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Aliases for ZNF581 Gene

Aliases for ZNF581 Gene

  • Zinc Finger Protein 581 2 3 5
  • HSPC189 3

External Ids for ZNF581 Gene

Previous GeneCards Identifiers for ZNF581 Gene

  • GC19P060847
  • GC19P060849
  • GC19P056154
  • GC19P052465

Summaries for ZNF581 Gene

GeneCards Summary for ZNF581 Gene

ZNF581 (Zinc Finger Protein 581) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is FIZ1.

UniProtKB/Swiss-Prot for ZNF581 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF581 Gene

Genomics for ZNF581 Gene

Regulatory Elements for ZNF581 Gene

Enhancers for ZNF581 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF581 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF581 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF581 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF581 Gene

55,635,459 bp from pter
55,645,623 bp from pter
10,165 bases
Plus strand

Genomic View for ZNF581 Gene

Genes around ZNF581 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF581 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF581 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF581 Gene

Proteins for ZNF581 Gene

  • Protein details for ZNF581 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 581
    Protein Accession:
    Secondary Accessions:
    • B2RDM6

    Protein attributes for ZNF581 Gene

    197 amino acids
    Molecular mass:
    22010 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF581 Gene

Proteomics data for ZNF581 Gene at MOPED

Post-translational modifications for ZNF581 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF581 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF581 Gene

Domains & Families for ZNF581 Gene

Gene Families for ZNF581 Gene

Protein Domains for ZNF581 Gene

Suggested Antigen Peptide Sequences for ZNF581 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 C2H2-type zinc fingers.
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF581: view

Function for ZNF581 Gene

Molecular function for ZNF581 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF581: view

Animal Model Products

CRISPR Products

miRNA for ZNF581 Gene

miRTarBase miRNAs that target ZNF581

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF581 Gene

Localization for ZNF581 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF581 Gene

Subcellular locations from

Jensen Localization Image for ZNF581 Gene COMPARTMENTS Subcellular localization image for ZNF581 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF581 Gene

Pathways & Interactions for ZNF581 Gene

SuperPathways for ZNF581 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF581 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZNF581 Gene

Drugs & Compounds for ZNF581 Gene

No Compound Related Data Available

Transcripts for ZNF581 Gene

Unigene Clusters for ZNF581 Gene

Zinc finger protein 581:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF581 Gene

No ASD Table

Relevant External Links for ZNF581 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF581 Gene

mRNA expression in normal human tissues for ZNF581 Gene

Protein differential expression in normal tissues from HIPED for ZNF581 Gene

This gene is overexpressed in CD8 Tcells (45.8) and Fetal ovary (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF581 Gene

SOURCE GeneReport for Unigene cluster for ZNF581 Gene Hs.20768

genes like me logo Genes that share expression patterns with ZNF581: view

Protein tissue co-expression partners for ZNF581 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF581 Gene

Orthologs for ZNF581 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF581 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF581 35
  • 85.96 (n)
  • 86.29 (a)
ZNF581 36
  • 86 (a)
(Pan troglodytes)
Mammalia ZNF581 35
  • 97.59 (n)
  • 95.88 (a)
ZNF581 36
  • 94 (a)
(Canis familiaris)
Mammalia ZNF581 36
  • 88 (a)
(Monodelphis domestica)
Mammalia ZNF581 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 12 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730373 35
  • 60.56 (n)
  • 58.45 (a)
(Danio rerio)
Actinopterygii ZNF581 36
  • 13 (a)
Species with no ortholog for ZNF581:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF581 Gene

Gene Tree for ZNF581 (if available)
Gene Tree for ZNF581 (if available)

Paralogs for ZNF581 Gene

Paralogs for ZNF581 Gene

(439) SIMAP similar genes for ZNF581 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF581: view

Variants for ZNF581 Gene

Sequence variations from dbSNP and Humsavar for ZNF581 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12982230 -- 55,644,641(+) GCCCT(C/T)CCCGT reference, missense
rs1045630 -- 55,645,530(+) GGCTT(C/T)TGCGC utr-variant-3-prime
rs139893945 -- 55,644,998(+) GTGGG(C/T)GGCCC reference, missense
rs140278783 -- 55,644,775(+) GTGGA(C/T)GAGGA reference, synonymous-codon
rs73062519 -- 55,644,002(+) AGGCC(C/G)GGCGA intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF581 Gene

Variant ID Type Subtype PubMed ID
dgv4025n71 CNV Loss 21882294
nsv912500 CNV Loss 21882294
nsv912501 CNV Loss 21882294
nsv2553 CNV Insertion 18451855
nsv912503 CNV Loss 21882294
nsv912504 CNV Loss 21882294

Variation tolerance for ZNF581 Gene

Residual Variation Intolerance Score: 39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.13% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF581 Gene

Disorders for ZNF581 Gene

Relevant External Links for ZNF581

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF581 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF581 Gene

Publications for ZNF581 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for ZNF581 Gene

Sources for ZNF581 Gene