Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF582 Gene

Aliases for ZNF582 Gene

  • Zinc Finger Protein 582 2 3 5

External Ids for ZNF582 Gene

Previous GeneCards Identifiers for ZNF582 Gene

  • GC19M061588
  • GC19M061589
  • GC19M056894
  • GC19M053203
  • GC19M056887

Summaries for ZNF582 Gene

Entrez Gene Summary for ZNF582 Gene

  • The protein encoded by this gene is a zing finger protein and putative transcription factor that is highly methylated in cervical cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for ZNF582 Gene

ZNF582 (Zinc Finger Protein 582) is a Protein Coding gene. Diseases associated with ZNF582 include Cervical Adenocarcinoma. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF345.

UniProtKB/Swiss-Prot for ZNF582 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF582 Gene

Genomics for ZNF582 Gene

Regulatory Elements for ZNF582 Gene

Enhancers for ZNF582 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF582 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF582 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF582 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF582 Gene

Chromosome:
19
Start:
56,374,832 bp from pter
End:
56,393,585 bp from pter
Size:
18,754 bases
Orientation:
Minus strand

Genomic View for ZNF582 Gene

Genes around ZNF582 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF582 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF582 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF582 Gene

Proteins for ZNF582 Gene

  • Protein details for ZNF582 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NG8-ZN582_HUMAN
    Recommended name:
    Zinc finger protein 582
    Protein Accession:
    Q96NG8
    Secondary Accessions:
    • B4DQZ9
    • B7Z9R3
    • Q6PJT6

    Protein attributes for ZNF582 Gene

    Size:
    517 amino acids
    Molecular mass:
    60498 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH11796.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAG61111.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAH14399.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW72447.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ZNF582 Gene

Proteomics data for ZNF582 Gene at MOPED

Post-translational modifications for ZNF582 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF582 Gene

Domains & Families for ZNF582 Gene

Gene Families for ZNF582 Gene

Protein Domains for ZNF582 Gene

Suggested Antigen Peptide Sequences for ZNF582 Gene

Graphical View of Domain Structure for InterPro Entry

Q96NG8

UniProtKB/Swiss-Prot:

ZN582_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF582: view

Function for ZNF582 Gene

Molecular function for ZNF582 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF582: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF582 Gene

Localization for ZNF582 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF582 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF582 Gene COMPARTMENTS Subcellular localization image for ZNF582 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ZNF582 Gene

Pathways & Interactions for ZNF582 Gene

SuperPathways for ZNF582 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF582: view

Pathways by source for ZNF582 Gene

2 Reactome pathways for ZNF582 Gene

Interacting Proteins for ZNF582 Gene

Gene Ontology (GO) - Biological Process for ZNF582 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF582: view

No data available for SIGNOR curated interactions for ZNF582 Gene

Drugs & Compounds for ZNF582 Gene

No Compound Related Data Available

Transcripts for ZNF582 Gene

Unigene Clusters for ZNF582 Gene

Zinc finger protein 582:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF582 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2:
SP3: -

Relevant External Links for ZNF582 Gene

GeneLoc Exon Structure for
ZNF582
ECgene alternative splicing isoforms for
ZNF582

Expression for ZNF582 Gene

mRNA expression in normal human tissues for ZNF582 Gene

SOURCE GeneReport for Unigene cluster for ZNF582 Gene Hs.244391

genes like me logo Genes that share expression patterns with ZNF582: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF582 Gene

Orthologs for ZNF582 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF582 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF582 35
  • 89.23 (n)
  • 87.43 (a)
chimpanzee
(Pan troglodytes)
Mammalia ZNF582 35
  • 99.55 (n)
  • 99.42 (a)
ZNF582 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF582 36
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6654 36
  • 21 (a)
OneToMany
Species with no ortholog for ZNF582:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF582 Gene

ENSEMBL:
Gene Tree for ZNF582 (if available)
TreeFam:
Gene Tree for ZNF582 (if available)

Paralogs for ZNF582 Gene

(485) SIMAP similar genes for ZNF582 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF582: view

Variants for ZNF582 Gene

Sequence variations from dbSNP and Humsavar for ZNF582 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11883260 - 56,390,027(+) CCACT(C/G)TCTCC nc-transcript-variant, reference, missense
VAR_070557 -
VAR_070558 -
rs7257019 -- 56,385,503(+) caaca(C/T)agcaa intron-variant
rs12978696 -- 56,384,127(+) AAAGC(C/T)TTCCC nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZNF582 Gene

Variant ID Type Subtype PubMed ID
nsv912516 CNV Gain 21882294

Variation tolerance for ZNF582 Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF582 Gene

Human Gene Mutation Database (HGMD)
ZNF582

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF582 Gene

Disorders for ZNF582 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF582 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cervical adenocarcinoma
  • adenocarcinoma cervix uteri
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF582

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF582
genes like me logo Genes that share disorders with ZNF582: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF582 Gene

Publications for ZNF582 Gene

  1. Methylomic analysis identifies frequent DNA methylation of zinc finger protein 582 (ZNF582) in cervical neoplasms. (PMID: 22815913) Huang R.L. … Lai H.C. (PLoS ONE 2012) 2 3 67
  2. Comparison of HPV genotyping and methylated ZNF582 as triage for women with equivocal liquid-based cytology results. (PMID: 25945131) Liou Y.L. … Zhou H.H. (Clin Epigenetics 2015) 3
  3. Concordance analysis of methylation biomarkers detection in self-collected and physician-collected samples in cervical neoplasm. (PMID: 25985991) Chang C.C. … Lai H.C. (BMC Cancer 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. High Methylation Rate of LMX1A, NKX6-1, PAX1, PTPRR, SOX1, and ZNF582 Genes in Cervical Adenocarcinoma. (PMID: 24407576) Chang C.C. … Lai H.C. (Int. J. Gynecol. Cancer 2014) 3

Products for ZNF582 Gene

Sources for ZNF582 Gene

Content