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Aliases for ZNF582 Gene

Aliases for ZNF582 Gene

  • Zinc Finger Protein 582 2 3

External Ids for ZNF582 Gene

Summaries for ZNF582 Gene

GeneCards Summary for ZNF582 Gene

ZNF582 (Zinc Finger Protein 582) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF529.

UniProtKB/Swiss-Prot for ZNF582 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF582 Gene

Genomics for ZNF582 Gene

Genomic Location for ZNF582 Gene

Start:
56,375,178 bp from pter
End:
56,393,586 bp from pter
Size:
18,409 bases
Orientation:
Minus strand

Genomic View for ZNF582 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF582 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF582 Gene

Regulatory Elements for ZNF582 Gene

Proteins for ZNF582 Gene

  • Protein details for ZNF582 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NG8-ZN582_HUMAN
    Recommended name:
    Zinc finger protein 582
    Protein Accession:
    Q96NG8
    Secondary Accessions:
    • B4DQZ9
    • B7Z9R3
    • Q6PJT6

    Protein attributes for ZNF582 Gene

    Size:
    517 amino acids
    Molecular mass:
    60498 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH11796.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAG61111.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAH14399.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW72447.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ZNF582 Gene

Proteomics data for ZNF582 Gene at MOPED

Post-translational modifications for ZNF582 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF582 Gene

No data available for DME Specific Peptides for ZNF582 Gene

Domains for ZNF582 Gene

Gene Families for ZNF582 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF582 Gene

UniProtKB/Swiss-Prot:

ZN582_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q96NG8
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q96NG8
Similarity:
  • Contains 10 C2H2-type zinc fingers.:
    • Q96NG8
genes like me logo Genes that share domains with ZNF582: view

Function for ZNF582 Gene

Molecular function for ZNF582 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF582 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF582: view

Phenotypes for ZNF582 Gene

GenomeRNAi human phenotypes for ZNF582:
genes like me logo Genes that share phenotypes with ZNF582: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF582 Gene

Localization for ZNF582 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF582 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF582 Gene COMPARTMENTS Subcellular localization image for ZNF582 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF582 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF582: view

Pathways for ZNF582 Gene

SuperPathways for ZNF582 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF582: view

Pathways by source for ZNF582 Gene

2 Reactome pathways for ZNF582 Gene

Interacting Proteins for ZNF582 Gene

Gene Ontology (GO) - Biological Process for ZNF582 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF582: view

Transcripts for ZNF582 Gene

Unigene Clusters for ZNF582 Gene

Zinc finger protein 582:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF582 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2:
SP3: -

Relevant External Links for ZNF582 Gene

GeneLoc Exon Structure for
ZNF582
ECgene alternative splicing isoforms for
ZNF582

Expression for ZNF582 Gene

mRNA expression in normal human tissues for ZNF582 Gene

SOURCE GeneReport for Unigene cluster for ZNF582 Gene Hs.244391

genes like me logo Genes that share expressions with ZNF582: view

Orthologs for ZNF582 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF582 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF582 36
  • 99.55 (n)
  • 99.42 (a)
ZNF582 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF582 36
  • 89.23 (n)
  • 87.43 (a)
dog
(Canis familiaris)
Mammalia ZNF582 37
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6654 37
  • 21 (a)
OneToMany
Species with no ortholog for ZNF582:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF582 Gene

ENSEMBL:
Gene Tree for ZNF582 (if available)
TreeFam:
Gene Tree for ZNF582 (if available)

Paralogs for ZNF582 Gene

Selected SIMAP similar genes for ZNF582 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF582: view

Variants for ZNF582 Gene

Sequence variations from dbSNP and Humsavar for ZNF582 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs740868 -- 56,382,697(-) atata(A/G)TATCT downstream-variant-500B, intron-variant
rs1017102 -- 56,381,263(+) AACTT(A/C)TTGAG intron-variant
rs2215410 -- 56,391,088(+) GAAAC(A/G)ACTGA intron-variant
rs2288860 -- 56,390,251(+) GCCGA(A/C)AGCGC intron-variant
rs2304127 -- 56,385,205(+) AGCGA(A/G)TATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF582 Gene

Variant ID Type Subtype PubMed ID
nsv912516 CNV Gain 21882294

Relevant External Links for ZNF582 Gene

HapMap Linkage Disequilibrium report
ZNF582
Human Gene Mutation Database (HGMD)
ZNF582

Disorders for ZNF582 Gene

No disorders were found for ZNF582 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF582 Gene

Publications for ZNF582 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Methylomic analysis identifies frequent DNA methylation of zinc finger protein 582 (ZNF582) in cervical neoplasms. (PMID: 22815913) Huang R.L. … Lai H.C. (PLoS ONE 2012) 2 3
  4. High Methylation Rate of LMX1A, NKX6-1, PAX1, PTPRR, SOX1, and ZNF582 Genes in Cervical Adenocarcinoma. (PMID: 24407576) Chang C.C. … Lai H.C. (Int. J. Gynecol. Cancer 2014) 3
  5. Methylated ZNF582 gene as a marker for triage of women with Pap smear reporting low-grade squamous intraepithelial lesions - a Taiwanese Gynecologic Oncology Group (TGOG) study. (PMID: 25134998) Lin H. … Yu M.H. (Gynecol. Oncol. 2014) 3

Products for ZNF582 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF582
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF582
    • Block miRNA regulation of ZNF582 using miScript Target Protectors

    Sources for ZNF582 Gene

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