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Aliases for ZNF581 Gene

Aliases for ZNF581 Gene

  • Zinc Finger Protein 581 2 3
  • HSPC189 3

External Ids for ZNF581 Gene

Summaries for ZNF581 Gene

GeneCards Summary for ZNF581 Gene

ZNF581 (Zinc Finger Protein 581) is a Protein Coding gene. An important paralog of this gene is ZNF524.

UniProtKB/Swiss-Prot for ZNF581 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF581 Gene

Genomics for ZNF581 Gene

Genomic Location for ZNF581 Gene

55,635,459 bp from pter
55,645,623 bp from pter
10,165 bases
Plus strand

Genomic View for ZNF581 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF581 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF581 Gene

Regulatory Elements for ZNF581 Gene

Proteins for ZNF581 Gene

  • Protein details for ZNF581 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 581
    Protein Accession:
    Secondary Accessions:
    • B2RDM6

    Protein attributes for ZNF581 Gene

    197 amino acids
    Molecular mass:
    22010 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF581 Gene

Proteomics data for ZNF581 Gene at MOPED

Post-translational modifications for ZNF581 Gene

No Post-translational modifications

Other Protein References for ZNF581 Gene

No data available for DME Specific Peptides for ZNF581 Gene

Domains for ZNF581 Gene

Gene Families for ZNF581 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF581 Gene


  • Contains 4 C2H2-type zinc fingers.:
    • Q9P0T4
genes like me logo Genes that share domains with ZNF581: view

Function for ZNF581 Gene

Molecular function for ZNF581 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF581 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF581: view

miRNA for ZNF581 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF581 Gene

Localization for ZNF581 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF581 Gene

Subcellular locations from

Jensen Localization Image for ZNF581 Gene COMPARTMENTS Subcellular localization image for ZNF581 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF581 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF581: view

Pathways for ZNF581 Gene

SuperPathways for ZNF581 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF581 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF581: view

No data available for Pathways by source for ZNF581 Gene

Transcripts for ZNF581 Gene

Unigene Clusters for ZNF581 Gene

Zinc finger protein 581:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF581 Gene

No ASD Table

Relevant External Links for ZNF581 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF581 Gene

mRNA expression in normal human tissues for ZNF581 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF581 Gene

SOURCE GeneReport for Unigene cluster for ZNF581 Gene Hs.20768

genes like me logo Genes that share expressions with ZNF581: view

Orthologs for ZNF581 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF581 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF581 36
  • 97.59 (n)
  • 95.88 (a)
ZNF581 37
  • 94 (a)
(Bos Taurus)
Mammalia ZNF581 36
  • 85.96 (n)
  • 86.29 (a)
ZNF581 37
  • 86 (a)
(Canis familiaris)
Mammalia ZNF581 37
  • 88 (a)
(Monodelphis domestica)
Mammalia ZNF581 37
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 12 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 23 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730373 36
  • 60.56 (n)
  • 58.45 (a)
(Danio rerio)
Actinopterygii ZNF581 37
  • 13 (a)
Species with no ortholog for ZNF581:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF581 Gene

Gene Tree for ZNF581 (if available)
Gene Tree for ZNF581 (if available)

Paralogs for ZNF581 Gene

Paralogs for ZNF581 Gene

Selected SIMAP similar genes for ZNF581 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF581: view

Variants for ZNF581 Gene

Sequence variations from dbSNP and Humsavar for ZNF581 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1045630 -- 55,645,530(+) GGCTT(C/T)TGCGC utr-variant-3-prime
rs11084406 -- 55,645,081(+) GGGGA(A/G)CGCCC reference, synonymous-codon
rs12982230 -- 55,644,641(+) GCCCT(C/T)CCCGT reference, missense
rs36031918 -- 55,644,388(+) CCTTT(-/T)AGGGG intron-variant
rs73062519 -- 55,644,002(+) AGGCC(C/G)GGCGA intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF581 Gene

Variant ID Type Subtype PubMed ID
dgv4025n71 CNV Loss 21882294
nsv912500 CNV Loss 21882294
nsv912501 CNV Loss 21882294
nsv2553 CNV Insertion 18451855
nsv912503 CNV Loss 21882294
nsv912504 CNV Loss 21882294

Relevant External Links for ZNF581 Gene

HapMap Linkage Disequilibrium report

Disorders for ZNF581 Gene

Relevant External Links for ZNF581

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with ZNF581: view

No data available for UniProtKB/Swiss-Prot for ZNF581 Gene

Publications for ZNF581 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3

Products for ZNF581 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF581
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF581
    • Block miRNA regulation of ZNF581 using miScript Target Protectors

    Sources for ZNF581 Gene

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