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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF582 Gene

protein-coding   GIFtS: 47
GCID: GC19M056887

Zinc Finger Protein 582

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 5821 2

External Ids:    HGNC: 264211   Entrez Gene: 1479482   Ensembl: ENSG000000188697   UniProtKB: Q96NG83   

Export aliases for ZNF582 gene to outside databases

Previous GC identifers: GC19M061588 GC19M061589 GC19M056894 GC19M053203


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF582 Gene: 
ZNF582 (zinc finger protein 582) is a protein-coding gene. Diseases associated with ZNF582 include mastitis, and cervicitis, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF79.

UniProtKB/Swiss-Prot: ZN582_HUMAN, Q96NG8
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF582 gene promoter:
         USF1   STAT1   NCX/Ncx   CUTL1   Nkx2-5   YY1   SREBP-1a   POU2F1   USF-1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF582 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF582

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF582


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF582 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF582 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M056887:  view genomic region     (about GC identifiers)

Start:
56,887,413 bp from pter      End:
56,904,914 bp from pter
Size:
17,502 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN582_HUMAN, Q96NG8 (See protein sequence)
Recommended Name: Zinc finger protein 582  
Size: 517 amino acids; 60498 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH11796.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: Q6PJT6

Explore the universe of human proteins at neXtProt for ZNF582: NX_Q96NG8

Explore proteomics data for ZNF582 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96NG8

  • ZNF582 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF582 Protein Expression
    REFSEQ proteins: NP_653291.1  
    ENSEMBL proteins: 
     ENSP00000468679   ENSP00000301310   ENSP00000465619   ENSP00000466875   ENSP00000466452  
     ENSP00000465639  
    Reactome Protein details: Q96NG8
    Human Recombinant Protein Products for ZNF582: 
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    Novus Biologicals ZNF582 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZNF582 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF582 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96NG8

    ProtoNet protein and cluster: Q96NG8

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN582_HUMAN, Q96NG8
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF582 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN582_HUMAN, Q96NG8
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF582 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF582:
     Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF582 
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF582


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF582 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF582
        Generic Transcription Pathway
    Gene Expression



    ZNF582 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF582

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF582 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF582 (ZN582)

    Search CenterWatch for drugs/clinical trials and news about ZNF582 / ZN582

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF582 gene: 
    NM_144690.1  

    Unigene Cluster for ZNF582:

    Zinc finger protein 582
    Hs.244391  [show with all ESTs]
    Unigene Representative Sequence: AK055489
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589143 ENST00000301310(uc002qmz.1 uc002qmy.3) ENST00000586929
    ENST00000587778 ENST00000593145 ENST00000589895
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF582
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF582
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF582
    Sirion Biotech Customized lentivirus for stable overexpression of ZNF582 
                         Customized lentivirus expression plasmids for stable overexpression of ZNF582 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF582
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF582
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF582

    Additional mRNA sequence: 

    AK055489.1 AK299036.1 AK316028.1 BC011796.2 BC056238.1 BC101008.1 BC101009.1 BC101010.1 
    BC101011.1 

    5 DOTS entries:

    DT.207262  DT.101968493  DT.100650742  DT.430305  DT.91678496 

    24/46 AceView cDNA sequences (see all 46):

    CD637159 AW300494 CD637150 CD637152 BX104812 AA361275 AW449232 BM021131 
    AW131655 AK055489 CD637160 CD637151 CD637161 CD637157 BE549691 CD637153 
    NM_144690 AI807339 BG432829 AW058529 AI199619 W74314 CD637155 BC056238 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF582    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:              -     -                                 
    SP2:                                                      
    SP3:                    -                                 


    ECgene alternative splicing isoforms for ZNF582

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF582 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATCCCTTAC
    ZNF582 Expression
    About this image


    See ZNF582 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF582

    SOURCE GeneReport for Unigene cluster: Hs.244391
        SABiosciences Custom PCR Arrays for ZNF582
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF582

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF582 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF5821 zinc finger protein 582 89.04(n)
    85.88(a)
      100686346  XM_003432631.2  XP_003432679.2 


    ENSEMBL Gene Tree for ZNF582 (if available)
    TreeFam Gene Tree for ZNF582 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF582 gene
    ZNF792  ZNF5702  ZFP302  ZNF5292  ZNF7902  ZNF4832  ZNF3832  ZNF1812  
    ZNF2872  ZNF4712  ZFP822  ZNF2502  ZNF8792  ZNF354C2  ZNF742  ZNF5832  
    ZNF4852  ZNF4542  ZFP902  ZFP142  ZNF3312  ZNF354A2  ZNF4612  ZNF3112  
    ZNF354B2  ZNF3452  ZNF5682  ZNF342  ZNF5652  
    18/527 SIMAP similar genes for ZNF582 using alignment to 4 protein entries:     ZN582_HUMAN (see all proteins) (see all similar genes):
    ZNF818P    kr-znf3    ZNF78L1    ZNF721    DKFZp666C237    HZF36
    ZNF250    ZNF420    ZNF573    ZNF    ZNF146    ZNF471
    ZNF140    HZF16    HZF30    ZNF132    ZNF730    ZNF833P

    ZNF582 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/258 SNPs in ZNF582 are shown (see all 258)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1469057301,2
    --56894231(+) TGAGGC/TCCACT 1 -- ds50010--------
    rs1392188681,2
    --56894262(+) AGACAC/GCTGCA 1 -- ds50010--------
    rs736212391,2
    C--56894266(+) AGCTGC/TAGCAG 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1432310941,2
    --56894280(+) CAGGCA/GTCATG 1 -- ds50010--------
    rs1838570281,2
    --56894284(+) CATCAC/TGTTCT 1 -- ds50010--------
    rs1133302261,2
    C--56894301(+) AAAATG/ATTTAA 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1437809521,2
    --56894342(+) ATGATA/GAACCT 1 -- ds50010--------
    rs1481069981,2
    --56894386(+) GCCCCA/GGCAGA 1 -- ds50010--------
    rs1893394361,2
    --56894464(+) TGATAG/TTCTCA 1 -- ds50010--------
    rs93047751,2
    C,F,H--56894608(+) AAATTT/CAGATT 1 -- ds500111Minor allele frequency- C:0.09NS EA NA WA 1300

    HapMap Linkage Disequilibrium report for ZNF582 (56887413 - 56904914 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF582:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv912516CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZNF582:    About MalaCards
    mastitis    cervicitis


    ZNF582 for disorders           About GeneDecksing


    Export disorders for ZNF582 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF582 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF582)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Methylomic analysis identifies frequent DNA methylatio n of zinc finger protein 582 (ZNF582) in cervical neoplasms. (PubMed id 22815913)1 Huang R.L....Lai H.C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 147948 HGNC: 26421 AceView: ZNF582 Ensembl:ENSG00000018869 euGenes: HUgn147948
    ECgene: ZNF582 H-InvDB: ZNF582

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF582 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF582 gene:
    Search GeneIP for patents involving ZNF582

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
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