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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF581 Gene

protein-coding   GIFtS: 45
GCID: GC19P056154

Zinc Finger Protein 581

  Search for ZNF581
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 5811 2

External Ids:    HGNC: 250171   Entrez Gene: 515452   Ensembl: ENSG000001714257   UniProtKB: Q9P0T43   

Export aliases for ZNF581 gene to outside databases

Previous GC identifers: GC19P060847 GC19P060849 GC19P052465


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF581 Gene: 
ZNF581 (zinc finger protein 581) is a protein-coding gene. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF362.

UniProtKB/Swiss-Prot: ZN581_HUMAN, Q9P0T4
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF581 gene promoter:
         E2F-4   E2F-3a   Spz1   E2F-5   E2F-2   Tal-1beta   E2F   E2F-1   PPAR-gamma2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF581 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF581

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF581


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

ZNF581 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF581 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P056154:  view genomic region     (about GC identifiers)

Start:
56,146,825 bp from pter      End:
56,156,989 bp from pter
Size:
10,165 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN581_HUMAN, Q9P0T4 (See protein sequence)
Recommended Name: Zinc finger protein 581  
Size: 197 amino acids; 22010 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B2RDM6

Explore the universe of human proteins at neXtProt for ZNF581: NX_Q9P0T4

Explore proteomics data for ZNF581 at MOPED 

ZNF581 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

ZNF581 Protein Expression

REFSEQ proteins: NP_057619.1  
ENSEMBL proteins: 
 ENSP00000466047   ENSP00000466338   ENSP00000270451   ENSP00000466564  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

ZNF581 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ZNF: Zinc fingers, C2H2-type

3 InterPro protein domains:
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q9P0T4

ProtoNet protein and cluster: Q9P0T4

1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN581_HUMAN, Q9P0T4
Similarity: Contains 4 C2H2-type zinc fingers


ZNF581 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZN581_HUMAN, Q9P0T4
Function: May be involved in transcriptional regulation

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding ----
GO:0003677DNA binding IEA--
GO:0008270zinc ion binding ----
GO:0046872metal ion binding IEA--
     
ZNF581 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF581

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/13 Interacting proteins for ZNF581 (Q9P0T42, 3 ENSP000002704514) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
InteractantInteraction Details
GeneCardExternal ID(s)
RBPMSQ930622, 3, ENSP000003401764MINT-66946 I2D: score=5 STRING: ENSP00000340176
DAZAP2Q150382, 3, ENSP000004049684MINT-66802 I2D: score=4 STRING: ENSP00000404968
HNRNPCP079102, 3, ENSP000003196904MINT-67435 I2D: score=4 STRING: ENSP00000319690
TRIM23P364062, 3, ENSP000002315244MINT-67743 I2D: score=5 STRING: ENSP00000231524
KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-68012 I2D: score=5 STRING: ENSP00000377582
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-dependent IEA--
GO:0006355regulation of transcription, DNA-dependent IEA--

ZNF581 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF581 (ZN581)

Search CenterWatch for drugs/clinical trials and news about ZNF581 / ZN581

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF581 gene: 
NM_016535.3  

Unigene Cluster for ZNF581:

Zinc finger protein 581
Hs.20768  [show with all ESTs]
Unigene Representative Sequence: BC071620
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000587252 ENST00000585995 ENST00000270451(uc002qln.3 uc002qlq.3)
ENST00000588537
miRNA
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Inhib. RNA
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF581

Additional mRNA sequence: 

AF151023.2 AK026203.1 AK315603.1 BC001219.1 BC010097.2 BC071620.1 BC071845.1 

3 DOTS entries:

DT.214955  DT.91707473  DT.75152690 

24/374 AceView cDNA sequences (see all 374):

BI909057 BU947898 BM925190 AI246907 NM_016202 BU957315 BM768406 AI540673 
AA809976 BU902332 CB129949 BU632370 BC071620 AI679440 AI864430 CR601401 
BM811442 BM998114 BM710177 BQ774311 CR619004 NM_207115 BC071845 AJ713243 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF581 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCAGAGCCTT
ZNF581 Expression
About this image


See ZNF581 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF581

SOURCE GeneReport for Unigene cluster: Hs.20768
    SABiosciences Custom PCR Arrays for ZNF581
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF581
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF581

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZNF581 gene from 3/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia ZNF5811 zinc finger protein 581 86.46(n)
88.83(a)
  611254  XM_848896.1  XP_853989.1 
lizard
(Anolis carolinensis)
Reptilia --
ZNF8656
Uncharacterized protein
21(a)
13(a)
many ↔ many
many ↔ many
GL343279.1(624270-625394)
GL343279.1(637229-650798)
zebrafish
(Danio rerio)
Actinopterygii BX323458.16
Uncharacterized protein
8(a)
1 → many
16(15308342-15311002)


ENSEMBL Gene Tree for ZNF581 (if available)
TreeFam Gene Tree for ZNF581 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ZNF581 gene
ZNF3622  ZNF5802  ZNF5242  ZNF3842  
18/440 SIMAP similar genes for ZNF581 using alignment to 2 protein entries:     ZN581_HUMAN (see all proteins) (see all similar genes):
ZNF78L1    A-328A3.4    ZFS-1    ZNF286B    DKFZp547L155    ZFS-6
ZNF16    ZNF729    ZNF92    ZNF167    ZNF429    ZNF43
ZNF546    ZNF675    ZNF83    ZNF93    ZNF99    ZNF85

ZNF581 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/48 SNPs in ZNF581 are shown (see all 48)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs730625191,2
--56155368(+) AGGCCC/GGGCGA 1 -- int10--------
rs1931550751,2
--56155666(+) GCAGAA/GGAGGT 1 -- int10--------
rs1847879061,2
--56155865(+) CTGTGG/TTGCTG 1 -- int10--------
rs1895341361,2
C--56155904(+) TCCCAG/TCTCCC 1 -- int10--------
rs1437251291,2
C,F--56156032(+) CCCAGA/CACCTG 2 E A mis11Minor allele frequency- C:0.00NA 4448
rs2006666901,2
--56156040(+) CTGGAC/GCTTCC 2 P A mis10--------
rs1471500851,2
C--56156086(+) AAGGCC/TCAACC 2 P L mis11Minor allele frequency- T:0.00NA 4542
rs1402787831,2
F--56156141(+) GTGGAC/TGAGGA 2 D syn11Minor allele frequency- T:0.00NA 4546
rs2001209181,2
--56156147(+) GAGGAA/GTCACA 2 E syn10--------
rs1506929941,2
C,F--56156348(+) ATTCAC/TCTGGC 2 H syn12Minor allele frequency- T:0.01NA EU 5561

HapMap Linkage Disequilibrium report for ZNF581 (56146825 - 56156989 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for ZNF581:    About this table     
Variant IDTypeSubtypePubMed ID
nsv2553CNV Insertion18451855
nsv912504CNV Loss21882294
nsv912501CNV Loss21882294
nsv912500CNV Loss21882294
nsv912503CNV Loss21882294
dgv4025n71CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF581 for disorders           About MalaCards

ZNF581 for disorders           About GeneDecksing

Genetic Association Database (GAD): ZNF581

Export disorders for ZNF581 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ZNF581 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF581)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
  4. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 51545 HGNC: 25017 AceView: HSU79303andZNF580andZNF581 Ensembl:ENSG00000171425 euGenes: HUgn51545
ECgene: ZNF581 H-InvDB: ZNF581

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ZNF581 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for ZNF581 gene:
Search GeneIP for patents involving ZNF581

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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