152478, AL833236
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588635 ENST00000537943 ENST00000539211 ENST00000333201(uc002qnc.2 uc010ygm.1)
    ENST00000391778 ENST00000436972 ENST00000585612 ENST00000291598(uc010ygl.1)

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    hsa-miR-98 hsa-miR-3146 hsa-let-7d hsa-miR-520d-5p hsa-miR-586 hsa-miR-202 hsa-let-7c hsa-let-7i
    SwitchGear 3'UTR luciferase reporter plasmidZNF583 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Additional mRNA sequence: AL833236.1 

    7 DOTS entries:

    DT.40300816  DT.100016637  DT.40130516  DT.101955290  DT.121504548  DT.121504550  DT.110386 

    24 AceView cDNA sequences:

    BF507502 AA626677 CB108180 CD357699 BF515666 AL833236 BX280489 BM810088 
    BV205843 BM811289 AI147574 NM_152478 AI086545 AK055592 AU253911 AI215964 
    AW449915 AA994388 AU253910 AF024698 BX111721 N58534 BP338954 R47252 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF583    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:        -     -     -     -                 -           -                     
    SP2:                                            -           -                     
    SP3:                          -                 -           -                     
    SP4:                                            -                                 
    SP5:                                                                              


    ECgene alternative splicing isoforms for ZNF583

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF583 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF583 Expression
    About this image


    See ZNF583 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF583

    SOURCE GeneReport for Unigene clusters: Hs.146854 Hs.745489
        SABiosciences Custom PCR Arrays for ZNF583
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF583 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp5831 , 5 zinc finger protein 5831, 5 85.27(n)1
    82.75(a)1
      7 (3.66 cM)5
    2130111  NM_001033249.31  NP_001028421.11 
     63156605 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    29(a)
    25(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343619.1(331915-364667)
    GL343198.1(3555609-3559742)


    ENSEMBL Gene Tree for ZNF583 (if available)
    TreeFam Gene Tree for ZNF583 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF583 gene
    ZNF792  ZNF5702  ZFP302  ZNF5292  ZNF7902  ZNF4832  ZNF3832  ZNF1812  
    ZNF2872  ZNF5822  ZNF4712  ZFP822  ZNF2502  ZNF8792  ZNF354C2  ZNF742  
    ZNF4852  ZNF4542  ZFP902  ZFP142  ZNF3312  ZNF354A2  ZNF4612  ZNF3112  
    ZNF354B2  ZNF3452  ZNF5682  ZNF342  ZNF5652  
    18/511 SIMAP similar genes for ZNF583 using alignment to 3 protein entries:     ZN583_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    ZNF527    kr-znf3    ZNF573    ZNF721    ZNF471
    ZNF519    ZNF761    ZNF616    HZF30    ZNF554    ZNF675
    ZNF208    ZFS-4    ZNF845    ZNF91    ZNF730    ZNF624

    ZNF583 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/460 SNPs in ZNF583 are shown (see all 460)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1818435571,2
    --56913543(+) TATGAC/GACTGT 1 -- us2k10--------
    rs1130485151,2
    C--56913567(+) TTTGAT/CACAAG 1 -- us2k12Minor allele frequency- C:0.04NA 122
    rs1858067121,2
    --56913572(+) TACAAA/GCCCTA 1 -- us2k10--------
    rs756714431,2
    C--56913670(+) CCTGTA/TATCCC 1 -- us2k10--------
    rs1512780091,2
    C--56913752(+) ACCCCA/GTCTCT 3 -- us2k10--------
    rs1400145501,2
    --56913761(+) CTACTA/GAAAAT 3 -- us2k10--------
    rs1909649701,2
    --56913799(+) ACGTGC/TCTGTA 3 -- us2k10--------
    rs1831532361,2
    --56913969(+) GTTGCA/GTTTGT 3 -- us2k10--------
    rs1866713641,2
    --56914049(+) TAAATA/GAAGCA 3 -- us2k10--------
    rs1453378561,2
    C--56914254(+) CATTTG/TGTATG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF583 (56909335 - 56947404 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF583:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv912516CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF583 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF583)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 147949 HGNC: 26427 AceView: ZNF583 Ensembl:ENSG00000198440 euGenes: HUgn147949
    ECgene: ZNF583 H-InvDB: ZNF583

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF583 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF583 gene:
    Search GeneIP for patents involving ZNF583

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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