ZNF581 Gene
protein-coding GIFtS: 43
GCID: GC19P056154
|
|
zinc finger protein 581
| |
Aliases
for ZNF581 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 5811 2 | | FLJ225501 | | HSPC1891 |
Export aliases for ZNF581 gene to outside databasesPrevious GC identifers: GC19P060847 GC19P060849 GC19P052465 |
Summaries
for ZNF581 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN581_HUMAN, Q9P0T4Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF581 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF581 gene promoter:
E2F-4 E2F-3a Spz1 E2F-5 E2F-2 Tal-1beta E2F E2F-1 PPAR-gamma2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF581
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF581 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.42 Ensembl cytogenetic band: 19q13.42 HGNC chromosome: 19ZNF581 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P056154: view genomic region
(about GC identifiers)
Start:
|
56,146,825 bp from pter |
End:
|
56,156,989 bp from pter |
Size:
|
10,165 bases |
Orientation:
|
plus strand |
|
Proteins
for ZNF581 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN581_HUMAN, Q9P0T4 (See
protein sequence)Recommended Name: Zinc finger protein 581 Size: 197 amino acids; 22010 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B2RDM6Explore the universe of human proteins at neXtProt for ZNF581: NX_Q9P0T4
ZNF581 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057619.1
ENSEMBL proteins: ENSP00000466047 ENSP00000466338 ENSP00000270451 ENSP00000466564
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF581 for ontologies About GeneDecksing
ZNF581 Antibody Products:
Assay Products for ZNF581: |
Protein
Domains /
Families
for ZNF581 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF581 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9P0T4ProtoNet protein and cluster: Q9P0T4 1 Blocks protein family: IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN581_HUMAN, Q9P0T4Similarity: Contains 4 C2H2-type zinc fingers |
Function
for ZNF581 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN581_HUMAN, Q9P0T4Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF581
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF581
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF581 (NM_016535) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF581 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF581 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF581 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF581 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF581 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF581
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/13 Interacting proteins for ZNF581 (Q9P0T42, 3 ENSP000002704514) via UniProtKB, MINT, STRING, and/or I2D (see all 13)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| RBPMS | Q930622, 3, ENSP000003401764 | MINT-66946 I2D:
score=5 STRING: ENSP00000340176 | | DAZAP2 | Q150382, 3, ENSP000004049684 | MINT-66802 I2D:
score=4 STRING: ENSP00000404968 | | HNRNPC | P079102, 3, ENSP000003196904 | MINT-67435 I2D:
score=4 STRING: ENSP00000319690 | | TRIM23 | P364062, 3, ENSP000002315244 | MINT-67743 I2D:
score=5 STRING: ENSP00000231524 | | KRTAP4-12 | Q9BQ662, 3, ENSP000003775824 | MINT-68012 I2D:
score=5 STRING: ENSP00000377582 |
About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF581 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF581 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF581
Search CenterWatch for drugs/clinical trials and news about ZNF581 / ZN581
|
Transcripts
for ZNF581 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF581 gene: NM_016535.3 Unigene Cluster for ZNF581: Zinc finger protein 581 Hs.20768 [show with all ESTs]Unigene Representative Sequence: BC0716204 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000587252 ENST00000585995 ENST00000270451(uc002qln.3 uc002qlq.3)
ENST00000588537
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF581
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF581
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF581 (NM_016535) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF581 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF581 |
Additional cDNA sequence: AF151023.2 AK026203.1 AK315603.1 BC001219.1 BC010097.2 BC071620.1 BC071845.1 3 DOTS entries: DT.214955 DT.91707473 DT.75152690 24/374 AceView cDNA sequences (see all 374): BU632370 BC010097 CR608767 CR619004 CR604697 CR601401 BM712801 CR597631 NM_207115 NM_016535 CR609067 CA415470 CD674137 CR622650 AI679948 BC001219 AI540673 CB129949 BM998114 CR609477 BQ477323 BF058512 BM925190 BM931984
GeneLoc Exon Structure
|
Expression
for ZNF581 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF581 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAGAGCCTT
About this image
See ZNF581 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF581
SOURCE GeneReport for Unigene cluster: Hs.20768
SABiosciences Custom PCR Arrays for ZNF581
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF581
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF581 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF581 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF581 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF581 |
Orthologs
for ZNF581 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF581 gene from 2/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
13(a) |
1 → many |
GL343279.1(637229-650798) |
zebrafish
(Danio rerio) |
Actinopterygii |
BX323458.16 |
-- |
9(a) |
1 → many |
16(15308342-15311002) |
Species with no ortholog for ZNF581
ENSEMBL Gene Tree for ZNF581 (if available)
TreeFam Gene Tree for ZNF581 (if available) |
Paralogs
for ZNF581 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF581 gene
- ZNF7682 ZNF7872 ZNF3582 ZNF5242 ZNF5752 ZNF5802 ZNF702
18/446 SIMAP similar genes for ZNF581 using alignment to 2 protein entries: ZN581_HUMAN (see all proteins)
(see all similar genes):ZNF78L1 A-328A3.4 ZFS-1 ZNF286B ZNF85 DKFZp547L155
ZFS-6 ZNF16 ZNF729 ZNF92 ZKSCAN7 ZNF167
ZNF429 ZNF43 ZNF546 ZNF675 ZNF83 ZNF93
ZNF581 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF581 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF581 (56146825 - 56156989 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF581: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF581 |
|
Disorders
/ Diseases
for ZNF581 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF581 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF581 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF581) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF581 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF581 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF581 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF581 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF581 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF581 gene:
Search GeneIP for patents involving ZNF581
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF581 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF581 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF581 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF581 | | | OriGene Protein Over-expression Lysate for ZNF581 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF581 | | OriGene 3'-UTR Clone for ZNF581 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF581 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF581 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ZNF581 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF581 | | OriGene Custom Protein Services for ZNF581 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF581 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF581 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF581 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF581 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF581 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF581 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ZNF581 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ZNF581 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF581 |
|  |  |  | | | | ThermoFisher Antibodies for ZNF581 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF581 |
|
|
|
|
