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ZNF582 Gene

protein-coding   GIFtS: 48
GCID: GC19M056887

Zinc Finger Protein 582

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 5821 2

External Ids:    HGNC: 264211   Entrez Gene: 1479482   Ensembl: ENSG000000188697   OMIM: 6156005   UniProtKB: Q96NG83   

Export aliases for ZNF582 gene to outside databases

Previous GC identifers: GC19M061588 GC19M061589 GC19M056894 GC19M053203


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF582 Gene:
ZNF582 (zinc finger protein 582) is a protein-coding gene. An important paralog of this gene is ZNF79.

UniProtKB/Swiss-Prot: ZN582_HUMAN, Q96NG8
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF582 gene promoter:
         USF1   STAT1   NCX/Ncx   CUTL1   Nkx2-5   YY1   SREBP-1a   POU2F1   USF-1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF582 promoter sequence
   Search Chromatin IP Primers for ZNF582

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF582


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF582 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF582 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M056887:  view genomic region     (about GC identifiers)

Start:
56,887,413 bp from pter      End:
56,904,914 bp from pter
Size:
17,502 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN582_HUMAN, Q96NG8 (See protein sequence)
Recommended Name: Zinc finger protein 582  
Size: 517 amino acids; 60498 Da
Sequence caution: Sequence=AAH11796.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAG61111.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAH14399.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=EAW72447.1;
Type=Erroneous gene model prediction;
Secondary accessions: B4DQZ9 B7Z9R3 Q6PJT6

Explore the universe of human proteins at neXtProt for ZNF582: NX_Q96NG8

Explore proteomics data for ZNF582 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF582 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_653291.1  
    ENSEMBL proteins: 
     ENSP00000468679   ENSP00000301310   ENSP00000465619   ENSP00000466875   ENSP00000466452  
     ENSP00000465639  
    Reactome Protein details: Q96NG8

    ZNF582 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZNF582

     
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    antibodies-online peptides for ZNF582

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    antibodies-online antibodies for ZNF582 (5 products) 

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    Cloud-Clone Corp. CLIAs for ZNF582
    Search eBioscience for ELISAs for ZNF582 
    antibodies-online kits for ZNF582 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96NG8

    ProtoNet protein and cluster: Q96NG8

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN582_HUMAN, Q96NG8
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF582           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN582_HUMAN, Q96NG8
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF582           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF582:
     Increased S DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF582

    miRNA
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF582


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN582_HUMAN, Q96NG8: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF582           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF582 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF582           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF582
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF582
    Interactions:

        Search GeneGlobe Interaction Network for ZNF582

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF582           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF582 (ZN582)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF582 gene: 
    NM_144690.1  

    Unigene Cluster for ZNF582:

    Zinc finger protein 582
    Hs.244391  [show with all ESTs]
    Unigene Representative Sequence: AK055489
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589143 ENST00000301310(uc002qmz.1 uc002qmy.3) ENST00000586929
    ENST00000587778 ENST00000593145 ENST00000589895
    miRNA
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    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF582
    Clone
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF582
      QuantiFast Probe-based Assays in human, mouse, rat ZNF582

    Additional mRNA sequence: 

    AK055489.1 AK299036.1 AK316028.1 BC011796.2 BC056238.1 BC101008.1 BC101009.1 BC101010.1 
    BC101011.1 

    5 DOTS entries:

    DT.207262  DT.101968493  DT.100650742  DT.430305  DT.91678496 

    Selected AceView cDNA sequences (see all 46):

    CD637161 CD637160 CD637157 BX104812 CD637151 CD637153 AW300494 NM_144690 
    BE549691 AW131655 CD637159 AK055489 AW449232 BM021131 CD637150 AA361275 
    CD637152 AW058529 BM021385 AI807339 BG432829 W79248 W74314 AI199619 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF582    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:              -     -                                 
    SP2:                                                      
    SP3:                    -                                 


    ECgene alternative splicing isoforms for ZNF582

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF582 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATCCCTTAC
    ZNF582 Expression
    About this image

    ZNF582 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF582 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.244391
        Custom PCR Arrays for ZNF582
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF582

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF582 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF5826
    zinc finger protein 582
    86(a)
    1 ↔ 1
    1(101548238-101563617)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG66546
    --
    21(a)
    1 → many
    3R(11036999-11039380)


    ENSEMBL Gene Tree for ZNF582 (if available)
    TreeFam Gene Tree for ZNF582 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF582 gene
    ZNF792  ZNF5702  ZFP302  ZNF5292  ZNF286B2  ZNF7902  ZNF3832  ZNF1812  
    ZNF2872  ZNF4712  ZFP822  ZNF286A2  ZNF2502  ZNF8792  ZNF354C2  ZNF742  
    ZNF5832  ZNF3912  ZNF5542  ZNF4542  ZFP902  ENSG000001876072  ZFP142  ZNF3312  
    ZNF354A2  ZNF4612  ZNF354B2  ZNF342  ZNF5272  ZNF5652  
    Selected SIMAP similar genes for ZNF582 using alignment to 3 protein entries:     ZN582_HUMAN (see all proteins) (see all similar genes):
    ZNF721    ZNF471    ZNF420    DKFZp666C237    HZF36    ZNF573
    ZNF250    ZNF649    ZNF730    ZNF140    ZFP30    ZNF546
    ZNF146    ZNF350    ZNF229    ZNF66    ZNF850    HZF30

    Find genes that share paralogs with ZNF582           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF582 (see all 260)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1469057301,2
    --56894231(+) TGAGGC/TCCACT 1 -- ds50010--------
    rs1392188681,2
    --56894262(+) AGACAC/GCTGCA 1 -- ds50010--------
    rs736212391,2
    C--56894266(+) AGCTGC/TAGCAG 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1432310941,2
    --56894280(+) CAGGCA/GTCATG 1 -- ds50010--------
    rs1838570281,2
    --56894284(+) CATCAC/TGTTCT 1 -- ds50010--------
    rs1133302261,2
    C--56894301(+) AAAATG/ATTTAA 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1437809521,2
    --56894342(+) ATGATA/GAACCT 1 -- ds50010--------
    rs1481069981,2
    --56894386(+) GCCCCA/GGCAGA 1 -- ds50010--------
    rs1893394361,2
    --56894464(+) TGATAG/TTCTCA 1 -- ds50010--------
    rs93047751,2
    C,F,H--56894608(+) AAATTT/CAGATT 1 -- ds500111Minor allele frequency- C:0.09NS EA NA WA 1300

    HapMap Linkage Disequilibrium report for ZNF582 (56887413 - 56904914 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF582:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912516CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF582
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF582

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615600    OMIM disorders: --


    Find genes that share disorders with ZNF582           About GenesLikeMe


    Export disorders for ZNF582 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF582 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF582)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Identification of pathogenic gene variants in small families with intellectually disabled siblings by exome sequencing. (PubMed id 24123876)2 Schuurs-Hoeijmakers J.H.... de Brouwer A.P. (J. Med. Genet. 2013)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Methylomic analysis identifies frequent DNA methylation of zinc finger protein 582 (ZNF582) in cervical neoplasms. (PubMed id 22815913)1 Huang R.L....Lai H.C. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 147948 HGNC: 26421 AceView: ZNF582 Ensembl:ENSG00000018869 euGenes: HUgn147948
    ECgene: ZNF582 H-InvDB: ZNF582

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF582 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF582 gene:
    Search GeneIP for patents involving ZNF582

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