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Aliases for ZNF582 Gene

Aliases for ZNF582 Gene

  • Zinc Finger Protein 582 2 3 5

External Ids for ZNF582 Gene

Previous GeneCards Identifiers for ZNF582 Gene

  • GC19M061588
  • GC19M061589
  • GC19M056894
  • GC19M053203
  • GC19M056887

Summaries for ZNF582 Gene

Entrez Gene Summary for ZNF582 Gene

  • The protein encoded by this gene is a zing finger protein and putative transcription factor that is highly methylated in cervical cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for ZNF582 Gene

ZNF582 (Zinc Finger Protein 582) is a Protein Coding gene. Diseases associated with ZNF582 include Cervical Adenocarcinoma. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF565.

UniProtKB/Swiss-Prot for ZNF582 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF582 Gene

Genomics for ZNF582 Gene

Regulatory Elements for ZNF582 Gene

Enhancers for ZNF582 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F056507 1.2 FANTOM5 ENCODE 2 -114.6 -114589 2.1 ZNF76 SIN3A YY1 ZNF121 GLIS2 ZNF366 KLF7 ZNF391 EGR2 ZNF280D ENSG00000269696 ZNF667 ZNF471 ZNF583 ZNF835 ZNF470 ZFP28 ZNF71 SMIM17 ZNF582
GH19F056392 1 ENCODE 0.8 +0.1 129 1.5 ATF1 ARNT CREB3L1 ZNF133 SIN3A ZNF48 BRCA1 ZNF2 ETS1 YY1 ZNF543 ZNF582-AS1 ZNF805 LOC100506374 ZNF264 ZNF581 U2AF2 ENSG00000267523 ZNF628 ZNF548
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF582 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF582 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001420184 84 1799 ATF1 ARNT CREB3L1 ZNF133 SIN3A ZNF48 BRCA1 ZNF2 ETS1 YY1

Genomic Location for ZNF582 Gene

Chromosome:
19
Start:
56,374,832 bp from pter
End:
56,393,585 bp from pter
Size:
18,754 bases
Orientation:
Minus strand

Genomic View for ZNF582 Gene

Genes around ZNF582 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF582 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF582 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF582 Gene

Proteins for ZNF582 Gene

  • Protein details for ZNF582 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NG8-ZN582_HUMAN
    Recommended name:
    Zinc finger protein 582
    Protein Accession:
    Q96NG8
    Secondary Accessions:
    • B4DQZ9
    • B7Z9R3
    • Q6PJT6

    Protein attributes for ZNF582 Gene

    Size:
    517 amino acids
    Molecular mass:
    60498 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH11796.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAG61111.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAH14399.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW72447.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ZNF582 Gene

Post-translational modifications for ZNF582 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF582 Gene

Domains & Families for ZNF582 Gene

Gene Families for ZNF582 Gene

Protein Domains for ZNF582 Gene

Suggested Antigen Peptide Sequences for ZNF582 Gene

Graphical View of Domain Structure for InterPro Entry

Q96NG8

UniProtKB/Swiss-Prot:

ZN582_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF582: view

Function for ZNF582 Gene

Molecular function for ZNF582 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF582 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF582: view
genes like me logo Genes that share phenotypes with ZNF582: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF582 Gene

Localization for ZNF582 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF582 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF582 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF582 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF582: view

Pathways & Interactions for ZNF582 Gene

SuperPathways for ZNF582 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF582: view

Pathways by source for ZNF582 Gene

2 Reactome pathways for ZNF582 Gene

Interacting Proteins for ZNF582 Gene

Gene Ontology (GO) - Biological Process for ZNF582 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF582: view

No data available for SIGNOR curated interactions for ZNF582 Gene

Transcripts for ZNF582 Gene

Unigene Clusters for ZNF582 Gene

Zinc finger protein 582:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF582 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2:
SP3: -

Relevant External Links for ZNF582 Gene

GeneLoc Exon Structure for
ZNF582
ECgene alternative splicing isoforms for
ZNF582

Expression for ZNF582 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF582 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF582 Gene:

ZNF582

SOURCE GeneReport for Unigene cluster for ZNF582 Gene:

Hs.244391
genes like me logo Genes that share expression patterns with ZNF582: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF582 Gene

Orthologs for ZNF582 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF582 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF582 34 35
  • 99.55 (n)
cow
(Bos Taurus)
Mammalia ZNF582 34
  • 89.23 (n)
dog
(Canis familiaris)
Mammalia ZNF582 35
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6654 35
  • 21 (a)
OneToMany
Species where no ortholog for ZNF582 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF582 Gene

ENSEMBL:
Gene Tree for ZNF582 (if available)
TreeFam:
Gene Tree for ZNF582 (if available)

Paralogs for ZNF582 Gene

(485) SIMAP similar genes for ZNF582 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF582: view

Variants for ZNF582 Gene

Sequence variations from dbSNP and Humsavar for ZNF582 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs149022328 Uncertain significance 56,384,383(+) CCTTC(C/T)CACAT nc-transcript-variant, reference, missense
rs369155373 Uncertain significance 56,390,040(+) CATCC(A/C)GGGCT nc-transcript-variant, reference, missense
rs10401365 -- 56,392,122(+) ACCCA(C/T)ATGTT intron-variant, upstream-variant-2KB
rs10427126 -- 56,391,826(+) GCGAC(A/G)GTAGA nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs111416762 -- 56,390,387(+) GACCA(A/G)GTTGC nc-transcript-variant, reference, synonymous-codon

Variation tolerance for ZNF582 Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF582 Gene

Human Gene Mutation Database (HGMD)
ZNF582
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF582

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF582 Gene

Disorders for ZNF582 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF582 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cervical adenocarcinoma
  • adenocarcinoma cervix uteri
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF582

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF582
genes like me logo Genes that share disorders with ZNF582: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF582 Gene

Publications for ZNF582 Gene

  1. Methylomic analysis identifies frequent DNA methylation of zinc finger protein 582 (ZNF582) in cervical neoplasms. (PMID: 22815913) Huang R.L. … Lai H.C. (PLoS ONE 2012) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Comparison of HPV genotyping and methylated ZNF582 as triage for women with equivocal liquid-based cytology results. (PMID: 25945131) Liou Y.L. … Zhou H.H. (Clin Epigenetics 2015) 3 64
  5. Concordance analysis of methylation biomarkers detection in self-collected and physician-collected samples in cervical neoplasm. (PMID: 25985991) Chang C.C. … Lai H.C. (BMC Cancer 2015) 3 64

Products for ZNF582 Gene

Sources for ZNF582 Gene

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