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Aliases for ZNF583 Gene

Aliases for ZNF583 Gene

  • Zinc Finger Protein 583 2 3 5
  • Zinc Finger Protein L3-5 4

External Ids for ZNF583 Gene

Previous GeneCards Identifiers for ZNF583 Gene

  • GC19P061611
  • GC19P061612
  • GC19P056930
  • GC19P053224
  • GC19P056932
  • GC19P056934
  • GC19P056936
  • GC19P056941
  • GC19P056946
  • GC19P056953
  • GC19P056962

Summaries for ZNF583 Gene

GeneCards Summary for ZNF583 Gene

ZNF583 (Zinc Finger Protein 583) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF345.

UniProtKB/Swiss-Prot for ZNF583 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF583 Gene

Genomics for ZNF583 Gene

Regulatory Elements for ZNF583 Gene

Enhancers for ZNF583 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF583 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF583 Gene

56,397,966 bp from pter
56,436,035 bp from pter
38,070 bases
Plus strand

Genomic View for ZNF583 Gene

Genes around ZNF583 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF583 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF583 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF583 Gene

Proteins for ZNF583 Gene

  • Protein details for ZNF583 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 583
    Protein Accession:
    Secondary Accessions:
    • O14850
    • Q2NKK3

    Protein attributes for ZNF583 Gene

    569 amino acids
    Molecular mass:
    66033 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF583 Gene

Proteomics data for ZNF583 Gene at MOPED

Post-translational modifications for ZNF583 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF583 Gene

No data available for DME Specific Peptides for ZNF583 Gene

Domains & Families for ZNF583 Gene

Gene Families for ZNF583 Gene

Protein Domains for ZNF583 Gene

Suggested Antigen Peptide Sequences for ZNF583 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF583: view

Function for ZNF583 Gene

Molecular function for ZNF583 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF583 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZNF583: view
genes like me logo Genes that share phenotypes with ZNF583: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF583 Gene

Localization for ZNF583 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF583 Gene

Subcellular locations from

Jensen Localization Image for ZNF583 Gene COMPARTMENTS Subcellular localization image for ZNF583 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF583 Gene

Pathways & Interactions for ZNF583 Gene

SuperPathways for ZNF583 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF583: view

Pathways by source for ZNF583 Gene

2 Reactome pathways for ZNF583 Gene

Interacting Proteins for ZNF583 Gene

Gene Ontology (GO) - Biological Process for ZNF583 Gene


No data available for SIGNOR curated interactions for ZNF583 Gene

Drugs & Compounds for ZNF583 Gene

No Compound Related Data Available

Transcripts for ZNF583 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF583 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - - - - -
SP2: - -
SP3: - - -
SP4: -

Relevant External Links for ZNF583 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF583 Gene

mRNA expression in normal human tissues for ZNF583 Gene

Protein differential expression in normal tissues from HIPED for ZNF583 Gene

This gene is overexpressed in Retina (50.3) and Esophagus (18.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF583 Gene

SOURCE GeneReport for Unigene cluster for ZNF583 Gene Hs.146854

genes like me logo Genes that share expression patterns with ZNF583: view

Protein tissue co-expression partners for ZNF583 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF583 Gene

Orthologs for ZNF583 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF583 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF583 35
  • 89.34 (n)
  • 90.41 (a)
ZNF583 36
  • 90 (a)
(Mus musculus)
Mammalia Zfp583 35
  • 85.27 (n)
  • 82.75 (a)
Zfp583 16
Zfp583 36
  • 83 (a)
(Pan troglodytes)
Mammalia ZNF583 35
  • 99.59 (n)
  • 99.82 (a)
ZNF583 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zfp583 35
  • 83.8 (n)
  • 82.57 (a)
(Canis familiaris)
Mammalia ZNF583 36
  • 91 (a)
Species with no ortholog for ZNF583:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF583 Gene

Gene Tree for ZNF583 (if available)
Gene Tree for ZNF583 (if available)

Paralogs for ZNF583 Gene

(512) SIMAP similar genes for ZNF583 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF583: view

Variants for ZNF583 Gene

Sequence variations from dbSNP and Humsavar for ZNF583 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12976917 - 56,423,628(+) GACCT(A/T)TCGAA reference, missense
rs12976615 -- 56,410,287(+) GTAAT(G/T)AAAAA intron-variant
rs12976916 -- 56,423,627(+) AGACC(A/T)TTCGA reference, synonymous-codon
rs12981443 -- 56,417,581(+) tatat(A/G)tattg intron-variant
rs12984960 -- 56,418,343(+) gctga(C/T)ttgga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF583 Gene

Variant ID Type Subtype PubMed ID
nsv912516 CNV Gain 21882294

Variation tolerance for ZNF583 Gene

Residual Variation Intolerance Score: 12.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.08% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF583 Gene

Disorders for ZNF583 Gene

Relevant External Links for ZNF583

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF583 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF583 Gene

Publications for ZNF583 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF583 Gene

Sources for ZNF583 Gene